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Conserved domains on  [gi|19343497|ref|NP_597963|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Ursus americanus]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.33e-44

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 139.30  E-value: 1.33e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 19343497  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.33e-44

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 139.30  E-value: 1.33e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 19343497  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 6.63e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 61.43  E-value: 6.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497    3 VVYVNIFLAFIVSLMGLLiYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 19343497   83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.33e-44

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 139.30  E-value: 1.33e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 19343497  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 5.35e-28

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 97.34  E-value: 5.35e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497  11 AFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTDYV 90
Cdd:MTH00126 11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                ....*...
gi 19343497  91 QNLNLLQC 98
Cdd:MTH00126 91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.31e-26

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 93.76  E-value: 1.31e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 19343497  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.40e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 86.20  E-value: 1.40e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 19343497  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 6.63e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 61.43  E-value: 6.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497    3 VVYVNIFLAFIVSLMGLLiYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 19343497   83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 7.22e-14

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 61.11  E-value: 7.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   9 FLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTD 88
Cdd:MTH00181  6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                ....*...
gi 19343497  89 YVQNLNLL 96
Cdd:MTH00181 86 HLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 8-97 1.35e-11

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 55.69  E-value: 1.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00043  8 ILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVLLSRNHNS 87

                        90
                ....*....|
gi 19343497  88 DYVQNLNLLQ 97
Cdd:MTH00043 88 DLVASLNLLQ 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 8-98 7.43e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 51.29  E-value: 7.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLfVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00013  8 LSISPFISMFNLSLQRKHLLMSLLSLEAMILSL-ALFIPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVLMTRSYGN 86

                        90
                ....*....|.
gi 19343497  88 DYVQNLNLLQC 98
Cdd:MTH00013 87 DMLKSLTSNKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 1.22e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 50.61  E-value: 1.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   9 FLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNnhFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGL--ISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 19343497  89 YVQNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 6.23e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 48.82  E-value: 6.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLanMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00188  9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKEL--YLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                        90
                ....*....|.
gi 19343497  88 DYVQNLNLLQC 98
Cdd:MTH00188 87 DYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 8-92 7.42e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 45.53  E-value: 7.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVlnNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00162  7 FLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYL--SFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGN 84


                ....*
gi 19343497  88 DYVQN 92
Cdd:MTH00162 85 DYFSS 89
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 8-97 4.03e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 33.50  E-value: 4.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497   8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00001  9 VVILFLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGT 88

                        90
                ....*....|
gi 19343497  88 DYVQNLNLLQ 97
Cdd:MTH00001 89 ISLKSLNSLR 98
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 7.10e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 33.08  E-value: 7.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19343497  12 FIVSLMGLLIYRSHLMSSLLCLEGMMLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQ 91
Cdd:MTH00180 13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                ....*.
gi 19343497  92 NLNLLQ 97
Cdd:MTH00180 93 SLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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