NCBI Conserved Domain Search

Conserved domains on [gi|22129389|ref|NP_666937|]

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olfactory receptor family 10 subfamily A member 48 [Mus musculus]

Protein Classification

olfactory receptor( domain architecture ID 11607024)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 10, subfamily A olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

27-300

5.29e-147

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 414.16 E-value: 5.29e-147

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15225   4 FVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15225  84 GGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15225 164 ACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15225 244 PETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

27-300

5.29e-147

Pssm-ID: 320353 Cd Length: 277 Bit Score: 414.16 E-value: 5.29e-147

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15225   4 FVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15225  84 GGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15225 164 ACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15225 244 PETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

30-303

1.16e-46

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 158.43 E-value: 1.16e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389    30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK--SKYSP 267
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRfgHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 22129389   268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVKL 303
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

PHA02638

CC chemokine receptor-like protein; Provisional

19-255

9.48e-03

CC chemokine receptor-like protein; Provisional

Pssm-ID: 165021 [Multi-domain] Cd Length: 417 Bit Score: 37.30 E-value: 9.48e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   19 FPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIP-MYLFlqNLSVVEASFsttvMPEMLVVLTSEKATISFGG-- 95
Cdd:PHA02638  94 YPSISEYIKIFYIIIFILGLFGNAAIIMILFCKKIKTITdIYIF--NLAISDLIF----VIDFPFIIYNEFDQWIFGDfm 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   96 --CFAQTYFILLFggTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTaTVSVTWVF---SFPFCGP 170
Cdd:PHA02638 168 ckVISASYYIGFF--SNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLII-TSPAYFIFeasNIIFSAQ 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  171 SKINHISCEVPAVLELACAD--TFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMpsttgrQKAFSTCASHLTSVT 248
Cdd:PHA02638 245 DSNETISNYQCTLIEDNEKNniSFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKQL------KKSKKTKSIIIVSII 318


                 ....*..
gi 22129389  249 LFYSTAC 255
Cdd:PHA02638 319 IICSLIC 325

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

27-300

5.29e-147

Pssm-ID: 320353 Cd Length: 277 Bit Score: 414.16 E-value: 5.29e-147

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15225   4 FVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15225  84 GGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15225 164 ACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15225 244 PETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-293

4.26e-127

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 363.34 E-value: 4.26e-127

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd13954   3 LFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd13954  83 LGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd13954 163 LSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd13954 243 SSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

24-293

1.00e-116

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 337.17 E-value: 1.00e-116

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFI 103
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAV 183
Cdd:cd15230  81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 184 LELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKS 263
Cdd:cd15230 161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129389 264 KYSPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15230 241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

27-293

2.64e-114

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 330.99 E-value: 2.64e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15911   4 FLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15911  84 AATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15911 164 SCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTS 243

                       250       260
                ....*....|....*....|....*..
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15911 244 RDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

27-293

9.37e-114

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 329.62 E-value: 9.37e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15237   4 FILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15237  84 GVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15237 164 ACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHS 243

                       250       260
                ....*....|....*....|....*..
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15237 244 PDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

24-300

1.02e-113

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 329.61 E-value: 1.02e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFI 103
Cdd:cd15231   1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAV 183
Cdd:cd15231  81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 184 LELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKS 263
Cdd:cd15231 161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129389 264 KYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15231 241 GYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

10-303

9.56e-111

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 322.78 E-value: 9.56e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  10 EFILLGFSHFPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKA 89
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  90 TISFGGCFAQTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCG 169
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 170 PSKINHISCEVPAVLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTL 249
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129389 250 FYSTACMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVKL 303
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

27-299

3.45e-110

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 320.65 E-value: 3.45e-110

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15421   4 FSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15421  84 GGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15421 164 SCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHS 243

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15421 244 PEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

11-297

4.31e-110

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 320.81 E-value: 4.31e-110

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  11 FILLGFSHFPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKAT 90
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  91 ISFGGCFAQTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGP 170
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 171 SKINHISCEVPAVLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLF 250
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129389 251 YSTACMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMK 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-293

1.42e-109

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 319.04 E-value: 1.42e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15912   3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15912  83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15912 163 LSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSS 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15912 243 SLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-300

1.80e-109

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 319.16 E-value: 1.80e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15229   3 LFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15229  83 FAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLP 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15229 163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15229 243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

27-293

1.53e-108

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 316.47 E-value: 1.53e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15431   4 FVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTwVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15431  84 GITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVL-TMPLHFCGPNVINHFFCEVQALLKL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15431 163 ACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSS 242

