Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  93 LHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEanDGNEKMLKLAKAIYKKYILdNNGIVSRQIKPATKSFIK 172
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMS--DSEEKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFIK 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 71896671 173 DCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08707  78 ECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71896671   755 NITVAYYFRGEPIPYRT--SVKGRIVTLGQFKELLTKKGSYKYYFKKVSYEFDCgvVFEEVREDDAILPIFEEKIIGKV 831
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIkiHKPGGQITLGDFKELLPKKGNYRYFFKTLDPEFGT--VKEEITDDDDILPLWEGKIVAKV 77

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  93 LHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEanDGNEKMLKLAKAIYKKYILdNNGIVSRQIKPATKSFIK 172
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMS--DSEEKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFIK 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 71896671 173 DCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08707  78 ECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671     92 SLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEAndgNEKMLKLAKAIYKKYIlDNNGIVSRQIKPATKSFI 171
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAED---DEERIAKAREIYDKFL-SPNAPKEVNLDSDLREKI 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 71896671    172 KDCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLEY 213
Cdd:smart00315  77 EENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  15 DLGSSFTEDAPRPPVPGEEGDLVSSDGRQYNHSfYSSKSDSLKNEASIATPRRPDLDLGYEPEGSASPTP 84
Cdd:cd11582   1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHS-YSNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Domain present in Dishevelled and axin; Domain of unknown function.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671    753 CENITVAYYFRGEPIPYRTSVKGR--IVTLGQFKELLTKKGsYKYYFKKVSYEFDcGVVFEEVREDDAILPIFEEKIIGK 830
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPaeRVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78

                   ....*
gi 71896671    831 VEKVD 835
Cdd:smart00021  79 LVSVE 83

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  93 LHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEanDGNEKMLKLAKAIYKKYILdNNGIVSRQIKPATKSFIK 172
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMS--DSEEKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFIK 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 71896671 173 DCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08707  78 ECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671     92 SLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEAndgNEKMLKLAKAIYKKYIlDNNGIVSRQIKPATKSFI 171
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAED---DEERIAKAREIYDKFL-SPNAPKEVNLDSDLREKI 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 71896671    172 KDCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLEY 213
Cdd:smart00315  77 EENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  15 DLGSSFTEDAPRPPVPGEEGDLVSSDGRQYNHSfYSSKSDSLKNEASIATPRRPDLDLGYEPEGSASPTP 84
Cdd:cd11582   1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHS-YSNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  97 LDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDgnEKMLKLAKAIYKKYILDNNgIVSRQIKPATKSFIKDCVT 176
Cdd:cd07440   1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSD--EELKSKAKEIYDKYISKDA-PKEINIPESIREEIEENLE 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 71896671 177 KLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd07440  78 EPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  96 LLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEandGNEKMLKLAKAIYKKYI-LDNNGIVSRQIKpaTKSFIKDC 174
Cdd:cd08712   4 LLSHKDGLEAFTRFLKTEFSEENIEFWIACEDYKKSK---TPQQIHLKAKAIYEKFIqTDAPKEVNLDFH--TKEVTTNS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 71896671 175 VTKlhidPAM--FDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08712  79 IEQ----PTLtsFDAAQSRVYQLMEQDSYPRFLKSDIYLD 114

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  93 LHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDGNEKmlklAKAIYKKYILDNngiVSRQIKPATKSfiK 172
Cdd:cd08715   1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKTESDLLPCK----AEEIYKEFVQSD---AAKQINIDFRT--R 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 71896671 173 DCVTKLHIDP--AMFDQAQTEIQTMMEENTYPLFLKSDIYL 211
Cdd:cd08715  72 ESTAKKIKAPtpTCFDEAQKVIYILMERDSYPRFLKSDIYL 112

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 71896671   470 ENPESILDEHVQRVMKTPGCQSPgtGRHSPKSRSPDG 506
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSP--GRHSPRSRSPDS 35

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  96 LLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEAndgNEKMLKLAKAIYKKYILdnngivsrqiKPATKSFIKDCV 175
Cdd:cd08709   4 LLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKS---PQKLTSKAKKIYTDFIE----------KEAPKEINIDFQ 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 71896671 176 TKLHI-----DPAM--FDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08709  71 TKTLIaqniqEATSgcFTAAQKRVYSLMENNSYPRFLESEFYQE 114

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  88 KWAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEAndgNEKMLKLAKAIYKKYIlDNNGIVSRQIKPAT 167
Cdd:cd08711   7 RWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRS---TAKLVSKAHRIFEEFV-DVQAPREVNIDFQT 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 71896671 168 KSFIKDCVTKLHIdpAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08711  83 REATRKNLQEPSL--TCFDQAQGKVHSLMEKDSYPRFLRSKMYLD 125

