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Conserved domains on  [gi|66346674|ref|NP_150648|]
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intermembrane lipid transfer protein VPS13A isoform A [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2104 5.16e-91

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 333.00  E-value: 5.16e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    4 ESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAVL 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   84 EEIYLLIVPSSRIkydplKEEKQLMEAKQQELKRIEEAKQKVVDQEQHLP------EKQDTFAEKLVTQIIKNLQVKISS 157
Cdd:COG5043   83 EDIYLLISPQAKN-----SLTREELPQSQQALKQRQLDSWEILRETLEESssspniSRKQSFIESLITKLIDNIQIYIED 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  158 IHIRYEDDITN-RDKPLSFGISLQNLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLK 236
Cdd:COG5043  158 IHLRFEDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLENFQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  237 NGIvnENIVPEGYDFVFRPISANAKLVMNR-RSDfdfSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYR 315
Cdd:COG5043  238 PMI--AEKSPAYNEYILKPVRGTAKVSINKlPTD---EIPRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  316 KFKPDVPLHHHAREWWAYAIHGVLEvNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDv 395
Cdd:COG5043  313 KYRPKSTPKEKPLEWFKYIILVVLD-SIHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYD- 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  396 fnITIARQTAEVEVKKAGYKIYKEgvKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLyEAIGYSET 475
Cdd:COG5043  391 --LIKYRSRLFRSLAKRRNSIYLK--PQTHKLQGWFSGLWNGKPQAQDEDTLASTDKTAAELTDQEQKDFF-SEIEPVGQ 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  476 AVDPTLLktfeaLKFFVHLKSMSIVLRENHQKPELVDIVIEEFsTLIVQRpgaqaikfeTKIDSFHITGLPD-------- 547
Cdd:COG5043  466 LYSDTVN-----LDVEVSIAKGSFVIQKHIRKINLISQRFENF-KSKFSL---------NKLDLFDGATNPElkpyrsir 530

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  548 NSEKPRLLSSLD----DAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPP--KEVHLAQLTAATL 621
Cdd:COG5043  531 NKPKVRESESLQeieeESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtKIEHVSEWVYSAA 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  622 TKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIfSPTSNLLLLDLGHLKVTSKsRSELPDVKQgEANLKEI 701
Cdd:COG5043  611 ATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCT-DPKSPTLFLDAGRISIHSQ-LVEDAIIKK-FRELQTL 687

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  702 MDRAYDSFDIQLTSVQLLYSRVGDNWREARKlSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKK 781
Cdd:COG5043  688 ENLMYDRFTISLFNVRCLIGPDYEGKRELPK-GKCDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQ 766

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  782 LQGIMELIESIPKPEPVTEvsapvksfqiqtstslgtsqisqkiIPLLELPSVSEDDSEEEFfdapcsplEEPLQFPTGV 861
Cdd:COG5043  767 YKVIINLMSNILPTISVDE-------------------------INGDYQQFSSASLPPPFF--------DIKDNFQIEN 813

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  862 KSIRTRKLQKQDCSVNMTTFKIRFevpKVLIEFYHLVGDCELSVVEILVLgLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941
Cdd:COG5043  814 HANEQTAAKFHAQQIFAFYFKVDY---FICSGLDSRSENYLVPVLRARLE-FYFDLVARKFNLRVTSNSNDIVDKEFTYP 889

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  942 DENKKPVY--LVTTLDNTMEDLLTLEYVKAEKNVPDlkSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNIL--PQS 1017
Cdd:COG5043  890 SSLCDNLLsrSSPKPKNNFDDTVFIEYKSIDYDVLD--SVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFtsPND 967

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1018 EEKSAPVSTTETEDKGD---VIKKLALKLSTNEdiITLqilaeLSCLQIFIQDqkCNISEIKiegldseMIMRPSETEIN 1094
Cdd:COG5043  968 EYMIGEDPELTRKISDVeniKIEDANVRLDNND--IFL-----YDCIQLFATV--LSYGAFM-------HMEEREKFFLQ 1031

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1095 AKLRNIIVLDSDITAIYKKA-VYITGKEVFSFKMVSYmdatagSAYTDMNVVDIQVNLIVGCIEVVFVTkflySILAFID 1173
Cdd:COG5043 1032 LRLMDLELKNHEKSNNPDSTiVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSLHFYFIE----SYFNFLS 1101

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1174 NFQAAKqalaeATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVAdfgLITMTNTFHMITesqssP 1253
Cdd:COG5043 1102 KFKRFK-----VSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCRMQ---LIIKPGSFYAFS-----K 1168

