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Conserved domains on  [gi|55742736|ref|NP_653167|]
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zinc finger protein 700 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-64 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 55742736    23 PVAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIG 64
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-633 2.28e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 2.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 221 TYKCKFCGKAFHSFSLYLIHERTHTGEKPYEC--KQCGKSFTYSATLQIHERTHTGEKPYECSKCDKAFHSSSSYHRHER 298
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 299 SHMGE-KPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQY-GEGLSYLISFQTHIRMNSgerpykcKICGKGFYSAKS 376
Cdd:COG5048 113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 377 FQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYEC--KQCGKAFRSASQLRVHGGTHTgeKPYECKECGKA 454
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 455 FRSTSHLRVHGRTHTGE-------KPYECKECGKAFRYVKHLQIHERTEKHIRMPSgeRPYKC--SICEKGFYSAKSFQT 525
Cdd:COG5048 264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESL--KPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 526 HEKTHTGEKPYEC--NQCGKAFR-----CCNSLRYHERTHTGEKPYEC--KQCGKAFRSASHLRMHERTHTGEKPYECK- 595
Cdd:COG5048 342 HILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 55742736 596 -QCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSAS 633
Cdd:COG5048 422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 674-725 4.78e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.78e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 55742736 674 KPYeCKHCGNGFTSAKILQIHARthigEKHYECKECGKAFNYFSSLHIHART 725
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
634-657 5.78e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.78e-04
                          10        20
                  ....*....|....*....|....
gi 55742736   634 NLQMHERTHTGEKPYECKECEKAF 657
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-64 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 55742736    23 PVAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIG 64
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
24-66 1.14e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 1.14e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 55742736     24 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIGKK 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-63 4.35e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.28  E-value: 4.35e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 55742736  24 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSI 63
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-633 2.28e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 2.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 221 TYKCKFCGKAFHSFSLYLIHERTHTGEKPYEC--KQCGKSFTYSATLQIHERTHTGEKPYECSKCDKAFHSSSSYHRHER 298
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 299 SHMGE-KPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQY-GEGLSYLISFQTHIRMNSgerpykcKICGKGFYSAKS 376
Cdd:COG5048 113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 377 FQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYEC--KQCGKAFRSASQLRVHGGTHTgeKPYECKECGKA 454
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 455 FRSTSHLRVHGRTHTGE-------KPYECKECGKAFRYVKHLQIHERTEKHIRMPSgeRPYKC--SICEKGFYSAKSFQT 525
Cdd:COG5048 264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESL--KPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 526 HEKTHTGEKPYEC--NQCGKAFR-----CCNSLRYHERTHTGEKPYEC--KQCGKAFRSASHLRMHERTHTGEKPYECK- 595
Cdd:COG5048 342 HILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 55742736 596 -QCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSAS 633
Cdd:COG5048 422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
578-603 1.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.96e-04
                          10        20
                  ....*....|....*....|....*.
gi 55742736   578 HLRMHERTHTGEKPYECKQCGKAFSC 603
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 674-725 4.78e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.78e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 55742736 674 KPYeCKHCGNGFTSAKILQIHARthigEKHYECKECGKAFNYFSSLHIHART 725
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
634-657 5.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.78e-04
                          10        20
                  ....*....|....*....|....
