|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
28-441 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 567.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLRMVPCM-VVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:cd17399 81 IGAVIRVISSLpFVDPSFRFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 187 KKGEDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 266
Cdd:cd17399 161 KSSEDIFLLLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 267 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 346
Cdd:cd17399 240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 347 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTV 421
Cdd:cd17399 320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTV 399
|
410 420
....*....|....*....|
gi 31542731 422 SLLLMAGLCTFFSCILAVFF 441
Cdd:cd17399 400 PLLVMAGLAAVLAIIFVVFF 419
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
28-441 |
5.15e-154 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 446.85 E-value: 5.15e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLRMVPCmvvGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17334 81 LGSVLKCIPL---GQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 188 KGED-IPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEK-------FLDGLKLLMWNKAYVILAVCLGGMI 259
Cdd:cd17334 158 PPKGtKKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNsehvileLQKSISELLRNEPFVLLAVAFSIMM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 260 GISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQ---LQ 336
Cdd:cd17334 238 GVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 337 GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVrrsepslstcqqgedP 416
Cdd:cd17334 318 YVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------P 382
|
410 420
....*....|....*....|....*
gi 31542731 417 LDWTVSLLLMAGLCTFFSCILAVFF 441
Cdd:cd17334 383 TPTESKYLLWFILCTVGSCLGALFF 407
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
28-398 |
2.01e-62 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 210.56 E-value: 2.01e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLRmvpCMVVGTqNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17398 81 LGAWLK---LFSSSP-DLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 188 KGEDIP-----LMLGVYTIPA-GVVCLLSTICLWESVPPTPPSAGAASSTSEK-----FLDGLKLLMWNKAYVILAVCLG 256
Cdd:cd17398 157 NSENKDeigkgLSILFYGVAGiCTALFILVIIFFKEKPPIPPSRAQAAAQELRsedqsYLGSLKRLFKNKGFLLLLITYG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 257 GMIGISASFSALLEQ-ILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQL 335
Cdd:cd17398 237 INTGVYYAISTLLNQmVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTLD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31542731 336 QGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTAL 398
Cdd:cd17398 316 LGSIWVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
28-399 |
1.38e-41 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 154.60 E-value: 1.38e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLRmvpCMVVGtQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17455 81 LGAWVK---CASVR-PDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 188 K--------GEDIPLMLGVYTIPAGVVCLLsTICLWESVPPTPPSAGAA-----SSTSEKFLDGLKLLMWNKAYVILAVC 254
Cdd:cd17455 157 NtvddidlmGHNISIMFYGTAAVSTLLFIL-TIIVFKEKPPLPPSQAQAvlqgiPSEDYSYKQSIINLFKNVPFVLLLIS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 255 LGGMIGISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFAL 331
Cdd:cd17455 236 YGIMTGTFYSVSTLLNQMIIT--HYEGeevNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTF 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31542731 332 VSQLqGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALT 399
Cdd:cd17455 314 TLDL-GYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
28-396 |
2.63e-41 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 153.22 E-value: 2.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAE-------DLVLSMeqiNWLSLVYLVVSTPFgvaaIWILDSVGLRAATI 100
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPafgwsdsDIALLA---NWGPIGFVPTFFFM----AWLMDVKGLRIAVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 101 LGAWLNFAGSVLRMVPcmvvgTQNPFAFLM--GGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVA 178
Cdd:cd17397 74 SSAFLVAAGTGLRCIP-----VPNHLATWLihIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAAS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 179 NVLSpvlvkkgediPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAgAASSTSEKFLDGLKLLMWNKAYVILAVCLGGM 258
Cdd:cd17397 149 FLIG----------PLVLMYLEFGWSALIFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGILSLLKNKRFWLIALAYGIP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 259 IGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEatKIGLCLFSLACVPFALVSQLQ-- 336
Cdd:cd17397 218 TGVYAGWSGVLDVNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSGATGSFLWFTLIClk 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31542731 337 ---GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMT 396
Cdd:cd17397 296 llpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
28-394 |
2.23e-36 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 139.92 E-value: 2.23e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLRmvpcmvVGTQNP--FAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVL 185
