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Conserved domains on  [gi|42542386|ref|NP_543142|]
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organic anion transporter 7 [Homo sapiens]

Protein Classification

solute carrier organic anion transporter( domain architecture ID 13024332)

solute carrier organic anion transporter is a major facilitator superfamily (MFS) transporter that mediates the Na(+)-independent high affinity transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, and the thyroid hormones thyroxine and triiodothyronine, among others

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
109-517 4.94e-174

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 494.89  E-value: 4.94e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17374   1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17374  81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 269 YFVIFLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17374 161 FFLFFLYSWWLP-------------------------------------------------------------------- 172
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 349 KRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP 428
Cdd:cd17374 173 KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVP 252
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 429 QEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFI 508
Cdd:cd17374 253 QEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPIL 332

                ....*....
gi 42542386 509 SGFAFLLLP 517
Cdd:cd17374 333 AGLLALLLP 341
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
109-517 4.94e-174

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 494.89  E-value: 4.94e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17374   1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17374  81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 269 YFVIFLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17374 161 FFLFFLYSWWLP-------------------------------------------------------------------- 172
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 349 KRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP 428
Cdd:cd17374 173 KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVP 252
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 429 QEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFI 508
Cdd:cd17374 253 QEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPIL 332

                ....*....
gi 42542386 509 SGFAFLLLP 517
Cdd:cd17374 333 AGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
11-527 5.53e-115

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 350.47  E-value: 5.53e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386    11 GDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVhildndtvsdNDTGALSQDALLRISIPLDSNMRPEKCRR 90
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRL----------PDAANLSSRCELNLTLPRLPDGRPESCLR 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386    91 FVHPQWQLLHLNGTFPNTS----DADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHL 166
Cdd:TIGR00898  71 FMVDQWANPSLLGCEPLKLsdlgLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   167 SDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFM 246
Cdd:TIGR00898 151 SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   247 TLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKnardtLTLEILKSTMKK 326
Cdd:TIGR00898 231 LLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLSLSLEK 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   327 ELeAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNR 406
Cdd:TIGR00898 306 DL-SSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGR 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   407 RASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPL 486
Cdd:TIGR00898 385 RYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPF 464
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 42542386   487 MMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDT 527
Cdd:TIGR00898 465 LVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
141-484 1.30e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.42  E-value: 1.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:COG2814  43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 221 IAEWAT--HRFQAMGITLGMCPSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLlesarwliinnkpeegLK 297
Cdd:COG2814 123 IADLVPpeRRGRALGLLGAGLGLGPALgPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL----------------LP 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 298 ELRKAAHRSGMKNARDTLTLeilkstmkkeleaaqkkkpslcemlhmpnicKRISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:COG2814 187 ESRPAARARLRGSLRELLRR-------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 378 NVF--------LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLreVLATLGLGASALA 449
Cdd:COG2814 236 EVLglsasaagLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLL--LALFLLGFGFGLL 313
                       330       340       350
                ....*....|....*....|....*....|....*
gi 42542386 450 NTLAFAHGNEVIPTIIRARAMGINATFANIAGALA 484
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
141-485 7.96e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.86  E-value: 7.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALAL 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   221 IAEWATHRFQAMGITLGMCPSGIAFMT---LAGLAFAIRDWHILQLVVSVPYFVIFLTsswllesarWLIINNKPEEGLK 297
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALgplLGGLLASLFGWRAAFLILAILSLLAAVL---------LLLPRPPPESKRP 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   298 ELRKAAHRSGMKNARDTLTLEILKStmkkeleaaqkkkpslcemlhmpnickrISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWL----------------------------LLALLLFGFAFFGLLTYLPLYQEVLGL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   378 NVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLA-----IIFVPQEMQTLREVLATLGLGAsALANTL 452
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalgllLLSLTLSSLWLLLALLLLGFGF-GLVFPA 311
                         330       340       350
                  ....*....|....*....|....*....|...
gi 42542386   453 AFAHGNEVIPTIIRARAMGINATFANIAGALAP 485
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
155-286 2.35e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 49.96  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386  155 GMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGI---AAMSlitNTIMLIAEWATHRFQA 231
Cdd:PRK11551  62 GLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglgGALP---NLIALTSEAVGPRLRG 138
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386  232 MGITLGMC--PSGIAFMTLAGLAFAI-RDW-HILQLVVSVPYFVIFLTSSWLLESARWL 286
Cdd:PRK11551 139 TAVSLMYCgvPFGGALASVIGVLAAGdAAWrHIFYVGGVGPLLLVPLLMRWLPESRAFA 197
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
109-517 4.94e-174

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 494.89  E-value: 4.94e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17374   1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17374  81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 269 YFVIFLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17374 161 FFLFFLYSWWLP-------------------------------------------------------------------- 172
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 349 KRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP 428
Cdd:cd17374 173 KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVP 252
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 429 QEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFI 508
Cdd:cd17374 253 QEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPIL 332

                ....*....
gi 42542386 509 SGFAFLLLP 517
Cdd:cd17374 333 AGLLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
11-527 5.53e-115

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 350.47  E-value: 5.53e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386    11 GDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVhildndtvsdNDTGALSQDALLRISIPLDSNMRPEKCRR 90
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRL----------PDAANLSSRCELNLTLPRLPDGRPESCLR 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386    91 FVHPQWQLLHLNGTFPNTS----DADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHL 166
Cdd:TIGR00898  71 FMVDQWANPSLLGCEPLKLsdlgLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   167 SDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFM 246
Cdd:TIGR00898 151 SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   247 TLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKnardtLTLEILKSTMKK 326
Cdd:TIGR00898 231 LLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLSLSLEK 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   327 ELeAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNR 406
Cdd:TIGR00898 306 DL-SSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGR 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   407 RASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPL 486
Cdd:TIGR00898 385 RYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPF 464
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 42542386   487 MMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDT 527
Cdd:TIGR00898 465 LVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
114-517 6.35e-97

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 298.18  E-value: 6.35e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 114 EPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALA 193
Cdd:cd17446   4 EPCTDGWVYDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 194 PTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQA-MGITLGMCPSgIAFMTLAGLAFAIRDWHILQLVVSVPYFVI 272
Cdd:cd17446  84 PSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAvVGTLLGYCYT-LGQLILAGVAYAIRDWRWLQLAVSLPFFIF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 273 FLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkKPSLCemlhmpnickris 352
Cdd:cd17446 163 FLYSWWFP------------------------------------------------------RITFC------------- 175
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 353 lLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQ 432
Cdd:cd17446 176 -LSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQ 254
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 433 TLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFA 512
Cdd:cd17446 255 TVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILSGIA 334

                ....*
gi 42542386 513 FLLLP 517
Cdd:cd17446 335 ACFLP 339
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
119-517 7.63e-70

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 227.46  E-value: 7.63e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 119 GWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLI 198
Cdd:cd17317   1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 199 YCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSW 278
Cdd:cd17317  81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 279 LLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnicKRISLLSFTR 358
Cdd:cd17317 161 LP--------------------------------------------------------------------RRTIIVGLIW 172
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 359 FANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVL 438
Cdd:cd17317 173 FVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTL 252
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386 439 ATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLP 517
Cdd:cd17317 253 ALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
109-517 8.35e-58

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 196.49  E-value: 8.35e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17447   1 SDLPVVPCQNGWVYDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17447  81 ASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 269 YFVIFLTSSWLlesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17447 161 CAPGIITWWWV--------------------------------------------------------------------- 171
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 349 KRISLLS-FTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFV 427
Cdd:cd17447 172 PKISLCTgIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILI 251
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 428 PQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPF 507
Cdd:cd17447 252 PSEFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVAL 331
                       410
                ....*....|
gi 42542386 508 ISGFAFLLLP 517
Cdd:cd17447 332 LAGGVAFLLP 341
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
109-517 3.36e-39

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 146.07  E-value: 3.36e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17376   1 TQIEQEPCLDGWEYSQDVYLSTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP-SGIAFMTLAGLAFAIRDWHILQLVVSV 267
Cdd:cd17376  81 LQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCIfYAIGYMLLPLFAYFIRDWRMLLLALTL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 268 PYFVIFltsswllesARWLIInnkpeeglkelrkaahrsgmknarDTLTLeilkstmkkeleaaqkkkpsLCEMLHMpni 347
Cdd:cd17376 161 PGVLCV---------PLWWFI------------------------PITTI--------------------MSLLLWM--- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 348 ckrisllsftrfANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFV 427
Cdd:cd17376 185 ------------AISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLV 252
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 428 PQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPF 507
Cdd:cd17376 253 PTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTV 332
                       410
                ....*....|
gi 42542386 508 ISGFAFLLLP 517
Cdd:cd17376 333 LIGILTLFLP 342
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
113-517 4.70e-32

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 126.31  E-value: 4.70e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 113 MEPCVDGWVYDRISfsSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAAL 192
Cdd:cd17379   5 LSPCQDGWVYNTPR--SSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 193 APTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ-AMGITLGMCPSgIAFMTLAGLAFAIRDWHILQLVVSVPYFv 271
Cdd:cd17379  83 SPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRrTVGIVYQMFFT-LGLLILPGIAYFIPHWRWLQLAVTLPNF- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 272 IFLTSSWLlesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnICKRI 351
Cdd:cd17379 161 LFLLYYWF-------------------------------------------------------------------IPKHT 173
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 352 SLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEM 431
Cdd:cd17379 174 FILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPDL 253
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 432 QTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISG 510
Cdd:cd17379 254 HWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYrLAEIWLELPLIVFGVLALVAG 333

                ....*..
gi 42542386 511 FAFLLLP 517
Cdd:cd17379 334 GLVLLLP 340
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
115-517 3.70e-31

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 123.71  E-value: 3.70e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 115 PCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAP 194
Cdd:cd17375   7 SCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 195 TFLIYCSLRFLSGIAAMSLITNTIMLIAE--------WAT---HRFQAMGItlgmcpsgiafMTLAGLAFAIRDWHILQL 263
Cdd:cd17375  87 DYYSFVIVRFLLAMVSSGYLVVVFVYVTEftgikartWASmhvHAFFAVGI-----------MVVALVGYLVRTWWIYQI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 264 VVSVPYfVIFLTSSWLLesarwliinnkpeeglkelrkaahrsgmknARDTLTleilkstmkkeleaaqkkkpslcemlh 343
Cdd:cd17375 156 ILSLVT-IPFILCCWML------------------------------PKRTIT--------------------------- 177
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 344 mpnickrISLLSFTrfaNFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLA 423
Cdd:cd17375 178 -------VWLIWFT---GSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACML 247
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 424 IIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYG 503
Cdd:cd17375 248 IMVIPQDYEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVG 327
                       410
                ....*....|....
gi 42542386 504 VFPFISGFAFLLLP 517
Cdd:cd17375 328 IMAFLSGILTLMLP 341
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
126-517 1.88e-27

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 113.22  E-value: 1.88e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 126 SFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSD-RFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRF 204
Cdd:cd17378  16 GSKVSIVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRF 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 205 LSGIAAMSLITNTIMLIAE--WATHRFQA-----MGITLGmcpsgiaFMTLAGLAF-AIRDWHILQLVVSVPyfVIFLTS 276
Cdd:cd17378  96 LTGFGRSGIGTCALVLATEpvGPKWRGQVgmstfFFFVLG-------FMSLPGIAYlNGSSWRVLYFWTSIP--ALIYCI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 277 SWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnICKRISLLSF 356
Cdd:cd17378 167 LVYL------------------------------------------------------------------FARRLLAVMV 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 357 TRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQT-LR 435
Cdd:cd17378 181 IGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTsLQ 260
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 436 EVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLL 515
Cdd:cd17378 261 IALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLGLFALG 340

                ..
gi 42542386 516 LP 517
Cdd:cd17378 341 LP 342
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
121-517 3.50e-26

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 109.87  E-value: 3.50e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 121 VYDRISFSStIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFV-LRWCYLQVaIVGTCAALAPTFLIY 199
Cdd:cd17377  18 VHFSSSFTS-IVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVyLTGLALDI-LFAYFNALAPSYEFF 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 200 CSLRFLSGI--AAMSLItnTIMLIAEWATHRFQAMGITLG-MC-PSGIAFMTLAGlaFAIRDWHILQLVVSVPYFVIFLt 275
Cdd:cd17377  96 AVSRFLVGVmnGGMSLV--AFVLLNECVGKSYWALAGSLGgLFfAVGIAQYALLG--YFIRSWRTLAVVVNLQGTLVFL- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 276 sswllesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkPSLCemlhmpnICKRISLLS 355
Cdd:cd17377 171 ------------------------------------------------------------LSLF-------IPGRTLILM 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 356 FTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLAN--CVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQT 433
Cdd:cd17377 184 YVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYplCIYLINQKWSGRRRTLAGFLFLGGIACLLVMFVPEKKDS 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 434 LR------EVLATLG-LGASALANtLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFP 506
Cdd:cd17377 264 GVfavvnsTSLSLLGkLTISAAFN-IVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVFGASG 342
                       410
                ....*....|.
gi 42542386 507 FISGFAFLLLP 517
Cdd:cd17377 343 LSAGLLSLLLP 353
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
122-514 6.06e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 94.80  E-value: 6.06e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 122 YDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCS 201
Cdd:cd06174  10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 202 LRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGI-----AFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTS 276
Cdd:cd06174  90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVggilgPLLGGILASSLGFGWRAVFLIAAALALLAAILL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 277 SWLLESARWLIINNKPEEGLKELrkaahrsgmknardtltleilkstmKKELEAAQKKKPSLCEMLhmpnickrISLLSF 356
Cdd:cd06174 170 LLVVPDPPESARAKNEEASSKSV-------------------------LKLLKRVLKNPGLWLLLL--------AIFLVN 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 357 TRFANFMAYFGLNLHVQHLGNNVF--LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTL 434
Cdd:cd06174 217 LAYYSFSTLLPLFLLDLGGLSVAVagLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 435 REVLATLGLGAsALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPL---MMILSVYSPPLPWIIYGVFPFISGF 511
Cdd:cd06174 297 LLLLLLLGFGL-GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLlagFLLAATFGLTGAFLVLAVLLLLAAI 375

                ...
gi 42542386 512 AFL 514
Cdd:cd06174 376 LLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
141-484 1.30e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.42  E-value: 1.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:COG2814  43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 221 IAEWAT--HRFQAMGITLGMCPSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLlesarwliinnkpeegLK 297
Cdd:COG2814 123 IADLVPpeRRGRALGLLGAGLGLGPALgPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL----------------LP 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 298 ELRKAAHRSGMKNARDTLTLeilkstmkkeleaaqkkkpslcemlhmpnicKRISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:COG2814 187 ESRPAARARLRGSLRELLRR-------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 378 NVF--------LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLreVLATLGLGASALA 449
Cdd:COG2814 236 EVLglsasaagLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLL--LALFLLGFGFGLL 313
                       330       340       350
                ....*....|....*....|....*....|....*
gi 42542386 450 NTLAFAHGNEVIPTIIRARAMGINATFANIAGALA 484
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
122-522 2.11e-19

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 89.93  E-value: 2.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 122 YDRISFS---STIVTEWDLvcdSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLI 198
Cdd:COG2271  24 LDRSNLSvaaPPLQADLGL---SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 199 YCSLRFLSGIAAMSLITNTIMLIAEWAT--HRFQAMGITLGMCPSGIAFMTLAGLAFAIR-DWHILQLVVSVPYFVIFLT 275
Cdd:COG2271 101 LLLLRFLLGLGEAGFFPAALKLIAEWFPpkERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLILGLPGLLLALL 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 276 SSWllesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnickrisLLS 355
Cdd:COG2271 181 RFW--------------------------------------------------------------------------LLA 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 356 FTRFANFMAYFGLNLH-------VQHLGN-NVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLL--MFLLAICLLAII 425
Cdd:COG2271 187 LAYFLVYFALYGFLTWlptylveVRGLSLaQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLAALALLLLA 266
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 426 FVPQEMQTLreVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMM--ILSVYSPPLPWIIYG 503
Cdd:COG2271 267 LLPSPALAI--ALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLA 344
                       410
                ....*....|....*....
gi 42542386 504 VFPFISGFAFLLLPETRNK 522
Cdd:COG2271 345 ALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
141-485 7.96e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.86  E-value: 7.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALAL 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   221 IAEWATHRFQAMGITLGMCPSGIAFMT---LAGLAFAIRDWHILQLVVSVPYFVIFLTsswllesarWLIINNKPEEGLK 297
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALgplLGGLLASLFGWRAAFLILAILSLLAAVL---------LLLPRPPPESKRP 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   298 ELRKAAHRSGMKNARDTLTLEILKStmkkeleaaqkkkpslcemlhmpnickrISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWL----------------------------LLALLLFGFAFFGLLTYLPLYQEVLGL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   378 NVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLA-----IIFVPQEMQTLREVLATLGLGAsALANTL 452
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalgllLLSLTLSSLWLLLALLLLGFGF-GLVFPA 311
                         330       340       350
                  ....*....|....*....|....*....|...
gi 42542386   453 AFAHGNEVIPTIIRARAMGINATFANIAGALAP 485
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
116-515 2.73e-18