                       250       260
                ....*....|....*....|....*..
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15431 243 SDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

23-300

1.81e-106

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 311.46 E-value: 1.81e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  23 QVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYF 102
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 103 ILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPA 182
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 183 VLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK 262
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129389 263 SKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

11-303

1.96e-106

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 311.90 E-value: 1.96e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  11 FILLGFSHFPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKAT 90
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  91 ISFGGCFAQTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGP 170
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 171 SKINHISCEVPAVLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLF 250
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129389 251 YSTACMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVKL 303
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

24-302

1.07e-105

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 309.63 E-value: 1.07e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFI 103
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAV 183
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 184 LELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKS 263
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129389 264 KYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-299

1.85e-104

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 306.18 E-value: 1.85e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15420 243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-299

1.51e-102

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 301.53 E-value: 1.51e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15419   3 LFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15419  83 FGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15419 163 LSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVS 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15419 243 SPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEA 276

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-302

1.99e-102

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 301.21 E-value: 1.99e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15416   3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15416  83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15416 163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15416 243 SMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-299

2.07e-102

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 301.24 E-value: 2.07e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGA 276

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

27-293

2.77e-101

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 297.83 E-value: 2.77e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASF-STTVMPEMLVVLTSEKaTISFGGCFAQTYFILL 105
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYiSVTVPKSIANSLTNTR-SISFLGCVAQVFLFIF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15227  83 FAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15227 163 LSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDS 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15227 243 PSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-302

6.30e-100

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 294.94 E-value: 6.30e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15417   3 LFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15417  83 MGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15417 163 LSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15417 243 SQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

26-293

7.07e-100

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 294.53 E-value: 7.07e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15947 243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-300

1.29e-98

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 291.64 E-value: 1.29e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15424  83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15424 163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15424 243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

11-302

5.03e-97

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 287.80 E-value: 5.03e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  11 FILLGFSHFPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKAT 90
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  91 ISFGGCFAQTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGP 170
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 171 SKINHISCEVPAVLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLF 250
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129389 251 YSTACMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-293

2.54e-96

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 285.31 E-value: 2.54e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15232   3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15232  83 SLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15232 163 LSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15232 243 SPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

31-293

2.71e-96

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 285.42 E-value: 2.71e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGTE 110
Cdd:cd15430   8 LIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACAD 190
Cdd:cd15430  88 CVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 191 TFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYSPDTK 270
Cdd:cd15430 168 ISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISD 247

                       250       260
                ....*....|....*....|...
gi 22129389 271 KLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15430 248 KLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

27-293

4.88e-96

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 284.51 E-value: 4.88e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15918   4 FGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15918  84 GDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15918 164 SCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHS 243

                       250       260
                ....*....|....*....|....*..
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15918 244 ASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-293

6.17e-96

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 284.18 E-value: 6.17e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15224 163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15224 243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

26-300

1.82e-95

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 283.50 E-value: 1.82e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15434 163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15434 243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

24-302

4.34e-94

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 280.06 E-value: 4.34e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFI 103
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAV 183
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 184 LELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKS 263
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129389 264 KYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15409 241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

26-300

9.08e-92

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 273.97 E-value: 9.08e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15432   3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15432  83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15432 163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15432 243 SHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

24-302

2.06e-91

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 273.14 E-value: 2.06e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFI 103
Cdd:cd15415   1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAV 183
Cdd:cd15415  81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 184 LELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKS 263
Cdd:cd15415 161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129389 264 KYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15415 241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-300

5.31e-91

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 272.14 E-value: 5.31e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15234   3 LFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15234  83 FGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15234 163 LACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTH 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15234 243 SSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-293

1.39e-89

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 268.09 E-value: 1.39e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15914   3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15914  83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15914 163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15914 243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

11-303

3.98e-89

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 267.81 E-value: 3.98e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  11 FILLGFSHFPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKAT 90
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  91 ISFGGCFAQTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGP 170
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 171 SKINHISCEVPAVLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLF 250
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129389 251 YSTACMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVKL 303
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-300

1.33e-88

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 266.21 E-value: 1.33e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15414   3 LFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15414  83 FVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15414 163 LSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15414 243 SLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-293

1.64e-87

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 263.02 E-value: 1.64e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15913   3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15913 163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15913 243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-302

2.10e-87

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 263.11 E-value: 2.10e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15412   3 LFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15412  83 LVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15412 163 LSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEE 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15412 243 SVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-300

