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Conserved domains on  [gi|41281720|ref|NP_653146|]
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GAS2-like protein 1 isoform beta [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 1.54e-71

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409117  Cd Length: 142  Bit Score: 228.36  E-value: 1.54e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  18 PFRSSEAYVEAMKEDLADWLNALYSLGLpgSGDGFLTGLATGTTLCQHANAVTEA---------ARALAAARPTRGVAFQ 88
Cdd:cd21268   1 PFKSSEEYLYAMKEDLAEWLNTLYNLDI--TADNFFEKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41281720  89 AHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268  79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 4.07e-43

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 149.28  E-value: 4.07e-43
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281720   208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 292-657 1.59e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   292 SPQRGSPTPSPRPGSPVPGSERRSSRPEVTPISLRGTKEG----------PETPLRPRDQLPPLPRSRRYSGDSDSSASS 361
Cdd:PHA03247 2563 APDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSPAANEPDPHP 2642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   362 AQSGPMGARSDDSATGsRRERPSHRPTSclPASPRRPTAPRSQSRDRldRGRPRVAPGGRGAQLSTSSPARRTRSQSREE 441
Cdd:PHA03247 2643 PPTVPPPERPRDDPAP-GRVSRPRRARR--LGRAAQASSPPQRPRRR--AARPTVGSLTSLADPPPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   442 QAVLMVRRDRDGQHSWVARGRGGGGSGGSGRSTPQTPRALS-------PAAPRPSRGPSPGPELAAT-----PASIFRTP 509
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArppttagPPAPAPPAAPAAGPPRRLTrpavaSLSESRES 2797

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   510 LQLDPQQEQQLFRRLEEEFLANARALEAAASHTPMGSAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGESGRTANGLPG 589
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA 2877

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281720   590 PRSQALSSSSDEGSPYLAVGGALdaTRSSLAGPEPSLTWARGRMDTQPDRKPSRIPTPRGPRRPSGPI 657
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESFAL--PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 1.54e-71

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 228.36  E-value: 1.54e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  18 PFRSSEAYVEAMKEDLADWLNALYSLGLpgSGDGFLTGLATGTTLCQHANAVTEA---------ARALAAARPTRGVAFQ 88
Cdd:cd21268   1 PFKSSEEYLYAMKEDLAEWLNTLYNLDI--TADNFFEKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41281720  89 AHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268  79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 4.07e-43

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 149.28  E-value: 4.07e-43
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281720   208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 1.96e-40

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 142.20  E-value: 1.96e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281720    206 RNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 3.73e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 63.07  E-value: 3.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720    27 EAMKEDLADWLNALYSLGLPGSG-DGFLTGLATGTTLCQHANAVTEAaralaaarptrgvAFQAHSVAPGSFMARDNVAS 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRvTNFTTDLRDGLALCALLNKLAPG-------------LVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 41281720   106 FIGWCRAELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 2.05e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.01  E-value: 2.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720     31 EDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTEAARALAAARPtrgvafqahsvAPGSFMARDNVASFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAA-----------SLSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 41281720    111 RAELGVPEvlMFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 EKLGGKVV--LFEPEDLVEgPKLILGVIWTL 98
PHA03247 PHA03247
large tegument protein UL36; Provisional
 292-657 1.59e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   292 SPQRGSPTPSPRPGSPVPGSERRSSRPEVTPISLRGTKEG----------PETPLRPRDQLPPLPRSRRYSGDSDSSASS 361
Cdd:PHA03247 2563 APDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSPAANEPDPHP 2642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   362 AQSGPMGARSDDSATGsRRERPSHRPTSclPASPRRPTAPRSQSRDRldRGRPRVAPGGRGAQLSTSSPARRTRSQSREE 441
Cdd:PHA03247 2643 PPTVPPPERPRDDPAP-GRVSRPRRARR--LGRAAQASSPPQRPRRR--AARPTVGSLTSLADPPPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   442 QAVLMVRRDRDGQHSWVARGRGGGGSGGSGRSTPQTPRALS-------PAAPRPSRGPSPGPELAAT-----PASIFRTP 509
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArppttagPPAPAPPAAPAAGPPRRLTrpavaSLSESRES 2797

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   510 LQLDPQQEQQLFRRLEEEFLANARALEAAASHTPMGSAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGESGRTANGLPG 589
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA 2877

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281720   590 PRSQALSSSSDEGSPYLAVGGALdaTRSSLAGPEPSLTWARGRMDTQPDRKPSRIPTPRGPRRPSGPI 657
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESFAL--PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 1.79e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 45.68  E-value: 1.79e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 41281720  97 FMARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199  67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 1.54e-71

