NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|110625789|ref|NP_082318|]
View 

DNA excision repair protein ERCC-8 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 1.98e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  40 RIHGSGVNTLDIEPVeGRYMLSGGSDGVVVLYDLENasRQPHYTCKavcsvgrshpdVHKYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200    6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET--GELLRTLK-----------GHTGPVRDVAASADGTYLA-SGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 120 FDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRH 198
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 199 DYIlATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGD 278
Cdd:cd00200  148 TFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 279 --------NTLVNYGKVCNDSRkglqFAVSCGcssefvfvpHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELY 350
Cdd:cd00200  211 clgtlrghENGVNSVAFSPDGY----LLASGS---------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|.
gi 110625789 351 SGSRDCNILAW 361
Cdd:cd00200  278 SGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 1.98e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  40 RIHGSGVNTLDIEPVeGRYMLSGGSDGVVVLYDLENasRQPHYTCKavcsvgrshpdVHKYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200    6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET--GELLRTLK-----------GHTGPVRDVAASADGTYLA-SGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 120 FDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRH 198
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 199 DYIlATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGD 278
Cdd:cd00200  148 TFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 279 --------NTLVNYGKVCNDSRkglqFAVSCGcssefvfvpHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELY 350
Cdd:cd00200  211 clgtlrghENGVNSVAFSPDGY----LLASGS---------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|.
gi 110625789 351 SGSRDCNILAW 361
Cdd:cd00200  278 SGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
5-361 6.16e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789   5 LSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERIHGSGVNTLDIEPvEGRYMLSGGSDGVVVLYDLenASRQPHYTC 84
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL--ATGKLLRTL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  85 KAvcsvgrshpdvHKYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGT 163
Cdd:COG2319  159 TG-----------HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrHDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTA 243
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 244 HNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGD--NTLVNYGKVCND---SRKGLQFAVSCGcssefvfvphGSTIAV 318
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTLTGHTGAVRSvafSPDGKTLASGSD----------DGTVRL 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 110625789 319 YAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 9.75e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 9.75e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 110625789   175 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
176-215 2.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 110625789  176 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-281 2.58e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 172 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA----------------SGCLLT---LDQH 229
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwniKGNLLSgtcVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110625789 230 ----NGKKSQAAESANTaHNGKVNGLCFTSDGL-----HLLTIG-TDNRMR---LW---NSSSGDNTL 281
Cdd:PTZ00420 191 mhiiDPRKQEIASSFHI-HDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWdlkNTTSALVTM 257
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 1.98e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  40 RIHGSGVNTLDIEPVeGRYMLSGGSDGVVVLYDLENasRQPHYTCKavcsvgrshpdVHKYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200    6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET--GELLRTLK-----------GHTGPVRDVAASADGTYLA-SGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 120 FDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRH 198
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 199 DYIlATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGD 278
Cdd:cd00200  148 TFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 279 --------NTLVNYGKVCNDSRkglqFAVSCGcssefvfvpHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELY 350
Cdd:cd00200  211 clgtlrghENGVNSVAFSPDGY----LLASGS---------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|.
gi 110625789 351 SGSRDCNILAW 361
Cdd:cd00200  278 SGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
5-361 6.16e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789   5 LSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERIHGSGVNTLDIEPvEGRYMLSGGSDGVVVLYDLenASRQPHYTC 84
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL--ATGKLLRTL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  85 KAvcsvgrshpdvHKYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGT 163
Cdd:COG2319  159 TG-----------HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrHDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTA 243
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 244 HNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGD--NTLVNYGKVCND---SRKGLQFAVSCGcssefvfvphGSTIAV 318
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTLTGHTGAVRSvafSPDGKTLASGSD----------DGTVRL 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 110625789 319 YAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
42-273 4.63e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 4.63e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  42 HGSGVNTLDIEPvEGRYMLSGGSDGVVVLYDLenASRQPHYTckavcsvgrshPDVHKYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319  203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDL--ATGKLLRT-----------LTGHSGSVRSVAFSP-DGRLLASGSAD 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDY 200
Cdd:COG2319  268 GTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110625789 201 iLATASADSRVKLWDVRrASGCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWN 273
Cdd:COG2319  345 -LASGSDDGTVRLWDLA-TGELLRTL---------------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-273 6.35e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 6.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  42 HGSGVNTLDIEPvEGRYMLSGGSDGVVVLYDLENasrqphYTCKAVCsvgRSHPDvhkySVETVQWyPHDTGMFTSSSFD 121
Cdd:cd00200   92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET------GKCLTTL---RGHTD----WVNSVAF-SPDGTFVASSSQD 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrHDY 200
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGY 232