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1254 PPVIDLiTIKLSEMRL------YRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEwyQEVPCFNVNAQLKPMEFILSQED 1327
Cdd:COG5043 1169 CPVVEK-NSKLSIFSCelrkgeFSTAVPSSGHHDVLLEELNIHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1328 ITTIFKTLhgniwyekDGSASPAVTKDQYSATSG---VTTNASHHSGgatvvtAAVVEVHSRALLVKTT-LNISFKTDDL 1403
Cdd:COG5043 1246 HLILLDLI--------DVVTTFFRIDSSFSTSENlprELDSEFDRSG------TPVKLKHSKKTVVETLdILFTFKLPKI 1311

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1404 TMVLYSpgpkqASFTDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHV-KKATPRMIGLTVGFD-- 1480
Cdd:COG5043 1312 RLNLYT-----GTFGIHGGDLTGLHNILFFEIGLDYGFYSSGTVYAEFSIASFRIEDVNPIKdVVFLDVIEYSTNTHNll 1386

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1481 -----KKDMMDIKYRKVrdgcvtdaVFQEMYIcASVEFLQTVANVF---LEAYTTGTAVETSVQTWTA--KEEVPTQESV 1550
Cdd:COG5043 1387 vngclEYDSQGRLLNLV--------LDIDKMF-LNLDYLYSIWSIFvhwLRAYYSHLDYLVEQEYFNMgnPNQVACGEES 1457

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1551 KWEINVIIKNPEIVFVADMTKNDAPALVI-TTQCEIcykgnLENSTMTAAIKDLQVRACPFLPVKRKGKIttvLQPCDLF 1629
Cdd:COG5043 1458 YKLYRITIVDTTLVFVRDASDMNSYAIPFfFGQFLV-----TQQSIFTVTANNMGIFACKMSETANINQL---LDDFGIR 1529

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1630 YQTTQKGTDPQVI--DMSVKSLTLKVSPVIINTMITITSALYT------TKETIPEETASSTahlweKKDTKTLKMWFLE 1701
Cdd:COG5043 1530 FTISQHCSEKIQIitTLDFDSLLLRISVNDFLLLQTILRRIYNfiyalyDKETTDEELEKRT-----KDGQLALNPDFLA 1604

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1702 ESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHRtvPMLLAKSR-FSGEGKNWSSLINLHCQLELEVHYYNEMFG 1780
Cdd:COG5043 1605 ASVPTAQPSSVFGIRLCSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRS 1682

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1781 VWEPLLEPLEIDQTedfrpwnlgikmkkkakmaIVESDPeeenykvpeyKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1860
Cdd:COG5043 1683 HWEPVLEPWKVGVH-------------------ISRNDS----------KTAVHVFSREIADIVLTPRLIATLHFIFTKL 1733

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1861 TEaaTGSSADFVKDlAPFMILNSLGLTISVSPsdSFSVLNIPMAKSYVLKNGESLSMDYIRTKdnDHFNAMTSLSSKLFf 1940
Cdd:COG5043 1734 IS--TPFPIERKCD-APYRIVNYTQTAVSVWA--QFENAADSVECVRHLPNNTSTPWKFEEWR--QMQDVVSQDQDRVY- 1805

                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1941 illTPVNHSTAD-----KIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGS-KKVTIRSPVQIRNHFSVPLSVYEGD-- 2012
Cdd:COG5043 1806 ---IGVHVSNSKyeslrHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEIEVVFCDsd 1882

                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2013 ----TLLGTASPENEFNIPLG-SYRSFIFLKP--EDENYQMCEGIDFEEIIKNDGALL---KKKCRSKNPSKESFLINIV 2082
Cdd:COG5043 1883 giqrSQIYHISPEESCSLPIEtAYLYSIRIRPvsEDKFNWSSQAISWKSLVDNQQSIVtclRQHSRDNTWSTPSCKFVGL 1962

                       2170      2180
                 ....*....|....*....|....
gi 66346674 2083 PE--KDNLTSLSVYSEDGWDLPYI 2104
Cdd:COG5043 1963 HVvaNDELYSLVIVNEHDLPLMKL 1986
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2766-2943 1.45e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


:

Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 226.27  E-value: 1.45e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2766 YEYFHISPIKLHLSVSLSSGREeakdskQNGGLIPVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVI 2845
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSERVN------LEESLEKSNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2846 RHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKIT 2925
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66346674   2926 GAMAKGVAAMTMDEDYQQ 2943
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2598-3098 2.17e-55

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 215.52  E-value: 2.17e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2598 DTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTM- 2676
Cdd:COG5043 1991 DLEVKGVLLLKGVGISLIDRKDQELAYMTNVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEi 2070