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 86.50  E-value: 2.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 116 CVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPT 195
Cdd:cd17316   9 FFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 196 FLIYCSLRFLSGIAAMSLITNTIMLIAEWATHR-------FQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17316  89 PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKrrgfalgLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALP 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 269 YFVIFLtsswllesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnIC 348
Cdd:cd17316 169 ALLALL------------------------------------------------------------------------LR 176
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 349 KRISLLSFTRFANFMAYFGLNL-------HVQHLGNNVFLLQTLFGAVI-LLANCVAPWALKYMNRRASQMLLMFLLAIC 420
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTflptylqTVLGLSPATSSLYLLLISLGaLVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAP--LMMILSVYSPPLP 498
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPplIALLLASTGGTGV 336
                       410
                ....*....|....*..
gi 42542386 499 WIIYGVFPFISGFAFLL 515
Cdd:cd17316 337 PALILALLAIVALIVAL 353
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
119-520 1.95e-17

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 84.28  E-value: 1.95e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 119 GWVYDRISFS------STIVTEWDLVCDSQSLTSvakFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAAL 192
Cdd:cd17371   7 GWALDGFDLLllglvlPALIAEFGLDEAEAGLLG---TVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 193 APTFLIYCSLRFLSGIAAMSLITNTIMLIAE-WAT-HRFQAMGITLGMCPSGIAFMT-LAGLAFAIRD----WHILQLVV 265
Cdd:cd17371  84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEyVPArHRGKALGYVQSGWAVGWLLATlLAALLFPLLPpeiaWRVLFLLG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 266 SVPYFVIFLTSSWLLESARWLIinnkpeeglkelRKAAHRSGmknardtltleilkstmkkeleaaqKKKPSLCEMLHMP 345
Cdd:cd17371 164 ALPALLVLFIRRFVKEPPQWQA------------ARAARRHF-------------------------ADRPSLRELFSPP 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 346 NicKRISLLSF--TRFANFMAYFGLN---------LHVQHLGNNVFLLQTLFGAviLLANCVAPWALKYMNRRASQMLLM 414
Cdd:cd17371 207 L--LRTTLLASllATGALGGYYGITTwlpsyltgeRGLSFEGSAGYLVVTILGG--FLGYLAGGFLADRIGRRNNFALFA 282
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 415 FLLAICLLAIIFVPQEMQTLREVLATLGLGASA-LANTLAFAhgNEVIPTIIRARAMGINATFANIAGALAPLM--MILS 491
Cdd:cd17371 283 LGSAISILLYFFLPLSPTLILILGFPLGFFASGpFSGMGAYL--TELFPTAVRATAQGFCYNVGRIIGALFPFLvgFLAT 360
                       410       420
                ....*....|....*....|....*....
gi 42542386 492 VYSPPLPWIIYGVFPFISGFAFLLLPETR 520
Cdd:cd17371 361 SGSLGTAIAVFAAVYYIAGLVLALLLPET 389
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
128-471 2.09e-17

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 84.33  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   128 SSTIVTEWDLvcDSQSLTSVAKFVfMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSG 207
Cdd:TIGR00895  40 APAISAEWGL--DPVQLGFLFSAG-LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   208 IAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMT---LAGLAFAIRDWHILQLVVSV-PYFVIFLTSSWLLESA 283
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVggfLAGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESI 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   284 RWLIInNKPEEGLKELRKAAHRSGMKnardtltleilKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFM 363
Cdd:TIGR00895 197 DFLVS-KRPETVRRIVNAIAPQMQAE-----------AQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLV 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   364 AYFGLN-----LHVQHLGNN----VFLLQTLFGAVIllANCVAPWALKYMNRRAsqMLLMFLLAICLLAIIFvpqEMQTL 434
Cdd:TIGR00895 265 GVYFLTnwlpkLMVELGFSLslaaTGGALFNFGGVI--GSIIFGWLADRLGPRV--TALLLLLGAVFAVLVG---STLFS 337
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 42542386   435 REVLATLGLGASALAN---TLAFAHGNEVIPTIIRARAMG 471
Cdd:TIGR00895 338 PTLLLLLGAIAGFFVNggqSGLYALMALFYPTAIRATGVG 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
141-516 2.56e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.78  E-value: 2.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:cd17325  29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMAL 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 221 IAEWAT--HRFQAMGITLGMCPSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARwliinnkpeeglk 297
Cdd:cd17325 109 IADIAPpeERGRAMGIFSSAIGLGFLIgPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR------------- 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 298 elrkaahrsgmknardtltleilkSTMKKELEAAQKKKPSLCEMLHMPnickRISLLSFTRFANFMA----YFGLNLHVQ 373
Cdd:cd17325 176 ------------------------PPPNKRAVSAARLRSGLRLLLRDR----RLLALFLAIFVLAFAfgalEPFLPLYAA 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 374 HLGN-NVFLLQTLFGAVILLANCVAPWALKYMNR--RASQMLL-MFLLAICLLAIIFVPQeMQTLREVLATLGLGaSALA 449
Cdd:cd17325 228 ELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRigRKPLILIgLLLSAVALLLLPLATS-FWLLLLLLALLGLG-LGLV 305
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386 450 NTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLM--MILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLggFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
116-517 2.97e-17

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 83.29  E-value: 2.97e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 116 CVDGWVY-DRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAP 194
Cdd:cd17445   8 CDAGWNYtGLPGLTNNIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 195 TFLIYCSLRFLSG--IAAMSLITNTIMLIAEWATHRFQAMgITLGMCPSGIAFMTLaGLAFAIRDWHILQLVVSVPyFVI 272
Cdd:cd17445  88 SPSLFMAMRFLLGaaLAGVYLTLYLTRLELCDPPQRLLVA-MAGGLTMVGGHFLLL-GLALGCGSWRVLQGTITAP-LSL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 273 FLTSSWllesarwliinnkpeeglkelrkaahrSGMKNardtltleilkstmkkeleaaqkkkpslcemlhmpnickrIS 352
Cdd:cd17445 165 FLCYGC---------------------------PGVKN----------------------------------------LL 177
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 353 LLSFTrfaNFMAYfGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYM-------NRRASQMLLMFLLAICLLAII 425
Cdd:cd17445 178 ILGFT---TFIAH-AISHCYQSFSDDVRGTPSTFYLSYLLSTGTAGLACLFLcatvdrfGRRGILLLAMTLTGIASLILL 253
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 426 -FVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGV 504
Cdd:cd17445 254 gLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLAS 333
                       410
                ....*....|...
gi 42542386 505 FPFISGFAFLLLP 517
Cdd:cd17445 334 LALLAILSIMLLP 346
Sugar_tr pfam00083
Sugar (and other) transporter;
151-526 9.05e-17

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 82.70  E-value: 9.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   151 VFMAGMMVGGILGGHLSDRFGRrfvlRWCYLQVA---IVGT----CAALAPTFLIYCSLRFLSGIaAMSLITNTI-MLIA 222
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGR----KKSLLIANvlfVIGAvlqgAAKGKWSVYQLIVGRVLVGI-GVGGASVLApMYIS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   223 EWA--THR------FQaMGITLGMcPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEE 294
Cdd:pfam00083 129 EIApkKLRgalgslYQ-LAITFGI-LLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEE 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   295 GLKELRKaahrsGMKNARDTLTLEILKSTMKKELEAaqkKKPSLCEMLHMPNICKR----ISLLSFTRFA--NFMAYFG- 367
Cdd:pfam00083 207 AREVLAK-----LRGVPDVDRELDEIKDSLEAGQEA---EKASWKELFSTKTRRQRlligVMLQIFQQLTgiNAIFYYSt 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   368 ---LNLHVQhlgnNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLaIIFVPQEMQTLREVLATLGLG 444
Cdd:pfam00083 279 tifENLGLS----DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFV-ILGIVALLGVSKSDWAGIVAI 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   445 ASALANTLAFAHG---------NEVIPTIIRARAMGINATFANIAGALAPL--MMILSVYSPPLPWIIYGVFPFISG-FA 512
Cdd:pfam00083 354 VFIALFIAFFAMGwgpvpwvivSELFPLSVRSKAMALATAANWLANFLIGFlfPIITDAIGLGYTFFIFAGLLVLFIiFV 433
                         410
                  ....*....|....
gi 42542386   513 FLLLPETRNKPLFD 526
Cdd:pfam00083 434 FFFVPETKGRTLEE 447
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
151-523 1.55e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 81.47  E-value: 1.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:COG2223  48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRR 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 231 --AMGITLGMCPSGIAFMT-LAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLesarwliinNKPEEGLKELRKAAHRSg 307
Cdd:COG2223 128 glALGLAAGGGNLGAAVAAfLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFL---------RDPPAGAAAAAKASLRD- 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 308 mknardtlTLEILKStmkkeleaaqkkkpslcemlhmpnicKRISLLSFTRFANFMAYFGLNLHVQHLGNNVF------- 380
Cdd:COG2223 198 --------QLEALRD--------------------------PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFglsaata 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 381 -LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLreVLATLGLG-ASALANTLAFAHGN 458
Cdd:COG2223 244 gLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF--LVLFLLLGlALGGGNGAVFALVP 321
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42542386 459 EVIPTIIRARAMGINATFANIAGALAPLMMILSV---YSPPLPWIIYGVFPFISGFAFLLLPETRNKP 523
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdatGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
112-517 4.93e-16

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 79.43  E-value: 4.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 112 DMEPCVDGWVYDRISFS-STIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCA 190
Cdd:cd17443   4 LAVLCTGGWPFSAAAGLgSNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 191 ALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPyf 270
Cdd:cd17443  84 ALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLP-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 271 VIFLTSSWLLESARWLIinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnickr 350
Cdd:cd17443 162 LLLLLLYWCFPSRNGLI--------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 351 islLSFTRF--ANFMAYFGLNLHVQHLGNNV-FLLQTLFGAVILLANCVapwALKYMNRRASQMLLMFLLAICLLAIIFV 427
Cdd:cd17443 179 ---LGFTAFigGGIRYCFARNLAPFVPTFYLpYFLQAGLEALACIFLCL---TVDRCGRRGVLLLGTIVTGLSSLLLLAL 252
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 428 PQEMQ-TLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFP 506
Cdd:cd17443 253 TQYLHgGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFASFA 332
                       410
                ....*....|.
gi 42542386 507 FISGFAFLLLP 517
Cdd:cd17443 333 VLSVLCILLLP 343
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
151-522 1.44e-15

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 79.23  E-value: 1.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWC-YLQV--AIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWA-T 226
Cdd:cd17357  57 IFFIGGAIGSFISAFLANRFGRKNGLLISnALLVvsSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISpS 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 227 HRFQAMGItlgMCPSGIAFMTLAGLAFAIR-------DWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEglkel 299
Cdd:cd17357 137 ELRGALGS---LTQIGVTLGILLGQVFGLPsvlgtetLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEE----- 208
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 300 rkAAHRSGMKNARDTLTLEILKSTMKKELEA-AQKKKPSLCEMLHMPNICKRISL---LSFTR-FANFMA--YFG----- 367
Cdd:cd17357 209 --EAEKSLKFLRGIEDDVDQELEEIKKESEQmGDQKQVSLMQLLRDPSLRLPLLLvlvVSASQqFSGINAifFYStfife 286
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 368 -LNLHVQHlgnnVFLLQTLFGAVILLANCVAPWALKYMNRRAsqmLLMFLLAICLLAIIFVPQEMQTLRE--VLATLGLG 444
Cdd:cd17357 287 nAGFSPQL----AEWANLGIGIVNVLSTIVGPFLIEKVGRRP---LLLISLSVCAVALLLMSVFLFLSEQnsWMSYGCIV 359
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 445 ASAL--------ANTLAFAHGNEVIPTIIRARAMG----INATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFIsgFA 512
Cdd:cd17357 360 AIFLfifffaigLGPIPWFIGAELFPQAPRSAAQSlgssVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLL--YL 437
                       410
                ....*....|
gi 42542386 513 FLLLPETRNK 522
Cdd:cd17357 438 YRYLPETKGR 447
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
124-278 1.30e-13

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 72.57  E-value: 1.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 124 RISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLR 203
Cdd:cd17444  17 RAGLVQNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLR 96
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42542386 204 FLSGIAAMSLITNTIMLIAEWA--THRFQAMGITLGMCPSGIAFMtlAGLAFAIRDWHILQLVVSVPYfvIFLTSSW 278
Cdd:cd17444  97 FFEGFCLAGIILSLYALRIELCppGHRFMITMVASFIAMAGQFLM--PGLAALCRDWQVLQAVIICPF--LLMLSYW 169
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
151-516 7.54e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 70.29  E-value: 7.54e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATH--R 228
Cdd:cd17474  42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGgeR 121
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 229 FQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLEsarwliinnKPEEGLKELRKAAHRSGM 308
Cdd:cd17474 122 AKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLP---------EPKEKAKSSSATKLRDLK 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 309 KNARDTLTLEILKSTMkkeleaaqkkkpslcemlhmpnickrisLLSFTRFAnFMAYFGLNLHvQHLGNNVF---LLQTL 385
Cdd:cd17474 193 KALRGRGLLTFLVSAF----------------------------LYFFLYFA-FLTYLPFLLE-LLYGISPIiigLLFAG 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 386 FG-AVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP-QEMQTLREVLATLGLGAS-ALANTLAfahgNEVIP 462
Cdd:cd17474 243 WSvLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPsLALLLIAIVLFGLGLGLNlPLLTTLV----TELAP 318
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42542386 463 TIIRARAMGINATFANIAGALAPLMM--ILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFglLLEIFGLSAPFLVGAAIALAAAVLLALL 374
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
151-288 9.28e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 69.07  E-value: 9.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT--HR 228
Cdd:COG0477  57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFParER 136
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42542386 229 FQAMGITLGMCPSGIAFMTLAGLAF-AIRDWHILQLVVSVPYFVIFLTSSWLLESARWLII 288
Cdd:COG0477 137 GRALGLWGAAIGLGLALGPLLGGLLvAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
155-524 6.60e-12

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 67.60  E-value: 6.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 155 GMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAP-TFLIYCSlRFLSGIaAMSLITNTI-MLIAEWATHRFQ-A 231
Cdd:cd17358  53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKdVWMLYLG-RFLAGF-GGGAASVVVpVYIAEIAPKNVRgA 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 232 MG-ITLGMCPSGIAFMTLAGLAFairDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKaahrsgMKN 310
Cdd:cd17358 131 LGsLNQLLVNIGILLGYVLGSFL---PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQF------LRG 201
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 311 ARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPN-----ICkrISLLSFTRF--ANFMAYFGLNLHVQ-HLGNNVFLL 382
Cdd:cd17358 202 KDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYlkplvIG--LGLMLFQQLsgINAVIFYASSIFDEaGSGLDPNTA 279
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 383 QTLFGAVILLANCVAPWALKYMNRRasqMLLMF---LLAICLLAI---IFVPQEMQTLREV-------------LATLGL 443
Cdd:cd17358 280 TIIIGVVQVVGTLVATLLVDRLGRR---PLLLVsaiGMGIGLLALglyFYLQEHGALLSSVswlplvglviyiiSFSIGL 356
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 444 GAsalantLAFAHGNEVIPTIIRARAMGI----NATFANIAGALAPLMMIlsVYSPPLPWIIYGVFPFISG-FAFLLLPE 518
Cdd:cd17358 357 GP------LPWVIMSEIFPAKIKGLAGSLvtlvNWLFAFIVTKTFPFLTL--AWGASGTFWIFAGICGLALvFVLLFVPE 428

                ....*.
gi 42542386 519 TRNKPL 524
Cdd:cd17358 429 TKGKSL 434
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
120-517 2.06e-11

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 65.62  E-value: 2.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 120 WVYDRISFSST-IVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLI 198
Cdd:cd17373   1 WDYGIRAGLVQnAVSKWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 199 YCSLRFLSGIAAMSLITNTIMLIAEWA--THRFQamgITLGMCPSGIA-FMTLAGLAFAIRDWHILQLVVSVPYFVIFLT 275
Cdd:cd17373  81 FSTLRFLEGFCLAGIILTLYLLRLELCdpGKRLM---ITMVASLVAVAgQFLMPGLAALCRDWRVLQALIICPFLLMLLY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 276 SSWLLESARWLIINNKPEEGlkeLRKAAHRSGMKNARDTLTLEILkstMKKELEAAqkkkpSLCEMLHMPNICKRISLLS 355
Cdd:cd17373 158 WSIFPKNILILGFNSLTGYG---IRHCFARSMMGHEPENFYLDYY---LTAGIAAV-----ACVFLCVTVDFLGRRGGLL 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 356 FtrfanFMAYFGLNLHVQhLGnnvfllqtlfgavilLANCVAPWALKYMNRRASQMLLMFLLAicllaiifvpqemqtlr 435
Cdd:cd17373 227 L-----FMILTGLASLLL-LG---------------LLNLIGKYSQHPDSGMSDSVKDKFSIA----------------- 268
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 436 evLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLL 515
Cdd:cd17373 269 --FSVLGLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHNQKGYFLQHVVFACCALLCILCILL 346

                ..
gi 42542386 516 LP 517
Cdd:cd17373 347 LP 348
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
153-274 2.41e-11

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 65.30  E-value: 2.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 153 MAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAM 232
Cdd:cd17365  44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSL 123
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 42542386 233 GITLGMCPSGIAFMTLAGLAFAIRD---WHILQLVVSVPYFVIFL 274
Cdd:cd17365 124 AVTLMFCGYPLGAALGGFLAAALIPafgWRSVFLLGGVPPLILLP 168
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
151-514 2.23e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.49  E-value: 2.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWA--THR 228
Cdd:cd17324  42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVppEKR 121
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 229 FQAMGI-----TLGMCpSGIAFMTLAGLAFairDWHILQLVVSVPYFVIFLTSSWLLESarwliinnkpeeglkelRKAA 303
Cdd:cd17324 122 GRAIGLvfsglTLGLV-LGRPLGGLLGQLL---GWRAAFLAIAVLALLAALLLWRLLPS-----------------LPPK 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 304 HRSGMKNARDtltleilkstmkkelEAAQKKKPSLceMLHMPnickrISLLSFTRFANFMAYFGLNLH--VQHLGNNVFL 381
Cdd:cd17324 181 KPGSLGLLSS---------------LLLLLRNPRL--RLAYL-----ITFLLFGGFFALYTYLAPFLTdvPGFSSSAIIG 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 382 LQTLFGAVILLANCVAP-WALKYMNRRAsqMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASA---LANTLAFAHG 457
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGrLADRGGRRAL--LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAahsALQTRVLRLA 316
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386 458 NEViptiiRARAMGINATFANIAGALAPLM--MILSVYSPPLPWIIYGVFPFISGFAFL 514
Cdd:cd17324 317 PEA-----RGLASSLYLAAYNLGGALGAALggLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
151-300 6.99e-08

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 54.88  E-value: 6.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:cd17433  49 VVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVR 128
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42542386 231 AmgiTLGMCPS-----GIAFMTLAGLAFairDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
Cdd:cd17433 129 G---TLGSCVQlmvviGIMGAYLAGLVL---DWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALR 197
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
141-516 7.07e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.54  E-value: 7.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY-LQVAIVGTCAALAPTFLIycSLRFLSGIAAMSLITNTIM 219
Cdd:cd06173  32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADlLRALLAAVLALLALLGSL--SLWLLLVLAFLLGIASAFF 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 220 LIAEWAT--------HRFQAMGI-TLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLlesarwliinN 290
Cdd:cd06173 110 GPARQALlpelvpkeQLVRANALnSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFI----------R 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 291 KPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMkkeleaaqkkkpslcemlhmpnickrISLLSFTRFANFMAYFGLNL 370
Cdd:cd06173 180 RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLL--------------------------LLALALFALLGGALTVLLPL 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 371 HVQ---HLGNNVF-LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLrevLATLGLGAS 446
Cdd:cd06173 234 LAKevlGGGAAGYgLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLL---AALFLLGLA 310
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42542386 447 -ALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMM--ILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:cd06173 311 gGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAglLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
153-292 1.00e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 54.11  E-value: 1.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 153 MAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHR---- 228
Cdd:cd17359  46 LLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEirgr 125
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42542386 229 ---FQAMGITLGMCpsgIAFMTLAGLA-FAIRDWHILQ------LVVSVPYFVIFLTSSWLLESARWLIINNKP 292
Cdd:cd17359 126 lvsLNQLMIVFGQL---LAYIVNYLIAnAGGADWLGAEgwrwmlGLEAIPAILFLLGMLFIPESPRWLVSKGKP 196
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
134-517 1.44e-07

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 53.66  E-value: 1.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 134 EWDLVCDSQSLTSVAKFVfmaGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIaAMSL 213
Cdd:cd17441  28 EWRLPSWQVALLTSVVFI---GMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGF-GIGG 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 214 ITNTIMLIAEWATHRFQAMGITLGMC--PSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESAR------ 284
Cdd:cd17441 104 VPQSVTLYAEFLPMKSRAKCILLIEVfwALGTVFeVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARywttil 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 285 -WLIInnkpeeglkeLRKAAHRSGMKnardTLTLEILKSTMKKELEAAQKKKPSlcemlhMPNICKRISLLSFTRfanfm 363
Cdd:cd17441 184 lWFIW----------FSNAFSYYGLV----LLTTELFQAGDVCSGSSGKKVEGK------CSLECEYLTTSDYMD----- 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 364 ayfglnlhvqhlgnnvFLLQTL--FGAVIllancVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTlrEVLATL 441
Cdd:cd17441 239 ----------------LLWTTLseFPGLL-----VTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVGRFSL--TVLLFI 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 442 GLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAP----LMMILSVYsppLPWIIYGVFPFISGFAFLLLP 517
Cdd:cd17441 296 ARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPfiaqVMLESSVY---LTLSVYSGCCLLAAIASCFLP 372
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
119-487 2.38e-07

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 52.92  E-value: 2.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 119 GWVYDR-----ISFSSTIV-TEWDLVCDSQSLTSVAKFVfmaGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAAL 192
Cdd:cd17372   7 GWVAEAmemmlLSFVGPAVqCEWNLSAWQVALITSVVFA---GMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 193 APTFLIYCSLRFLSGIaAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIR---DWHILQLVVSVPY 269
Cdd:cd17372  84 APNYMWLIILRCLVGL-GLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMprlGWRWLLAFSSVPS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 270 FVIFLTSSWLLESAR--WLII--NNKPEEGL----KELRKAAHRSGMKNARDtltleilkstmkkeleAAQKKKPSLCEM 341
Cdd:cd17372 163 SLLLVFYRWTPKTTLllWVIWfgNAFAYYGVvlltTELNNSHNVCGSKSDSD----------------SGESPTEKQCRN 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 342 LHMPNIckrisllsFTRFANFMAYFGLNLhvqhlgnnvfllqtlfgavillancVAPWALKYMNRRASQMLLMFLLAICL 421
Cdd:cd17372 227 SNDVDY--------RDVFIATFAEFPGLL-------------------------ISAAMIDRLGRKASMASMLFTCCIFL 273
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386 422 LaiifvPQEMQTLREVLATLGLGASAL---ANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLM 487
Cdd:cd17372 274 L-----LLLICQSPFILTVLLFGGRACisaAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFI 337
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
141-516 2.45e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.00  E-value: 2.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:cd17329  33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAM 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 221 IAEWATHRFQAMGITLG--MCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKE 298
Cdd:cd17329 113 IADVTTPENRTRAFSLLywAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 299 LRKAAHRsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnicKRISLLSFTRFANFMAYFGLN----LHVQH 374
Cdd:cd17329 193 YKIVLRD-------------------------------------------RAFLLFLLASFLISLIYFQLEstlpVYVVE 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 375 -LGNNVFLLQTLFGA----VILLANCVAPWALKyMNRRASQMLLMFLLAICLLAIIFVPQEMQ--------TLREVLATL 441
Cdd:cd17329 230 iLGLGESLLGLLLALnallIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVlilamivlTLGEMLVFP 308
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42542386 442 GlgASALANTLAfahgneviPTIIRARAMGINATFANIAGALAPLM--MILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:cd17329 309 A--VQTLVAALA--------PPDKRGSYMGFYALAWGLGRAIGPLVggLLLDLLGPGLPWLILAALGLIAAALLLGL 375
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
142-522 3.25e-07