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110625789 201 ILATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWN 273
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGE-CVQTL---------------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
42-217 2.07e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 2.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  42 HGSGVNTLDIEPvEGRYMLSGGSDGVVVLYDLenASRQPHYTckavcsvgrshPDVHKYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319  245 HSGSVRSVAFSP-DGRLLASGSADGTVRLWDL--ATGELLRT-----------LTGHSGGVNSVAFSP-DGKLLASGSDD 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDY 200
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386

                        170
                 ....*....|....*..
gi 110625789 201 iLATASADSRVKLWDVR 217
Cdd:COG2319  387 -LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-361 2.29e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 178 CSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVRRASgCLLTLDQHNGKKSQAAESAN---------------- 241
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADgtylasgssdktirlw 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 242 -----------TAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGdntlvnygkVCNDSRKGLQFAVSCGCSSEF-VF 309
Cdd:cd00200   79 dletgecvrtlTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG---------KCLTTLRGHTDWVNSVAFSPDgTF 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110625789 310 VPHGS---TIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:cd00200  150 VASSSqdgTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 9.75e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 9.75e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 110625789   175 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
158-361 8.20e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 8.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRAsgCLLTLdqhngkksqaa 237
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA--LLATL----------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 238 esanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGdntlvnygkVCNDSRKGLQFAVSCgcsseFVFVPHGSTIA 317
Cdd:COG2319   75 ----LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---------LLLRTLTGHTGAVRS-----VAFSPDGKTLA 136

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110625789 318 ---------VYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:COG2319  137 sgsadgtvrLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 pfam00400
WD domain, G-beta repeat;
176-215 2.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 110625789  176 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-281 2.58e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 172 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA----------------SGCLLT---LDQH 229
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwniKGNLLSgtcVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110625789 230 ----NGKKSQAAESANTaHNGKVNGLCFTSDGL-----HLLTIG-TDNRMR---LW---NSSSGDNTL 281
Cdd:PTZ00420 191 mhiiDPRKQEIASSFHI-HDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWdlkNTTSALVTM 257
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 82-279 5.68e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 5.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  82 YTCKAVCSVGRshpDVHKYSVE--------TVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-AADVFNFEETVYSHHMSPA 152
Cdd:PLN00181 510 FECESIIKDGR---DIHYPVVElasrsklsGICWNSYIKSQVASSNFEGVVQVWDVARSQlVTEMKEHEKRVWSIDYSSA 586

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789 153 ATKhcLVAVGTRGPKVQLCDLKSGSCSHILQGhRQEILAVSWSPRHDYILATASADSRVKLWDVRRASGCLLTLdqhngk 232
Cdd:PLN00181 587 DPT--LLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTM------ 657

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 110625789 233 ksqaaesanTAHNGKVNGLCFTsDGLHLLTIGTDNRMRLWN---SSSGDN 279
Cdd:PLN00181 658 ---------IGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmSISGIN 697
WD40 COG2319
WD40 repeat [General function prediction only];
42-131 9.07e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 9.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625789  42 HGSGVNTLDIEPvEGRYMLSGGSDGVVVLYDLenASRQPHYTCKAvcsvgrshpdvHKYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319  329 HTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL--ATGELLRTLTG-----------HTGAVTSVAFSP-DGRTLASGSAD 393

                         90
                 ....*....|
gi 110625789 122 KTLKVWDTNT 131
Cdd:COG2319  394 GTVRLWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 173-218 3.03e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 3.03e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 110625789 173 LKSGSCSHI--LQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRR 218
Cdd:PTZ00421 110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 323-361 6.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 6.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 110625789   323 SGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-273 1.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.52e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110625789   242 TAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWN 273
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
324-361 1.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 110625789  324 GERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH