NCBI Conserved Domain Search

Conserved domains on [gi|22129455|ref|NP_666810|]

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olfactory receptor 697 [Mus musculus]

Protein Classification

olfactory receptor family 2 protein( domain architecture ID 11607568)

olfactory receptor family 2 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-301

3.11e-144

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 407.32 E-value: 3.11e-144

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

Name

Accession

Description

Interval

E-value

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-301

3.11e-144

Pssm-ID: 320543 Cd Length: 277 Bit Score: 407.32 E-value: 3.11e-144

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-305

2.01e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 139.94 E-value: 2.01e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455    33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455   113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455   193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHN--PKQ 270
Cdd:pfam13853 163 KVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNvpPLL 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 22129455   271 DNILSVFYTIVTPALNPLIHSLRNKEVTGALRKVL 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-301

3.11e-144

Pssm-ID: 320543 Cd Length: 277 Bit Score: 407.32 E-value: 3.11e-144

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-301

2.87e-119

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 344.05 E-value: 2.87e-119

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-294

4.02e-108

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 315.58 E-value: 4.02e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

31-294

6.83e-107

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 312.52 E-value: 6.83e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFL--YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd15230   5 VLFLliYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLA 188
Cdd:cd15230  85 TTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 189 CADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNP 268
Cdd:cd15230 165 CSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSL 244

                       250       260
                ....*....|....*....|....*.
gi 22129455 269 KQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15230 245 DQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

26-294

5.27e-104

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 304.97 E-value: 5.27e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15237   2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15237 162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15237 242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

26-301

2.47e-100

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 296.06 E-value: 2.47e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15235 243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

12-305

6.33e-98

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 290.80 E-value: 6.33e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  12 FILVGILNGSDSPELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNT 91
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  92 ISFGGCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKS 171
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 172 RHIRHLFCEIPPLLDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMY 251
Cdd:cd15943 162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 252 YGALTVMYFLPSSYHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRKVL 305
Cdd:cd15943 242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-294

1.77e-95

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 283.58 E-value: 1.77e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFL-YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIE 104
Cdd:cd15227   1 ILHFVLFLLiYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPL 184
Cdd:cd15227  81 IFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 185 LDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSS 264
Cdd:cd15227 161 LKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129455 265 YHNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15227 241 DSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-297

2.84e-95

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 283.44 E-value: 2.84e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  12 FILVGILNGSDSPELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  92 ISFGGCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKS 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 172 RHIRHLFCEIPPLLDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMY 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129455 252 YGALTVMYFLPSSYHNPKQDNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-303

1.99e-94

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 281.12 E-value: 1.99e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15419 242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

33-294

9.19e-94

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 279.11 E-value: 9.19e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15918   9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15918  89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDN 272
Cdd:cd15918 169 HLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDS 248

                       250       260
                ....*....|....*....|..
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15918 249 VAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

25-301

1.30e-93

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 278.88 E-value: 1.30e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  25 ELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIE 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 185 LDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSS 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129455 265 YHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

35-301

4.09e-93

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 277.61 E-value: 4.09e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  35 YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLL 114
Cdd:cd15231  11 YLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTSS 194
Cdd:cd15231  91 LAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 195 YKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDNIL 274
Cdd:cd15231 171 NEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDKDTLI 250

                       250       260
                ....*....|....*....|....*..
gi 22129455 275 SVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15231 251 SVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

21-305

1.62e-92

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 276.56 E-value: 1.62e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  21 SDSPEL-LCATITFL--YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGC 97
Cdd:cd15406   3 TDQPELqLPLFLLFLgiYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPEC 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  98 ALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHL 177
Cdd:cd15406  83 MTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHY 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 178 FCEIPPLLDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTV 257
Cdd:cd15406 163 FCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIF 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 258 MYFLPSSYHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRKVL 305
Cdd:cd15406 243 MYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-301

2.26e-92

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 275.75 E-value: 2.26e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-305

4.37e-92

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 275.69 E-value: 4.37e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  12 FILVGIlngSDSPEL---LCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLR 88
Cdd:cd15410   1 FILLGF---TDYPELqvpLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  89 DNTISFGGCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSF 168
Cdd:cd15410  78 DKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSF 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 169 CKSRHIRHLFCEIPPLLDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVV 248
Cdd:cd15410 158 CGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAI 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129455 249 GMYYGALTVMYFLPSSYHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRKVL 305
Cdd:cd15410 238 TIFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

33-294

1.80e-91

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 273.33 E-value: 1.80e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15431   9 IVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALgFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15431  89 LLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTV-IPVLTMPLHFCGPNVINHFFCEVQALLKLACSDT 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDN 272
Cdd:cd15431 168 SLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDK 247

                       250       260
                ....*....|....*....|..
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15431 248 IISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

33-303

2.19e-91

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 273.36 E-value: 2.19e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15417   9 GIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15417  89 FLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDN 272
Cdd:cd15417 169 FISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDK 248

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15417 249 VASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-294

2.69e-91

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 272.82 E-value: 2.69e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15912 242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-303

1.58e-90

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 271.62 E-value: 1.58e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  12 FILVGILNGSDSPELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  92 ISFGGCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKS 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 172 RHIRHLFCEIPPLLDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMY 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 252 YGALTVMYFLPSSYHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

35-301

2.73e-90

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 270.62 E-value: 2.73e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  35 YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLL 114
Cdd:cd15229  11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTSS 194
Cdd:cd15229  91 LSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFA 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 195 YKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDNIL 274
Cdd:cd15229 171 NKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVF 250

                       250       260
                ....*....|....*....|....*..
gi 22129455 275 SVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15229 251 SIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

33-303

7.73e-89

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 266.88 E-value: 7.73e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15411   9 VIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTEC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15411  89 FLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDN 272
Cdd:cd15411 169 HVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDK 248

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15411 249 VASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

31-294

1.55e-88

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 265.89 E-value: 1.55e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFL--YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd15911   5 LLFLviYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLA 188
Cdd:cd15911  85 ATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 189 CADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNP 268
Cdd:cd15911 165 CSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSR 244

                       250       260
                ....*....|....*....|....*.
gi 22129455 269 KQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15911 245 DLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

34-303

2.03e-87

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 263.50 E-value: 2.03e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15409  10 IYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTS 193
Cdd:cd15409  90 LLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPS 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDNI 273
Cdd:cd15409 170 INELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMM 249

                       250       260       270
                ....*....|....*....|....*....|
gi 22129455 274 LSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15409 250 DSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

34-301

3.41e-86

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 260.03 E-value: 3.41e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15429  10 MYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFI 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTS 193
Cdd:cd15429  90 LLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTS 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDNI 273
Cdd:cd15429 170 LNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEKM 249

                       250       260
                ....*....|....*....|....*...
gi 22129455 274 LSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15429 250 ISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-294

8.93e-86

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 258.71 E-value: 8.93e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELV 106
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 107 LGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLD 186
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 187 LACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYH 266
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129455 267 NPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15947 243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

33-303

9.68e-86

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 259.18 E-value: 9.68e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15413   9 VIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISEL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15413  89 FLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDN 272
Cdd:cd15413 169 HEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDK 248

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15413 249 MASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

32-294

1.25e-85

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 258.34 E-value: 1.25e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAE 111
Cdd:cd15232   8 LFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 112 DLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACAD 191
Cdd:cd15232  88 LLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 192 TSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQD 271
Cdd:cd15232 168 TSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKD 247

                       250       260
                ....*....|....*....|...
gi 22129455 272 NILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15232 248 KVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

33-301

3.05e-84

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 255.19 E-value: 3.05e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15234   9 SMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15234  89 FLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDN 272
Cdd:cd15234 169 LINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTA 248

                       250       260
                ....*....|....*....|....*....
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15234 249 VASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-305

8.20e-84

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 254.71 E-value: 8.20e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  12 FILVGILNGSDSPELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  92 ISFGGCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKS 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 172 RHIRHLFCEIPPLLDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMY 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 252 YGALTVMYFLPSSYHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRKVL 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

30-303

4.21e-83

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 252.34 E-value: 4.21e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  30 TITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGG 109
Cdd:cd15407   6 IFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFAT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 110 AEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLAC 189
Cdd:cd15407  86 VENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 190 ADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPK 269
Cdd:cd15407 166 SDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMD 245

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129455 270 QDNILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15407 246 TDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-301

1.35e-82

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 250.81 E-value: 1.35e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15424  82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15424 162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15424 242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

27-303

5.86e-82

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 249.21 E-value: 5.86e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELV 106
Cdd:cd15416   3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 107 LGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLD 186
Cdd:cd15416  83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 187 LACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYH 266
Cdd:cd15416 163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129455 267 NPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15416 243 SMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-294

1.40e-81

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 248.05 E-value: 1.40e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15430   2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15430  82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15430 242 NAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

35-294

4.71e-81

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 246.81 E-value: 4.71e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  35 YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLL 114
Cdd:cd15224  11 YVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWIlsiqmaLGFTINTM------HYSFCKSRHIRHLFCEIPPLLDLA 188
Cdd:cd15224  91 LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWL------SGFLISMIkvyfisQLSFCGPNVINHFFCDISPLLNLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 189 CADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNP 268
Cdd:cd15224 165 CTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSF 244

                       250       260
                ....*....|....*....|....*.
gi 22129455 269 KQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15224 245 DSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

32-304

2.60e-80

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 245.46 E-value: 2.60e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAE 111
Cdd:cd15418   9 LLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 112 DLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACAD 191
Cdd:cd15418  89 CFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDD 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 192 TSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQD 271
Cdd:cd15418 169 TRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRD 248

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129455 272 NILSVFYTIVTPALNPLIHSLRNKEVTGALRKV 304
Cdd:cd15418 249 KVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

27-306

3.58e-79

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 242.33 E-value: 3.58e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFL--YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIE 104
Cdd:cd15414   1 IPLFLLFLlvYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPL 184
Cdd:cd15414  81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 185 LDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSS 264
Cdd:cd15414 161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22129455 265 YHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRKVLG 306
Cdd:cd15414 241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIR 282

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-301

3.96e-79

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 242.00 E-value: 3.96e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15428 242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

31-303

1.09e-78

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 241.16 E-value: 1.09e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGA 110
Cdd:cd15415   7 FLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 111 EDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACA 190
Cdd:cd15415  87 EGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 191 DTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQ 270
Cdd:cd15415 167 DTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQ 246

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129455 271 DNILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15415 247 EKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

33-294

6.15e-78

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 238.74 E-value: 6.15e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15915   9 LLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15915  89 MLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMP-SNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQD 271
Cdd:cd15915 169 SLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQD 248

                       250       260
                ....*....|....*....|...
gi 22129455 272 NILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15915 249 RIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

26-301

4.76e-77

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 236.99 E-value: 4.76e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15432   2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15432  82 GLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15432 162 KLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15432 242 SSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-303

1.69e-76

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 235.37 E-value: 1.69e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15412 162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGALRK 303
Cdd:cd15412 242 ESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-294

1.74e-75

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 232.75 E-value: 1.74e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15946 242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

35-301

7.78e-75

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 231.15 E-value: 7.78e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  35 YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLL 114
Cdd:cd15405  11 YVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYV 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTSS 194
Cdd:cd15405  91 LTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 195 YKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDNIL 274
Cdd:cd15405 171 NELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKVS 250

                       250       260
                ....*....|....*....|....*..
gi 22129455 275 SVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15405 251 SVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-294

3.07e-74

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 229.40 E-value: 3.07e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTssyklvvYLVGVFML----ILPLTAIFF---SYARILFTVLHMPSnESRKKALVTCSSHMTVVGMYYGALTVM 258
Cdd:cd15226 162 KLACTDT-------YVLELMVVansgLISLVCFLLlliSYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGPCIFI 233

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 259 YFLPSSyhNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15226 234 YVWPFS--TFPVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

33-294

1.94e-72

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 224.78 E-value: 1.94e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15939   9 LIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15939  89 FLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTvLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNpkQDN 272
Cdd:cd15939 169 YVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFP--IDK 245

                       250       260
                ....*....|....*....|..
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15939 246 VVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

34-301

6.06e-72

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 223.88 E-value: 6.06e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15236  10 MYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTS 193
Cdd:cd15236  90 LLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTS 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDNI 273
Cdd:cd15236 170 LNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIV 249

                       250       260
                ....*....|....*....|....*...
gi 22129455 274 LSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15236 250 ASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

31-301

2.23e-71

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 222.31 E-value: 2.23e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFL--YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd15228   5 VLFLafYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLA 188
Cdd:cd15228  85 STECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 189 CADTSSYKLVVYL-VGVFMLILpLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSyhN 267
Cdd:cd15228 165 CADTSIAETVSFTnVGLVPLTC-FLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP--S 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129455 268 PKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15228 242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-294

4.99e-70

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 218.72 E-value: 4.99e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15913 242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

34-301

4.11e-69

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 216.55 E-value: 4.11e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRD-NTISFGGCALQMFIELVLGGAED 112
Cdd:cd15916  10 IYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLGSTEC 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15916  90 FLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYL------VGVFMLILpltaifFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSyh 266
Cdd:cd15916 170 TINELVIFAsigvvaLGCFILIL------LSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS-- 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129455 267 NPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15916 242 KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-294

4.33e-69

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 216.08 E-value: 4.33e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15914 242 YSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

25-301

9.20e-69

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 215.43 E-value: 9.20e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  25 ELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIE 104
Cdd:cd15433   1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPL 184
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 185 LDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSS 264
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129455 265 YHNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15433 241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-301

2.10e-67

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 211.96 E-value: 2.10e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

34-294

1.25e-64

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 204.60 E-value: 1.25e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15940  10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTS 193
Cdd:cd15940  90 LLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTY 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMpSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSyhNPKQDNI 273
Cdd:cd15940 170 LIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST--SFSEDKV 246

                       250       260
                ....*....|....*....|.
gi 22129455 274 LSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15940 247 VSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

34-301

4.03e-63

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 201.12 E-value: 4.03e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15942  10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTS 193
Cdd:cd15942  90 LYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTA 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHnpKQDNI 273
Cdd:cd15942 170 FNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD--PLDGV 247

                       250       260
                ....*....|....*....|....*...
gi 22129455 274 LSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15942 248 VAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

32-301

4.01e-59

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 190.83 E-value: 4.01e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLH-VPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRD-NTISFGGCALQMFIELVLGG 109
Cdd:cd15941   8 LLIYLLTVLGNLLILLTIGSDPHLHgLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHFLAS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 110 AEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLAC 189
Cdd:cd15941  88 TECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLAC 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 190 ADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSyhNPK 269
Cdd:cd15941 168 ADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS--SQA 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 22129455 270 QDNILSVFYTIVTPALNPLIHSLRNKEVTGAL 301
Cdd:cd15941 246 GAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

33-294

5.61e-59

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 190.24 E-value: 5.61e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15936   9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15936  89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTvLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPssYHNPKQDN 272
Cdd:cd15936 169 FLLELLMVSNSGLVTLLIFFILLISYTVILVK-IRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARP--FQTFPMDK 245

                       250       260
                ....*....|....*....|..
gi 22129455 273 ILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15936 246 AVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

34-297

3.06e-57

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 185.96 E-value: 3.06e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15223  10 LYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTS 193
Cdd:cd15223  90 ILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYF-------LPSSYH 266
Cdd:cd15223 170 INSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyrfgktIPPDVH 249

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129455 267 npkqdNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15223 250 -----VLLSVLYILIPPALNPIIYGVRTKEI 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-294

2.57e-56

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 183.15 E-value: 2.57e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15938   2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15938  82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVlhmPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15938 162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HnpKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15938 239 F--PVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

33-297

1.98e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 181.33 E-value: 1.98e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15917   9 AMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15917  89 GVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPS-SYHNPKQD 271
Cdd:cd15917 169 RVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRfGHHVPPHV 248

                       250       260
                ....*....|....*....|....*..
gi 22129455 272 NI-LSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15917 249 HIlLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-294

1.78e-53

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 176.11 E-value: 1.78e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRL-HVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIE 104
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPL 184
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 185 LDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTvLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSS 264
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129455 265 yhNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15935 241 --SSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

33-297

2.96e-52

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 172.98 E-value: 2.96e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15950   9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15950  89 GVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADP 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYY-GALTVMYFLPSSYHNPKQD 271
Cdd:cd15950 169 RPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTQRFGQGVPPHT 248

                       250       260
                ....*....|....*....|....*..
gi 22129455 272 NIL-SVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15950 249 QVLlADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-294

1.44e-51

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 171.07 E-value: 1.44e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMLILPLTAIFFSYArILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPssY 265
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYA-FLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP--F 238

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15937 239 RSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

33-297

7.89e-51

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 169.39 E-value: 7.89e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15221   9 SMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15221  89 AILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADI 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SS---YKLVVYLVGVfmlILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHN-P 268
Cdd:cd15221 169 TVniwYGLTVALLTV---GLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHiP 245

                       250       260       270
                ....*....|....*....|....*....|
gi 22129455 269 KQDNI-LSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15221 246 RHVHIlLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

35-297

1.01e-47

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 161.39 E-value: 1.01e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  35 YTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLL 114
Cdd:cd15952  11 YLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAV 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNY-MILMSPRVCWLMVTAsWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADTs 193
Cdd:cd15952  91 LVAMAFDRYVAICNPLRYtTILTNKVISVIALGI-VLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASI- 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 syKLVVY--LVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHN-PKQ 270
Cdd:cd15952 169 --RINIIygLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNiPRY 246

                       250       260
                ....*....|....*....|....*...
gi 22129455 271 DNIL-SVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15952 247 IHILlANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

32-297

6.45e-46

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 156.65 E-value: 6.45e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAE 111
Cdd:cd15953   8 CLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIME 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 112 DLLLAFMAYDRYVAICHPLNY-MILMSPRVCWLMVTASwILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACA 190
Cdd:cd15953  88 SAVLVAMAFDRYVAICNPLRYaTILTNSRIAKLGLVGL-IRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 191 DTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHN--P 268
Cdd:cd15953 167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQGiaP 246

                       250       260
                ....*....|....*....|....*....
gi 22129455 269 KQDNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15953 247 HIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

33-297

1.49e-44

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 153.04 E-value: 1.49e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15222   9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYM-ILMSPRVCWLMVTASwILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACAD 191
Cdd:cd15222  89 SVLLAMAFDRFVAICNPLRYAsILTNSRIAKIGLAIV-LRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 192 T---SSYKLVVYLvgvFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYG---ALTVMY----FL 261
Cdd:cd15222 168 TrvnSIYGLFVVL---STMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVpmiGLSMVHrfgkHA 244

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129455 262 PSSYHnpkqdNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15222 245 SPLVH-----VLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

33-297

1.92e-43

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 150.19 E-value: 1.92e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15951   9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15951  89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGAlTVMYFLPSSY-HN-PKQ 270
Cdd:cd15951 169 RVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIP-ALFSFLTHRFgHNvPPH 247

                       250       260
                ....*....|....*....|....*...
gi 22129455 271 DNIL-SVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15951 248 VHILiANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

33-297

2.40e-41

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 144.62 E-value: 2.40e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15956   9 FIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15956  89 GVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGAT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHN--PKQ 270
Cdd:cd15956 169 TVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSvpSAA 248

                       250       260
                ....*....|....*....|....*..
gi 22129455 271 DNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15956 249 HVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

33-297

4.09e-41

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 144.28 E-value: 4.09e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15948  10 SAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMES 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWL--MVTASWILSIQMALGFTINTMHYsfCKSRHIRHLFCEIPPLLDLACA 190
Cdd:cd15948  90 AVLLAMAFDRYVAICNPLRYATILTNSVITKigLAALARAVTLMTPLPFLLRRLPY--CRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 191 DTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYgaltVMYFLPSSYHN--- 267
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFY----TPVVLSSTMHRfar 243

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129455 268 ---PKQDNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15948 244 hvaPHVHILLANFYLLFPPMMNPIVYGVKTKQI 276

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-305

2.01e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 139.94 E-value: 2.01e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455    33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455   113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455   193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHN--PKQ 270
Cdd:pfam13853 163 KVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNvpPLL 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 22129455   271 DNILSVFYTIVTPALNPLIHSLRNKEVTGALRKVL 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

34-297

1.59e-37

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 134.90 E-value: 1.59e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15955  10 MFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCW---LMVTASWILSIQMALGFTINTMHysFCKSRHIRHLFCEIPPLLDLACA 190
Cdd:cd15955  90 ILLAMALDRYVAICHPLRHSSILTPQVLLgigVLVVVRAVVLIIPCPLLIKLRLH--HFRSTVISHSYCEHMAVVKLAAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 191 DTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYgALTVMYFLPSSY-HN-- 267
Cdd:cd15955 168 DVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFY-TLAFFSFFAHRFgHHva 246

                       250       260       270
                ....*....|....*....|....*....|
gi 22129455 268 PKQDNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15955 247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

42-289

5.35e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 127.41 E-value: 5.35e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455    42 NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLL-RDNTISFGGCALQMFIELVLGGAEDLLLAFMAY 120
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455   121 DRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIrhlFCEIPPLLDLACadtssYKLVVY 200
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT---VCFIDFPEDLSK-----PVSYTL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455   201 LVGVFMLILPLTAIFFSYARILFTVLHMPS-------NESRKKALVTCSSHMTVVGMYYGALTVMYFLPSSYHNPKQDNI 273
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRKSASkqksserTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233

                         250       260
                  ....*....|....*....|..
gi 22129455   274 LSVFYTI------VTPALNPLI 289
Cdd:pfam00001 234 LDKALSVtlwlayVNSCLNPII 255

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-297

1.20e-34

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 127.59 E-value: 1.20e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  10 SGFILVGILNGSDSPELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRD 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  90 NTISFGGCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 170 KSRHIRHLFCEIPPLLDLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVG 249
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22129455 250 MYYGALTVMYFLPSSYHN--PKQDNILSVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15949 242 AFYVPIAVSSLIHRFGQNvpPPTHILLANFYLLIPPMLNPIVYGVRTKQI 291

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

33-297

2.31e-32

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 121.08 E-value: 2.31e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15954   9 FMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLACADT 192
Cdd:cd15954  89 GVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANI 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYFLP--SSYHNPKQ 270
Cdd:cd15954 169 RVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHrfGGHHITPH 248

                       250       260
                ....*....|....*....|....*...
gi 22129455 271 DNIL-SVFYTIVTPALNPLIHSLRNKEV 297
Cdd:cd15954 249 IHIImANLYLLLPPMMNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

29-294

1.24e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 100.44 E-value: 1.24e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCeipplldla 188
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP--------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 189 caDTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLH--------------MPSNESRKKALVTCsshMTVVGM---- 250
Cdd:cd00637 154 --DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTL---LIVVVVfllc 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129455 251 ---YYGALTVMYFLPSSYHNPKQDNILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd00637 229 wlpYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-296

1.04e-17

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 81.07 E-value: 1.04e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINtmhysfcksrhiRHLFCEIPPLL 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVG------------WRDETQPSVVD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 186 DLACADTSSYKLVVYLVGVFMliLPLTAIFFSYARILFTVLHmpsnesRKKALVTCSshmTVVGMYYGA---LTVMYFLp 262
Cdd:cd14967 149 CECEFTPNKIYVLVSSVISFF--IPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLLCwlpFFIIYLV- 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22129455 263 sSYHNPKqDNILSVFYTIVT------PALNPLIHSLRNKE 296
Cdd:cd14967 217 -SAFCPP-DCVPPILYAVFFwlgylnSALNPIIYALFNRD 254

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

25-236

4.17e-13

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 68.39 E-value: 4.17e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  25 ELLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIE 104
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYmILMSPRVCWLMVTASWILSiqmalgftintmhysfcksrhirhLFCEIPPL 184
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYG------------------------LFWALPPL 135

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22129455 185 L----------------DLACADTSSYKLVVYLVgVFMLILPLTAIFFSYARILFTVLHMPSNESRKK 236
Cdd:cd14969 136 FgwssyvpegggtscsvDWYSKDPNSLSYIVSLF-VFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRK 202

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

26-292

5.57e-11

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 62.37 E-value: 5.57e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFL-LRDNTISFGGCALQMFIE 104
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL--GFTINTMHYSFC-KSRHIRHLFCEI 181
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIpiLFLMGIQYLNGPlPGPVPDSAVCTL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 182 PPlldlacaDTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSN--ESRKKALVTC------SSHMTVVGMyYG 253
Cdd:cd14979 162 VV-------DRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIkkGTRAQGTRNVelslsqQARRQVVKM-LG 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 254 ALTVMYF---LPssYH--------NPKQDNILSVFYTIVTP----------ALNPLIHSL 292
Cdd:cd14979 234 AVVIAFFvcwLP--FHaqrlmfsyASKEDTFLFDFYQYLYPisgilfylssAINPILYNL 291

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

32-301

5.68e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 61.92 E-value: 5.68e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLlTSVITPKAVMDFLLRDNTIS-FGGCALQMFIELVLGGA 110
Cdd:cd14972   6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL-AGIAFVFTFLSVLLVSLTPSpATWLLRKGSLVLSLLAS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 111 EDLLLAfMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALgftINTMHYSFCksrhirhlFCEIPPLLDLACA 190
Cdd:cd14972  85 AYSLLA-IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL---LPVLGWNCV--------LCDQESCSPLGPG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 191 DTSSYkLVVYLVGVFMlilPLTAIFFSYARILFTV-LHMPSNESRKKALVTCSSHMTVVGMYYGALTVMYF----LPSS- 264
Cdd:cd14972 153 LPKSY-LVLILVFFFI---ALVIIVFLYVRIFWCLwRHANAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFlvcwLPLLi 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129455 265 -----YHNPKQDNILSVFYTIVTPAL-----NPLIHSLRNKEVTGAL 301
Cdd:cd14972 229 llvldVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

29-153

6.35e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 61.87 E-value: 6.35e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLtsvitpkAVMDFL---LRDNTISFGG----CALQM 101
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLV-------ALFNVLpqlIWDITYRFYGgdllCRLVK 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 102 FIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILmSPRVCWLMVTASWILSI 153
Cdd:cd15196  78 YLQVVGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSL 128

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

32-153

3.75e-09

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 56.79 E-value: 3.75e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTL-----ALTSNGLLLLVITVD--TRLHVPMYLLLGQLSLIDLLLTSVITPKAVMdfLLRDNTISFGG--CALQMF 102
Cdd:cd15055   1 VLLYIVlssisLLTVLGNLLVIISIShfKQLHTPTNLLLLSLAVADFLVGLLVMPFSMI--RSIETCWYFGDtfCKLHSS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129455 103 IELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15055  79 LDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSA 129

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-236

5.88e-09

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 56.10 E-value: 5.88e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAvMDFLLRdNTISFGG--CALQMFI 103
Cdd:cd15314   2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPS-MVRSVE-TCWYFGDlfCKIHSSF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRhlfCEIPP 183
Cdd:cd15314  80 DITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHVA---CEGGC 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129455 184 LLDLACADTSSYKLVV-YLVGVFMLILPLTaIFF---SYARILFTVLHMPSNESRKK 236
Cdd:cd15314 157 LVFFSKVSSVVGSVFSfYIPAVIMLCIYLK-IFLvaqRQARSIQSARTKSGASSSKM 212

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

30-228

2.97e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 54.14 E-value: 2.97e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  30 TITFLYT----LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd14993   2 VLIVLYVvvflLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS----IQMALGFTINTMHYSFCKSRHIRhlFC-E 180
Cdd:cd14993  82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAiiimLPLLVVYELEEIISSEPGTITIY--ICtE 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 181 IPPLLDLACAdtssYKLVVYlvgVFMLILPLTAIFFSYARILFTVLHM 228
Cdd:cd14993 160 DWPSPELRKA----YNVALF---VVLYVLPLLIISVAYSLIGRRLWRR 200

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

26-296

6.30e-08

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 53.11 E-value: 6.30e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMdFLLRDNTiSFGG--CALQMFI 103
Cdd:cd15051   2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAI-YELRGEW-PLGPvfCNIYISL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMA-----LGFtiNTMHYSFCKSRHIRHLF 178
Cdd:cd15051  80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSflpihLGW--NTPDGRVQNGDTPNQCR 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 179 CEIPPlldlacadtsSYKLVVYLVGVFmliLPLTAIFFSYARILFTV---------LHMPSNESRKKALVTCSSHMTVV- 248
Cdd:cd15051 158 FELNP----------PYVLLVAIGTFY---LPLLIMCGVYLRIFRIAreqakrinaLTPASTANSSKSAATAREHKATVt 224

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22129455 249 -GMYYGALTVM---YFLPSSYHNPKQDNILSVFYTIVT------PALNPLIHSLRNKE 296
Cdd:cd15051 225 lAAVLGAFIICwfpYFTYFTYRGLCGDNINETALSVVLwlgyanSALNPILYAFLNRD 282

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

26-236

7.74e-08

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 52.83 E-value: 7.74e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTI--NTMHYSFCKSRHIRHLFCEIPP 183
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVfsQTVEILVTQDGQEEEICVLDRE 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129455 184 LLDLACADTSSYkLVVYLVgvfmlilPLTAIFFSYARILFTVLHMPSNESRKK 236
Cdd:cd15012 161 MFNSKLYDTINF-IVWYLI-------PLLIMTVLYSKISIVLWKSSSIEARRK 205

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

29-227

9.29e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 52.84 E-value: 9.29e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPkAVMDFLLRDNTISFG--GCALQMFIELV 106
Cdd:cd15005   5 TTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFP-FVMASVRHGSGWIYGalSCKVIAFLAVL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 107 LGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSrhirhlfceippllD 186
Cdd:cd15005  84 FCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIRE--------------E 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 22129455 187 LACA-DTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLH 227
Cdd:cd15005 150 DQCTfEHRSYKANDTLGFMLVLAVVIAATHLVYLKLLIFLRH 191

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

26-157

1.18e-07

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 51.95 E-value: 1.18e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLrdNTISFGGCALQMFIEL 105
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELT--GRWILGQVLCDIWISL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 106 --VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15064  80 dvTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL 133

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

31-151

1.29e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 52.06 E-value: 1.29e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFLYTLALTSNGLLLLVITVD--TRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLlrDNTISFGG--CALQMFIELV 106
Cdd:cd15317   5 IVLVLAMLITVSGNLVVIISIShfKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTV--ETCWYFGDlfCKFHTGLDLL 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129455 107 LGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWIL 151
Cdd:cd15317  83 LCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

29-225

1.43e-07

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 51.99 E-value: 1.43e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSV-ITPK----AVMDFLLRDNtisfgGCALQMFI 103
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFtVLTQiiweATGEWVAGDV-----LCRIVKYL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYmiLMSPRVCWLMVTASW----ILSIQMALGFTINTMHYSF--CKSRHIrhl 177
Cdd:cd14986  80 QVVGLFASTYILVSMSLDRYQAIVKPMSS--LKPRKRARLMIVVAWvlsfLFSIPQLVIFVERELGDGVhqCWSSFY--- 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 178 fceipplldlacaDTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTV 225
Cdd:cd14986 155 -------------TPWQRKVYITWLATYVFVIPLIILSYCYGRILRTI 189

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

36-157

2.29e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 51.10 E-value: 2.29e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  36 TLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMdfLLRDNTISFGGCALQMFIELVLGGAEDLLL 115
Cdd:cd14968  12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAIL--ISLGLPTNFHGCLFMACLVLVLTQSSIFSL 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129455 116 AFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd14968  90 LAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL 131

7tmA_PAR4

cd15372

protease-activated receptor 4, member of the class A family of seven-transmembrane G ...

34-226

3.44e-07

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 320494 [Multi-domain] Cd Length: 274 Bit Score: 50.52 E-value: 3.44e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLA----LTSNGLLLLVITVDTRlHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLlrDNTISFGGCALQMFIELVLGG 109
Cdd:cd15372   6 LYTLVflvgLPANGLALWVLATQVK-RLPSTIFLINLAVADLLLILVLPFKISYHFL--GNNWPFGEGLCRVVTAFFYGN 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 110 --AEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIrhlFCEipPLLDL 187
Cdd:cd15372  83 myCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNIT---LCH--DVLPL 157

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 22129455 188 ACADTSSYKLVVYLVgVFMLILPLTAIFFSYARILFTVL 226
Cdd:cd15372 158 DEQDTYLFYYFACLA-VLGFLLPLVVILFCYGSVLHTLL 195

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

29-169

3.80e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 50.71 E-value: 3.80e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHV--PMYLLLGQLSLIDLLLTSVITPkAVMDFLLRDNTISFGG--CALQMFIE 104
Cdd:cd14981   5 APPALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSP-VVLAVYASNFEWDGGQplCDYFGFMM 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMA----LGFTINTMHY--SFC 169
Cdd:cd14981  84 SFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAslplLGLGSYVLQYpgTWC 154

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

39-158

4.87e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 50.43 E-value: 4.87e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  39 LTSNGLLLLVITVD--TRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLlrDNTISFGG--CALQMFIELVLGGAEDLL 114
Cdd:cd15312  13 LTVFGNLMVIISIShfKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSV--ESCWYFGDlfCKIHSSLDMMLSTTSIFH 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALG 158
Cdd:cd15312  91 LCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFG 134

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

26-152

6.40e-07

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 49.66 E-value: 6.40e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMdFLLRDNTISFGG--CALQMFI 103
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSIL-HEMTGGYWLFGRdwCDVWHSF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15067  80 DVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICS 128

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

26-227

7.33e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 49.88 E-value: 7.33e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSViTPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15079   2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVcWLMVTASWIlsiqMALGFTIntMHYSFCKSRHIRHLF---CEIP 182
Cdd:cd15079  81 LSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKA-LLLILFIWL----YALPWAL--LPLLFGWGRYVPEGFltsCSFD 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 22129455 183 PLldlacADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLH 227
Cdd:cd15079 154 YL-----TRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVFA 193

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

26-225

8.04e-07

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 49.63 E-value: 8.04e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTsvitpkAVMDFLLRdnTIS-------FG--G 96
Cdd:cd15337   2 LIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFS------AVNGFPLK--TISsfnkkwiWGkvA 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  97 CALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYsfcksrhirh 176
Cdd:cd15337  74 CELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRY---------- 143

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 177 lfceIPPLLDLACA-D--TSSYKLVVYLVGVFML--ILPLTAIFFSYARILFTV 225
Cdd:cd15337 144 ----VPEGFQTSCTfDylSRDLNNRLFILGLFIFgfLCPLLIIIFCYVNIIRAV 193

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

26-222

1.10e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 49.03 E-value: 1.10e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15054   2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd15054  82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVEGQC 161

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 22129455 186 DLACadTSSYKLVVYLVGVFmliLPLTAIFFSYARIL 222
Cdd:cd15054 162 RLLV--SLPYALVASCLTFF---LPSGAICFTYCRIL 193

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

29-296

1.11e-06

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 49.03 E-value: 1.11e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSiqmalgFTINTMHYSFCKSRHIRHLFCEIPPLLDLA 188
Cdd:cd15063  85 TASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLS------FVICFPPLVGWNDGKDGIMDYSGSSSLPCT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 189 CADTSSYKLVVY-LVGVFMliLPLTAIFFSYARILFTVlhmpsnESRKKALVTCSshmTVVGMY---YGALTVMYFLPSS 264
Cdd:cd15063 159 CELTNGRGYVIYsALGSFY--IPMLVMLFFYFRIYRAA------RMETKAAKTVA---IIVGCFifcWLPFFTVYLVRAF 227

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129455 265 YHNPKQDNILSVFYTI--VTPALNPLIHSLRNKE 296
Cdd:cd15063 228 CEDCIPPLLFSVFFWLgyCNSALNPCIYALFSRD 261

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

26-157

1.16e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 49.18 E-value: 1.16e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15334   2 LISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDI 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15334  82 TCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISM 133

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

37-295

1.18e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 48.96 E-value: 1.18e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITP-KAVMDFllrDNTISFG--GCALQMFIELVLGGAEDL 113
Cdd:cd15073  13 ISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPfSAASDL---HGSWKFGyaGCQWYAFLNIFFGMASIG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMiLMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSrhirHLFCEIppllDLACADtS 193
Cdd:cd15073  90 LLTVVAVDRYLTICRPDLGR-KMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPT----GATCTI----NWRKND-S 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYgALTVM----------YFLPS 263
Cdd:cd15073 160 SFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSV-IMIVMflvawspysiVCLWA 238

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129455 264 SYHNPKQdniLSVFYTIVTPAL-------NPLIHSLRNK 295
Cdd:cd15073 239 SFGEPKK---IPPWMAIIPPLFaksstfyNPCIYVIANK 274

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

26-247

1.40e-06

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 48.80 E-value: 1.40e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKavMDFLLRDNTISFG-----GCALQ 100
Cdd:cd14982   2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFR--IYYYLNGGWWPFGdflcrLTGLL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 101 MFIELVLGGaedLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINtmHYSFCKSRHIRHLFCE 180
Cdd:cd14982  80 FYINMYGSI---LFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLL--RSTIAKENNSTTCFEF 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129455 181 IPPLLdlacadTSSYKLVVYLVgVFMLILPLTAIFFSYARILFTVLHMP----SNESRKKALVTCSSHMTV 247
Cdd:cd14982 155 LSEWL------ASAAPIVLIAL-VVGFLIPLLIILVCYSLIIRALRRRSkqsqKSVRKRKALRMILIVLAV 218

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

37-153

1.40e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 49.04 E-value: 1.40e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLlltsVITPKAVMDFLLRDNTISFGG----CALQMFIELVLGGAED 112
Cdd:cd15387  13 LALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADL----VVAVFQVLPQLIWDITFRFYGpdflCRLVKYLQVVGMFAST 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVcwlMVTASWILSI 153
Cdd:cd15387  89 YMLLLMSIDRCLAICQPLRSLHRRSDRV---YVLFSWLLSL 126

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

37-221

1.60e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 48.58 E-value: 1.60e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMdFLLRDNTISFGG--CALQMFIELVLGGAEDLL 114
Cdd:cd15394  13 VGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLA-YAFEPRGWVFGRfmCYFVFLMQPVTVYVSVFT 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMilMSPRVCWLMVTASWILSIQMALGFTINTMHYSFcksrhIRHLF--CEippllDLACADT 192
Cdd:cd15394  92 LTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEF-----KGLDFsiCE-----EFWFGQE 159

                       170       180
                ....*....|....*....|....*....
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARI 221
Cdd:cd15394 160 KQRLAYACSTLLITYVLPLLAISLSYLRI 188

7tmA_GPR83

cd15389

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...

26-221

1.64e-06

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.

Pssm-ID: 320511 [Multi-domain] Cd Length: 285 Bit Score: 48.87 E-value: 1.64e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15389   2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMilMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCeippll 185
Cdd:cd15389  82 CSVYVSTLTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRC------ 153

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 22129455 186 dLACADTSSYKLVVYL-VGVFML--ILPLTAIFFSYARI 221
Cdd:cd15389 154 -LPSFPEPSDLFWKYLdLATFILqyVLPLLIIGVAYTRV 191

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

26-221

1.70e-06

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 48.62 E-value: 1.70e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLytLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPkavmdFLLRDNTIS--FGG---CALQ 100
Cdd:cd15205   4 VITYVLIFV--LALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIP-----FTLLQNISSnwLGGafmCKMV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 101 MFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGF----TINTMHYSFCKSRHIrh 176
Cdd:cd15205  77 PFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMlfvqQLEVKYDFLYEKRHV-- 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 22129455 177 lFCEipplldLACADTSSYKLVVYLVGVFMLILPLTAIFFSYARI 221
Cdd:cd15205 155 -CCL------ERWYSPTQQKIYTTFILVILFLLPLTTMLFLYSRI 192

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

26-153

1.75e-06

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 48.38 E-value: 1.75e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15335   2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISI 129

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

29-248

2.51e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 47.98 E-value: 2.51e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYT----LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIE 104
Cdd:cd15203   1 IILILLYGliivLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMilMSPRVCWLMVTASWILSIQMALGFTINT-MHYSFCKSRHIRHLFCEipp 183
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSLPLAIFQeLSDVPIEILPYCGYFCT--- 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22129455 184 lldlACADTSSYKLVvYLVGVFML--ILPLTAIFFSYARILFtVLHMPSNESRKKALVTCSSHMTVV 248
Cdd:cd15203 156 ----ESWPSSSSRLI-YTISVLVLqfVIPLLIISFCYFRISL-KLRKRVKKKRGKRTLSSRRRRSEL 216

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

37-294

3.53e-06

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 47.81 E-value: 3.53e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKavmdFLLRD--NTISFG--GCALQMFIELVLGGAED 112
Cdd:cd15000  12 FGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWM----FLVHDffQNYVLGsvGCKLEGFLEGSLLLASV 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMIlmSPRVCWLMVTASWILSIQMALGFTIntmhYSFCKSRHIRHlfceippLLDLACA-D 191
Cdd:cd15000  88 LALCAVSYDRLTAIVLPSEARL--TKRGAKIVIVITWIVGLLLALPLAI----YRSYRERQWKN-------FLETYCAeN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 192 TSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVLHMPSNESRKKALVTCSSHMTVVGMYYGAL----------TVMYFL 261
Cdd:cd15000 155 TQVLPIYWHVIITVLVWLPLGIMLICYSAIFWKLDKYERRVLRREHPSVVRYKKKAAKTLFIVLitfvvcripfTALIFY 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129455 262 psSYHNPKQDNIL-------------SVFYTIVTPALNPLIHSLRN 294
Cdd:cd15000 235 --RYKLVPNDNTQnsvsgsfhilwfaSKYLMFLNAAVNPLIYGFTN 278

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

42-153

5.10e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 47.28 E-value: 5.10e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  42 NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTIsFGG--CALQMFIELVLGGAEDLLLAFMA 119
Cdd:cd14997  18 NVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWL-LGEfmCKLVPFVELTVAHASVLTILAIS 96

                        90       100       110
                ....*....|....*....|....*....|....
gi 22129455 120 YDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd14997  97 FERYYAICHPLQAKYVCTKRRALVIIALIWLLAL 130

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

32-294

5.43e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 47.04 E-value: 5.43e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTS---NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd15050   5 IALSTISLITvilNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVAS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTiNTMHYSFCKSRHIRHLFCEipplldla 188
Cdd:cd15050  85 TASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPIL-GWHHFARGGERVVLEDKCE-------- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 189 cADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTVlhmpsNESRKKAL---VTCSSHMTVVGMYYGALTVMYFLPSSY 265
Cdd:cd15050 156 -TDFHDVTWFKVLTAILNFYIPSLLMLWFYAKIFKAV-----NRERKAAKqlgFIMAAFILCWIPYFILFMVIAFCKNCC 229

                       250       260
                ....*....|....*....|....*....
gi 22129455 266 HNPKQdnILSVFYTIVTPALNPLIHSLRN 294
Cdd:cd15050 230 NENLH--MFTIWLGYINSTLNPFIYPLCN 256

7tmA_NTSR

cd15130

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

63-157

7.04e-06

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320258 [Multi-domain] Cd Length: 281 Bit Score: 46.86 E-value: 7.04e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  63 LGQLSLIDLLLTSVITPKAVMDFLLRDNTISFG--GCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRV 140
Cdd:cd15130  42 LGSLALSDLLILLLAMPVELYNFIWVHHPWAFGdaGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSR 121

                        90
                ....*....|....*..
gi 22129455 141 CWLMVTASWILSIQMAL 157
Cdd:cd15130 122 TKKFISAIWLASALLAI 138

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

34-157

8.63e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 46.51 E-value: 8.63e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDL 113
Cdd:cd15330  10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIL 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129455 114 LLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15330  90 HLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISI 133

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

115-237

1.03e-05

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 46.26 E-value: 1.03e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAlgftINTMHYS--FCKSRHIRHLFC-EIPPlldlacaD 191
Cdd:cd15098  93 LVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMA----SPVAVHQdlVHHWTASNQTFCwENWP-------E 161

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129455 192 TSSYKLVVYLVGVFMLILPLTAIFFSYARILFTvLHMPSNESRKKA 237
Cdd:cd15098 162 KQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNH-LHKKLKNMSKKS 206

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

37-225

1.23e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 46.17 E-value: 1.23e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLA 116
Cdd:cd15083  13 IGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 117 FMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYsfcksrhirhlfceIPPLLDLAC-----AD 191
Cdd:cd15083  93 AIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRY--------------VLEGLLTSCsfdylSR 158

                       170       180       190
                ....*....|....*....|....*....|....
gi 22129455 192 TSSYKLVVYLVGVFMLILPLTAIFFSYARILFTV 225
Cdd:cd15083 159 DDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAV 192

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

33-222

1.39e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 45.92 E-value: 1.39e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd14971   9 LIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTIntmHYSFCKSRHIRHLFCEipplldLACADT 192
Cdd:cd14971  89 FTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLA---LHRLRNYTPGNRTVCS------EAWPSR 159

                       170       180       190
                ....*....|....*....|....*....|
gi 22129455 193 SSYKLVVYLVGVFMLILPLTAIFFSYARIL 222
Cdd:cd14971 160 AHRRAFALCTFLFGYLLPLLLICVCYAAML 189

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

43-152

1.50e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 45.62 E-value: 1.50e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  43 GLLLLVITVD--TRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLlrDNTISFGG--CALQMFIELVLGGAEDLLLAFM 118
Cdd:cd15318  17 GNLFVVVTVShfKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSV--ESCWYFGDsfCRLHTCLDTLFCLTSIFHLCFI 94

                        90       100       110
                ....*....|....*....|....*....|....
gi 22129455 119 AYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15318  95 SIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVP 128

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

26-225

1.53e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 45.96 E-value: 1.53e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMIlmSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFCEI--PP 183
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEdwPE 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 22129455 184 LLDLAcadtssYKLVVYLVGVFMLILPLTAIFFSYARILFTV 225
Cdd:cd15202 160 RADLF------WKYYDLALFILQYFLPLLVISFAYARVGIKL 195

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

24-221

1.54e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 45.73 E-value: 1.54e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  24 PELLCATITFLytLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFI 103
Cdd:cd15001   1 PVIIVYVITFV--LGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMA--LGFTINTMHYSFCKSRHIRHLFCEI 181
Cdd:cd15001  79 QLLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILAspVLFGQGLVRYESENGVTVYHCQKAW 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 22129455 182 PplldlacadtSSYKLVVYLVGVFMLI--LPLTAIFFSYARI 221
Cdd:cd15001 159 P----------STLYSRLYVVYLAIVIffIPLIVMTFAYARD 190

7tmA_GnRHR_vertebrate

cd15383

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...

31-243

2.11e-05

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320505 [Multi-domain] Cd Length: 295 Bit Score: 45.44 E-value: 2.11e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITF-LYTLALTSNGLLLLVITVDTR---LHVPMylLLGQLSLIDLLLTSVITPkavMDFLLRDNTISFGG---CALQMFI 103
Cdd:cd15383   6 VTFvLFVLSACSNLAVLWSATRNRRrklSHVRI--LILHLAAADLLVTFVVMP---LDAAWNVTVQWYAGdlaCRLLMFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNymILMSPRVCWLMVTASWILSIQMALGFTIntmhysfcksrhIRHLFCEIPP 183
Cdd:cd15383  81 KLFAMYSSAFVTVVISLDRHAAILNPLA--IGSARRRNRIMLCAAWGLSALLALPQLF------------LFHTVTATPP 146

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22129455 184 LLDLACADTSSYKL----VVYLVGVF--MLILPLTAIFFSYARILFTVLH-MPSNESRKKALVTCSS 243
Cdd:cd15383 147 VNFTQCATHGSFPAhwqeTLYNMFTFfcLFLLPLLIMIFCYTRILLEISRrMKEKKDSAKNEVALRS 213

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

42-153

2.43e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 45.04 E-value: 2.43e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  42 NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLrdNTISFGGCALQMFI--ELVLGGAEDLLLAFMA 119
Cdd:cd15061  17 NLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLL--GYWPLGSHLCDFWIslDVLLCTASILNLCCIS 94

                        90       100       110
                ....*....|....*....|....*....|....
gi 22129455 120 YDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15061  95 LDRYFAITYPLKYRTKRSRRLAITMILAVWVISL 128

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

26-222

2.45e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 45.28 E-value: 2.45e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15959   2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRhlfCEIPPll 185
Cdd:cd15959  82 LCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEEAQR---CYDNP-- 156

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 22129455 186 dlACADTSSYKLVVYLVGVFMLILPLTAIFFSYARIL 222
Cdd:cd15959 157 --RCCDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVF 191

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-152

2.66e-05

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 44.95 E-value: 2.66e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRdnTISFGGCALQMFI-- 103
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSG--YWPFGEILCDVWIsf 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15329  80 DVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLS 128

7tmA_Mu_opioid_R

cd15090

opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...

30-157

2.76e-05

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320218 [Multi-domain] Cd Length: 279 Bit Score: 44.99 E-value: 2.76e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  30 TITFLYT----LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVItPKAVMDFLLrdNTISFGG--CALQMFI 103
Cdd:cd15090   2 TIMALYSivcvVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTL-PFQSVNYLM--GTWPFGNilCKIVISI 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15090  79 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL 132

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

26-157

2.92e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 44.79 E-value: 2.92e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLaltSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15333   9 VLLALITLATTL---SNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDI 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15333  86 TCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISL 137

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

37-157

3.08e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 44.76 E-value: 3.08e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLL--VITVDTRLHVPMYLLLgQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLL 114
Cdd:cd15219  12 VSLLSNLLVLLcfLYSAELRKQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLS 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15219  91 MAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSL 133

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

34-228

3.89e-05

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 44.70 E-value: 3.89e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPkavMDFLLRDNTISFGG---CALQMFIELVLGGA 110
Cdd:cd15195  10 LFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP---MDAVWNYTVEWLAGdlmCRVMMFLKQFGMYL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 111 EDLLLAFMAYDRYVAICHPLNymILMSPRVCWLMVTASWILSIqmalgftINTMHYSFcksrhirhLFCEIPPLLD---- 186
Cdd:cd15195  87 SSFMLVVIALDRVFAILSPLS--ANQARKRVKIMLTVAWVLSA-------LCSIPQSF--------IFSVLRKMPEqpgf 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 187 LACADTSSYKL-----VVYLVGVFML-ILPLTAIFFSYARILFTVLHM 228
Cdd:cd15195 150 HQCVDFGSAPTkkqerLYYFFTMILSfVIPLIITVTCYLLILFEISKM 197

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

32-235

3.95e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 44.51 E-value: 3.95e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLHVP--MYLLlgQLSLIDLLLtsVITPKAVMDFLLRDNTISFGGCALQMFIELVLGG 109
Cdd:cd14984   8 SLVFLLGLVGNSLVLLVLLYYRKLRSMtdVYLL--NLALADLLF--VLTLPFWAVYAADGWVFGSFLCKLVSALYTINFY 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 110 AEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIqmalGFTINTMHYSFCKSRhIRHLFCEipPLLDLAC 189
Cdd:cd14984  84 SGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALAL----LLSLPEFIFSQVSEE-NGSSICS--YDYPEDT 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 22129455 190 ADTSSYKLVVYLVgVFMLILPLTAIFFSYARILFTVLHMPSNESRK 235
Cdd:cd14984 157 ATTWKTLLRLLQN-ILGFLLPLLVMLFCYSRIIRTLLRARNHKKHR 201

7tmA_SWS1_opsin

cd15076

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...

26-296

4.00e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320204 [Multi-domain] Cd Length: 280 Bit Score: 44.42 E-value: 4.00e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLS----LIDLLLTSVITPKAVMDFLLRDNTIsfggCALQM 101
Cdd:cd15076   2 LQAAFMGFVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISlagfIFCIFSVFPVFVASAQGYFFFGRTV----CALEA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 102 FIELVLGGAEDLLLAFMAYDRYVAICHPLNYMiLMSPRVCWLMVTASWILSIQMALGftintmhYSFCKSRHirhlfceI 181
Cdd:cd15076  78 FVGSLAGLVTGWSLAFLAFERYIVICKPFGNF-RFGSKHALGAVVATWIIGIGVSLP-------PFFGWSRY-------I 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 182 PPLLDLACAD-----TSSYK--LVVYLVGVFMLILPLTAIFFSYARILFTV----LHMPSNESRKKALVTCSSHMTV-VG 249
Cdd:cd15076 143 PEGLQCSCGPdwytvGTKYRseYYTWFLFIFCFIVPLSIIIFSYSQLLGALravaAQQQESASTQKAEREVSRMVVVmVG 222

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 250 MY------YGALTvMYFLPSSYHNPKQDNI-LSVFYTIVTPALNPLIHSLRNKE 296
Cdd:cd15076 223 SFclcyvpYAALA-MYMVNNRDHGLDLRLVtIPAFFSKSSCVYNPIIYCFMNKQ 275

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

42-220

4.05e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 44.18 E-value: 4.05e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  42 NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLAFMAYD 121
Cdd:cd15210  18 NLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLN 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 122 RYVAICHPLNYMILMSPRVCWLMVTASWILSIQMalgFTINTMHYSFCKSRHIRHLFCEIpplldLACADTSSYKLVVYL 201
Cdd:cd15210  98 RYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGS---FLPLWLGIWGRFGLDPKVCSCSI-----LRDKKGRSPKTFLFV 169

                       170
                ....*....|....*....
gi 22129455 202 VGVfmlILPLTAIFFSYAR 220
Cdd:cd15210 170 FGF---VLPCLVIIICYAR 185

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

37-221

4.39e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 44.21 E-value: 4.39e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLH-VPMYLLLgQLSLIDLLLTSVITPkAVMDFLLRDNTIsFG--GCALQMFIELVLGGAEDL 113
Cdd:cd15390  13 VAIGGNLIVIWIVLAHKRMRtVTNYFLV-NLAVADLLISAFNTV-FNFTYLLYNDWP-FGlfYCKFSNFVAITTVAASVF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 114 LLAFMAYDRYVAICHPLNYMilMSPRVCWLMVTASWILSIQMALGF----TINTMHYSFCKSRhiRHLFCEIPPlldlac 189
Cdd:cd15390  90 TLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQllysTTETYYYYTGSER--TVCFIAWPD------ 159

                       170       180       190
                ....*....|....*....|....*....|....
gi 22129455 190 aDTSSYKLVVYLVGVFML--ILPLTAIFFSYARI 221
Cdd:cd15390 160 -GPNSLQDFVYNIVLFVVtyFLPLIIMAVAYTRV 192

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

31-225

4.78e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 44.16 E-value: 4.78e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFLYTLALTSNGLLLLVITVDtRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRD-NTISFGGCALQMFIELVLG- 108
Cdd:cd14978   7 LPVICIFGIIGNILNLVVLTRK-SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYsSSFLSYFYAYFLPYIYPLAn 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 ---GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIqmalGFTINTMHYSFCKSRHIRHLFCEIPPLL 185
Cdd:cd14978  86 tfqTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSL----LLNLPRFFEYEVVECENCNNNSYYYVIP 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22129455 186 DLACA-DTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTV 225
Cdd:cd14978 162 TLLRQnETYLLKYYFWLYAIFVVLLPFILLLILNILLIRAL 202

7tmA_Kappa_opioid_R

cd15091

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...

26-152

5.03e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320219 [Multi-domain] Cd Length: 282 Bit Score: 44.17 E-value: 5.03e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVItPKAVMDFLLrdNTISFGG--CALQMFI 103
Cdd:cd15091   2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLM--NSWPFGDvlCKIVISI 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15091  79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLS 127

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

34-158

6.60e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 43.73 E-value: 6.60e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITP-KAVMDFLLRdntISFGG--CALQMFIELVLGGA 110
Cdd:cd15325  10 FILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPfSAIFEILGY---WAFGRvfCNIWAAVDVLCCTA 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 111 EDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALG 158
Cdd:cd15325  87 SIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIG 134

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

29-157

7.42e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 43.61 E-value: 7.42e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLlltsVITPKAVMDFLLRDNTISFGG----CALQMFIE 104
Cdd:cd15388   5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADL----VVAFFQVLPQLVWDITDRFRGpdvlCRLVKYLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLnyMILMSPRVCW-LMVTASWILSIQMAL 157
Cdd:cd15388  81 VVGMFASSYMIVAMTFDRHQAICRPM--VTFQKGRARWnGPVCVAWAISLILSL 132

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

37-223

9.14e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 43.44 E-value: 9.14e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVItPKAVMDFLLrdNTISFGG--CALQMFIELVLGGAEDLL 114
Cdd:cd14970  13 VGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLL--GYWPFGEvmCKIVLSVDAYNMFTSIFC 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTIntmhysfcKSRHIRHLFCEIPPLLDL-ACADTS 193
Cdd:cd14970  90 LTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVII--------FARTLQEEGGTISCNLQWpDPPDYW 161

                       170       180       190
                ....*....|....*....|....*....|
gi 22129455 194 SYKLVVYlVGVFMLILPLTAIFFSYARILF 223
Cdd:cd14970 162 GRVFTIY-TFVLGFAVPLLVITVCYSLIIR 190

7tmA_GPR65_TDAG8

cd15365

proton-sensing G protein-coupled receptor 65, member of the class A family of ...

33-236

1.01e-04

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.

Pssm-ID: 320487 [Multi-domain] Cd Length: 277 Bit Score: 43.23 E-value: 1.01e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTsVITPKAVmDFLLRDNTISFGG--CALQMFIELVLGGA 110
Cdd:cd15365   9 FVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYI-VILPLWI-DYLWNGDNWTLSGfvCIFSAFLLYTNFYT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 111 EDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILsiQMALGFTINTMHYSFCKSRHIRHLFCEIPPLLDLAca 190
Cdd:cd15365  87 STALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLL--EICFNAVILTWEDSFHESSSHTLCYDKFPLEDWQA-- 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 22129455 191 dtsSYKLVVYLVGvfmLILPLTAIFFSYARILFTVLHMPSNESRKK 236
Cdd:cd15365 163 ---RLNLFRICLG---YLLPLLIILFCYWKIYQAVRSNQATEDQEK 202

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

31-166

1.15e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 43.10 E-value: 1.15e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMdFLLRDNTISFGG--CALQMFIELVLG 108
Cdd:cd15053   7 LLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVY-VEVNGGKWYLGPilCDIYIAMDVMCS 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMA--LGFTINTMHY 166
Cdd:cd15053  86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIAcpLLFGLNNVPY 145

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

37-158

1.19e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 42.96 E-value: 1.19e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLA 116
Cdd:cd15326  13 FAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLC 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129455 117 FMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALG 158
Cdd:cd15326  93 AISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIG 134

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

29-152

1.22e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 42.89 E-value: 1.22e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLlltsVITPKAVMDFLLRDNTISFGG----CALQMFIE 104
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADL----VVAFFQVLPQLCWDITYRFYGpdflCRIVKHLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRvCWLMVTASWILS 152
Cdd:cd15385  81 VLGMFASTYMLVMMTADRYIAICHPLKTLQQPTKR-SYLMIGSAWALS 127

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

37-158

1.35e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 42.86 E-value: 1.35e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLA 116
Cdd:cd15062  13 FAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLC 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129455 117 FMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALG 158
Cdd:cd15062  93 VISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIG 134

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

32-221

1.41e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 42.73 E-value: 1.41e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRdNTISFGG--CALQMFIELVLGG 109
Cdd:cd15392   8 STIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLIL-QYWPFGEfmCPVVNYLQAVSVF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 110 AEDLLLAFMAYDRYVAICHPLNymILMSPRVCWLMVTASWILSIQMALGFTINTmhysfcksrhirHLFCEIPPLLDLA- 188
Cdd:cd15392  87 VSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAITS------------RLFEDSNASCGQYi 152

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 22129455 189 CADTSSYKLVVYLVGVFMLIL----PLTAIFFSYARI 221
Cdd:cd15392 153 CTESWPSDTNRYIYSLVLMILqyfvPLAVLVFTYTRI 189

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

37-157

1.43e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 42.86 E-value: 1.43e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLlltsVITPKAVMDFLLRDNTISFGG----CALQMFIELVLGGAED 112
Cdd:cd15386  13 VATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDL----VVALFQVLPQLIWEITYRFQGpdllCRAVKYLQVLSMFAST 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129455 113 LLLAFMAYDRYVAICHPLNymILMSP-RVCWLMVTASWILSIQMAL 157
Cdd:cd15386  89 YMLIMMTVDRYIAVCHPLR--TLQQPsRQAYLMIGATWLLSCILSL 132

7tmA_GPR4

cd15366

proton-sensing G protein-coupled receptor 4, member of the class A family of ...

33-239

1.48e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.

Pssm-ID: 320488 [Multi-domain] Cd Length: 280 Bit Score: 42.86 E-value: 1.48e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVItPKAVMDFLLRDNTI-SFGGCALQMFI---ELVLG 108
Cdd:cd15366   9 IVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATL-PLWIDYFLHRDNWIhGPESCKLFGFIfytNIYIS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAedlLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAlgfTINTMHYSFCKSRHiRHLFC-EIPPLLDL 187
Cdd:cd15366  88 IA---FLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGAN---SAPLFHDELFRDRY-NHTFCfEKYPMEDW 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 188 AcADTSSYKLvvyLVGvfmLILPLTAIFFSYARILFTVLHMPSNESRKKALV 239
Cdd:cd15366 161 V-AWMNLYRV---FVG---FLFPWVLMLFSYRGILRAVRGNVSTEQQEKAKI 205

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-152

1.55e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 42.80 E-value: 1.55e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLlTSVITpkaVMDFLLRDNTISF----GGCALQMFIE 104
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC-VGLIN---VLTDIIWRITVEWragdFACKVIRYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMilMSPRVCWLMVTASWILS 152
Cdd:cd15197  81 VVVTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILS 126

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

66-153

2.24e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 42.30 E-value: 2.24e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  66 LSLIDLLLTSVITP-KAVMDFLlrdNTISFGG-CALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWL 143
Cdd:cd15320  44 LAVSDLLVAVLVMPwKAVAEIA---GFWPFGSfCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFI 120

                        90
                ....*....|
gi 22129455 144 MVTASWILSI 153
Cdd:cd15320 121 MISVAWTLSV 130

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

33-152

2.66e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 41.95 E-value: 2.66e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15065   8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASI 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15065  88 LNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILS 127

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

31-225

2.73e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 41.88 E-value: 2.73e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLlrDNTISFG--GCALQMFIELVLG 108
Cdd:cd15074   7 LTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAF--AHRWLFGdiGCVFYGFCGFLFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCwLMVTASWIlsiqMALGFTIntmhysfcksrhirhlfceiPPLLD-- 186
Cdd:cd15074  85 CCSINTLTAISIYRYLKICHPPYGPKLSRRHVC-IVIVAIWL----YALFWAV--------------------APLVGwg 139

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129455 187 --------LAC-------ADTSSYKLVVYLVGVFMLILPLTAIFFSYARILFTV 225
Cdd:cd15074 140 sygpepfgTSCsidwtgaSASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKV 193

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

26-153

2.74e-04

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 41.92 E-value: 2.74e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15049   2 LICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15049  82 VASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISF 129

7tmA_Bombesin_R-like

cd15927

bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...

32-236

3.22e-04

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.

Pssm-ID: 320593 [Multi-domain] Cd Length: 294 Bit Score: 41.87 E-value: 3.22e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVI-TVDTRLHVPmYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGA 110
Cdd:cd15927   8 ALIFLVGVLGNGTLILIFlRNKSMRNVP-NIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 111 EDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTI--NTMHYSFCKSRHIRHLFCEIPPLLDL- 187
Cdd:cd15927  87 SVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIfsHVVTFTLTDNQTIQICYPYPQELGPNy 166

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129455 188 ACADTSSYKLVVYLVgvfmlilPLTAIFFSY---ARILFT----------VLHMPSNESRKK 236
Cdd:cd15927 167 PKIMVLLRFLVYYLI-------PLLIIGVFYvlmARHLIRstrnigsgqnQAAQRQIEARKK 221

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

26-152

3.22e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 41.49 E-value: 3.22e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd17790   2 LIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd17790  82 VASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLIS 128

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

42-237

3.38e-04

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 41.51 E-value: 3.38e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  42 NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLAFMAYD 121
Cdd:cd15096  18 NSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLD 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 122 RYVAICHPLNYMILMSPRVCWLMVTASWIL----SIQMALGFTINTMHYSFCKSRHIRHLfceipplldlacaDTSSYKL 197
Cdd:cd15096  98 RYLAVVHPITSMSIRTERNTLIAIVGIWIVilvaNIPVLFLHGVVSYGFSSEAYSYCTFL-------------TEVGTAA 164

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 22129455 198 VVYLVGVFML--ILPLTAIFFSYARILFTVLHMPSNESRKKA 237
Cdd:cd15096 165 QTFFTSFFLFsyLIPLTLICVLYMLMLRRLRRQKSPGGRRSA 206

7tmA_NTSR1

cd15355

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...

63-214

3.72e-04

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320477 [Multi-domain] Cd Length: 310 Bit Score: 41.76 E-value: 3.72e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  63 LGQLSLIDLLLTSVITPKAVMDFLLRDNTISFG--GCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRV 140
Cdd:cd15355  42 LASLALSDLLILLLAMPVELYNFIWVHHPWAFGdaACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSR 121

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129455 141 CWLMVTASWILSIQMALGFtINTMHYSFCKSRHIRHLFCEipplldlACADTSSYKLVVYLVGVFMLILPLTAI 214
Cdd:cd15355 122 TKKFISAIWLASALLAIPM-LFTMGEQNRSGTHPGGLICT-------PIVDTSTLKVVIQVNAFLSFLFPMLVI 187

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

37-219

4.20e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 41.48 E-value: 4.20e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLA 116
Cdd:cd15307  13 GTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLC 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 117 FMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFtinTMHYSFCKSRHIRHLFCEIPplldlacadTSSYK 196
Cdd:cd15307  93 TISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPL---SLMYSKDHASVLVNGTCQIP---------DPVYK 160

                       170       180
                ....*....|....*....|...
gi 22129455 197 LVVYLVGVFmliLPLTAIFFSYA 219
Cdd:cd15307 161 LVGSIVCFY---IPLGVMLLTYC 180

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

29-296

4.45e-04

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 41.26 E-value: 4.45e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTR--LHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLrdNTISFGGCALQMF--IE 104
Cdd:cd15060   3 TTILLSVIIAFTIVGNILVILSVFTYrpLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLL--GKWLFGIHLCQMWltCD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALgftintmhysfcksrhirhlfceiPPL 184
Cdd:cd15060  81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISV------------------------PPL 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 185 L-----------DLACADTSSYKLVVY-LVGVFMliLPLTAIFFSYARILFtvlhmpSNESRKKALVTCSSHMTVVGMYY 252
Cdd:cd15060 137 IgwndwpenfteTTPCTLTEEKGYVIYsSSGSFF--IPLLIMTIVYVKIFI------ATSKERRAARTLGIIMGVFVVCW 208

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 253 GALTVMY----FLPSSYHNPKQDNILsVFYTIVTPALNPLIHSLRNKE 296
Cdd:cd15060 209 LPFFLMYvilpFCETCSPSAKVVNFI-TWLGYVNSALNPVIYTIFNLD 255

7tmA_NTSR2

cd15356

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...

66-157

5.40e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320478 [Multi-domain] Cd Length: 285 Bit Score: 41.00 E-value: 5.40e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  66 LSLIDLLLTSVITPKAVMDFLLRDNTISFG--GCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWL 143
Cdd:cd15356  45 LALSDLLILLISVPIELYNFVWFHYPWVFGdlVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKW 124

                        90
                ....*....|....
gi 22129455 144 MVTASWILSIQMAL 157
Cdd:cd15356 125 LLALIWASSLGFAL 138

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

61-224

5.69e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 40.88 E-value: 5.69e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  61 LLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRV 140
Cdd:cd14992  37 YFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 141 CWLMVTASWILSIQMA---LGFTINTMHYSFCKSRHIRhlFCEIPPlldlacaDTSSYKLVVYLVGVFMLI--LPLTAIF 215
Cdd:cd14992 117 TVIIIITIWVVSLLLAipqLYYATTEVLFSVKNQEKIF--CCQIPP-------VDNKTYEKVYFLLIFVVIfvLPLIVMT 187


                ....*....
gi 22129455 216 FSYARILFT 224
Cdd:cd14992 188 LAYARISRE 196

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

27-228

6.09e-04

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 40.66 E-value: 6.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELV 106
Cdd:cd15401   3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 107 LGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL-GFTINTMHYSfcksrhirhlfceiPPLL 185
Cdd:cd15401  83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVpNFFVGSLQYD--------------PRIY 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 22129455 186 DLACADT--SSYKLVVYLVgvfMLILPLTAIFFSYARILFTVLHM 228
Cdd:cd15401 149 SCTFAQTvsSSYTITVVVV---HFIVPLSIVTFCYLRIWVLVIQV 190

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

27-152

6.19e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 40.69 E-value: 6.19e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLrdNTISFGG--CALQMFIE 104
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELM--GYWYFGQvwCNIYLALD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129455 105 LVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15323  81 VLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLIS 128

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

37-221

6.56e-04

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 40.85 E-value: 6.56e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLA 116
Cdd:cd15393  13 VAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLT 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 117 FMAYDRYVAICHPLNYMilMSPRVCWLMVTASWILSIQMALGFTINTMHYSFC-KSRHIRHLFCeIPPLLDLACADTSSY 195
Cdd:cd15393  93 VIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVALPVALALRVEELTdKTNNGVKPFC-LPVGPSDDWWKIYNL 169

                       170       180
                ....*....|....*....|....*.
gi 22129455 196 KLVvylvgVFMLILPLTAIFFSYARI 221
Cdd:cd15393 170 YLV-----CVQYFVPLVIICYAYTRI 190

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

30-157

6.80e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 40.88 E-value: 6.80e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  30 TITFLYTLALTSNGLLLLVITVDTRLH--VPMYLLLgQLSLIDLLLTSVITP-KAVMDFLlrdNTISFGG-CALQMFIEL 105
Cdd:cd15057   6 ILYLLVLLTLLGNALVIAAVLRFRHLRskVTNYFIV-SLAVSDLLVAILVMPwAAVNEVA---GYWPFGSfCDVWVSFDI 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15057  82 MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISF 133

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

42-221

8.90e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 40.51 E-value: 8.90e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  42 NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAEDLLLAFMAYD 121
Cdd:cd15058  18 NLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVD 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 122 RYVAICHPLNYMILMSPRVCWLMVTASWILSiqMALGFTINTMHYSfcKSRHIRHLFCEIPPlldlACADTSSYKLVVYL 201
Cdd:cd15058  98 RYIAITRPLRYQVLLTKRRARVIVCVVWIVS--ALVSFVPIMNQWW--RANDPEANDCYQDP----TCCDFRTNMAYAIA 169

                       170       180
                ....*....|....*....|
gi 22129455 202 VGVFMLILPLTAIFFSYARI 221
Cdd:cd15058 170 SSVVSFYIPLLIMIFVYARV 189

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

29-153

1.30e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 39.78 E-value: 1.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd15928   5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15928  85 YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAI 129

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

26-153

1.44e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 39.84 E-value: 1.44e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLlrDNTISFGG--CALQMFI 103
Cdd:cd15316   2 ILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSV--ESCWYFGEsfCTFHTCC 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15316  80 DVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSL 129

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

121-221

1.45e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 39.62 E-value: 1.45e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 121 DRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGF----TINTMHYSFCKSRHIRH-LFCEIPPLLDlacadtsSY 195
Cdd:cd15134  98 ERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFaiqtRIVYLEYPPTSGEALEEsAFCAMLNEIP-------PI 170

                        90       100
                ....*....|....*....|....*.
gi 22129455 196 KLVVYLVGVFMLILPLTAIFFSYARI 221
Cdd:cd15134 171 TPVFQLSTFLFFIIPMIAIIVLYVLI 196

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

33-170

1.66e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 39.55 E-value: 1.66e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDflLRDN---TISFGGCALQMFIELVLGG 109
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVS--IRNGsawTYSVLSCKIVAFMAVLFCF 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129455 110 AEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCK 170
Cdd:cd15217  87 HAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIR 147

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

42-301

1.95e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 39.38 E-value: 1.95e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  42 NGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKavmdfLLRDNTISFGGCALQMFIE----LVLGGAEDLLLAF 117
Cdd:cd15102  18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLAN-----ILLSGARTLRLSPAQWFLRegsmFVALSASVFSLLA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 118 MAYDRYVAICHPLNYMILMSPRVcWLMVTASWILSIQM----ALGFTInTMHYSFCKSrhirhlfceIPPLLdlacadts 193
Cdd:cd15102  93 IAIERHLTMAKMKPYGASKTSRV-LLLIGACWLISLLLgglpILGWNC-LGALDACST---------VLPLY-------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 194 SYKLVVYLVGVFMLIlpLTAIFFSYARILFTV----LHMPSNESRKKALVTCSSHMTVVGMY---YGALTVMYFLPSSYH 266
Cdd:cd15102 154 SKHYVLFCVTIFAGI--LAAIVALYARIYCLVrasgRKATRASASPRSLALLKTVLIVLLVFiacWGPLFILLLLDVACP 231

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129455 267 NPKQDNILSVFYTIV----TPALNPLIHSLRNKEVTGAL 301
Cdd:cd15102 232 VKTCPILYKADWFLAlavlNSALNPIIYTLRSRELRRAV 270

7tmA_PAR

cd15162

protease-activated receptors, member of the class A family of seven-transmembrane G ...

26-236

2.14e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 341328 [Multi-domain] Cd Length: 280 Bit Score: 38.97 E-value: 2.14e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKavMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFK--IAYHIHGNNWIFGEALCRLVTVA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGG--AEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRhlfCEIPP 183
Cdd:cd15162  80 FYGNmyCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITT---CHDVL 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129455 184 LLDLACADTSSYKLVVYLVGVFmliLPLTAIFFSYARILFTVLHMPSNESRKK 236
Cdd:cd15162 157 PEQLLVGDWFYYFLSLAIVGFL---IPFILTASCYVATIRTLAALEDENSEKK 206

7tmA_ET-BR

cd15976

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...

33-217

2.14e-03

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.

Pssm-ID: 320642 [Multi-domain] Cd Length: 296 Bit Score: 39.07 E-value: 2.14e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15976   9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMA----LGFTINTMHYsfcKSRHIRhlFCEIPPLLDLA 188
Cdd:cd15976  89 LSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAvpeaIGFDMITMDY---KGELLR--ICLLHPIQKTA 163

                       170       180       190
                ....*....|....*....|....*....|
gi 22129455 189 CAD-TSSYKLVVYLVGVFMLILPLTAIFFS 217
Cdd:cd15976 164 FMQfYKTAKDWWLFSFYFCLPLACTAVFYT 193

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

97-152

2.45e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 38.79 E-value: 2.45e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129455  97 CALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15297  73 CDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLS 128

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

27-157

2.55e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 38.75 E-value: 2.55e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELV 106
Cdd:cd15321   9 IAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVL 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129455 107 LGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15321  89 FCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISL 139

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

34-153

3.22e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 38.51 E-value: 3.22e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHV-PMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15104   9 LSPLIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASV 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15104  89 LSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSG 129

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

32-171

3.30e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 38.70 E-value: 3.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  32 TFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAE 111
Cdd:cd15978   8 SLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVS 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 112 DLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKS 171
Cdd:cd15978  88 TFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRI 147

7tmA_Delta_opioid_R

cd15089

opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...

30-164

3.33e-03

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320217 [Multi-domain] Cd Length: 281 Bit Score: 38.39 E-value: 3.33e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  30 TITFLYT----LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVItPKAVMDFLLrdNTISFGG--CALQMFI 103
Cdd:cd15089   2 AITALYSvvcvVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTL-PFQSAKYLM--ETWPFGEllCKAVLSI 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSiqMALGFTINTM 164
Cdd:cd15089  79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLS--SGVGVPIMVM 137

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

31-165

3.37e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 38.45 E-value: 3.37e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFLYTLALTSNGLLLLVITVDTRLH-VPMYLLLgQLSLIDLLLTSVITPKAVM-DFLLRDNTISFGGCALQMFIELVLG 108
Cdd:cd15052   7 LLLLVIATIGGNILVCLAISLEKRLQnVTNYFLM-SLAIADLLVGLLVMPLSILtELFGGVWPLPLVLCLLWVTLDVLFC 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129455 109 GAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMH 165
Cdd:cd15052  86 TASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGII 142

7tmA_P2Y11

cd15376

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...

25-236

3.40e-03

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320498 [Multi-domain] Cd Length: 284 Bit Score: 38.52 E-value: 3.40e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  25 ELLCATITFLYTLALTSNGL-LLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFI 103
Cdd:cd15376   1 DFLWPILGVEFLVAVLGNGLaLWLFVTRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIqmalGFTINTMHYSFCKSRHIRHLFCeipp 183
Cdd:cd15376  81 FTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVA----ALSAPVLSFSHLEVERHNKTEC---- 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22129455 184 lldLACADTS------SYKLVVYLVGVfmlILPLTAIFFSYARILFTVLHMPSNESRKK 236
Cdd:cd15376 153 ---LGTAVDSrlptylPYSLFLAVVGC---GLPFLLTLASYLAIVWAVLRSPGITTLEK 205

7tmA_NPFFR

cd15207

neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...

27-248

3.79e-03

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.

Pssm-ID: 320335 [Multi-domain] Cd Length: 291 Bit Score: 38.37 E-value: 3.79e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFLytLALTSNGLLLLVITVDTRLH-VPMYLLLgQLSLIDLLLTSVITPkavmdFLLRDNTIS---FGG--CALQ 100
Cdd:cd15207   5 VSYSLIFL--LCVVGNVLVCLVVAKNPRMRtVTNYFIL-NLAVSDLLVGVFCMP-----FTLVDNILTgwpFGDvmCKLS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 101 MFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMilMSPRVCWLMVTASWILSIQMAL--GFTINTMHYSFCKSRHIRhlF 178
Cdd:cd15207  77 PLVQGVSVAASVFTLVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMIpqALVLEVKEYQFFRGQTVH--I 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 179 C-EIPPLLDLACADTSSYKLVVYlvgvfmlILPLTAIFFSYARILFTVLHMPS------------NESRKKALVTcssHM 245
Cdd:cd15207 153 CvEFWPSDEYRKAYTTSLFVLCY-------VAPLLIIAVLYVRIGYRLWFKPVpgggsasreaqaAVSKKKVRVI---KM 222


                ...
gi 22129455 246 TVV 248
Cdd:cd15207 223 LIV 225

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

26-152

3.88e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 38.09 E-value: 3.88e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLrdNTISFGG--CALQMFI 103
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELM--GYWYFGSvwCEIWLAL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15059  80 DVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIIS 128

7tmA_SREB2_GPR85

cd15218

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...

26-170

3.89e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320346 [Multi-domain] Cd Length: 330 Bit Score: 38.47 E-value: 3.89e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPkAVMDFLLRDNTISFGG--CALQMFI 103
Cdd:cd15218   2 LKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFP-FVFTSVKNGSTWTYGTltCKVIAFL 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22129455 104 ELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCK 170
Cdd:cd15218  81 GVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIR 147

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

37-165

4.21e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 38.24 E-value: 4.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQ--------MFIELVLG 108
Cdd:cd15103  13 VSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsMICSSLLA 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129455 109 GAEDLLLafMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMH 165
Cdd:cd15103  93 SICSLLA--IAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYSDS 147

7tmA_PGI2

cd15141

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...

29-152

5.79e-03

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.

Pssm-ID: 320269 [Multi-domain] Cd Length: 301 Bit Score: 37.88 E-value: 5.79e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  29 ATITFLYTLALTSNGLLLLVITVDTR----LHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGG----CALQ 100
Cdd:cd15141   5 ATSTLMFAAGVVGNLLALGILGVHRKerrtKSSAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAAgqplCHLF 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 101 MFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILS 152
Cdd:cd15141  85 AFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFG 136

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

37-157

6.24e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 37.84 E-value: 6.24e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLlrDNTISFGGCALQMFIELVLGGAEDLLLA 116
Cdd:cd15070  13 CAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL--GVTIHFYSCLFMSCLLVVFTHASIMSLL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22129455 117 FMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15070  91 AIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGL 131

7tmA_HCAR-like

cd14991

hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...

37-221

6.81e-03

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).

Pssm-ID: 320122 [Multi-domain] Cd Length: 280 Bit Score: 37.43 E-value: 6.81e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAvmDFLLRDNTISFG--GCALQMFIELVLGGAEDLL 114
Cdd:cd14991  13 LGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRI--DYYLRGEHWIFGeaWCRVNLFMLSVNRSASIAF 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTmHYSFCKSRHIRHLFceipplldLACADTSS 194
Cdd:cd14991  91 LTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLST-LLTVNSNKSSCHSF--------SSYTKPSL 161

                       170       180
                ....*....|....*....|....*..
gi 22129455 195 YKLVVYLVGVFMLILPLTAIFFSYARI 221
Cdd:cd14991 162 SIRWHNALFLLEFFLPLGLIVFCSVRI 188

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

34-156

7.39e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 37.51 E-value: 7.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVM-DFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15308  10 LILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYsEFQGGVWTLSPVLCDALMTMDVMLCTASI 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129455 113 LLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMA 156
Cdd:cd15308  90 FNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVA 133

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

31-153

7.42e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 37.52 E-value: 7.42e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  31 ITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGA 110
Cdd:cd15215   6 IVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129455 111 EDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSI 153
Cdd:cd15215  86 GVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSV 128

7tmA_GPR12

cd15961

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...

36-157

7.52e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320627 [Multi-domain] Cd Length: 268 Bit Score: 37.31 E-value: 7.52e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  36 TLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFggcalqMFIELVLGGAEDLLL 115
Cdd:cd15961  12 TLISCENAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILNFIFAYLLQSEAAKL------VTVGLIVASFSASVC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129455 116 AFMA--YDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15961  86 SLLAitVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGL 129

7tmA_BRS-3

cd15123

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...

26-232

7.80e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.

Pssm-ID: 320251 [Multi-domain] Cd Length: 294 Bit Score: 37.59 E-value: 7.80e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  26 LLCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIEL 105
Cdd:cd15123   2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 106 VLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKS-RHIRHLFCEIPPL 184
Cdd:cd15123  82 TSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPeKNTTFEACAPYPV 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129455 185 LDLACADTSSykLVVYLVgvfMLILPLTAI---FFSYARILF-TVLHMPSNE 232
Cdd:cd15123 162 SEKILQEIHS--LLCFLV---FYIIPLSIIsvyYFLIARTLYkSTFNMPAEE 208

7tmA_tmt_opsin

cd15086

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...

33-225

7.87e-03

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.

Pssm-ID: 320214 [Multi-domain] Cd Length: 276 Bit Score: 37.41 E-value: 7.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  33 FLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELVLGGAED 112
Cdd:cd15086   9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 113 LLLAFMAYDRYVAICHPlNYMILMSPRVCWLMVTASWILSiqmalgftintmhysfcksrhirhLFCEIPPLL------- 185
Cdd:cd15086  89 ISLAVLSYERYCTLLRP-TEADVSDYRKAWLGVGGSWLYS------------------------LLWTLPPLLgwssygp 143

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 22129455 186 ---------DLACADTSSYKLVVYLVgVFMLILPLTAIFFSYARILFTV 225
Cdd:cd15086 144 egpgttcsvQWTSRSANSISYIICLF-IFCLLLPFLVMVYCYGRLLYAI 191

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

66-153

8.59e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 37.24 E-value: 8.59e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  66 LSLIDLLLTSVITP-KAVMDFLlrdNTISFGG-CALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNYMILMSPRVCWL 143
Cdd:cd15319  43 LAVSDLFVALLVMPwKAVAEVA---GYWPFGAfCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALV 119

                        90
                ....*....|
gi 22129455 144 MVTASWILSI 153
Cdd:cd15319 120 MISVAWTLSV 129

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-221

8.66e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 37.37 E-value: 8.66e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  27 LCATITFLYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFGGCALQMFIELV 106
Cdd:cd15208   3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 107 LGGAEDLLLAFMAYDRYVAICHPLnyMILMSPRVCWLMVTASWILSIQMALGFTINTMHYSFCKSRHIRHLFceipplld 186
Cdd:cd15208  83 SVSVSVLTLSCIALDRWYAICHPL--MFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPLANKTILL-------- 152

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 22129455 187 LACADT---SSYKLVVYLVGVF-MLILPLTAIFFSYARI 221
Cdd:cd15208 153 TVCDERwsdSIYQKVYHICFFLvTYLLPLCLMILAYFQI 191

7tmA_GPR61_GPR62-like

cd15220

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...

37-157

9.36e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.

Pssm-ID: 410633 [Multi-domain] Cd Length: 264 Bit Score: 37.04 E-value: 9.36e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  37 LALTSNGLLLLVITVDTRLHvpMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTISFG--GCALQMFIELVLGGAEDLL 114
Cdd:cd15220  12 TALVGNTAVMVVIAKTPHLR--KFAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGeaECRVYIFLSVCLVSASILT 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129455 115 LAFMAYDRYVAICHPLNYMILMSPRVCWLMVTASWILSIQMAL 157
Cdd:cd15220  90 ISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGL 132

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

62-221

9.48e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 37.00 E-value: 9.48e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  62 LLGQLSLIDLLLTSVITPKAVMDFLLrdNTISFGG--CALQMFIELVLGGAEDLLLAFMAYDRYVAICHPLNyMILMSPR 139
Cdd:cd15002  39 LILNLSAADLLLLLFSVPFRAAAYSK--GSWPLGWfvCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTK-QVTIKQR 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455 140 VCWLMVTASWILsiqmALGFTINTMHYSFCKSRHIRHL-FCEIPPLLDlacADTSSYKLVVYLVGvfmLILPLTAIFFSY 218
Cdd:cd15002 116 RITAVVASIWVP----ACLLPLPQWLFRTVKQSEGVYLcILCIPPLAH---EFMSAFVKLYPLFV---FCLPLTFALFYF 185


                ...
gi 22129455 219 ARI 221
Cdd:cd15002 186 WRA 188

7tmA_GPR135

cd15212

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...

34-157

9.70e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320340 [Multi-domain] Cd Length: 285 Bit Score: 37.06 E-value: 9.70e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129455  34 LYTLALTSNGLLLLVITVDTRLHVPMYLLLGQLSLIDLLLTSVITPKAVMDFLLRDNTIsFG--GCALQMFIELVLGGAE 111
Cdd:cd15212  10 IFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWL-FGdrLCLANGFFNACFGIVS 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129455 112 DLLLAFMAYDRYVAICHPLNYMILmSPRVCWLMVtASWILSIQMAL 157
Cdd:cd15212  89 TLTMTLISFDRYYAIVRQPQGKIG-RRRALQLLA-AAWLTALGFSL 132

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01