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 52.72  E-value: 3.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 142 QSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTC----AALAPTFLIYCSLRFLSGIAAmSLITNT 217
Cdd:cd17431  49 TTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNL-LAFAGAAlmglSKLAKSYEMLILGRFIIGLYC-GLTTGL 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 218 I-MLIAEWA-TH------RFQAMGITLGMCPSGIafmtlAGLAFAIRD---WHILQLVVSVPYFVIFLTSSWLLESARWL 286
Cdd:cd17431 127 VpMYIGEISpTAlrgalgTLHQLGIVVGILISQI-----FGLEFILGTeelWPLLLGFTIVPAILQLALLPFCPESPRYL 201
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 287 IINNKPEEglkelrKAahRSGMKNARDTLTLEILKSTMKKELEAAQK-KKPSLCEMLHMPNICKRISLLSFTRFA----- 360
Cdd:cd17431 202 LINRNEEE------EA--KSVLKKLRGTTDVSEDIQEMKEESRQMMReKKVTILELFRSSSYRQPIIIAIVLQLSqqlsg 273
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 361 -NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC--LLAIIFVPQEMQ---TL 434
Cdd:cd17431 274 iNAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVERAGRRTLHLIGLGGMAICaiLMTIALLLLEGYpwmSY 353
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 435 REVLATLGLGASalantlaFAHGNEVIPTII---------RARAMGInATFANIAGALAPLMMILSV--YSPPLPWIIYG 503
Cdd:cd17431 354 VSIVAIFGFVAF-------FEIGPGPIPWFIvaelfsqgpRPAAMAV-AGFSNWTSNFIVGMCFQYIanLCGPYVFIIFT 425
                       410       420
                ....*....|....*....|
gi 42542386 504 VFPFI-SGFAFLLLPETRNK 522
Cdd:cd17431 426 VFLLTfFIFTYFKVPETKGK 445
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
141-255 3.56e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 52.56  E-value: 3.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLrFLSGIAAMSLITNTIML 220
Cdd:cd17478 228 SLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVL 306
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 42542386 221 IAE-WATHRFQAMGITLGMCpsgiafMTLAGLAFAI 255
Cdd:cd17478 307 AQElLPGNVGLASGLMMGLS------FGLGGIGAPV 336
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
356-520 7.02e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.51  E-value: 7.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 356 FTRFANFMAYFGLNLHVQHLGNNVFLLQ---TLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQ 432
Cdd:COG2814  21 LSGLGIGIVLPALPLIAADLGASPAQAGlvvTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 433 TLrevLATLGLG-ASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLM--MILSVYSPPLPWIIYGVFPFIS 509
Cdd:COG2814 101 LL---AARFLQGlGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLggLLADLFGWRWVFLVNAVLALLA 177
                       170
                ....*....|..
gi 42542386 510 GF-AFLLLPETR 520
Cdd:COG2814 178 LLlLLRLLPESR 189
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
157-517 7.80e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 7.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 157 MVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT----HRF--- 229
Cdd:cd17473  49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEgeerAKMlgl 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 230 QAMGITLGmcpsGIAFMTLAGLAFAIrDWHILQLVVSVPYFVIFLTSSWLLESARwliinnkpeeglkelrkaahrsgmk 309
Cdd:cd17473 129 QSAAMSLG----GVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPAR------------------------- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 310 nardtltleilKSTMKKELEAAQKKKPSLcemlhmpnicKRISLLSFTRFANFMAYFGLN----LHVQHLGNNVFLLQTL 385
Cdd:cd17473 179 -----------KSKSAASPGAATAAALPW----------KRVLPIYFLAFLAMLLFYVIPiqlpFLLQERGGGSAALIGL 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 386 FGAVILLANCVAPWALKYMNRR---ASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGAS-ALANTLAFAhgNEVI 461
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRRlgkRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWA--MSLV 315
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386 462 PTIIRARAMGINATFANIAGALAPLMMILSV---YSPPLPWIIYGVFPFISGFAFLLLP 517
Cdd:cd17473 316 PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnltGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
151-282 1.29e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 50.65  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTCA-ALAPTFLIYCSLRFLSGIaAMSLITNTI-MLIAEWA-TH 227
Cdd:cd17315  42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAV-LYVIGALLsALAPNVWVLIVGRFLLGL-GVGLASVLVpLYISEIApAK 119
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386 228 RFQAMGITLGMCPS-GIAFMTLAGLAFAIRD---WHILQLVVSVPYFVIFLTSSWLLES 282
Cdd:cd17315 120 IRGALGTLNQLMITfGILLAYLLGLALSLSPpgwWRLMFALAAVPALLQLLLMFFLPES 178
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
155-286 2.35e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 49.96  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386  155 GMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGI---AAMSlitNTIMLIAEWATHRFQA 231
Cdd:PRK11551  62 GLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglgGALP---NLIALTSEAVGPRLRG 138
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386  232 MGITLGMC--PSGIAFMTLAGLAFAI-RDW-HILQLVVSVPYFVIFLTSSWLLESARWL 286
Cdd:PRK11551 139 TAVSLMYCgvPFGGALASVIGVLAAGdAAWrHIFYVGGVGPLLLVPLLMRWLPESRAFA 197
MFS_1 pfam07690
Major Facilitator Superfamily;
354-539 3.48e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   354 LSFTRFANFMAYFGLN-----LHVQHLGNNVF---LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAII 425
Cdd:pfam07690   1 LFLAAFLAALGRSLLGpalplLLAEDLGISPTeigLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   426 FVPQEMQTLreVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMM--ILSVYSPPLPWIIYG 503
Cdd:pfam07690  81 FASSLWLLL--VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGglLASLFGWRAAFLILA 158
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 42542386   504 VFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPR 539
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
150-274 9.39e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 9.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLIT--NTIMLIAEWATH 227
Cdd:COG0738  50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVaaNPYVAALGPETA 129
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42542386 228 R--------FQAMGITLGmcPSGIAFMTLAGLAFAirdWHILQLVVSVPYFVIFL 274
Cdd:COG0738 130 AsrlnllhaFFSLGALLG--PLLGGLLILLGLSLS---WHLPYLILAVLLLLLAL 179
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
123-208 3.29e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.03  E-value: 3.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 123 DRISFSSTIVTEWDLVCDSQSLTSVAKFV------FMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTF 196
Cdd:cd17330   8 DALGFGIVFPVLPFYVREFNKLGASGYYVgllqssYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL 87
                        90
                ....*....|..
gi 42542386 197 LIYCSLRFLSGI 208
Cdd:cd17330  88 WLLFLARFLDGL 99
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
141-258 3.53e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.11  E-value: 3.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTCAALAPTFLIYCSLRF--LSGIAAMSLITNTI 218
Cdd:cd17355 243 SPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA-LRALGLALLLLLPFPPLALLLFaaLFGLGWGATVPLTA 321
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 42542386 219 MLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDW 258
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
359-519 7.64e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.28  E-value: 7.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 359 FANFMAYFG-------LNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEM 431
Cdd:cd17489   3 LANFFFFLSfylllpvLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 432 QTLREVLATLGLGAS-ALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPL--MMILSVYSPPLPWIIYGVFPFI 508
Cdd:cd17489  83 SVALLLVLRLIHGIGwGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAlgLFLYQHLGFAVLFIVAAVLALL 162
                       170
                ....*....|.
gi 42542386 509 SGFAFLLLPET 519
Cdd:cd17489 163 ALLLVFLVKDP 173
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
151-215 1.16e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.48  E-value: 1.16e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGrrfvLRWC-YLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLIT 215
Cdd:cd17502 127 VFGIASVAGPLIGGAFTDHLS----WRWCfYINLPIGGLALALLRTILLSSIFGFLFGGALFGLIY 188
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
151-285 1.61e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.07  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGT-CAALAPTFLIYCSLRFLSGIaAMSLITNTIMLIA--EWATH 227
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL-LAAVGLlLALLAPGPWLALIGLALVGL-GLSLMFPTIFSLAldGLGKR 331
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386 228 RFQAMGITLGMCPSGIAFMTLA-GLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARW 285
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPLiGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
141-227 1.64e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.09  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCylqvAIVGTCAALAPTFLIYCSLR-----FLSGIAAMSLIT 215
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC----ALLGALAALLLPLVPGLPLAllvllFLWGGAAGPLYT 296
                        90
                ....*....|..
gi 42542386 216 NTIMLIAEWATH 227
Cdd:cd17477 297 LALALAGDRLPG 308
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
385-516 2.03e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 43.71  E-value: 2.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 385 LFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLreVLATLGLGASALANTLAFAHGNEVIPTI 464
Cdd:cd17319 226 LAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAV--ILLSLAGFGIGAASPVFWSLPADLLPGE 303
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42542386 465 IRARAMGINATFANIAGALAPLMM---ILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:cd17319 304 AAATAGGLINSGGNLGGFVAPLLIgylVDATGSYTAAFLFLAAVALLAALLVLLL 358
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
140-254 2.72e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 2.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 140 DSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPT-----FLIYCslrFLSGIAAMSLI 214
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnlwlLLVLA---ALAGIGLGAIL 337
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 42542386 215 TNTIMLIA------EWATHRfQAMGITLGMcpsgIAFMTLAGLAFA 254
Cdd:COG2211 338 VLPWAMLAdvvdydEWKTGR-RREGLYFGI----FTFAIKLGQALA 378
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
351-523 3.14e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.18  E-value: 3.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 351 ISLLSF-TRFANFMAYFGLNLHVQHLGNN---VFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIF 426
Cdd:cd06174   1 LLLGFFlTGLARGLISPLLPALLQSFGLSasqLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 427 VPQemqtLREVLATLGLG--ASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPW----I 500
Cdd:cd06174  81 APS----FWLLLLGRFLLglGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWravfL 156
                       170       180
                ....*....|....*....|...
gi 42542386 501 IYGVFPFISGFAFLLLPETRNKP 523
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPES 179
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
151-210 3.37e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.95  E-value: 3.37e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTCA-ALAPTFLIYCSLRFLSGIAA 210
Cdd:cd17320  42 AYLLGFALGQLLYGPLSDRFGRRPVLLAGLL-LFILASLLcALASSIEQLLIARFLQGLGA 101
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
351-523 4.12e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.95  E-value: 4.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 351 ISLLSFTRFANFMAYFG-LNLHVQHLGNNVF---LLQTLFGAVILLANCVA-PWALKYMNRRAsqMLL-MFLLAICLLAI 424
Cdd:cd17325   1 LSLALFLDMLGYGIIIPiLPLYAESLGASVAqigLIVAAYALAQLLFSPPAgRLSDRFGRKRL--LLLgLLLLAVSTLLF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 425 IFVPQEMQTLreVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMM--ILSVYSPPLPWIIY 502
Cdd:cd17325  79 AFATSYWQLL--LARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGglLADALGYRAPFLVC 156
                       170       180
                ....*....|....*....|..
gi 42542386 503 GVFPFISG-FAFLLLPETRNKP 523
Cdd:cd17325 157 AALALLALvLALLLLPEPRPPP 178
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
134-309 4.37e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 43.04  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   134 EWDLvCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCylqVAIVGTCAALAP-----TFLIYCslRFLSGI 208
Cdd:TIGR01299 194 EKDL-CIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLIC---LSVNGFFAFFSSfvqgyGFFLFC--RLLSGF 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   209 AAMSLITNTIMLIAE-----------------WATHRFQAMGITLGMCPS-GIAFMTlaGLAFAIRDWHILQLVVSVPYF 270
Cdd:TIGR01299 268 GIGGAIPIVFSYFAEflaqekrgehlswlcmfWMIGGIYAAAMAWAIIPHyGWSFQM--GSAYQFHSWRVFVIVCAFPCV 345
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 42542386   271 VIFLTSSWLLESARWLIINNKPEEGLKELrKAAHRSGMK 309
Cdd:TIGR01299 346 FAIGALTFMPESPRFFLENGKHDEAWMIL-KLIHDTNMR 383
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
151-512 4.38e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.55  E-value: 4.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT--HR 228
Cdd:cd17477  39 AYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATneNR 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 229 FQAMGItlgmcpsgiaFMTLAGLAFAIRdwhilQLVVSVPY---FVIFLTSSWLLESArwLIINNKPEEGLKELRKAAHR 305
Cdd:cd17477 119 GRVLGL----------YSTVLGLGFALG-----PLLLALVGtagALPFLIAAVLLLLA--LVPLLLTRRAAPEIEEAESI 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 306 SGMKnardtltleilkstmkkeleAAQKKKPSLCEMLhmpnickrISLLSFTRFANFMAYFGLNLH--VQHLGnnvfllq 383
Cdd:cd17477 182 SLRR--------------------LLRIAPLALLGAF--------VAGFLEGAFYSLLPLYGLRLGlsVAQAA------- 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 384 tLFGAVILLANCVAPWALKY----MNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALaNTLAFAHGNE 459
Cdd:cd17477 227 -LLLAAFVLGGLLLQWPLGWladrFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL-YTLALALAGD 304
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42542386 460 VIPTIIRARAMGINATFANIAGALAPLM--MILSVYSPP-LPWIIYGVFPFISGFA 512
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLagALMDAFGPHgLFLFLAAVALLFLLFL 360
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
125-250 6.62e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.18  E-value: 6.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 125 ISFSSTIVTEWDlVCDSQSLTSVAkfVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRF 204
Cdd:cd17323  19 SPALPQIAEDFH-VSEEVANLGVS--LFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 42542386 205 LSGIAAMSLITNTIMLIAE-WATH-RFQAMGITLGMCPSGIAFMTLAG 250
Cdd:cd17323  96 LQGFFGSSPLAIGAGTIADlFTPEeRGKAMGVYSLGPLLGPALGPIIG 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
326-538 6.71e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.20  E-value: 6.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 326 KELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLN-----LHVQHLGNN---VFLLQTLFGAVILLANCVA 397
Cdd:COG2211 205 KERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAalllyYFKYVLGLSaalVGLLLALYFLAALLGAPLW 284
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 398 PWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIP-----TIIRARA--M 470
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewkTGRRREGlyF 364
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 471 GINATFANIAGALAPLM--MILSV--YSPPLP-------------WIIYGVFPFISGFAFLLLPETRNKplFDTIQDEKN 533
Cdd:COG2211 365 GIFTFAIKLGQALAGALagLLLALfgYVAGAAqspsaltgirllfFLLPAVLLLLAALLLLFYPLTRER--HAEIRAELA 442