7.57e-87

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 261.65 E-value: 7.57e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15428  83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15428 163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

26-302

8.35e-87

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 261.49 E-value: 8.35e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15413 163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15413 243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-293

1.52e-86

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 260.49 E-value: 1.52e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

24-302

3.21e-86

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 260.05 E-value: 3.21e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFI 103
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAV 183
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 184 LELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKS 263
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129389 264 KYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVK 302
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

15-303

2.53e-85

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 258.07 E-value: 2.53e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  15 GFSHFPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFG 94
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  95 GCFAQTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKIN 174
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 175 HISCEVPAVLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTA 254
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129389 255 CMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVKL 303
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-299

5.01e-84

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 254.28 E-value: 5.01e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSky 265
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP-- 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAA 274

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

23-303

1.79e-83

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 253.17 E-value: 1.79e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  23 QVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYF 102
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 103 ILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPA 182
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 183 VLELACADTflfEVYSFTGTILL---VLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYL 259
Cdd:cd15418 161 LVKLACDDT---RVYELILYFILgfnVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYS 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22129389 260 QPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVKL 303
Cdd:cd15418 238 RPSSSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-300

5.07e-83

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 251.60 E-value: 5.07e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKA-TISFGGCFAQTYFIL 104
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGkVISFGGCVAQLYFFH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 105 LFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVL 184
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 185 ELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSK 264
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129389 265 YSPDtkKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15916 243 EALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

26-293

9.56e-83

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 250.69 E-value: 9.56e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQIL-FTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSK 264
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIIsFLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                       250       260
                ....*....|....*....|....*....
gi 22129389 265 YSPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

27-293

7.23e-82

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 248.28 E-value: 7.23e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15939   4 FVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15939  84 GGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTvLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15939 164 ACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFP 242

                       250       260
                ....*....|....*....|....*..
gi 22129389 267 PDtkKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15939 243 ID--KVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-293

6.98e-81

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 245.96 E-value: 6.98e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15226   3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15226  83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVlRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15226 163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDtkKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15226 242 PVD--KFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-293

3.02e-79

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 241.85 E-value: 3.02e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15936   3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15936  83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTvLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15936 163 LACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVK-IRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDtkKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15936 242 PMD--KAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-299

5.01e-77

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 236.61 E-value: 5.01e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-293

5.87e-77

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 235.80 E-value: 5.87e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15940   3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15940  83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMpSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15940 163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDtkKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15940 242 SED--KVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

26-300

1.31e-75

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 232.76 E-value: 1.31e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15433  83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15433 163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15433 243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

26-300

6.95e-75

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 230.78 E-value: 6.95e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDtkKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15942 243 PLD--GVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-300

1.19e-74

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 230.38 E-value: 1.19e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

27-300

9.35e-73

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 225.42 E-value: 9.35e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS 266
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

30-300

8.93e-69

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 215.48 E-value: 8.93e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLH-IPMYLFLQNLSVVEASFSTTVMPEMLV-VLTSEKATISFGGCFAQTYFILLFG 107
Cdd:cd15941   7 FLLIYLLTVLGNLLILLTIGSDPHLHgLPMYHFLGHLSFLDACLSSVTVPKVLAgLLTLSGRTISFEGCVVQLYAFHFLA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 108 GTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELA 187
Cdd:cd15941  87 STECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 188 CADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSkySP 267
Cdd:cd15941 167 CADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS--SQ 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15941 245 AGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

30-300

8.74e-67

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 210.23 E-value: 8.74e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15223   7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15223  87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYL--QPKSKYSP 267
Cdd:cd15223 167 DTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKTIPP 246

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd15223 247 DVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-293

8.27e-65

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 205.00 E-value: 8.27e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLD-HSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFIL 104
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADpHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 105 LFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVL 184
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 185 ELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTvLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSK 264
Cdd:cd15935 163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                       250       260
                ....*....|....*....|....*....
gi 22129389 265 YSPDtkKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15935 242 SSVD--KVASVFYTLITPALNPLIYTLRN 268

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

30-296

6.33e-64

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 202.90 E-value: 6.33e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS--P 267
Cdd:cd15917 167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHvpP 246

                       250       260
                ....*....|....*....|....*....
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEM 296
Cdd:cd15917 247 HVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-293

2.95e-63

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 200.87 E-value: 2.95e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILftvLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDtkKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15938 240 PVD--KHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