Cdd:cd17456 81 LGAWIK------TGSARPdlFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 186 VKKGEDIPLMLG----VYTIPAGVVCLLS--TICLWESVPPTPPS---AGAASSTSEK--FLDGLKLLMWNKAYVILAVC 254
Cdd:cd17456 155 VPNIDDLDELAYhisiMFYGTAAVATLLFilVIIVFQEKPKIPPSqaqAAIQSIPSQDysYLQSILRLLKNVNFILLVVS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 255 LGGMIGISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLA-CVPFA 330
Cdd:cd17456 235 YGLNTGCFYALSTLLNRMVIF--HYPGeevNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTT-LAVYIMSLVgMVVYT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31542731 331 LVSQLqGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLA 394
Cdd:cd17456 312 FTLNL-GHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTIS 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-398 |
1.22e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 91.10 E-value: 1.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 27 ARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAwln 106
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 107 fagsVLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:COG2223 78 ----LLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 187 KKGeDIPLMLGVYtipaGVVCLLSTICLWESVPPTPPSAGAASSTSEK-FLDGLKLLMWNKAYVILAVCLGGMIGISASF 265
Cdd:COG2223 154 AAF-GWRNAFLIL----GILLLVVAVLAWLFLRDPPAGAAAAAKASLRdQLEALRDPRFWLLSLLYFGTFGSFIGFSSWL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 266 SALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKhfteATKIGLCLFSLACVPFALVSQLQGQTLALAAT 345
Cdd:COG2223 229 PPYLVDQF---GLSAATAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGSLWLFLVL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 31542731 346 CSLLGLF-GFSVGPVAMELAVecSFPVGE-GAATGMIFVLGQAEGILIMLAMTAL 398
Cdd:COG2223 302 FLLLGLAlGGGNGAVFALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-401 |
6.19e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 6.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 36 ISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMV 115
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 116 PcmvvgtqNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDI-PL 194
Cdd:cd06174 81 A-------PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 195 MLGVYTIPAGVVCLLSTICLweSVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILC 274
Cdd:cd06174 154 VFLIAAALALLAAILLLLVV--PDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 275 ASGHSSG-FSGLCGALFITFGILGALALGPYVDRtkHFTEATKIGLCLFSLACVPFALVsqLQGQTLALAATCSLLGLFG 353
Cdd:cd06174 232 DLGGLSVaVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 31542731 354 FSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVR 401
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-384 |
3.77e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.47 E-value: 3.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 27 ARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLN 106
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 107 FAGSVLRmvpcmvvGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHqRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:COG2807 94 AAGLLLR-------SLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 187 kKGEDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSekfldglklLMWNKAYVILAVCLGGMIGISASFS 266
Cdd:COG2807 166 -AALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS---------LWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 267 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHfteatKIGLCLFSLACVPFALVSQLQGQTLALAATC 346
Cdd:COG2807 236 AWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 31542731 347 SLLGLFGFSVGPVAMELAVECSFPVGE-GAATGMIFVLG 384
Cdd:COG2807 311 VLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVG 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-447 |
6.23e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 85.69 E-value: 6.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:COG2271 87 LATLL----FGFATS---FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 188 KGeDIPLMLGVYTIPAGVVCLLSTICLWesvpptppsagaasstsekfldglkllmwnkayVILAVCLGGMIGISASFSA 267
Cdd:COG2271 160 AF-GWRAAFLILGLPGLLLALLRFWLLA---------------------------------LAYFLVYFALYGFLTWLPT 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 268 LLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRtkhFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCS 347
Cdd:COG2271 206 YLVEVR---GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLF 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 348 LLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTvrrsepslstcqqgeDPLDWTVSLLLMA 427
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL---------------DATGYQAAFLLLA 344
|
410 420
....*....|....*....|
gi 31542731 428 GLCtFFSCILAVFFHTPYRR 447
Cdd:COG2271 345 ALA-LLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
28-386 |
2.99e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.40 E-value: 2.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:COG2814 87 LGSLL----CALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 188 KGeDIPLMLGVytipAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWnkAYVILAVCLGGMIGISASFSA 267
Cdd:COG2814 160 LF-GWRWVFLV----NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 268 LLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtLALAATCS 347
Cdd:COG2814 233 YLQEVL---GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALF 304
|
330 340 350
....*....|....*....|....*....|....*....