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 228.36  E-value: 1.54e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  18 PFRSSEAYVEAMKEDLADWLNALYSLGLpgSGDGFLTGLATGTTLCQHANAVTEA---------ARALAAARPTRGVAFQ 88
Cdd:cd21268   1 PFKSSEEYLYAMKEDLAEWLNTLYNLDI--TADNFFEKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41281720  89 AHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268  79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 23-151 7.58e-49

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 167.45  E-value: 7.58e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  23 EAYVEAMKEDLADWLNALysLGLPGSGDGFLTGLATGTTLCQHANAVTE-----AARALAAARPTRGVAFQAHSVAPGSF 97
Cdd:cd21204   1 EEALLPMKEDLAEWLNDL--LGDDLTPDNFLDELRNGVVLCQLAQKIQEaaekaREAGKKNGPPPSYKLKCNENAKPGSF 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 41281720  98 MARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21204  79 FARDNVANFLRWCR-KLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 4.07e-43

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 149.28  E-value: 4.07e-43
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281720   208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 1.96e-40

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 142.20  E-value: 1.96e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281720    206 RNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 23-152 1.05e-24

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 100.01  E-value: 1.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  23 EAYVEAMKEDLADWLNALysLGLPGSGDGFLTGLATGTTLCQHANAVTE-------AARALAAARPTRGVAFQAHsvAP- 94
Cdd:cd21267   2 EASLLPMKEDLALWLTNL--LGKEITAESFMEKLDNGALLCQLAETLQEkfkensaDANKPGKSLPVRKIPCRAN--APs 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 41281720  95 GSFMARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21267  78 GSFFARDNTANFLSWCR-DVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 23-151 7.40e-24

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 97.22  E-value: 7.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  23 EAYVEAMKEDLADWLNALysLGLPGSGDGFLTGLATGTTLCQH----ANAVTEAARALAAAR-PTRGVAFQAHSvAPGSF 97
Cdd:cd21269   1 EATLVPMQEDLSIWLSGM--LGKEVKAERFMEELDNGVLLCQLigvlQSKIKECCSTEELKHfPMRKVPCKKDA-PSGSF 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 41281720  98 MARDNVASFIGWCRAeLGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21269  78 FARDNTANFLSWCRA-IGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 30-145 6.71e-14

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 68.13  E-value: 6.71e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  30 KEDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTEAARALAAARPTRgvafqahsvapgSFMARDNVASFIGW 109
Cdd:cd00014   1 EEELLKWINEVLGEELPVSITDLFESLRDGVLLCKLINKLSPGSIPKINKKPKS------------PFKKRENINLFLNA 68

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 41281720 110 CRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd00014  69 CK-KLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 3.73e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 63.07  E-value: 3.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720    27 EAMKEDLADWLNALYSLGLPGSG-DGFLTGLATGTTLCQHANAVTEAaralaaarptrgvAFQAHSVAPGSFMARDNVAS 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRvTNFTTDLRDGLALCALLNKLAPG-------------LVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 41281720   106 FIGWCRAELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 2.05e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.01  E-value: 2.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720     31 EDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTEAARALAAARPtrgvafqahsvAPGSFMARDNVASFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAA-----------SLSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 41281720    111 RAELGVPEvlMFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 EKLGGKVV--LFEPEDLVEgPKLILGVIWTL 98
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 51-145 1.44e-08

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 52.75  E-value: 1.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  51 GFLTGLATGTTLCQHANAVteaaralaaaRPTRGVAFQAhSVAPgsFMARDNVASFIGWCRAeLGVPEVLMFETEDLVLR 130
Cdd:cd21210  21 DLLDALKDGVVLCKLANRI----------LPADIRKYKE-SKMP--FVQMENISAFLNAARK-LGVPENDLFQTVDLFER 86

                        90
                ....*....|....*
gi 41281720 131 KNEKSVVLCLLEVAR 145
Cdd:cd21210  87 KNPAQVLQCLHALSR 101
PHA03247 PHA03247
large tegument protein UL36; Provisional
 292-657 1.59e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   292 SPQRGSPTPSPRPGSPVPGSERRSSRPEVTPISLRGTKEG----------PETPLRPRDQLPPLPRSRRYSGDSDSSASS 361
Cdd:PHA03247 2563 APDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSPAANEPDPHP 2642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   362 AQSGPMGARSDDSATGsRRERPSHRPTSclPASPRRPTAPRSQSRDRldRGRPRVAPGGRGAQLSTSSPARRTRSQSREE 441
Cdd:PHA03247 2643 PPTVPPPERPRDDPAP-GRVSRPRRARR--LGRAAQASSPPQRPRRR--AARPTVGSLTSLADPPPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   442 QAVLMVRRDRDGQHSWVARGRGGGGSGGSGRSTPQTPRALS-------PAAPRPSRGPSPGPELAAT-----PASIFRTP 509
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArppttagPPAPAPPAAPAAGPPRRLTrpavaSLSESRES 2797