30-296

7.26e-62

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 197.64 E-value: 7.26e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMT-YLQPKSK-YSP 267
Cdd:cd15950 167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSiYTQRFGQgVPP 246

                       250       260
                ....*....|....*....|....*....
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEM 296
Cdd:cd15950 247 HTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-293

2.51e-61

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 196.11 E-value: 2.51e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15937   3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15937  83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTqILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15937 163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYA-FLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                       250       260
                ....*....|....*....|....*...
gi 22129389 266 SPDtkKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd15937 242 PMD--KVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

30-295

1.40e-60

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 194.26 E-value: 1.40e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15222   7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15222  87 ESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTacMTYL----QPKSKY 265
Cdd:cd15222 167 DTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVP--MIGLsmvhRFGKHA 244

                       250       260       270
                ....*....|....*....|....*....|
gi 22129389 266 SPDTKKLMSLAYSLLTPLLNPLIYSLRNKE 295
Cdd:cd15222 245 SPLVHVLMANVYLLVPPVLNPIIYSVKTKQ 274

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

30-295

2.00e-55

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 180.95 E-value: 2.00e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK--SKYSP 267
Cdd:cd15221 167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRfgRHIPR 246

                       250       260
                ....*....|....*....|....*...
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKE 295
Cdd:cd15221 247 HVHILLANLYVLVPPMLNPIVYGVKTKQ 274

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

30-296

5.59e-55

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 179.88 E-value: 5.59e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLfEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYSPDT 269
Cdd:cd15952 167 SIRI-NIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPR 245

                       250       260
                ....*....|....*....|....*....
gi 22129389 270 KKLMSLA--YSLLTPLLNPLIYSLRNKEM 296
Cdd:cd15952 246 YIHILLAnlYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

30-295

1.29e-54

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 179.08 E-value: 1.29e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS--P 267
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNvpP 246

                       250       260
                ....*....|....*....|....*...
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKE 295
Cdd:cd15951 247 HVHILIANVYLLVPPMLNPIIYGVRTKQ 274

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

30-295

1.79e-50

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 168.21 E-value: 1.79e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK--SKYSP 267
Cdd:cd15953 167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRfgQGIAP 246

                       250       260
                ....*....|....*....|....*...
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKE 295
Cdd:cd15953 247 HIHIILANLYLLVPPMLNPIIYGVKTKE 274

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

30-296

3.92e-48

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 162.34 E-value: 3.92e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15956   7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15956  87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYS--P 267
Cdd:cd15956 167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSvpS 246

                       250       260
                ....*....|....*....|....*....
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEM 296
Cdd:cd15956 247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

30-303

1.16e-46

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 158.43 E-value: 1.16e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389    30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK--SKYSP 267
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRfgHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 22129389   268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRAVVKL 303
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

30-297

2.34e-45

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 155.06 E-value: 2.34e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK--SKYSP 267
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRfaRHVAP 247

                       250       260       270
                ....*....|....*....|....*....|
gi 22129389 268 DTKKLMSLAYSLLTPLLNPLIYSLRNKEMK 297
Cdd:cd15948 248 HVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

11-297

2.22e-44

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 153.01 E-value: 2.22e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  11 FILLGFSHFPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKAT 90
Cdd:cd15949   4 FILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  91 ISFGGCFAQTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGP 170
Cdd:cd15949  84 IPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRT 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 171 SKINHISCEVPAVLELACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLF 250
Cdd:cd15949 164 NIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAF 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129389 251 YSTACMTYLQPK--SKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMK 297
Cdd:cd15949 244 YVPIAVSSLIHRfgQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

30-296

1.54e-42

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 147.66 E-value: 1.54e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK---SKYS 266
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfggHHIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEM 296
Cdd:cd15954 247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

30-296

2.21e-38

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 136.82 E-value: 2.21e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWV-FSFPFCGPSKINHISCEVPAVLELAC 188
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIkLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 189 ADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPK--SKYS 266
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRfgHHVA 246

                       250       260       270
                ....*....|....*....|....*....|
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEM 296
Cdd:cd15955 247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

40-289

7.56e-29

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 111.24 E-value: 7.56e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389    40 GNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLV-VLTSEKATISFGGCFAQTYFILLFGGTECFLLGAMA 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   119 YDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPskiNHISCEVPAVLELACadtflFEVYS 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   199 FTGTILLVLVPFLLILLSYTQILFTVLRMPS-------TTGRQKAFSTCASHLTSVTLFYS----TACMTYLQPKSKYSP 267
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASkqksserTQRRRKALKTLAVVVVVFILCWLpyhiVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 22129389   268 DTKKLMSL--AYSLLTPLLNPLIY 289
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

