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Conserved domains on  [gi|158854007|ref|NP_079687|]
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PITH domain-containing protein 1 [Mus musculus]

Protein Classification

PITH domain-containing protein( domain architecture ID 10533196)

PITH (Proteasome-Interacting THioredoxin) domain-containing protein similar to human PITH domain-containing protein 1 (PITHD1) that promotes megakaryocyte differentiation by up-regulating RUNX1 expression

CATH:  2.60.120.470

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PITH pfam06201
PITH domain; This family was formerly known as DUF1000. The full-length, Txnl1, protein which ...
 31-175 4.18e-59

PITH domain; This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.


:

Pssm-ID: 461848  Cd Length: 148  Bit Score: 182.41  E-value: 4.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158854007   31 LYLRIDLERLQCLNESREGSGRGvFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGVIIMG---EDDDSHPSEMRL 107
Cdd:pfam06201   1 LYSYIDLDKVECLNEDDEGSGKR-FKPWDERLDDDKYLESDADEQLLIHIPFTGPVKLHSILIRTgtsSEEGSAPKTIKL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158854007  108 YKNIPQM-SFDDTerEPEQTFSLN-RDITGELEYATKISRFSNVYHLSIHISKN-FGADTTKIFYIGLRGE 175
Cdd:pfam06201  80 FINRRDNlDFDDA--EPTQEIELTeEDDDGVVEYPLRFVKFQNVSSLTLFFEDNnGGDDVTRIYYIGLRGE 148
 
Name Accession Description Interval E-value
PITH pfam06201
PITH domain; This family was formerly known as DUF1000. The full-length, Txnl1, protein which ...
 31-175 4.18e-59

PITH domain; This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.


Pssm-ID: 461848  Cd Length: 148  Bit Score: 182.41  E-value: 4.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158854007   31 LYLRIDLERLQCLNESREGSGRGvFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGVIIMG---EDDDSHPSEMRL 107
Cdd:pfam06201   1 LYSYIDLDKVECLNEDDEGSGKR-FKPWDERLDDDKYLESDADEQLLIHIPFTGPVKLHSILIRTgtsSEEGSAPKTIKL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158854007  108 YKNIPQM-SFDDTerEPEQTFSLN-RDITGELEYATKISRFSNVYHLSIHISKN-FGADTTKIFYIGLRGE 175
Cdd:pfam06201  80 FINRRDNlDFDDA--EPTQEIELTeEDDDGVVEYPLRFVKFQNVSSLTLFFEDNnGGDDVTRIYYIGLRGE 148
 
Name Accession Description Interval E-value
PITH pfam06201
PITH domain; This family was formerly known as DUF1000. The full-length, Txnl1, protein which ...
 31-175 4.18e-59

PITH domain; This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.


Pssm-ID: 461848  Cd Length: 148  Bit Score: 182.41  E-value: 4.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158854007   31 LYLRIDLERLQCLNESREGSGRGvFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGVIIMG---EDDDSHPSEMRL 107
Cdd:pfam06201   1 LYSYIDLDKVECLNEDDEGSGKR-FKPWDERLDDDKYLESDADEQLLIHIPFTGPVKLHSILIRTgtsSEEGSAPKTIKL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158854007  108 YKNIPQM-SFDDTerEPEQTFSLN-RDITGELEYATKISRFSNVYHLSIHISKN-FGADTTKIFYIGLRGE 175
Cdd:pfam06201  80 FINRRDNlDFDDA--EPTQEIELTeEDDDGVVEYPLRFVKFQNVSSLTLFFEDNnGGDDVTRIYYIGLRGE 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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