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Conserved domains on  [gi|123701962|ref|NP_080995|]
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lysosomal cobalamin transport escort protein LMBD1 isoform 1 [Mus musculus]

Protein Classification

LMBR1 domain-containing protein( domain architecture ID 6330)

LMBR1 domain-containing protein similar to fungal lysosomal cobalamin transporter that is required to export cobalamin from lysosomes allowing its conversion to cofactors

Gene Ontology:  GO:0007165

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LMBR1 super family cl04754
LMBR1-like membrane protein; Members of this family are integral membrane proteins that are ...
14-398 1.90e-12

LMBR1-like membrane protein; Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.


The actual alignment was detected with superfamily member pfam04791:

Pssm-ID: 461429  Cd Length: 471  Bit Score: 69.22  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962   14 IFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQI--E 91
Cdd:pfam04791   4 IFLLLFLLLFLLSLYLLRRYGRPKDVPAYVKLLVFLALALSFLIVLLLPLDIASTAYRQSSNSNEVLLYPCSYYWSWlpS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962   92 NTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKC--TQIKTALKYTLGFVVICALLLLVGAFVPLHLpnnnnst 169
Cdd:pfam04791  84 SLLLVLWRIVYWLSFLLTWLILPFMQFYSESGDFTGKGKLkrSLKENAIYYGLLLVIVLGLLIYLLILPGESL------- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  170 ewekvkllfedlgTGQGLAALSFSISSltLIGMLAAITYTAYGMSALPLNLIkGTRSTAY--------------ERLENT 235
Cdd:pfam04791 157 -------------LLRSLKPFLISLAN--TWGLFLLIILLGYGLVELPRSLW-RASNLGErlkrlyfkaaklntEKEEAE 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  236 EDIEEVEQHIQTIRSKSKDG----------------------RPLPARDRRALKQCEERLRTLRKRERHL-EFIENSWWT 292
Cdd:pfam04791 221 RELEDLLKQVSLLSQSISSSdlrdyietilnkvpeeitepseKSLASLHKQLIRALQRRLRTEDQWRKLLkKAFRLSKLT 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  293 K------FCGALRPLKIIWGIFFILVALLFVISLFlsnldkalhsagidsGFIIFGTNLSNPLNMLLPLLQTVFPLDYI- 365
Cdd:pfam04791 301 PtleyywYCLLLPYVLLILSVILALLSVIVVWSEL---------------TFFLIKPVLSLFALFIGLHASSSFGYFGIe 365
                         410       420       430
                  ....*....|....*....|....*....|....
gi 123701962  366 -LITIIIMYFIFTSMAGIRNIGIWFFwIRLYKIR 398
Cdd:pfam04791 366 lIEIIFILYLCLCAYSGLFKIKVFGF-YRLVPHH 398
 
Name Accession Description Interval E-value
LMBR1 pfam04791
LMBR1-like membrane protein; Members of this family are integral membrane proteins that are ...
14-398 1.90e-12

LMBR1-like membrane protein; Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.


Pssm-ID: 461429  Cd Length: 471  Bit Score: 69.22  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962   14 IFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQI--E 91
Cdd:pfam04791   4 IFLLLFLLLFLLSLYLLRRYGRPKDVPAYVKLLVFLALALSFLIVLLLPLDIASTAYRQSSNSNEVLLYPCSYYWSWlpS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962   92 NTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKC--TQIKTALKYTLGFVVICALLLLVGAFVPLHLpnnnnst 169
Cdd:pfam04791  84 SLLLVLWRIVYWLSFLLTWLILPFMQFYSESGDFTGKGKLkrSLKENAIYYGLLLVIVLGLLIYLLILPGESL------- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  170 ewekvkllfedlgTGQGLAALSFSISSltLIGMLAAITYTAYGMSALPLNLIkGTRSTAY--------------ERLENT 235
Cdd:pfam04791 157 -------------LLRSLKPFLISLAN--TWGLFLLIILLGYGLVELPRSLW-RASNLGErlkrlyfkaaklntEKEEAE 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  236 EDIEEVEQHIQTIRSKSKDG----------------------RPLPARDRRALKQCEERLRTLRKRERHL-EFIENSWWT 292
Cdd:pfam04791 221 RELEDLLKQVSLLSQSISSSdlrdyietilnkvpeeitepseKSLASLHKQLIRALQRRLRTEDQWRKLLkKAFRLSKLT 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  293 K------FCGALRPLKIIWGIFFILVALLFVISLFlsnldkalhsagidsGFIIFGTNLSNPLNMLLPLLQTVFPLDYI- 365
Cdd:pfam04791 301 PtleyywYCLLLPYVLLILSVILALLSVIVVWSEL---------------TFFLIKPVLSLFALFIGLHASSSFGYFGIe 365
                         410       420       430
                  ....*....|....*....|....*....|....
gi 123701962  366 -LITIIIMYFIFTSMAGIRNIGIWFFwIRLYKIR 398
Cdd:pfam04791 366 lIEIIFILYLCLCAYSGLFKIKVFGF-YRLVPHH 398
 
Name Accession Description Interval E-value
LMBR1 pfam04791
LMBR1-like membrane protein; Members of this family are integral membrane proteins that are ...
14-398 1.90e-12

LMBR1-like membrane protein; Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.


Pssm-ID: 461429  Cd Length: 471  Bit Score: 69.22  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962   14 IFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQI--E 91
Cdd:pfam04791   4 IFLLLFLLLFLLSLYLLRRYGRPKDVPAYVKLLVFLALALSFLIVLLLPLDIASTAYRQSSNSNEVLLYPCSYYWSWlpS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962   92 NTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKC--TQIKTALKYTLGFVVICALLLLVGAFVPLHLpnnnnst 169
Cdd:pfam04791  84 SLLLVLWRIVYWLSFLLTWLILPFMQFYSESGDFTGKGKLkrSLKENAIYYGLLLVIVLGLLIYLLILPGESL------- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  170 ewekvkllfedlgTGQGLAALSFSISSltLIGMLAAITYTAYGMSALPLNLIkGTRSTAY--------------ERLENT 235
Cdd:pfam04791 157 -------------LLRSLKPFLISLAN--TWGLFLLIILLGYGLVELPRSLW-RASNLGErlkrlyfkaaklntEKEEAE 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  236 EDIEEVEQHIQTIRSKSKDG----------------------RPLPARDRRALKQCEERLRTLRKRERHL-EFIENSWWT 292
Cdd:pfam04791 221 RELEDLLKQVSLLSQSISSSdlrdyietilnkvpeeitepseKSLASLHKQLIRALQRRLRTEDQWRKLLkKAFRLSKLT 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123701962  293 K------FCGALRPLKIIWGIFFILVALLFVISLFlsnldkalhsagidsGFIIFGTNLSNPLNMLLPLLQTVFPLDYI- 365
Cdd:pfam04791 301 PtleyywYCLLLPYVLLILSVILALLSVIVVWSEL---------------TFFLIKPVLSLFALFIGLHASSSFGYFGIe 365
                         410       420       430
                  ....*....|....*....|....*....|....
gi 123701962  366 -LITIIIMYFIFTSMAGIRNIGIWFFwIRLYKIR 398
Cdd:pfam04791 366 lIEIIFILYLCLCAYSGLFKIKVFGF-YRLVPHH 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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