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   510 LQLDPQQEQQLFRRLEEEFLANARALEAAASHTPMGSAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGESGRTANGLPG 589
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA 2877

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281720   590 PRSQALSSSSDEGSPYLAVGGALdaTRSSLAGPEPSLTWARGRMDTQPDRKPSRIPTPRGPRRPSGPI 657
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESFAL--PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 35-145 1.13e-06

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 47.69  E-value: 1.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  35 DWLNALYSLGLPgSGDGFLTGLATGTTLCQHANavteaaralaaarptrgvafqahSVAPGS----------FMARDNVA 104
Cdd:cd21207  12 DWIEAVTGEKLD-DGKDYEDVLKDGVILCKLIN-----------------------ILKPGSvkkintskmaFKLMENIE 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 41281720 105 SFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd21207  68 NFLTACK-GYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 35-140 1.22e-06

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 47.61  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  35 DWLNALYSLGLPgSGDGFLTGLATGTTLCQHANAVTEAARALAAArPTRGVAFQaHSvapgsfmarDNVASFIGWCRaEL 114
Cdd:cd21206  15 QWIEACLNEELP-PTTEFEEELRNGVVLAKLANKFAPKLVPLKKI-YDVGLQFR-HT---------DNINHFLRALK-KI 81

                        90       100
                ....*....|....*....|....*.
gi 41281720 115 GVPEVLMFETEDLVLRKNEKSVVLCL 140
Cdd:cd21206  82 GLPKIFHFETTDLYEKKNIPKVIYCL 107
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 1.79e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 45.68  E-value: 1.79e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 41281720  97 FMARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199  67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
PHA03247 PHA03247
large tegument protein UL36; Provisional
 297-620 9.35e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 9.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   297 SPTPSPRPGSPVPGSERRSSRPEVTPISLRG-------TKEGPETPLRPRDQLPPLPRSRRYSGDSDSSASSAQSGPMGA 369
Cdd:PHA03247 2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLAdppppppTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGP 2748

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   370 RSDDSATgsrreRPSHRPTSCLPASPRRPTAPRSQSRDRLDRGRPRVAPGGRGAQLSTSSPARRTRSQSREEQAVLMVRR 449
Cdd:PHA03247 2749 ATPGGPA-----RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   450 DRDGQHSWVARGRGGGGSGGSGRST-------------------PQTPRALSPAAPRPSRGPSPGPELAATPASIFRTPL 510
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPPPPPGPPPPslplggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPD 2903

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   511 QLDPQQEQQLFRR-LEEEFLANARALEAAASHTPMGSAPDPPAPDSAYCSSSSSSSSLSVLGGKCgqPGESGRTANGLPG 589
Cdd:PHA03247 2904 QPERPPQPQAPPPpQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV--PGRVAVPRFRVPQ 2981

                         330       340       350
                  ....*....|....*....|....*....|.
gi 41281720   590 PRSQALSSSSDEGSPYLAVGGALDATRSSLA 620
Cdd:PHA03247 2982 PAPSREAPASSTPPLTGHSLSRVSSWASSLA 3012
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 292-678 4.19e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 4.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  292 SPQRGSPTPSPRPGSPVPGSERRSSRPEVTPislrgTKEGPEtPLRPRDQLPPLPRSRRYSGDSDSSASSAQSGPMGARS 371
Cdd:PRK07764 400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ-----PAPAPA-PAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAA 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  372 DDSATGSRRERPSHRPTSCLPASPRRPTAPRSQSRDRLDRGR----------------------PRVApGGRGAQL---- 425
Cdd:PRK07764 474 PEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERwpeilaavpkrsrktwaillpeATVL-GVRGDTLvlgf 552

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  426 STSSPARRTRSQSREEQAVLMVRRDRDGQHSWVARGRGGGGSGGSGRSTPQTPRALSPAAPRPSRGPSPGPELAATPASI 505
Cdd:PRK07764 553 STGGLARRFASPGNAEVLVTALAEELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGA 632

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  506 FRTPlqldpqqeqqlfRRLEEEFLANARALEAAASHTPMGSAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGESGRTAN 585
Cdd:PRK07764 633 AAAP------------AEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQ 700