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2677 DSAPKPFTDVSIVMRSAGhsQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEvELFHKDIEAFKE-EYKTA 2755
Cdd:COG5043 2071 ENHLLPSRKFAVVKDSDS--AVTYDKYVTILLQELSIELDEDLALAYLEKLKFPGSKYMDD-KKFDDEIELPDIiINKSG 2147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2756 SLVdqsqvsLYEYFHISPIKLHLSVSlssgreeaKDSKQNGGLIPV----HSLNLLLKSIGATLTDVQDVVFKLAFFELN 2831
Cdd:COG5043 2148 SNI------YFEFLHLQPTRLHISFS--------RSSESSGEDGKVvpssNSYSDFYGMLAMTLGNINDAPVRLNSLLMD 2213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2832 YQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAI--QGPEEFVEGMALGLKAL 2909
Cdd:COG5043 2214 NARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVSDLFYEPYQGRFlvDNSQEWGIGIAKGGNSF 2293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2910 VGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREA-MNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQK 2988
Cdd:COG5043 2294 IKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRRLVrRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAAT 2373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2989 GGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS---EVESLRPPRFFNEDGVIRPYRLRDGTGNQMLQVM 3065
Cdd:COG5043 2374 NGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIKNTTTVLdyhDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTL 2453

                        490       500       510
                 ....*....|....*....|....*....|...
gi 66346674 3066 ENGRFAKYKYFTHVMINKTDMLmITRRGVLFVT 3098
Cdd:COG5043 2454 DAGKYPLDEYKFHDIINNVAVI-ISRDIHAIVT 2485
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2209-2356 1.10e-21

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 97.76  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2209 VAFHSPYWMVNKTGRMLQYKADG--------IHRKHPPNYKKPVLFSFqPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2280
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGnknkaagtLESHEGGRRLIPLMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2281 GAVKC--KGLKMDYQVGVTIDLSS--FNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDLEQCIPF-WPEYASSKL 2355
Cdd:pfam06650   82 NDVVLpsPNGQNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGELIPLhWLRNVEEKQ 161


                   .
gi 66346674   2356 L 2356
Cdd:pfam06650  162 L 162
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2104 5.16e-91

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 333.00  E-value: 5.16e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    4 ESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAVL 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   84 EEIYLLIVPSSRIkydplKEEKQLMEAKQQELKRIEEAKQKVVDQEQHLP------EKQDTFAEKLVTQIIKNLQVKISS 157
Cdd:COG5043   83 EDIYLLISPQAKN-----SLTREELPQSQQALKQRQLDSWEILRETLEESssspniSRKQSFIESLITKLIDNIQIYIED 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  158 IHIRYEDDITN-RDKPLSFGISLQNLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLK 236
Cdd:COG5043  158 IHLRFEDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLENFQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  237 NGIvnENIVPEGYDFVFRPISANAKLVMNR-RSDfdfSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYR 315
Cdd:COG5043  238 PMI--AEKSPAYNEYILKPVRGTAKVSINKlPTD---EIPRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  316 KFKPDVPLHHHAREWWAYAIHGVLEvNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDv 395
Cdd:COG5043  313 KYRPKSTPKEKPLEWFKYIILVVLD-SIHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYD- 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  396 fnITIARQTAEVEVKKAGYKIYKEgvKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLyEAIGYSET 475
Cdd:COG5043  391 --LIKYRSRLFRSLAKRRNSIYLK--PQTHKLQGWFSGLWNGKPQAQDEDTLASTDKTAAELTDQEQKDFF-SEIEPVGQ 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  476 AVDPTLLktfeaLKFFVHLKSMSIVLRENHQKPELVDIVIEEFsTLIVQRpgaqaikfeTKIDSFHITGLPD-------- 547
Cdd:COG5043  466 LYSDTVN-----LDVEVSIAKGSFVIQKHIRKINLISQRFENF-KSKFSL---------NKLDLFDGATNPElkpyrsir 530

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  548 NSEKPRLLSSLD----DAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPP--KEVHLAQLTAATL 621
Cdd:COG5043  531 NKPKVRESESLQeieeESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtKIEHVSEWVYSAA 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  622 TKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIfSPTSNLLLLDLGHLKVTSKsRSELPDVKQgEANLKEI 701
Cdd:COG5043  611 ATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCT-DPKSPTLFLDAGRISIHSQ-LVEDAIIKK-FRELQTL 687

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  702 MDRAYDSFDIQLTSVQLLYSRVGDNWREARKlSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKK 781
Cdd:COG5043  688 ENLMYDRFTISLFNVRCLIGPDYEGKRELPK-GKCDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQ 766