26-293

9.93e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 95.05 E-value: 9.93e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKInhiscevpavlE 185
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCC-----------C 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKA------------------FSTCASHLTSV 247
Cdd:cd00637 150 LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSnssrrrrrrrerkvtktlLIVVVVFLLCW 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 248 TLFYSTACMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRN 293
Cdd:cd00637 230 LPYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

30-299

1.38e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 83.38 E-value: 1.38e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd14967   6 LSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWvfsfpfcgpskiNHISCEVPAVLELACa 189
Cdd:cd14967  86 SILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVG------------WRDETQPSVVDCECE- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 dTFLFEVYSFTGTILLVLVPFLLILLSYTQIlFTVLRMPSTTGRQKAFSTCASHLT----SVTLFYSTACMTYLQPKSKY 265
Cdd:cd14967 153 -FTPNKIYVLVSSVISFFIPLLIMIVLYARI-FRVARRELKAAKTLAIIVGAFLLCwlpfFIIYLVSAFCPPDCVPPILY 230

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 266 spdtKKLMSLAYslLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd14967 231 ----AVFFWLGY--LNSALNPIIYALFNRDFRRA 258

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

31-299

1.79e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 66.51 E-value: 1.79e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFGGCFAQTYFILLFGGTE 110
Cdd:cd14968   8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINH-ISCEVPAVLELaca 189
Cdd:cd14968  86 IFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGgIQCLFEEVIPM--- 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 dtfLFEVY-SFTGTillVLVPFLLILLSYTQIlFTVLR-----MPSTTG-------RQKAFSTCASHLTSVTLF------ 250
Cdd:cd14968 163 ---DYMVYfNFFAC---VLVPLLIMLVIYLRI-FRVIRkqlrqIESLLRsrrsrstLQKEVKAAKSLAIILFLFalcwlp 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22129389 251 -YSTACMTYLQPkSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd14968 236 lHIINCITLFCP-ECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQT 284

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

25-300

1.71e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 60.68 E-value: 1.71e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  25 HMFGAFLVIYLVT-LTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFI 103
Cdd:cd14969   1 YVLAVYLSLIGVLgVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVkLVVCSWVLGIMTATvsvtwvfsFPFCGPSKI----NHISCE 179
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALI-LIAFIWLYGLFWAL--------PPLFGWSSYvpegGGTSCS 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 180 VPAVLelacaDTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHL-TSVTLFYSTACM-- 256
Cdd:cd14969 152 VDWYS-----KDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKkAEKKVAKMVLVMiv 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22129389 257 TYLQPKSKY-------SPDTKKLMSLAYSLLTPLL-------NPLIYSLRNKEMKRAV 300
Cdd:cd14969 227 AFLIAWTPYavvslyvSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

31-297

1.15e-09

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 58.41 E-value: 1.15e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFGGCFAQTYFILLFGGTE 110
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCLFLACFVLVLTQSS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTA-TVSVTWVFSFPFC------GPSKINHISCEVPAV 183
Cdd:cd15069  86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGlTPFLGWNKAMSATnnstnpADHGTNHSCCLISCL 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 184 LELACADTFLFeVYSFTGTILLVLVPFLLI-----LLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLF-------Y 251
Cdd:cd15069 166 FENVVPMSYMV-YFNFFGCVLPPLLIMLVIyikifLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFalcwlpvH 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129389 252 STACMTYLQPK-SKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMK 297
Cdd:cd15069 245 ILNCITLFQPEfSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFR 291

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

32-226

1.79e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 54.55 E-value: 1.79e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVE---ASFSttVMPEMLVvltseKATISFGG----CFAQTYF-- 102
Cdd:cd15196   9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADllvALFN--VLPQLIW-----DITYRFYGgdllCRLVKYLqv 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 103 ILLFGGTecFLLGAMAYDRFAAICYPLTYPMIMSKRIFVkLVVCSWVLGIMTATVSVTwVFSFPFCGPSkinhiscevpa 182
Cdd:cd15196  82 VGMYASS--YVLVATAIDRYIAICHPLSSHRWTSRRVHL-MVAIAWVLSLLLSIPQLF-IFSYQEVGSG----------- 146