                ....*
gi 42542386 534 ERKDP 538
Cdd:COG2211 443 ARRAA 447
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
154-285 7.01e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 41.87  E-value: 7.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 154 AGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFL----SGIAAMslitnTI-MLIAEWATHR 228
Cdd:cd17360  46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLvglgVGIASM-----TVpLYIAEAAPPR 120
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42542386 229 FQAMGITL-GMCPSG---IAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARW 285
Cdd:cd17360 121 IRGRLVTInVLFITGgqfVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRW 181
xylE PRK10077
D-xylose transporter XylE; Provisional
155-526 8.04e-04

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 41.99  E-value: 8.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386  155 GMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVG---------------TCAALAPTFLIYcslRFLSGIAA--MSLITNt 217
Cdd:PRK10077  67 GCIIGGALGGYCSNRFGRRDSLKIAAVLFFISAlgsawpefgftsigpDNTGYVPEFVIY---RIIGGIGVglASMLSP- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386  218 iMLIAEWAthrfqamgitlgmcPSGIAFMTLAGLAFAIrdwhIL-QLVVsvpYFVIFL-----TSSWLL----------- 280
Cdd:PRK10077 143 -MYIAEIA--------------PAHIRGKLVSFNQFAI----IFgQLVV---YFVNYFiarsgDASWLNtdgwrymfase 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386  281 ---------------ESARWLIINNKPEEGLKELRKAahrsgMKNARDTLTLEILKSTMKKELEAAQKkkpslcemlhmp 345
Cdd:PRK10077 201 aipallflmllyfvpETPRYLMSRGKQEQAEGILRKI-----MGNTLATQALQEIKHSLDHGRKTGGK------------ 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386  346 nickrisLLSFTRFANFMayfGLNLHV--QHLGNNVFL------------------LQTLF-GAVILLANCVAPWALKYM 404
Cdd:PRK10077 264 -------LLMFGVGVIVI---GVMLSVfqQFVGINVVLyyapeifktlgastdialLQTIIvGVINLTFTVLAIMTVDKF 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386  405 NRRASQM-------LLMFLLAICLLAiifvpqemqtlrevlATLGLGA--SALANTLAFAHG---------NEVIPTIIR 466
Cdd:PRK10077 334 GRKPLQIigalgmaIGMFSLGTAFYT---------------QAPGIVAllSMLFYVAAFAMSwgpvcwvllSEIFPNAIR 398
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42542386  467 ARAMGINATFANIAGALA----PLMMILSV----YSPPLPWIIYGVFPFISG-FAFLLLPETRNKPLFD 526
Cdd:PRK10077 399 GKALAIAVAAQWIANYFVswtfPMMDKNSWlvahFHNGFSYWIYGCMGVLAAlFMWKFVPETKGKTLEE 467
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
150-516 8.57e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 8.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIaAMSLITNTIMLIAEW---AT 226
Cdd:cd17489  38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI-GWGAFTTAAATLVADiipPS 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 227 HRFQAMGItLGMCpSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTsswllesarWLIINNKPEEglKELRKAAHRS 306
Cdd:cd17489 117 RRGEGIGY-YGLA-TTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLA---------LLLVFLVKDP--PPVAAEEAEA 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 307 GMKNARDTLTLEILKSTMkkeleaaqkkkpslcemlhmpnickrISLLSFTRFANFMAYfgLNLHVQHLG-NNVFLLQTL 385
Cdd:cd17489 184 GTRAFRRLVEKKVLPPAL--------------------------ILFLASIAYGAISTF--LPLYAAERGiSNAGLFFTV 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 386 FGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFvpqeMQTLREVLAT---LGLGASALANTLAFAHGNEVIP 462
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF----AGSPWMLLLAavlYGLGFGLLFPALQALAVDLVPP 311
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42542386 463 TiIRARAMGINATFANIAGALAPLM--MILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:cd17489 312 H-RRGAANGTFFIFFDLGIGLGGLLlgLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
138-309 2.18e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 40.78  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 138 VCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNT 217
Cdd:cd17439  29 MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIV 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 218 IMLIAE-----------------WATHRFQAMGITLGMCPS-GIAFMTlaGLAFAIRDWHILQLVVSVPYFVIFLTSSWL 279
Cdd:cd17439 109 FSYFSEflaqekrgehlswlcmfWMIGGIYASAMAWAIIPHyGWSFQM--GSAYQFHSWRVFVLVCAFPSVFAIGALTTM 186
                       170       180       190
                ....*....|....*....|....*....|
gi 42542386 280 LESARWLIINNKPEEGLKELrKAAHRSGMK 309
Cdd:cd17439 187 PESPRFFLENGKHDEAWMVL-KQVHDTNMR 215
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
138-309 2.40e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 40.55  E-value: 2.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 138 VCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCylqVAIVGTCAALAP-----TFLIYCslRFLSGIAAMS 212
Cdd:cd17363  29 MCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIA---LSVNGVFAFLSSfvqgyGFFLFC--RLLSGIGIGG 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 213 LITNTIMLIAE-----------------WATHRFQAMGITLGMCPS-GIAFMTlaGLAFAIRDWHILQLVVSVPYFVIFL 274
Cdd:cd17363 104 SIPIVFSYFAEflarekrgehlswlcmfWMIGGLYASAMAWAIIPHyGWGFSM--GTAYQFHSWRVFVIVCALPSVASVV 181
                       170       180       190
                ....*....|....*....|....*....|....*
gi 42542386 275 TSSWLLESARWLIINNKPEEGLKELRKaAHRSGMK 309
Cdd:cd17363 182 ALTFMPESPRFLLEVGKHDEAWMILKQ-VHDTNMR 215
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
151-299 2.42e-03