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  782 LQGIMELIESIPKPEPVTEvsapvksfqiqtstslgtsqisqkiIPLLELPSVSEDDSEEEFfdapcsplEEPLQFPTGV 861
Cdd:COG5043  767 YKVIINLMSNILPTISVDE-------------------------INGDYQQFSSASLPPPFF--------DIKDNFQIEN 813

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  862 KSIRTRKLQKQDCSVNMTTFKIRFevpKVLIEFYHLVGDCELSVVEILVLgLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941
Cdd:COG5043  814 HANEQTAAKFHAQQIFAFYFKVDY---FICSGLDSRSENYLVPVLRARLE-FYFDLVARKFNLRVTSNSNDIVDKEFTYP 889

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  942 DENKKPVY--LVTTLDNTMEDLLTLEYVKAEKNVPDlkSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNIL--PQS 1017
Cdd:COG5043  890 SSLCDNLLsrSSPKPKNNFDDTVFIEYKSIDYDVLD--SVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFtsPND 967

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1018 EEKSAPVSTTETEDKGD---VIKKLALKLSTNEdiITLqilaeLSCLQIFIQDqkCNISEIKiegldseMIMRPSETEIN 1094
Cdd:COG5043  968 EYMIGEDPELTRKISDVeniKIEDANVRLDNND--IFL-----YDCIQLFATV--LSYGAFM-------HMEEREKFFLQ 1031

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1095 AKLRNIIVLDSDITAIYKKA-VYITGKEVFSFKMVSYmdatagSAYTDMNVVDIQVNLIVGCIEVVFVTkflySILAFID 1173
Cdd:COG5043 1032 LRLMDLELKNHEKSNNPDSTiVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSLHFYFIE----SYFNFLS 1101

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1174 NFQAAKqalaeATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVAdfgLITMTNTFHMITesqssP 1253
Cdd:COG5043 1102 KFKRFK-----VSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCRMQ---LIIKPGSFYAFS-----K 1168

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1254 PPVIDLiTIKLSEMRL------YRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEwyQEVPCFNVNAQLKPMEFILSQED 1327
Cdd:COG5043 1169 CPVVEK-NSKLSIFSCelrkgeFSTAVPSSGHHDVLLEELNIHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1328 ITTIFKTLhgniwyekDGSASPAVTKDQYSATSG---VTTNASHHSGgatvvtAAVVEVHSRALLVKTT-LNISFKTDDL 1403
Cdd:COG5043 1246 HLILLDLI--------DVVTTFFRIDSSFSTSENlprELDSEFDRSG------TPVKLKHSKKTVVETLdILFTFKLPKI 1311

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1404 TMVLYSpgpkqASFTDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHV-KKATPRMIGLTVGFD-- 1480
Cdd:COG5043 1312 RLNLYT-----GTFGIHGGDLTGLHNILFFEIGLDYGFYSSGTVYAEFSIASFRIEDVNPIKdVVFLDVIEYSTNTHNll 1386

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1481 -----KKDMMDIKYRKVrdgcvtdaVFQEMYIcASVEFLQTVANVF---LEAYTTGTAVETSVQTWTA--KEEVPTQESV 1550
Cdd:COG5043 1387 vngclEYDSQGRLLNLV--------LDIDKMF-LNLDYLYSIWSIFvhwLRAYYSHLDYLVEQEYFNMgnPNQVACGEES 1457

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1551 KWEINVIIKNPEIVFVADMTKNDAPALVI-TTQCEIcykgnLENSTMTAAIKDLQVRACPFLPVKRKGKIttvLQPCDLF 1629
Cdd:COG5043 1458 YKLYRITIVDTTLVFVRDASDMNSYAIPFfFGQFLV-----TQQSIFTVTANNMGIFACKMSETANINQL---LDDFGIR 1529

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1630 YQTTQKGTDPQVI--DMSVKSLTLKVSPVIINTMITITSALYT------TKETIPEETASSTahlweKKDTKTLKMWFLE 1701
Cdd:COG5043 1530 FTISQHCSEKIQIitTLDFDSLLLRISVNDFLLLQTILRRIYNfiyalyDKETTDEELEKRT-----KDGQLALNPDFLA 1604

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1702 ESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHRtvPMLLAKSR-FSGEGKNWSSLINLHCQLELEVHYYNEMFG 1780
Cdd:COG5043 1605 ASVPTAQPSSVFGIRLCSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRS 1682

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1781 VWEPLLEPLEIDQTedfrpwnlgikmkkkakmaIVESDPeeenykvpeyKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1860
Cdd:COG5043 1683 HWEPVLEPWKVGVH-------------------ISRNDS----------KTAVHVFSREIADIVLTPRLIATLHFIFTKL 1733