gi 31542731 348 LLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQA 386
Cdd:COG2814 305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-390 |
1.52e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.23 E-value: 1.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 41 CSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPcmvv 120
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA---- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 121 gtqNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVkkgeDIPLMLGVYT 200
Cdd:pfam07690 83 ---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA----SLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 201 IpAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSS 280
Cdd:pfam07690 156 I-LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 281 GFSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLQGQTLALAAtCSLLGLFGFSVGPVA 360
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLSLTLSSLWLLLA-LLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|
gi 31542731 361 MELAVECSFPVGEGAATGMIFVLGQAEGIL 390
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
158-361 |
2.71e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 2.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 158 HQRATANMLATMSNPLGVLVANVLSPVLVKK-GEDIP----LMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGaassts 232
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAfGGDAAlgyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS------ 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 233 ekFLDGLKLLMWNKAYVIL-AVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRT-KH 310
Cdd:COG2211 217 --LKESLKALLKNRPFLLLlLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKK 294
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 31542731 311 FTeaTKIGLCLFSLACVPFALVSqlQGQTLALAATCSLLGLF--GFSVGPVAM 361
Cdd:COG2211 295 KA--FIIGLLLAALGLLLLFFLG--PGNLWLLLVLAALAGIGlgAILVLPWAM 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-392 |
1.46e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.65 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 51 APVADVIAEDLVLSMEQINWL----SLVYLVVSTPFGvaaiWILDSVGLRAATILGawlnFAGSVLRMVPCMVVGTqnpF 126
Cdd:cd17325 16 IPILPLYAESLGASVAQIGLIvaayALAQLLFSPPAG----RLSDRFGRKRLLLLG----LLLLAVSTLLFAFATS---Y 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 127 AFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKkgediplmLGVYTIP---A 203
Cdd:cd17325 85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPflvC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 204 GVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVC-LGGMIGISASFSAL---LEQILCASghs 279
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAiFVLAFAFGALEPFLplyAAELGGLS--- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 280 sgfSGLCGALFITFGILGALA---LGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSV 356
Cdd:cd17325 234 ---PAQIGLLFGAQGLASALSqppAGKLSDRIGRKPLIL-IGLLLSAVALLLLPLATSF----WLLLLLLALLGLGLGLV 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 31542731 357 GPVAMELAVECSFPVGEGAATG---MIFVLGQAEGILIM 392
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGlfnTAFSLGMVLGPLLG 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
28-384 |
2.84e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.85 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGsvlrmvpCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMsNPLGVLVANVLSPVLVK 187
Cdd:COG0738 85 LG-------LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 188 KGEDIPLMLGVYTIpaGVVCLLSTICLWESVPPTPPSAGAASSTSEKfldGLKLLMWNKAYVILAVCL----GGMIGISA 263
Cdd:COG0738 157 LGLSLSWHLPYLIL--AVLLLLLALLFLRSKLPEIEEEEEEAAGSAA---SLKSLLKNPRLLLGGLAIflyvGAEGAIGD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 264 SFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKhfteATKIGLCLFSLACVPFALVSQLQGQTLALA 343
Cdd:COG0738 232 WLPLYLKDVL---GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG----PVRLLRLSALLAAVGLLLALLAPGPWLALI 304
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 31542731 344 AtCSLLGlFGFSVG-PVAMELAVEcSFPVGEGAATGMIFVLG 384
Cdd:COG0738 305 G-LALVG-LGLSLMfPTIFSLALD-GLGKRTAAAVSAVLIMG 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
49-392 |
1.67e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 49 SFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGlRAATILGAWLNFAGSvlrmvpCMVVGTQNPFAF 128
Cdd:cd17474 17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFG-RKKVLLPGLLLFGIG------GLLCGLSDSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 129 LMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYTIPAGVVCL 208