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129389 183 vlELACADTFLFE----VYSFTGTILLVLVPFLLILLSYTQILFTVLR 226
Cdd:cd15196 147 --VYDCWATFEPPwglrAYITWFTVAVFVVPLIILAFCYGRICYVVWR 192

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

31-297

2.08e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 54.56 E-value: 2.08e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATisFGGCFAQTYFILLFGGTE 110
Cdd:cd15068   8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAA--CHGCLFIACFVLVLTQSS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMtatVSVTWVFSFPFCGPSKINHISCEV--PAVLELAC 188
Cdd:cd15068  86 IFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA---IGLTPMLGWNNCGQPKEGKNHSQGcgEGQVACLF 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 189 ADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLR------------MPSTTGRQKAFSTCASHLTSVTLF------ 250
Cdd:cd15068 163 EDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRqlkqmesqplpgERARSTLQKEVHAAKSLAIIVGLFalcwlp 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129389 251 -YSTACMTYLQPKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMK 297
Cdd:cd15068 243 lHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

30-239

2.20e-08

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 54.22 E-value: 2.20e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15096   7 FGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLgIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15096  87 SVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIV-ILVANIPVLFLHGVVSYGFSSEAYSYCTFLTEVGTAAQ 165

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129389 190 DTFL-FEVYSFtgtillvLVPFLLILLSYTQILFTVLRMPSTTGRQKAFST 239
Cdd:cd15096 166 TFFTsFFLFSY-------LIPLTLICVLYMLMLRRLRRQKSPGGRRSAESQ 209

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

27-226

2.42e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 54.26 E-value: 2.42e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAF-LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15083   3 LGIFiLIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLgimtatvSVTWVfSFPFCGPSKInhisceVPAVLE 185
Cdd:cd15083  83 FGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLY-------SLLWV-LPPLFGWSRY------VLEGLL 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 186 LAC-----ADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLR 226
Cdd:cd15083 149 TSCsfdylSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRR 194

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

29-227

2.85e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 54.14 E-value: 2.85e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEkaTISFGG--CFAQTYFILLF 106
Cdd:cd14993   6 LYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYR--PWVFGEvlCKAVPYLQGVS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGImtatvsvtwVFSFPFCGPSKINHISCEVPAVLEL 186
Cdd:cd14993  84 VSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAI---------IIMLPLLVVYELEEIISSEPGTITI 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 187 A-CADTFLFEV----YSFTGTILLVLVPFLLILLSYTQILFTVLRM 227
Cdd:cd14993 155 YiCTEDWPSPElrkaYNVALFVVLYVLPLLIISVAYSLIGRRLWRR 200

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

28-300

2.78e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 50.75 E-value: 2.78e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  28 GAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFG 107
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 108 GTECFLLgAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATV-SVTWvfsfpfcgpskiNHISCEVPavlel 186
Cdd:cd14972  83 ASAYSLL-AIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLpVLGW------------NCVLCDQE----- 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 187 ACADTFLFEVYSFTGTIL-LVLVPFLLILLSYTQILFTV--------LRMPSTTGRQKAFSTcASHLTSVTL-------- 249
Cdd:cd14972 145 SCSPLGPGLPKSYLVLILvFFFIALVIIVFLYVRIFWCLwrhanaiaARQEAAVPAQPSTSR-KLAKTVVIVlgvflvcw 223

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129389 250 --FYSTACMTYLQPKSKYSPDTKKLMsLAYSLLTPLLNPLIYSLRNKEMKRAV 300
Cdd:cd14972 224 lpLLILLVLDVLCPSVCDIQAVFYYF-LVLALLNSAINPIIYAFRLKEMRRAV 275

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

28-161

6.66e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 49.80 E-value: 6.66e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  28 GAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQT------- 100
Cdd:cd15103   5 EVFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHidnvids 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129389 101 YFILLFGGTECFLLgAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTW 161
Cdd:cd15103  85 MICSSLLASICSLL-AIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIY 144

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

32-241

1.42e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 48.91 E-value: 1.42e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFS-TTVMPEMLVVLTSEKAT-------ISFGGCFAqtyfi 103
Cdd:cd14986   9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWVAgdvlcriVKYLQVVG----- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 lLFGGTecFLLGAMAYDRFAAICYPltypMIMSKRifvklvvcSWVLGIMTAtvsVTWVFSFPFCGPSKINHISCEVpAV 183
Cdd:cd14986  84 -LFAST--YILVSMSLDRYQAIVKP----MSSLKP--------RKRARLMIV---VAWVLSFLFSIPQLVIFVEREL-GD 144