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1861 TEaaTGSSADFVKDlAPFMILNSLGLTISVSPsdSFSVLNIPMAKSYVLKNGESLSMDYIRTKdnDHFNAMTSLSSKLFf 1940
Cdd:COG5043 1734 IS--TPFPIERKCD-APYRIVNYTQTAVSVWA--QFENAADSVECVRHLPNNTSTPWKFEEWR--QMQDVVSQDQDRVY- 1805

                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1941 illTPVNHSTAD-----KIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGS-KKVTIRSPVQIRNHFSVPLSVYEGD-- 2012
Cdd:COG5043 1806 ---IGVHVSNSKyeslrHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEIEVVFCDsd 1882

                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2013 ----TLLGTASPENEFNIPLG-SYRSFIFLKP--EDENYQMCEGIDFEEIIKNDGALL---KKKCRSKNPSKESFLINIV 2082
Cdd:COG5043 1883 giqrSQIYHISPEESCSLPIEtAYLYSIRIRPvsEDKFNWSSQAISWKSLVDNQQSIVtclRQHSRDNTWSTPSCKFVGL 1962

                       2170      2180
                 ....*....|....*....|....
gi 66346674 2083 PE--KDNLTSLSVYSEDGWDLPYI 2104
Cdd:COG5043 1963 HVvaNDELYSLVIVNEHDLPLMKL 1986
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 139-371 1.99e-86

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 282.61  E-value: 1.99e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    139 FAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNV 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    219 KSQMFYLSDYDNS---LDDLKNGIVNENIVPEGYDFVFRPISANAKLVMNRRSDFDfSAPKINLEIELHNIAIEFNKPQY 295
Cdd:pfam16908   81 DSESLELLGDLDLeelLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66346674    296 FSIMELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVcPRLWMWSWKHIRKHRQKVKQYKELYKK 371
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIR-ERRRKWSWDYIKKRRDDRKEYIELYKK 234
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2766-2943 1.45e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 226.27  E-value: 1.45e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2766 YEYFHISPIKLHLSVSLSSGREeakdskQNGGLIPVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVI 2845
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSERVN------LEESLEKSNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2846 RHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKIT 2925
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66346674   2926 GAMAKGVAAMTMDEDYQQ 2943
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2598-3098 2.17e-55

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 215.52  E-value: 2.17e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2598 DTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTM- 2676
Cdd:COG5043 1991 DLEVKGVLLLKGVGISLIDRKDQELAYMTNVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEi 2070

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2677 DSAPKPFTDVSIVMRSAGhsQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEvELFHKDIEAFKE-EYKTA 2755
Cdd:COG5043 2071 ENHLLPSRKFAVVKDSDS--AVTYDKYVTILLQELSIELDEDLALAYLEKLKFPGSKYMDD-KKFDDEIELPDIiINKSG 2147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2756 SLVdqsqvsLYEYFHISPIKLHLSVSlssgreeaKDSKQNGGLIPV----HSLNLLLKSIGATLTDVQDVVFKLAFFELN 2831
Cdd:COG5043 2148 SNI------YFEFLHLQPTRLHISFS--------RSSESSGEDGKVvpssNSYSDFYGMLAMTLGNINDAPVRLNSLLMD 2213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2832 YQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAI--QGPEEFVEGMALGLKAL 2909
Cdd:COG5043 2214 NARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVSDLFYEPYQGRFlvDNSQEWGIGIAKGGNSF 2293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2910 VGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREA-MNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQK 2988
Cdd:COG5043 2294 IKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRRLVrRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAAT 2373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2989 GGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS---EVESLRPPRFFNEDGVIRPYRLRDGTGNQMLQVM 3065
Cdd:COG5043 2374 NGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIKNTTTVLdyhDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTL 2453

                        490       500       510
                 ....*....|....*....|....*....|...
gi 66346674 3066 ENGRFAKYKYFTHVMINKTDMLmITRRGVLFVT 3098
Cdd:COG5043 2454 DAGKYPLDEYKFHDIINNVAVI-ISRDIHAIVT 2485
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2209-2356 1.10e-21

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 97.76  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2209 VAFHSPYWMVNKTGRMLQYKADG--------IHRKHPPNYKKPVLFSFqPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2280
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGnknkaagtLESHEGGRRLIPLMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2281 GAVKC--KGLKMDYQVGVTIDLSS--FNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDLEQCIPF-WPEYASSKL 2355
Cdd:pfam06650   82 NDVVLpsPNGQNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGELIPLhWLRNVEEKQ 161


                   .
gi 66346674   2356 L 2356
Cdd:pfam06650  162 L 162
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 2946-3025 2.55e-17