Cdd:cd17474 90 LLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 209 LsticlwesVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMI---GISASFSALLEQILCASGHSSGFSgL 285
Cdd:cd17474 170 L--------FLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFlyfAFLTYLPFLLELLYGISPIIIGLL-F 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 286 CGALFITfgILGALALGPYVDRTKHFTEATKIGLCLFSLAcvpFALVSQLQGQTLALAATcSLLGLFGFSVGPVAMELAV 365
Cdd:cd17474 241 AGWSVLL--ALGSLFVGRLLKKRFGARRILVIGLLLYALS---LLLLGFVPSLALLLIAI-VLFGLGLGLNLPLLTTLVT 314
|
330 340 350
....*....|....*....|....*....|
gi 31542731 366 ECSFPVGEGAAT---GMIFVLGQAEGILIM 392
Cdd:cd17474 315 ELAPEEERGTASslyNFVRFLGQAVGPLLF 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-392 |
2.72e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.46 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 48 LSFAPVADVIAEDLVLSMEQINWL-SLVYLVVSTpFGVAAIWILDSVGLRAATILGAWL--------NFAGSVLRMVPCM 118
Cdd:cd17475 13 QGIPALAPFLQEDLHLSLAQVGLLlSALNLGVAV-SMLPAGWLLDRFGERRVLAVGLLLmgaaallmALVGSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 119 VVGTQNPFAFLMGGQslcalaqslvifspaKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKK-GEDIPLMLg 197
Cdd:cd17475 92 FLVGAGYGSVQPGGG---------------RAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHyGWRAAFVV- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 198 vytipAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFlDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILCASG 277
Cdd:cd17475 156 -----AGLVSILAAVLFWLFYREPPAASAATESASTLL-RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 278 H-SSGFSGLCGALFITFGILGALALGPYVDRtkHFTEATKIGLCLFSLACV-PFALVSQLQGQT--LALAATCSLLGLFG 353
Cdd:cd17475 230 GlSVVAAGALLAVAQLGGALGRIGLGRVSDR--VFGGRRRPVLVITAAIAAaALLVLSLLSPGTplWLLVLLLILLGLFA 307
|
330 340 350
....*....|....*....|....*....|....*....
gi 31542731 354 FSVGPVAMELAVECSFPVGEGAATGMIFVLGQAeGILIM 392
Cdd:cd17475 308 IGWNGLYLTLVAESAGPEQAGTALGLANTINFI-GIAIG 345
|
|
| PHA03381 |
PHA03381 |
tegument protein VP22; Provisional |
451-556 |
7.32e-05 |
|
tegument protein VP22; Provisional
Pssm-ID: 177618 [Multi-domain] Cd Length: 290 Bit Score: 45.00 E-value: 7.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 451 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 526
Cdd:PHA03381 83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
|
90 100 110
....*....|....*....|....*....|
gi 31542731 527 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 556
Cdd:PHA03381 160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
146-441 |
1.13e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.53 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 146 SPAKLAALwFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVyTIPAGVVCLLstICLWesVPPTPPSA 225
Cdd:cd17328 108 APTIIADL-FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV-TGVLGVLLAI--LLLL--FVREPPRG 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 226 GAA-----SSTSEKFLDGLKLLMWNKAYVIL---AVCLGGMIGISASFSALLEQ-ILCASGHSSGFSGLC-GALFITFGI 295
Cdd:cd17328 182 AAEggvmaKSTATSFLADLKALAKNPSFILStlgFTAVSFVTGALAFWAPTFFLrAFGVGDLSSADVGLIfGAITCIAGV 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 296 LGALALGPYVDRTKHFTEATKIGLCLFS-LACVPFALVSQLQGQT-LALAATCSLLGLFGFSV--GPVAMELaVECSFPV 371
Cdd:cd17328 262 LGVLLGGILADRLRRKTPRADPLVCAVGlLAAAPFLFLALVLALSnLLLAWVLLFLGEFLLSLnwAPVFAIL-LYVVIPT 340
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31542731 372 GEGAATGMIFV----LGQAEGILIMLAMTALTVRRSEPSLSTCQQgedpldWTVSLLlmagLCTFFSCILAVFF 441
Cdd:cd17328 341 RRSTASAIQILlshlLGDAGSPYLIGLISDLLRQNKDSPLAEAAS------LQYALL----LCSFVLVLGGFFF 404
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
31-379 |
1.27e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.46 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 31 VFLLAISLLnCSNATLWLsFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATIlgawlnfAGS 110
Cdd:cd17324 1 LLALALAAF-AIGTTEYV-IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLL-------VLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 111 VLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLvkkGE 190
Cdd:cd17324 72 LLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL---GQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 191 diplMLG--VYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSAL 268
Cdd:cd17324 149 ----LLGwrAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 269 LEQIlcaSGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALvsqlqGQTLALAATCSL 348
Cdd:cd17324 225 LTDV---PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG-----PSPLLLLVGLVL 296
|
330 340 350
....*....|....*....|....*....|.