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129389 184 LELACADTFLFE----VYSFTGTILLVLVPFLLILLSYTQILFTVLRmpstTGRQKAFSTCA 241
Cdd:cd14986 145 GVHQCWSSFYTPwqrkVYITWLATYVFVIPLIILSYCYGRILRTIWI----RSRQKTDRPIA 202

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

31-224

3.20e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 47.65 E-value: 3.20e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFG--GCFAQTYFILLFGG 108
Cdd:cd15074   8 TVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYP--LAIISAFAHRWLFGdiGCVFYGFCGFLFGC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVkLVVCSWVLGIMTATvsvtwvfsFPFCGPSK----INHISCEVPAVL 184
Cdd:cd15074  86 CSINTLTAISIYRYLKICHPPYGPKLSRRHVCI-VIVAIWLYALFWAV--------APLVGWGSygpePFGTSCSIDWTG 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 22129389 185 ELACADTFLFEVYSFtgtILLVLVPFLLILLSYTQILFTV 224
Cdd:cd15074 157 ASASVGGMSYIISIF---IFCYLLPVLIIVFSYVKIIRKV 193

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

28-220

3.43e-06

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 47.77 E-value: 3.43e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  28 GAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFG 107
Cdd:cd15208   5 ALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 108 GTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVcsWVLGIMTATVSVTWVFSFPFCG-PSKINhiscevpavLEL 186
Cdd:cd15208  85 SVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILII--WIVSLLIMIPQAIVMECSRVVPlANKTI---------LLT 153

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 22129389 187 ACADTFLFEVYSFTGTILLVLV----PFLLILLSYTQI 220
Cdd:cd15208 154 VCDERWSDSIYQKVYHICFFLVtyllPLCLMILAYFQI 191

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

32-299

6.46e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 46.55 E-value: 6.46e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATisFGGCFAQTYFIL-LFGGTE 110
Cdd:cd15064   9 LIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWI--LGQVLCDIWISLdVTCCTA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 111 CFL-LGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWvfsfpFCGPSKINHISCEVpavlelacA 189
Cdd:cd15064  87 SILhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFG-----WRTPDSEDPSECLI--------S 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTIllvLVPFLLILLSYTQILFTVLRmpsttgRQKAFSTCASHLTSVTL----FYSTACMTYLQPKSKY 265
Cdd:cd15064 154 QDIGYTIFSTFGAF---YIPLLLMLILYWKIYRAAAR------ERKAAKTLGIILGAFIVcwlpFFLVALIVPLCSHCWI 224

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMS-LAYslLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15064 225 PLALKSFFLwLGY--FNSLINPLIYTFFNKDFRKA 257

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

31-305

9.42e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 46.48 E-value: 9.42e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGTE 110
Cdd:cd15307   8 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTAS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGImtatvsvtwVFSFPFCGPSKINHISCEVPAVLELACAd 190
Cdd:cd15307  88 IMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSI---------AMSLPLSLMYSKDHASVLVNGTCQIPDP- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 191 tflfeVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLF--------------YSTACM 256
Cdd:cd15307 158 -----VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfvilwspffvlnlLPTVCA 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129389 257 TYLQPKSKYSPDTKKLMSLAYSlltpLLNPLIYSLRNKEMKRAVVK--LCQ 305
Cdd:cd15307 233 ECEERISHWVFDVVTWLGYASS----MVNPIFYTIFNKVFRQAFKKvlLCR 279

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

35-157

1.57e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 45.62 E-value: 1.57e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  35 LVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFGG--CFAQTYFILLFGGTECF 112
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLP--FSTIRSVESCWYFGDsfCRLHTCLDTLFCLTSIF 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129389 113 LLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATV 157
Cdd:cd15318  90 HLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSV 134

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

28-161

1.63e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 45.55 E-value: 1.63e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  28 GAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTY------ 101
Cdd:cd15351   5 GLFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidt 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 102 FILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTW 161
Cdd:cd15351  85 MICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

29-224

1.72e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 45.57 E-value: 1.72e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGG 108
Cdd:cd15202   6 AYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVH 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVcsWVLGIMTAtvsvtwvFSFPFCGPSKI--NHISCEVPAVLEL 186
Cdd:cd15202  86 VSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVI--WTLALAFA-------LPHAICSKLETfkYSEDIVRSLCLED 156

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 22129389 187 ACADTFLFE-VYSFTGTILLVLVPFLLILLSYTQILFTV 224
Cdd:cd15202 157 WPERADLFWkYYDLALFILQYFLPLLVISFAYARVGIKL 195

7tmA_GPR161

cd15214

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...