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 79.47  E-value: 2.55e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2946 REAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIK 3025
Cdd:pfam09333    1 ISLYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2104 5.16e-91

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 333.00  E-value: 5.16e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    4 ESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAVL 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   84 EEIYLLIVPSSRIkydplKEEKQLMEAKQQELKRIEEAKQKVVDQEQHLP------EKQDTFAEKLVTQIIKNLQVKISS 157
Cdd:COG5043   83 EDIYLLISPQAKN-----SLTREELPQSQQALKQRQLDSWEILRETLEESssspniSRKQSFIESLITKLIDNIQIYIED 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  158 IHIRYEDDITN-RDKPLSFGISLQNLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLK 236
Cdd:COG5043  158 IHLRFEDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLENFQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  237 NGIvnENIVPEGYDFVFRPISANAKLVMNR-RSDfdfSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYR 315
Cdd:COG5043  238 PMI--AEKSPAYNEYILKPVRGTAKVSINKlPTD---EIPRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  316 KFKPDVPLHHHAREWWAYAIHGVLEvNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDv 395
Cdd:COG5043  313 KYRPKSTPKEKPLEWFKYIILVVLD-SIHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYD- 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  396 fnITIARQTAEVEVKKAGYKIYKEgvKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLyEAIGYSET 475
Cdd:COG5043  391 --LIKYRSRLFRSLAKRRNSIYLK--PQTHKLQGWFSGLWNGKPQAQDEDTLASTDKTAAELTDQEQKDFF-SEIEPVGQ 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  476 AVDPTLLktfeaLKFFVHLKSMSIVLRENHQKPELVDIVIEEFsTLIVQRpgaqaikfeTKIDSFHITGLPD-------- 547
Cdd:COG5043  466 LYSDTVN-----LDVEVSIAKGSFVIQKHIRKINLISQRFENF-KSKFSL---------NKLDLFDGATNPElkpyrsir 530

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  548 NSEKPRLLSSLD----DAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPP--KEVHLAQLTAATL 621
Cdd:COG5043  531 NKPKVRESESLQeieeESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtKIEHVSEWVYSAA 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  622 TKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIfSPTSNLLLLDLGHLKVTSKsRSELPDVKQgEANLKEI 701
Cdd:COG5043  611 ATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCT-DPKSPTLFLDAGRISIHSQ-LVEDAIIKK-FRELQTL 687

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  702 MDRAYDSFDIQLTSVQLLYSRVGDNWREARKlSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKK 781
Cdd:COG5043  688 ENLMYDRFTISLFNVRCLIGPDYEGKRELPK-GKCDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQ 766

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  782 LQGIMELIESIPKPEPVTEvsapvksfqiqtstslgtsqisqkiIPLLELPSVSEDDSEEEFfdapcsplEEPLQFPTGV 861
Cdd:COG5043  767 YKVIINLMSNILPTISVDE-------------------------INGDYQQFSSASLPPPFF--------DIKDNFQIEN 813

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  862 KSIRTRKLQKQDCSVNMTTFKIRFevpKVLIEFYHLVGDCELSVVEILVLgLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941
Cdd:COG5043  814 HANEQTAAKFHAQQIFAFYFKVDY---FICSGLDSRSENYLVPVLRARLE-FYFDLVARKFNLRVTSNSNDIVDKEFTYP 889

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674  942 DENKKPVY--LVTTLDNTMEDLLTLEYVKAEKNVPDlkSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNIL--PQS 1017
Cdd:COG5043  890 SSLCDNLLsrSSPKPKNNFDDTVFIEYKSIDYDVLD--SVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFtsPND 967

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1018 EEKSAPVSTTETEDKGD---VIKKLALKLSTNEdiITLqilaeLSCLQIFIQDqkCNISEIKiegldseMIMRPSETEIN 1094
Cdd:COG5043  968 EYMIGEDPELTRKISDVeniKIEDANVRLDNND--IFL-----YDCIQLFATV--LSYGAFM-------HMEEREKFFLQ 1031

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1095 AKLRNIIVLDSDITAIYKKA-VYITGKEVFSFKMVSYmdatagSAYTDMNVVDIQVNLIVGCIEVVFVTkflySILAFID 1173
Cdd:COG5043 1032 LRLMDLELKNHEKSNNPDSTiVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSLHFYFIE----SYFNFLS 1101

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1174 NFQAAKqalaeATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVAdfgLITMTNTFHMITesqssP 1253
Cdd:COG5043 1102 KFKRFK-----VSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCRMQ---LIIKPGSFYAFS-----K 1168