gi 55742736   634 NLQMHERTHTGEKPYECKECEKAF 657
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-64 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 55742736    23 PVAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIG 64
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
24-66 1.14e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 1.14e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 55742736     24 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIGKK 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-63 4.35e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.28  E-value: 4.35e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 55742736  24 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSI 63
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-633 2.28e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 2.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 221 TYKCKFCGKAFHSFSLYLIHERTHTGEKPYEC--KQCGKSFTYSATLQIHERTHTGEKPYECSKCDKAFHSSSSYHRHER 298
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 299 SHMGE-KPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQY-GEGLSYLISFQTHIRMNSgerpykcKICGKGFYSAKS 376
Cdd:COG5048 113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 377 FQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYEC--KQCGKAFRSASQLRVHGGTHTgeKPYECKECGKA 454
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 455 FRSTSHLRVHGRTHTGE-------KPYECKECGKAFRYVKHLQIHERTEKHIRMPSgeRPYKC--SICEKGFYSAKSFQT 525
Cdd:COG5048 264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESL--KPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 526 HEKTHTGEKPYEC--NQCGKAFR-----CCNSLRYHERTHTGEKPYEC--KQCGKAFRSASHLRMHERTHTGEKPYECK- 595
Cdd:COG5048 342 HILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 55742736 596 -QCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSAS 633
Cdd:COG5048 422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-682 2.28e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 276 KPYECSKCDKAFHSSSSYHRHERSHMGEKPYQCKECGKAFAYT--SSLRRHERTHSGKKPYECKQyGEGLSYLISFQTHI 353
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSK-SLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 354 RMNSGERPYKCKICGKGFYSAKSFQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYECKQCGKAFRSASQL 433
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 434 RVhggTHTGEKPYECKECGKAFRSTSHLRVHGRTHTgEKPYECKECGKAFRYVKHLQIHERTEKHIRMPSGERPYKCSIC 513
Cdd:COG5048 191 NV---STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 514 EKGFYSAKSFQTHEKTHTG-EKPYECNQCGKAFRCCNSLRYHERT--HTGE--KPYEC--KQCGKAFRSASHLRMHERTH 586
Cdd:COG5048 267 TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 587 TGEKPYECK--QCGKAFSCASNLRKHGRTH-----TGEKPYEC--KQCGKAFRSASNLQMHERTHTGEKPYECK--ECEK 655
Cdd:COG5048 347 TSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                       410       420
                ....*....|....*....|....*..
gi 55742736 656 AFCKFSSFQIHERKHRGEKPYECKHCG 682
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-577 1.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 138 NSSFNMSIRGDTGHKAYEYQeygPKPYKCqqPKNKKAFRYRPSIRTQERDHTGEKPYACKV--CGKTFIFHSSIRRHMVM 215
Cdd:COG5048  11 SNNSVLSSTPKSTLKSLSNA---PRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 216 HSGDG-TYKCKFCGKAFHSFSLYLIHERTHTGEKPYECKQCGKSFTYSATLQIHERTHTGEKPYECSKC--DKAFHSSSS 292
Cdd:COG5048  86 HHNNPsDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNTPQSN 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 293 YHRHERSHMgekpyqcKECGKAFAYTSSLRRHERTHSGKKPYECKQYGEGLSYLISFQTHIRMNSGErPYKCKICGKGF- 371
Cdd:COG5048 166 SLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSp 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 372 ------YSAKSFQTHEKTHTGEKRYKCKQcGKAFNLSSSFRYHERIHTG-EKPYECKQCGKAFRSASQLRVH--GGTHTG 442
Cdd:COG5048 238 ksllsqSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSG 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 443 E--KPYECKE--CGKAFRSTSHLRVHGRTHTGEKPYECKECGkafRYVKHLQI-----HERTEKHIRmPSGERPYKC--S 511
Cdd:COG5048 317 EslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLN---SSSKFSPLlnnepPQSLQQYKD-LKNDKKSETlsN 392

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55742736 512 ICEKGFYSAKSFQTHEKTHTGEKPYECN--QCGKAFRCCNSLRYHERTHTGEKPYECKQCGKAFRSAS 577
Cdd:COG5048 393 SCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
444-742 5.08e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 5.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 444 KPYECKECGKAFRSTSHLRVHGRTHTGEKPYECKECGKAFRYV----------KHLQIHERTEKHIRMPSGERPYKCSIC 513
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsrhlrTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 514 EKGFYSAKSFQTHEKTHTGEKPY------------------ECNQCGKAFRCCNSLR-------------------YHER 556
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDpqlpdllsisnlrnnplpGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 557 THTGEKPYECKQCG--------------------------------------------------------------KAFR 574
Cdd:COG5048 192 VSTSIPSSSENSPLsssysipssssdqnlensssslplttnsqlspksllsqspsslsssdssssasesprsslptASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 575 SASHLRMHERTHTG-EKPYECKQCGKAFSCASNLRKHGRT--HTGE--KPYEC--KQCGKAFRSASNLQMHERTHTGEKP 647
Cdd:COG5048 272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 648 YECK--ECEKAF------CKFSSFQIHERKHRGEKPYECKHCGNG-FTSAKILQIHARTHIGEKHYECK--ECGKAFNYF 716
Cdd:COG5048 352 AKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRnFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                       410       420
                ....*....|....*....|....*.
gi 55742736 717 SSLHIHARTHMGEKPYECKDCGKAFS 742
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-409 8.75e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 8.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 229 KAFHSFSLYLIHERTHTG-EKPYECKQCGKSFTYSATLQIHERT--HTGE--KPYEC--SKCDKAFHSSSSYHRHERSHM 301
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 302 GEKPYQCKEC-------GKAFAYTSSLRRHERTHSGKKPYEC----KQYGEGLSYLISFQTHIRMNSGERPYKCKICGKG 370
Cdd:COG5048 348 SISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKS 427

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 55742736 371 FYSAKSFQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHE 409
Cdd:COG5048 428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 496-559 1.18e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 496 EKHIRMPS------GERPYKCSI--CEKGFYSAKSFQTH-------EKTH------------TGEKPYECNQCGKAFRCC 548
Cdd:COG5189 332 ERNIDTPSrmlkvkDGKPYKCPVegCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNL 411

                        90
                ....*....|.
gi 55742736 549 NSLRYHeRTHT 559
Cdd:COG5189 412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
578-603 1.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.96e-04
                          10        20
                  ....*....|....*....|....*.
gi 55742736   578 HLRMHERTHTGEKPYECKQCGKAFSC 603
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 674-725 4.78e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.78e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 55742736 674 KPYeCKHCGNGFTSAKILQIHARthigEKHYECKECGKAFNYFSSLHIHART 725
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
550-575 5.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 55742736   550 SLRYHERTHTGEKPYECKQCGKAFRS 575
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
634-657 5.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.78e-04
                          10        20
                  ....*....|....*....|....
gi 55742736   634 NLQMHERTHTGEKPYECKECEKAF 657
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 246-329 2.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742736 246 GEKPYECK--QCGKSFTYSATLQIHeRTHtgekpyecSKCDKAFHSSSSYHRHERSHMGEKPYQCKECGKAFAYTSSLRR 323
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 55742736 324 HeRTHS 329
Cdd:COG5189 417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-429 2.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 55742736   404 SFRYHERIHTGEKPYECKQCGKAFRS 429
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-317 2.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.52e-03
                          10        20
                  ....*....|....*....|...
gi 55742736   295 RHERSHMGEKPYQCKECGKAFAY 317
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
606-631 2.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.86e-03
                          10        20
                  ....*....|....*....|....*.
gi 55742736   606 NLRKHGRTHTGEKPYECKQCGKAFRS 631
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-261 3.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|..
gi 55742736   240 HERTHTGEKPYECKQCGKSFTY 261
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-547 4.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.37e-03
                          10        20
                  ....*....|....*....|....*.
gi 55742736   522 SFQTHEKTHTGEKPYECNQCGKAFRC 547
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-287 4.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.37e-03
                          10        20
                  ....*....|....*....|...
gi 55742736   265 LQIHERTHTGEKPYECSKCDKAF 287
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 5.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 55742736   460 HLRVHGRTHTGEKPYECKECGKAFRY 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 9.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.22e-03
                          10        20
                  ....*....|....*....|....*
gi 55742736   376 SFQTHEKTHTGEKRYKCKQCGKAFN 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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