gi 31542731 349 LGLFGFSVGPVAMELAVECSfPVGEGAATGM 379
Cdd:cd17324 297 WGLGFFAAHSALQTRVLRLA-PEARGLASSL 326
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
72-359 |
1.33e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 72 SLVYLVVSTPFGVAA------IWILDSVGLRAATILGAWLNFAGSVLRMVPCMVvgtqnpFAFLMGGQSlcalaqslVIF 145
Cdd:cd06173 44 FLPFLLFSPFAGVLAdrfdrrRLLILADLLRALLAAVLALLALLGSLSLWLLLV------LAFLLGIAS--------AFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 146 SPAKLAAL--WFPEHQRATANMLATMSNPLGVLVANVLSPVLVKK-GEDIPLMLGVYTIPAGVVCLLSTIclwesVPPTP 222
Cdd:cd06173 110 GPARQALLpeLVPKEQLVRANALNSLATQLARIIGPALGGLLVALlGPGGAFAINALSFLLSALLLLFIR-----RPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 223 PSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLeqILCASGHSSGFSGLCGALFITFGI---LGAL 299
Cdd:cd06173 185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLL--PLLAKEVLGGGAAGYGLLLAAFGVgalLGAL 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 300 ALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqTLALAAtcslLGLFGFSVGPV 359
Cdd:cd06173 263 LLGRLSKRRRRGR-LLLIGALLLGLALLVLGLSPSL---WLLLAA----LFLLGLAGGLF 314
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
30-385 |
1.78e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.18 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 30 WVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAG 109
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 110 SVLrmvpcmVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVanvLSPVLVKKG 189
Cdd:cd17355 82 LVL------LALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLV---FLPLGAALI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 190 EDIP--LMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEkFLDGLKLLMWNKAYVIL----AVCLGGMIGISA 263
Cdd:cd17355 153 EAFGwrTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS-PGSTLKEALRSASFWLLalafFLCGFAVVGLIV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 264 SFSALLeqilCASGHSSGFSGLCGALFITFGILGALALGPYVDRtkhfTEATKIGLCLFSLACVPFALVSQLQGQTLALA 343
Cdd:cd17355 232 HLVPYL----ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR----YSPRRLLAASYALRALGLALLLLLPFPPLALL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 31542731 344 ATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQ 385
Cdd:cd17355 304 LFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQ 345
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
47-395 |
1.92e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 47 WLSFAPVADVIAEDLVLSMEQInwlslvYLVVSTPFGVAAIWILdSVGLRAATILGAWLNFAGSVLRMVPCMVVG--TQN 124
Cdd:cd17341 15 WFLFAPLGPVIRDDLGLSTSQI------GLLVAIPVLAGALLRL-PYGFLCDRFGGRRVFIASLLLLLIPLLALAlaVSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 125 PFAFLMGGqSLCALAqsLVIFSPA-KLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYTIP- 202
Cdd:cd17341 88 YWGLLVLG-FLLGFA--GANFASGqPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVGWRNAFf 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 203 -AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKllmwNKAYVILA----VCLGGMIGISASFSALLEQILCASG 277
Cdd:cd17341 165 vPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLK----NYRTWILSllygVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 278 HSSGFSGLCGALfitFGILGALALGPYVDRT--KHFTEATKIGLCLFSLACVPFalvSQLQGQTLALAATCSLLGLFGFS 355
Cdd:cd17341 241 VTAGILAALFPL---AGALARPAGGWLSDRFggRRRLWWLFIVMTIGAALLSLS---LPTSGTNLVLFLALFVALGLGAG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 31542731 356 VGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAM 395
Cdd:cd17341 315 AGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLF 354
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
27-302 |
2.48e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.26 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 27 ARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLN 106
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 107 FAGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:COG0477 90 GLASLL----CGLAPS---PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 187 KK-GEDIPLMLGVytiPAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASF 265
Cdd:COG0477 163 AAlGWRWIFLINA---PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239
|
250 260 270
....*....|....*....|....*....|....*..