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1254 PPVIDLiTIKLSEMRL------YRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEwyQEVPCFNVNAQLKPMEFILSQED 1327
Cdd:COG5043 1169 CPVVEK-NSKLSIFSCelrkgeFSTAVPSSGHHDVLLEELNIHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1328 ITTIFKTLhgniwyekDGSASPAVTKDQYSATSG---VTTNASHHSGgatvvtAAVVEVHSRALLVKTT-LNISFKTDDL 1403
Cdd:COG5043 1246 HLILLDLI--------DVVTTFFRIDSSFSTSENlprELDSEFDRSG------TPVKLKHSKKTVVETLdILFTFKLPKI 1311

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1404 TMVLYSpgpkqASFTDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHV-KKATPRMIGLTVGFD-- 1480
Cdd:COG5043 1312 RLNLYT-----GTFGIHGGDLTGLHNILFFEIGLDYGFYSSGTVYAEFSIASFRIEDVNPIKdVVFLDVIEYSTNTHNll 1386

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1481 -----KKDMMDIKYRKVrdgcvtdaVFQEMYIcASVEFLQTVANVF---LEAYTTGTAVETSVQTWTA--KEEVPTQESV 1550
Cdd:COG5043 1387 vngclEYDSQGRLLNLV--------LDIDKMF-LNLDYLYSIWSIFvhwLRAYYSHLDYLVEQEYFNMgnPNQVACGEES 1457

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1551 KWEINVIIKNPEIVFVADMTKNDAPALVI-TTQCEIcykgnLENSTMTAAIKDLQVRACPFLPVKRKGKIttvLQPCDLF 1629
Cdd:COG5043 1458 YKLYRITIVDTTLVFVRDASDMNSYAIPFfFGQFLV-----TQQSIFTVTANNMGIFACKMSETANINQL---LDDFGIR 1529

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1630 YQTTQKGTDPQVI--DMSVKSLTLKVSPVIINTMITITSALYT------TKETIPEETASSTahlweKKDTKTLKMWFLE 1701
Cdd:COG5043 1530 FTISQHCSEKIQIitTLDFDSLLLRISVNDFLLLQTILRRIYNfiyalyDKETTDEELEKRT-----KDGQLALNPDFLA 1604

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1702 ESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHRtvPMLLAKSR-FSGEGKNWSSLINLHCQLELEVHYYNEMFG 1780
Cdd:COG5043 1605 ASVPTAQPSSVFGIRLCSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRS 1682

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1781 VWEPLLEPLEIDQTedfrpwnlgikmkkkakmaIVESDPeeenykvpeyKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1860
Cdd:COG5043 1683 HWEPVLEPWKVGVH-------------------ISRNDS----------KTAVHVFSREIADIVLTPRLIATLHFIFTKL 1733

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1861 TEaaTGSSADFVKDlAPFMILNSLGLTISVSPsdSFSVLNIPMAKSYVLKNGESLSMDYIRTKdnDHFNAMTSLSSKLFf 1940
Cdd:COG5043 1734 IS--TPFPIERKCD-APYRIVNYTQTAVSVWA--QFENAADSVECVRHLPNNTSTPWKFEEWR--QMQDVVSQDQDRVY- 1805

                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 1941 illTPVNHSTAD-----KIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGS-KKVTIRSPVQIRNHFSVPLSVYEGD-- 2012
Cdd:COG5043 1806 ---IGVHVSNSKyeslrHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEIEVVFCDsd 1882

                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2013 ----TLLGTASPENEFNIPLG-SYRSFIFLKP--EDENYQMCEGIDFEEIIKNDGALL---KKKCRSKNPSKESFLINIV 2082
Cdd:COG5043 1883 giqrSQIYHISPEESCSLPIEtAYLYSIRIRPvsEDKFNWSSQAISWKSLVDNQQSIVtclRQHSRDNTWSTPSCKFVGL 1962

                       2170      2180
                 ....*....|....*....|....
gi 66346674 2083 PE--KDNLTSLSVYSEDGWDLPYI 2104
Cdd:COG5043 1963 HVvaNDELYSLVIVNEHDLPLMKL 1986
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 139-371 1.99e-86

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 282.61  E-value: 1.99e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    139 FAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNV 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    219 KSQMFYLSDYDNS---LDDLKNGIVNENIVPEGYDFVFRPISANAKLVMNRRSDFDfSAPKINLEIELHNIAIEFNKPQY 295
Cdd:pfam16908   81 DSESLELLGDLDLeelLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66346674    296 FSIMELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVcPRLWMWSWKHIRKHRQKVKQYKELYKK 371
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIR-ERRRKWSWDYIKKRRDDRKEYIELYKK 234
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 569-793 1.88e-73