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  93 LHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDgneKMLKLAKAIYKKYIldnngivSRQikpATKSFIK 172
Cdd:cd08714   1 LENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSPS---KLSPKARKIYEEFI-------SVQ---ATKEVNL 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 71896671 173 DCVTK-------LHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08714  68 DSCTReetsrnmLEPTISCFDEAQKKIFTLMEKDSYRRFLKSRFYLD 114

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  66 RRPDLDLGYE--PEGSASPTPPYLK---WAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKqEANDG--NE 138
Cdd:cd08746  22 RRTSYEFRAEgiPNCEESPKPTLEEvcaWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKK-EANKSviEE 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71896671 139 KmlklAKAIYKKYIldnnGIVSRQiKPATKSFIKDCVTKLHIDPA--MFDQAQTEIQTMMEENTYPLFLKSDIY 210
Cdd:cd08746 101 K----ARIIYEDYI----SILSPK-EVSLDSRVREVINRNMLEPSqhTFDDAQLQIYTLMHRDSYPRFMNSAIY 165

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  96 LLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEAndgNEKMLKLAKAIYKKYILDNNGI---VSRQIKPATKSFIK 172
Cdd:cd08710   4 LLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRS---ATKLASRAHHIFEEFIRSEAPKevnIDHETRELTRTNLQ 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 71896671 173 DCVTklhidpAMFDQAQTEIQTMMEENTYPLFLKSDIY 210
Cdd:cd08710  81 AATT------SCFDVAQGKTRTLMEKDSYPRFLKSPAY 112

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  89 WAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFrKQEANdgNEKMLKLAKAIYKKYIldnnGIVSRQiKPATK 168
Cdd:cd08718   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEEL-KKEAN--KHVIEEKARLIYEDYI----SILSPK-EVSLD 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 71896671 169 SFIKDCVTKLHIDPA--MFDQAQTEIQTMMEENTYPLFLKSDIY 210
Cdd:cd08718  73 SRVREVINRNMLEPSphTFDDAQLQIYTLMHRDSYPRFLNSAIY 116

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  88 KWAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEAndgnEKMLKLAKAIYKKYILDNngiVSRQIKPAT 167
Cdd:cd08739   4 RWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKYGDQ----SKVKEKAEEIYKLFLAPG---ARRWINIDG 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 71896671 168 KSFIKDCVTKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08739  77 KTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKE 121

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671 105 LFRTFLKQEECADMLDFWFACSGFRKQEANdgnEKMLKLAKAIYKKYILDNngiVSRQIK---PATKSFIKDCVTKlhiD 181
Cdd:cd08716  13 IYATYLKTEHSDENIEFWLACETYKKIASQ---RKRISMARKLFASYIQPQ---APREINidsPTRKAIIRNIQEP---T 83

                        90       100
                ....*....|....*....|....*....
gi 71896671 182 PAMFDQAQTEIQTMMEENTYPLFLKSDIY 210
Cdd:cd08716  84 QSCFDEAQRIVYMHMERDSYPRFLESKFY 112

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  96 LLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDGNEkMLKLAKAIYKKYildnngIVSRQIKP----ATKSFI 171
Cdd:cd08742   4 LLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPAHDKKE-LSYRAREIFSKF------LCSKATTPvnidSQAQLA 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 71896671 172 KDCVTKLHidPAMFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08742  77 DDILNAPH--PDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 115

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  97 LDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQ----EANDGNEKML-KLAKAIYKKYILDNN--------GIVS--R 161
Cdd:cd08722   2 LDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFNRRilnpDLTDEEKQSLhKEAQEIYKTYFLPEApdrihfppDIVEeiK 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 71896671 162 QIKPATKSFIkdcvTKLHIDPAMFdQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08722  82 QILEGGPEKI----VKLRTSRPLF-EAYEHVYSLLESVFCPLFCHSDEYFI 127

Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS7 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. R7 RGS proteins are key modulators of the pharmacological effects of drugs involved in the development of tolerance and addiction. In addition, RGS7 was found to bind a component of the synaptic fusion complex, snapin, and some other proteins outside of G protein signaling pathways.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896671  88 KWAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDGNEKMlklaKAIYKKYILDNngiVSRQIKPAT 167
Cdd:cd08738   4 RWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRV----QEIWQEFLAPG---APSAINLDS 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 71896671 168 KSFikDCVTKLHIDPA--MFDQAQTEIQTMMEENTYPLFLKSDIYLE 212
Cdd:cd08738  77 KSY--DKTTQNVKDPGryTFEDAQEHIYKLMKSDSYPRFIRSSAYQE 121