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Conserved domains on  [gi|15231810|ref|NP_190910|]
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plasma membrane intrinsic protein 2A [Arabidopsis thaliana]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-266 4.74e-96

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 281.90  E-value: 4.74e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810    31 ELKKWSFYRAVIAEFVATLLFLYITVLTVIGYKIQSDtdaggvDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAV 110
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVS------SLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   111 TFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSyYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATD 190
Cdd:pfam00230  75 TLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231810   191 PKRSARDSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKskpWDDHWIFWVGPFIGAAIAAFYH 266
Cdd:pfam00230 154 DRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-266 4.74e-96

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 281.90  E-value: 4.74e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810    31 ELKKWSFYRAVIAEFVATLLFLYITVLTVIGYKIQSDtdaggvDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAV 110
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVS------SLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   111 TFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSyYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATD 190
Cdd:pfam00230  75 TLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231810   191 PKRSARDSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKskpWDDHWIFWVGPFIGAAIAAFYH 266
Cdd:pfam00230 154 DRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 39-269 1.51e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 230.22  E-value: 1.51e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  39 RAVIAEFVATLLFLYITVLTVIGYKIQSDTdaggvdcgGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAR 118
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGA--------SGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGG 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810 119 KVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGAN--------SLADGYSTGTGLAAEIIGTFVLVYTVFSATD 190
Cdd:cd00333  73 RFPLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15231810 191 PKRSArdsHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFV 269
Cdd:cd00333 153 DPNGP---PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 43-266 7.18e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 199.83  E-value: 7.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810    43 AEFVATLLFLYITVLTVIGYKIQSDTDAGGvdcgGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSL 122
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVG----GGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   123 PRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATDpKRSARDSHvpV 202
Cdd:TIGR00861  77 KRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG--G 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15231810   203 LAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSkPWDDHWIFWVGPFIGAAIAAFYH 266
Cdd:TIGR00861 154 FAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLA-GWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 36-271 3.45e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 180.71  E-value: 3.45e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  36 SFYRAVIAEFVAT--LLFLYITVLTVIGYKIqsdtdaggvdcGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFG 113
Cdd:COG0580   1 SLMKRLLAEFLGTfiLVLLGCGVVAVLAGTK-----------GGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810 114 LFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSL-------ADGYSTGTGLAAEIIGTFVLVYTVF 186
Cdd:COG0580  70 LAVAGRFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspAIGYSLGAAFLTEIIGTFVLVFVIL 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810 187 SATDPKRSARdshvpVLAPLPIGFAVFMVHLATIPITGTGINPARSFG---AAVIYNKSKPWDDHWIFWVGPFIGAAIAA 263
Cdd:COG0580 150 GITDKRAAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGprlFHALGKGGSDWGYLWVPIVAPILGAALAA 224


                ....*...
gi 15231810 264 FYHQFVLR 271
Cdd:COG0580 225 LLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 39-275 6.52e-38

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 134.14  E-value: 6.52e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   39 RAVIAEFVATLLFLYITVLTVIGYkiQSDTDAGGVDCGGVGILGIAWAFGgmIFILVYCTAGISGGHINPAVTFGLFLAR 118
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAF--NKLTDNGSTTPAGLVAAALAHAFA--LFVAVSVGANISGGHVNPAVTFGAFIGG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  119 KVSLPRALLYIIAQCLGAICGVGFVKaFQSSYYTRyggGANSLADGYSTGTGLAAEIIGTFVLVYTVF-SATDPKRsard 197
Cdd:PLN00027  97 NITLLRGILYWIAQLLGSVVACLLLK-FSTGGLET---SAFSLSSGVGVWNAFVFEIVMTFGLVYTVYaTAVDPKK---- 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15231810  198 SHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIynkSKPWDDHWIFWVGPFIGAAIAAFYHQFVLRASGS 275
Cdd:PLN00027 169 GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVV---SWTWTNHWVYWAGPLIGGGIAGLVYELIFIGSTT 243
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-266 4.74e-96