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 245.50  E-value: 1.88e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    569 FEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVH--LAQLTAATLTKLEEFRSKTATGLLYIIETQKVLD 646
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674    647 LKINLKASYIIVPQDGIfSPTSNLLLLDLGHLKVTSK--SRSELPDVKQG------EANLKEIMDRAYDSFDIQLTSVQL 718
Cdd:pfam16910   81 LDIDLQAPLIIVPEDYT-SKDSPCLILDAGHISVTSDlvDKSTIKEIKSKqsqqytEEDLKELESLMYDKFSLKLSDTQV 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66346674    719 LYSRVGDNWREARKLSVSTQ-HILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKKLQGIMELIE-SIP 793
Cdd:pfam16910  160 LIGPSGEDWKEALTEDDSSPlHILEPINLDLTLEKSILPKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLIDvSIP 236
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2766-2943 1.45e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 226.27  E-value: 1.45e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2766 YEYFHISPIKLHLSVSLSSGREeakdskQNGGLIPVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVI 2845
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSERVN------LEESLEKSNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2846 RHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKIT 2925
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66346674   2926 GAMAKGVAAMTMDEDYQQ 2943
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2598-3098 2.17e-55

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 215.52  E-value: 2.17e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2598 DTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTM- 2676
Cdd:COG5043 1991 DLEVKGVLLLKGVGISLIDRKDQELAYMTNVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEi 2070

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2677 DSAPKPFTDVSIVMRSAGhsQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEvELFHKDIEAFKE-EYKTA 2755
Cdd:COG5043 2071 ENHLLPSRKFAVVKDSDS--AVTYDKYVTILLQELSIELDEDLALAYLEKLKFPGSKYMDD-KKFDDEIELPDIiINKSG 2147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2756 SLVdqsqvsLYEYFHISPIKLHLSVSlssgreeaKDSKQNGGLIPV----HSLNLLLKSIGATLTDVQDVVFKLAFFELN 2831
Cdd:COG5043 2148 SNI------YFEFLHLQPTRLHISFS--------RSSESSGEDGKVvpssNSYSDFYGMLAMTLGNINDAPVRLNSLLMD 2213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2832 YQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAI--QGPEEFVEGMALGLKAL 2909
Cdd:COG5043 2214 NARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVSDLFYEPYQGRFlvDNSQEWGIGIAKGGNSF 2293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2910 VGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREA-MNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQK 2988
Cdd:COG5043 2294 IKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRRLVrRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAAT 2373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674 2989 GGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS---EVESLRPPRFFNEDGVIRPYRLRDGTGNQMLQVM 3065
Cdd:COG5043 2374 NGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIKNTTTVLdyhDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTL 2453

                        490       500       510
                 ....*....|....*....|....*....|...
gi 66346674 3066 ENGRFAKYKYFTHVMINKTDMLmITRRGVLFVT 3098
Cdd:COG5043 2454 DAGKYPLDEYKFHDIINNVAVI-ISRDIHAIVT 2485
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 3-117 2.71e-41

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 148.48  E-value: 2.71e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674      3 FESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAV 82
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVIE 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 66346674     83 LEEIYLLIVPSSR-IKYDPLKEEKQLMEAKQQELKR 117
Cdd:pfam12624   81 IEDVYLLAVPKDEsEEYDEEEEEKRELAAKKEKLAA 116
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2209-2356 1.10e-21

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 97.76  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2209 VAFHSPYWMVNKTGRMLQYKADG--------IHRKHPPNYKKPVLFSFqPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2280
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGnknkaagtLESHEGGRRLIPLMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2281 GAVKC--KGLKMDYQVGVTIDLSS--FNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDLEQCIPF-WPEYASSKL 2355
Cdd:pfam06650   82 NDVVLpsPNGQNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGELIPLhWLRNVEEKQ 161


                   .
gi 66346674   2356 L 2356
Cdd:pfam06650  162 L 162
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 2946-3025 2.55e-17

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 79.47  E-value: 2.55e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   2946 REAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIK 3025
Cdd:pfam09333    1 ISLYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1156-1259 5.61e-05

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 47.51  E-value: 5.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66346674   1156 IEVVFVTKFLYSILAF-------IDNFQAaKQALAEATVQA-AGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSE 1227
Cdd:pfam16910   21 LEIIYDPHFIEEVIDFfkppeshLELIGA-LMAAAEATLEGiKEQTRAGLEYALEEHKTLDLDIDLQAPLIIVPEDYTSK 99

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 66346674   1228 --NVFVADFGLITMT------NTFHMITESQSSPPPVIDL 1259
Cdd:pfam16910  100 dsPCLILDAGHISVTsdlvdkSTIKEIKSKQSQQYTEEDL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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