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720  586 GLPGPRSQALSSSSDEGSPYLAVGGALDATRSSLAGPEPSLTwargrmdTQPDRKPSRIPTPRGPRRPSGPIELGAWHAQ 665
Cdd:PRK07764 701 PAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP-------PEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773

                        410
                 ....*....|...
gi 41281720  666 HSVTPRTEPDSSM 678
Cdd:PRK07764 774 PPPSPPSEEEEMA 786
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 272-494 1.92e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   272 DPCRCSSSTHRLPQQRTGTFSPQRGSPTPSPRPGsPVPGSERRSSRPEVT-PISLRGTKEGPETPLRPRDQlPPLPRSRR 350
Cdd:PHA03307  230 DDAGASSSDSSSSESSGCGWGPENECPLPRPAPI-TLPTRIWEASGWNGPsSRPGPASSSSSPRERSPSPS-PSSPGSGP 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   351 YSGDSDSSASSAQSGPMGARSDDSATGSRRERPSHR-PTSCLPASPRRPTAPRSQSRdrldrgRPRVAPGGRGAQLSTSS 429
Cdd:PHA03307  308 APSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPgPSPSRSPSPSRPPPPADPSS------PRKRPRPSRAPSSPAAS 381

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41281720   430 PARRTRSQSREEQAVLMVRRDRDGQHSWVARGRGGGGSGGSGRSTPQTPRALSPAA-PRPSRGPSP 494
Cdd:PHA03307  382 AGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGePWPGSPPPP 447
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 294-654 3.82e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   294 QRGSPTPSPRPGSPVPGSERR---SSRPEVTPISLRGtkEGPETPLRPRDQLPPLPR--SRRYSGDSDSSASSAQSGPMG 368
Cdd:PHA03307   22 PRPPATPGDAADDLLSGSQGQlvsDSAELAAVTVVAG--AAACDRFEPPTGPPPGPGteAPANESRSTPTWSLSTLAPAS 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   369 ARSDDSATGSRRERPSHRPTSCLPASPRRPTAPRSQSRDRldRGRPRVAPGGRGAQLSTSSPARRTRSQSREEQAVLMVR 448
Cdd:PHA03307  100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR--PVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   449 RDRDGQHSWVARGRGGGGSGGSGRSTPQTPRALSPAAPRPSRGPSPGPELAATPASifRTPLQLDPQQEQQLFRRLEEEF 528
Cdd:PHA03307  178 SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAG--ASSSDSSSSESSGCGWGPENEC 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   529 LANARALEAAASHTPMGSAPDPPAPDSaycsssSSSSSLSVLGGKCGQPGESGRTANGLPGPR--SQALSSSSDEGSPYL 606
Cdd:PHA03307  256 PLPRPAPITLPTRIWEASGWNGPSSRP------GPASSSSSPRERSPSPSPSSPGSGPAPSSPraSSSSSSSRESSSSST 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 41281720   607 AVGGALDATRSSLAGPEP--SLTWARGRMDTQPDRKPSRIPTPRGPRRPS 654
Cdd:PHA03307  330 SSSSESSRGAAVSPGPSPsrSPSPSRPPPPADPSSPRKRPRPSRAPSSPA 379
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 276-627 4.33e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 4.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   276 CSSSTHRLPQQRTGTFSP-QRGSPTPSPRPGSPVPGSERRSSRPEVTPISLRGTKEGPetPLRPRDQLPPLPRSRRySGD 354
Cdd:PHA03307   89 TWSLSTLAPASPAREGSPtPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGP--PPAASPPAAGASPAAV-ASD 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   355 SDSSASSAQSGPMGARSDDSATGSRRERPSHRPTSCLPASPRRPTAPRSQSRDRLDRGRPRVAPGGRGAQLSTSSPARRT 434
Cdd:PHA03307  166 AASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESS 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   435 RSQSREEQAVLMVRRDRDGQHSWVARGRGGGGSGGSGrsTPQTPRAlSPAAPRPSRGPSPGPELAATPASifRTPLQLDP 514
Cdd:PHA03307  246 GCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRP--GPASSSS-SPRERSPSPSPSSPGSGPAPSSP--RASSSSSS 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281720   515 QQEQQLFRRLEEEFLANARALEAAASHTPMGS-APDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGESGRTANGLPGPRSQ 593
Cdd:PHA03307  321 SRESSSSSTSSSSESSRGAAVSPGPSPSRSPSpSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARR 400

                         330       340       350
                  ....*....|....*....|....*....|....
gi 41281720   594 ALSSSSDEGSPYLAVGGALDATRSSLAGPEPSLT 627
Cdd:PHA03307  401 RDATGRFPAGRPRPSPLDAGAASGAFYARYPLLT 434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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