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Conserved domains on  [gi|13376200|ref|NP_079088|]
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brain and acute leukemia cytoplasmic protein isoform 1 [Homo sapiens]

Protein Classification

BAALC_N domain-containing protein( domain architecture ID 10536972)

BAALC_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAALC_N pfam06989
BAALC N-terminus; This family represents the N-terminal region of the mammalian BAALC proteins. ...
 1-50 8.09e-28

BAALC N-terminus; This family represents the N-terminal region of the mammalian BAALC proteins. BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organizms. Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumours or cancer cell lines of non-neural tissue origin. It has been shown that blasts from a subset of patients with acute leukaemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms. Among patients with acute myeloid leukaemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukaemia. It has been suggested that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.


:

Pssm-ID: 369161  Cd Length: 50  Bit Score: 97.47  E-value: 8.09e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 13376200     1 MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGG 50
Cdd:pfam06989   1 MGCGGSRADAIEPRYYESWTRETESTWLTSTDSELPPSSIQASSGSEAGG 50
 
Name Accession Description Interval E-value
BAALC_N pfam06989
BAALC N-terminus; This family represents the N-terminal region of the mammalian BAALC proteins. ...
 1-50 8.09e-28

BAALC N-terminus; This family represents the N-terminal region of the mammalian BAALC proteins. BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organizms. Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumours or cancer cell lines of non-neural tissue origin. It has been shown that blasts from a subset of patients with acute leukaemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms. Among patients with acute myeloid leukaemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukaemia. It has been suggested that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.


Pssm-ID: 369161  Cd Length: 50  Bit Score: 97.47  E-value: 8.09e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 13376200     1 MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGG 50
Cdd:pfam06989   1 MGCGGSRADAIEPRYYESWTRETESTWLTSTDSELPPSSIQASSGSEAGG 50
 
Name Accession Description Interval E-value
BAALC_N pfam06989
BAALC N-terminus; This family represents the N-terminal region of the mammalian BAALC proteins. ...
 1-50 8.09e-28

BAALC N-terminus; This family represents the N-terminal region of the mammalian BAALC proteins. BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organizms. Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumours or cancer cell lines of non-neural tissue origin. It has been shown that blasts from a subset of patients with acute leukaemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms. Among patients with acute myeloid leukaemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukaemia. It has been suggested that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.


Pssm-ID: 369161  Cd Length: 50  Bit Score: 97.47  E-value: 8.09e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 13376200     1 MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSAAAPDSGPEAGG 50
Cdd:pfam06989   1 MGCGGSRADAIEPRYYESWTRETESTWLTSTDSELPPSSIQASSGSEAGG 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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