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 281.90  E-value: 4.74e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810    31 ELKKWSFYRAVIAEFVATLLFLYITVLTVIGYKIQSDtdaggvDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAV 110
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVS------SLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   111 TFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSyYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATD 190
Cdd:pfam00230  75 TLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231810   191 PKRSARDSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKskpWDDHWIFWVGPFIGAAIAAFYH 266
Cdd:pfam00230 154 DRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 39-269 1.51e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 230.22  E-value: 1.51e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  39 RAVIAEFVATLLFLYITVLTVIGYKIQSDTdaggvdcgGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAR 118
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGA--------SGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGG 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810 119 KVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGAN--------SLADGYSTGTGLAAEIIGTFVLVYTVFSATD 190
Cdd:cd00333  73 RFPLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15231810 191 PKRSArdsHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFV 269
Cdd:cd00333 153 DPNGP---PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 43-266 7.18e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 199.83  E-value: 7.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810    43 AEFVATLLFLYITVLTVIGYKIQSDTDAGGvdcgGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSL 122
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVG----GGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   123 PRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATDpKRSARDSHvpV 202
Cdd:TIGR00861  77 KRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG--G 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15231810   203 LAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSkPWDDHWIFWVGPFIGAAIAAFYH 266
Cdd:TIGR00861 154 FAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLA-GWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 36-271 3.45e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 180.71  E-value: 3.45e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  36 SFYRAVIAEFVAT--LLFLYITVLTVIGYKIqsdtdaggvdcGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFG 113
Cdd:COG0580   1 SLMKRLLAEFLGTfiLVLLGCGVVAVLAGTK-----------GGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810 114 LFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSL-------ADGYSTGTGLAAEIIGTFVLVYTVF 186
Cdd:COG0580  70 LAVAGRFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspAIGYSLGAAFLTEIIGTFVLVFVIL 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810 187 SATDPKRSARdshvpVLAPLPIGFAVFMVHLATIPITGTGINPARSFG---AAVIYNKSKPWDDHWIFWVGPFIGAAIAA 263
Cdd:COG0580 150 GITDKRAAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGprlFHALGKGGSDWGYLWVPIVAPILGAALAA 224


                ....*...
gi 15231810 264 FYHQFVLR 271
Cdd:COG0580 225 LLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 39-275 6.52e-38

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 134.14  E-value: 6.52e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   39 RAVIAEFVATLLFLYITVLTVIGYkiQSDTDAGGVDCGGVGILGIAWAFGgmIFILVYCTAGISGGHINPAVTFGLFLAR 118
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAF--NKLTDNGSTTPAGLVAAALAHAFA--LFVAVSVGANISGGHVNPAVTFGAFIGG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  119 KVSLPRALLYIIAQCLGAICGVGFVKaFQSSYYTRyggGANSLADGYSTGTGLAAEIIGTFVLVYTVF-SATDPKRsard 197
Cdd:PLN00027  97 NITLLRGILYWIAQLLGSVVACLLLK-FSTGGLET---SAFSLSSGVGVWNAFVFEIVMTFGLVYTVYaTAVDPKK---- 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15231810  198 SHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIynkSKPWDDHWIFWVGPFIGAAIAAFYHQFVLRASGS 275
Cdd:PLN00027 169 GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVV---SWTWTNHWVYWAGPLIGGGIAGLVYELIFIGSTT 243
PLN00166 PLN00166
aquaporin TIP2; Provisional
 39-266 2.25e-36

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 130.06  E-value: 2.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   39 RAVIAEFVATLLFLYITVLTVIGY-KIQSDtdaGGVDCGGVGILGIAWAFGgmIFILVYCTAGISGGHINPAVTFGLFLA 117
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFaKLTSD---AALDPAGLVAVAVAHAFA--LFVGVSIAANISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  118 RKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGgansLADGYSTGTGLAAEIIGTFVLVYTVF-SATDPKRSAr 196
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHG----VAAGLGAIEGVVMEIVVTFALVYTVYaTAADPKKGS- 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  197 dshVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIynkSKPWDDHWIFWVGPFIGAAIAAFYH 266
Cdd:PLN00166 169 ---LGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVV---SGDFSQIWIYWVGPLVGGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
 77-270 2.63e-33

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 121.61  E-value: 2.63e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   77 GVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQS-------- 148
Cdd:PRK05420  33 GIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVPYIIAQVVGGIAAAAVLYLIASgkagfdla 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  149 -SYYTRYGGGANSlADGYSTGTGLAAEIIGTFVLVYTVFSATdpkrsarDSHVPV-LAPLPIGFAVFMVHLATIPITGTG 226
Cdd:PRK05420 113 gSGFASNGYGEHS-PGGYSLLAALVCEVVLTAFFLLVILGAT-------DKRAPAgFAPIAIGLALTLIHLISIPVTNTS 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 15231810  227 INPARSFGAAvIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFVL 270
Cdd:PRK05420 185 VNPARSTGVA-LFVGGWALEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 39-270 1.58e-29

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 112.30  E-value: 1.58e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   39 RAVIAEFVATLLFLYITVLTVIGYKIQSDTDAGgvDCGGVGILGIAWAFGgmIFILVYCTAGISGGHINPAVTFGLFLAR 118
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKLMPDAAS--DPSSLLIVAIANAFA--LSSAVYIAANISGGHVNPAVTFGMAVGG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  119 KVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSLadgystgTGLAAEIIG---TFVLVYTVFSATDPKRSA 195
Cdd:PLN00167  99 HISVPTAMFYWISQMLASVMACLFLKVTTVGQHVPTYKIAEEM-------TGFGASVLEgvlTFGLVYTVYAAGDPRRGL 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15231810  196 RDShvpvLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKpwdDHWIFWVGPFIGAAIAAFYHQFVL 270
Cdd:PLN00167 172 LGA----IGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFK---NQAVYWVGPLLGGAVAGLLYDNVV 239
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 4-270 2.73e-20