gi 31542731 266 SALLEQILCASGHSSGFSGLCGALFITFGILGALALG 302
Cdd:COG0477 240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLL 276
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
29-351 |
2.30e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.47 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 29 RWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFA 108
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 109 G-SVLRMVPcmvvgtqNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHqRATANMLATMSNPLGVLV-ANVLSPVLV 186
Cdd:cd17314 81 GyTYLSYVF-------NSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLgSPLLRILWV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 187 KKGEDiplmlGVYTIpAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 266
Cdd:cd17314 153 FYGLA-----LVYTI-LGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 267 ALLEQILCAS-GHSSGFSGLCGALFITFGILGALALGPYVDR--TKHFTEATKIGLCLFSLACVPFAlvsqLQGQTLALA 343
Cdd:cd17314 227 ANMASLVRSLqLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFfgGRLSTLSILLTILGLGLCAFLFL----LKMTPVGLV 302
|
....*...
gi 31542731 344 ATCSLLGL 351
Cdd:cd17314 303 LTGSLLGF 310
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
34-394 |
3.47e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.30 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 34 LAISLLNCSNATLWLSFAPVADVIAEDLvLSMEQINWLSLVYLVvstpfGVAAIWILdsVGlRAATILG-AWLNFAGSVL 112
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSL-----AQAVLGPI--VG-RLSDLFGrRWFFIGGNLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 113 RMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALwFPEHQRATANMLATMSNPLGVLVANVLSPVLVKkgEDI 192
Cdd:cd06179 72 GVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASEL-VPNKYRGLVQGVVNLVASPGSALGPLIAGALVE--ANA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 193 PLMLGVYTIPAGVvCLLSTICLWESVPPTPPSAGAASSTSEKFLD----GLKLLM------------------WNKAYVI 250
Cdd:cd06179 149 AGWRWIFYINAIF-NALALILLFFFYHPPPRPQLHGSSTRQKLKRldwvGLFLLIaglvlfllglswggnpypWSSAHVI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 251 ----------------------------------------LAVC-LGGMIGISASfSALLEQILCASGHSSGFSGLCGAL 289
Cdd:cd06179 228 aplviggvlliafglyewkgtkdgllpprllfrgrnfaliLIVAfVEGMIFYSLN-IFWPQQISLLFTTDPLKAGLYQLP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 290 FITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVsqlQGQTLALAATCSLLGLFGFSVGPVAMELAVECSF 369
Cdd:cd06179 307 FGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLALI---TPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSV 383
|
410 420
....*....|....*....|....*....
gi 31542731 370 PVGE-GAATGMIF---VLGQAEGILIMLA 394
Cdd:cd06179 384 PPEDiGTASGLLGsarALGGAVGTAIFTS 412
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
28-188 |
6.20e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.13 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 28 RRWVFLLAISLLNCSNATLWlSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQY-AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 108 AGSVLrmvpcMVVGTQNPFAFLMGGqSLCALAQSLVIFSPAKLAALWFPEHqRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17353 80 LGFIL-----SAFAISLPLLFLGYG-VLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLIN 152
|
.
gi 31542731 188 K 188
Cdd:cd17353 153 T 153
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
48-440 |
6.73e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.09 E-value: 6.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 48 LSFApvADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRA--ATILGAW--LNFAGSVLRMVPCMVVgtq 123
Cdd:cd17319 22 ISVA--APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKvlAVSMLLWslFTALTGFATSLTSLYV--- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 124 npFAFLMGgqslcaLAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVkkgedipLMLG---VYT 200
Cdd:cd17319 97 --LRFLLG------VAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-------LLFGwrwAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 201 IPAGVVCLLSTICLWesvpptppsagaasstsekfldglkllmWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSS 280
Cdd:cd17319 162 IEGLLGLLLAVLWWF----------------------------YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 281 GFS-GLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFsLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGPV 359
Cdd:cd17319 214 LKQvGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLL-LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVF 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542731 360 AmelAVECSFPVGE--GAATGMIFVLGQAEGILIMLAMTALtvrrsepslstcqqgedpLDWTVS---LLLMAGLCTFFS 434
Cdd:cd17319 293 W---SLPADLLPGEaaATAGGLINSGGNLGGFVAPLLIGYL------------------VDATGSytaAFLFLAAVALLA 351
|
....*.
gi 31542731 435 CILAVF 440
Cdd:cd17319 352 ALLVLL 357
|
|
| |