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 40.59  E-value: 2.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:cd17434  49 VFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVR 128
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42542386 231 AMgitLGMCPSGIA-FMTLAGLAFA-IRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
Cdd:cd17434 129 GA---LGACPQIMAvFGSLALYALGlLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKAL 196
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
450-524 2.91e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 40.48  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   450 NTLAFAHGNEVIPTIIRARAMGINATFANI-----AGALAPLMMILSV--YSPPLPW-----IIYGVFPFISGFAFLLLP 517
Cdd:TIGR00887 410 NATTFIVPGEVFPTRYRSTAHGISAASGKAgaiigQFGFLYLAQHGDPtkGYPTGIWmghvlEIFALFMFLGILFTLLIP 489

                  ....*..
gi 42542386   518 ETRNKPL 524
Cdd:TIGR00887 490 ETKGKSL 496
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
379-511 3.30e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.87  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 379 VFLLQTLFGAVILLAncvAPWALKYMNRRASQMLL---MFLLAICLLAIIFVPQEMQTLREVLATLGLGAS----ALANT 451
Cdd:cd17504 219 AGLLLLPGALVMLIA---GPLAGRLIARVGPRRVLligLVISAVGLLLLALLHSSLWALVVALLLIGIGLGlafaSLPNI 295
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42542386 452 LAFAhgnevIPTIIRARAMGINATFANIAGALAPLM--MILSVYSPPlpwIIYGVFPFISGF 511
Cdd:cd17504 296 VVES-----VPPDRTGIATGMNTVLRTIGSAIGPAIagAILTTYTVS---ITSGGVPTEGAY 349
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
162-487 3.45e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.94  E-value: 3.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 162 LGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAmSLITNTIMLIAEwATHRFQAmGITLGMCPS 241
Cdd:cd17391  55 IWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFS-GYVPNATALIAS-QTPKEKS-GWALGTLST 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 242 GIAFMTLAG--LAFAIRDWHILQlvvsvpyFVIFLTSSWLLESARWLIINNKpeEGLKELRKAAHRSGMknardtltlEI 319
Cdd:cd17391 132 GVVAGTLIGplLGGFLADLFGIR-------NVFFITGGLLFLAFLLTLFFVK--EDFKPVEKKKMVSTK---------EV 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 320 LKSTMKKELEAAqkkkpslcemlhmpnickrISLLSF-TRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVIL---LANC 395
Cdd:cd17391 194 WNSVPNPSLLIS-------------------LFVTTFiIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSatgVSSL 254
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 396 V-APWALKYMNRRASQMLLmfLLAICLLAIIFVPQE-MQTLREVLA---TLGLGASAL---ANTLAfahgNEVIPTIIRA 467
Cdd:cd17391 255 LsAPRLGKLGDRIGHHRIL--LGALLASALLYIPQAfVQTPWQLGIlrfLLGLATGGLlpaINSLL----AKITPKEVAG 328
                       330       340
                ....*....|....*....|
gi 42542386 468 RAMGINATFANIAGALAPLM 487
Cdd:cd17391 329 RIFGYNQSFQYLGNVAGPLL 348
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
150-265 3.77e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 39.93  E-value: 3.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIA--AMSLITNTIMLIAEWATH 227
Cdd:cd17393  41 LALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAngALDVAMNAQGVAVERAYG 120
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 42542386 228 R-----FQAMGiTLGMCPSGIAFMTLAGLAFAiRDWHILQLVV 265
Cdd:cd17393 121 RpimssLHAMW-SLGGLAGALLGAAAIGAGVS-PGVHLLAAAV 161
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
151-268 4.04e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.46  E-value: 4.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVggiLGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:cd17321  42 LAFAALLL---LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERR 118
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 42542386 231 AMGITLGMCPSGIAFM---TLAGLAFAIRDWHILqLVVSVP 268
Cdd:cd17321 119 GRALGLWGAVVGIGAAlgpLLGGLLLELFGWRWI-FLINVP 158
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
377-516 5.01e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.23  E-value: 5.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 377 NNVFLLQTLFGAVILLANCVAPWALKYMNRRAsQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASAL---ANTLA 453
Cdd:cd17333  31 ADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRR-TLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILdtgANTFV 109
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42542386 454 FAHGNEViptiiRARAMGINATFANIAGALAPLM---MILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:cd17333 110 GALFEES-----SATRLNVLHGFFGLGALIGPLIatsLLTSELSWSWAYLIIGLIYLLLAILILLT 170
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
151-255 6.37e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 39.15  E-value: 6.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:cd17327  49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQ 128
                        90       100
                ....*....|....*....|....*
gi 42542386 231 AMGITLGMCPSGIAFMTLAGLAFAI 255
Cdd:cd17327 129 AKRIAFFYAAAGLGSIFGGLLAYGV 153
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
381-516 7.22e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.09  E-value: 7.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 381 LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQemqtlrevlaTLGLGASALANTLAFAHGNEV 460
Cdd:COG2807  57 LLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS----------VALLLAGTALIGAGIAVGNVL 126
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42542386 461 IPTII-------RARAMGINATFANIAGALAPLMM--ILSVYSPPLPWIIYGVFPFISGFAFLLL 516
Cdd:COG2807 127 LPGLIkrwfpdrVGLMTGLYTAAMGLGAALAAGLTvpLAAALGWRGALAVWALLALLALLLWLPL 191
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
141-196 7.98e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 38.78  E-value: 7.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTF 196
Cdd:cd17393 233 SAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSV 288
2_A_01_02 TIGR00880
Multidrug resistance protein;
152-250 8.27e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 36.86  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386   152 FMAGMMVGGILGGHLSDRFGRRFVLrWCYLQVAIVGTC-AALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT--HR 228
Cdd:TIGR00880   7 YALGQLIYSPLSGLLTDRFGRKPVL-LVGLFIFVLSTAmFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPpeER 85
                          90       100
                  ....*....|....*....|..
gi 42542386   229 FQAMGITLGMCPSGIAFMTLAG 250
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPPLG 107
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
141-259 8.93e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.68  E-value: 8.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542386 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 42542386 221 IAEWAT-HRFQAMGITLGMCPSGIAFMT-LAGLAFAIRDWH 259
Cdd:cd17324 312 VLRLAPeARGLASSLYLAAYNLGGALGAaLGGLVLDHGGWA 352
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
157-208 9.84e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.36  E-value: 9.84e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 42542386 157 MVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGI 208
Cdd:cd17390  45 LFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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