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 88.26  E-value: 2.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810    4 DVEAVPGEGFQTRDYQD--PPPAPFIDGAELKKW-SFYRAVIAEFVATLLFLYITvltvIGYKIQSDTDAGGVDCGGvgi 80
Cdd:PTZ00016  13 ELQLVPIQNNMDEEVAEaqKRPPGGQNFWAPREYrPNVREYVAEFLGTFVLLFFG----EGVVATTHTVGNNGDYLA--- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   81 LGIAWAFGgmIFILVYCTAGISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGG--- 157
Cdd:PTZ00016  86 ITIGWGLG--VTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPelp 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  158 ----ANSLADGYSTGTGLAA------EIIGTFVLVYTVFSATDPKRSARDSHVPVlaplPIGFAVFMVHLATIPITGTGI 227
Cdd:PTZ00016 164 wetmANGFAGVFATYPREGNfyaifsELILTAILLLVILAITDPNNCPAFNYLPV----AVGLLVFVIGISFGGNTGYAL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 15231810  228 NPARSFGA----AVIYNKSKPWDDHWIFW---VGPFIGAAIAAFYHQFVL 270
Cdd:PTZ00016 240 NPARDLGPrlfsAILWGSEVFTKDNYYFWvplVAPFVGAVLGMFLYDKFI 289
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 76-269 3.08e-18

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 82.26  E-value: 3.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   76 GGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVK-AFQSSYYTRY 154
Cdd:PLN00182  71 GTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRlMFNVTPEAFF 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  155 GggaNSLADgySTGTGLAAEIIGTFVLVYTVFSATDPKRSARDshvpvLAPLPIGFAVFMVHLATIPITGTGINPARSFG 234
Cdd:PLN00182 151 G---TTPTD--SSGQALVAEIIISFLLMFVISGVATDSRAVGE-----LAGIAVGMTIILNVFVAGPISGASMNPARSLG 220

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 15231810  235 AAVIYNKSKpwdDHWIFWVGPFIGAAIAAFYHQFV 269
Cdd:PLN00182 221 PAIVMGRYK---GIWVYIVGPFVGIIAGGFVYNLI 252
PLN00184 PLN00184
aquaporin NIP1; Provisional
 14-269 4.33e-18

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 82.38  E-value: 4.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   14 QTRDYQDPPPAPFIDGAELKKWSFYRAVIAEFVATLlFLYITVLTVIGYKIQSDTdaggvdcgGVGILGIAWAFGGMIFI 93
Cdd:PLN00184  30 EMEAIHNPKPLKKQDSLLSVSVPFLQKLIAEVLGTY-FLVFTGCASVVVNMQNDN--------VVTLPGIAIVWGLTIMV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   94 LVYCTAGISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSLADGYSTGTGLAA 173
Cdd:PLN00184 101 LIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGSSPVGSDLQA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  174 ---EIIGTFVLVYTVFSATDPKRSardshVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWddhWI 250
Cdd:PLN00184 181 fvmEFIVTFYLMFIISGVATDNRA-----IGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGI---WI 252

                        250
                 ....*....|....*....
gi 15231810  251 FWVGPFIGAAIAAFYHQFV 269
Cdd:PLN00184 253 YIVAPTLGAIAGAWVYNTV 271
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 39-271 2.07e-17

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 79.90  E-value: 2.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   39 RAVIAEFVATLLFLYITvltvigYKIQSDTDAGGvdcGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVT-----FG 113
Cdd:PLN00183  46 RMVLAEMVGTFILMFCV------CGIIASTQLSG---GEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTiafatFG 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  114 LFLARKVSlpralLYIIAQCLGAICGVGFVKAFqssyytrYGGGANSLADGYSTG--TGLAAEIIGTFVLVYTVFSATDP 191
Cdd:PLN00183 117 HFPWSKVP-----LYITAQTVGSVLATYVGVSV-------YGVKADLMTTKPAQGcsSAFWVEFIATFIVMFLAASLTSQ 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  192 KRSARDshvpvLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIynkSKPWDDHWIFWVGPFIGAAIAAF-YHQFVL 270
Cdd:PLN00183 185 PQSLGH-----LSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIV---SWDFKDIWIYITAPTIGAVAGALmFHLLRL 256


                 .
gi 15231810  271 R 271
Cdd:PLN00183 257 R 257
PLN00026 PLN00026
aquaporin NIP; Provisional
 36-263 7.98e-16

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 76.05  E-value: 7.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810   36 SFYRAVIAEFVATLLFLYITVLTVIgykIQSDTDaggvdcGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLF 115
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAATAGPI---VNQKYD------GAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFA 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231810  116 LARKVSLPRALLYIIAQCLGAICGvGFvkAFQSSYYTRYGGGANslADGYSTGTGLAAEIIGTFVLVYTVFS-ATDPKRs 194
Cdd:PLN00026 140 ALRHFPWKHVPAYIAAQVSASICA-SF--ALKGVFHPFMSGGVT--VPSVSTGQAFALEFIITFNLLFVVTAvATDTRA- 213

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15231810  195 ardshVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKpwdDHWIFWVGPFIGAAIAA 263
Cdd:PLN00026 214 -----VGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYR---AIWIYLVAPTLGALAGA 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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