29-298

2.14e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320342 [Multi-domain] Cd Length: 261 Bit Score: 45.32 E-value: 2.14e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFG--GCFAQTYFILLF 106
Cdd:cd15214   5 AIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLP--FVVTSSIRREWIFGvvWCNFSALLYLLI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPM-IMSKRIFVKLVvcswvlgimtatvsVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15214  83 SSASMLTLGAIAIDRYYAVLYPMVYPMkITGNRAVLALV--------------YIWLHSLIGCLPPLFGWSSLEFDRFKW 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFTGTILLVLVPFLLILLSYTqILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15214 149 MCVAAWHKEAGYTAFWQVWCALLPFVVMLVCYG-FIFRVARANQCKAFITILVVLGAFVTTWGPYMVVISTEALWGKNSV 227

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129389 266 SPDTKKLMSLaYSLLTPLLNPLIYSLRNKEMKR 298
Cdd:cd15214 228 SPQLETLATW-LSFTSAVCHPLIYGLWNKTVRK 259

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

29-150

2.35e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 45.13 E-value: 2.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFGG--CFAQTYFILLF 106
Cdd:cd15317   6 VLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP--FSMIRTVETCWYFGDlfCKFHTGLDLLL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVL 150
Cdd:cd15317  84 CTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

30-222

3.61e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 44.59 E-value: 3.61e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFsTTVMPEMLVVLTSEkaTISFGG--CFAQTYFILLFG 107
Cdd:cd14970   7 YSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLG--YWPFGEvmCKIVLSVDAYNM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 108 GTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLgimtATVSVTWVFSFPFCGPSKINHISCevpaVLELA 187
Cdd:cd14970  84 FTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWAL----SLVLGLPVIIFARTLQEEGGTISC----NLQWP 155

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 22129389 188 CADTF---LFEVYSFtgtILLVLVPFLLILLSYTQILF 222
Cdd:cd14970 156 DPPDYwgrVFTIYTF---VLGFAVPLLVITVCYSLIIR 190

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

31-299

5.35e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 43.84 E-value: 5.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMP-EMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15052   8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKR-IFVKLVvcswvlgimtatvsVTWVFSFPFCGPSKINHISCEVPAVLELAC 188
Cdd:cd15052  88 SIMHLCTISLDRYMAIRYPLRTRRNKSRTtVFLKIA--------------IVWLISIGISSPIPVLGIIDTTNVLNNGTC 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 189 ADTflFEVYSFTGTILLVLVPFLLILLSYTqilftvLRMPSTTGRQKA----------FSTCAS--HLTSVTLFYSTACM 256
Cdd:cd15052 154 VLF--NPNFVIYGSIVAFFIPLLIMVVTYA------LTIRLLSNEQKAskvlgivfavFVICWCpfFITNILTGLCEECN 225

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129389 257 TYLQPkskyspdtkKLMS----LAYslLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15052 226 CRISP---------WLLSvfvwLGY--VSSTINPIIYTIFNKTFRRA 261

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

30-155

6.48e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 43.61 E-value: 6.48e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd14971   7 FALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHA 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTA 155
Cdd:cd14971  87 SIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVA 132

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

32-167

7.60e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 43.60 E-value: 7.60e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMP-EMLVVLTSEKATISFGGCFAQTYFILLFGGTE 110
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPfVMASVRHGSGWIYGALSCKVIAFLAVLFCFHS 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPF 167
Cdd:cd15005  89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTF 145

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

25-224

7.86e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 43.72 E-value: 7.86e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  25 HMFGAF-LVIYLVTLTGNAtIVTVIFLDH-SLHIPMYLFLQNLSVVEASFSTTvMPEMLVvlTSEKATISFGGCFAQTYF 102
Cdd:cd15079   1 YLLGFIyIFLGIVSLLGNG-LVIYIFSTTkSLRTPSNMLVVNLAISDFLMMIK-MPIFIY--NSFYEGWALGPLGCQIYA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 103 IL--LFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVvcswvlgimtatvsVTWVFSFPFCGPSKINHISCEV 180
Cdd:cd15079  77 FLgsLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLIL--------------FIWLYALPWALLPLLFGWGRYV 142

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 22129389 181 PAVLELAC-----ADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFTV 224
Cdd:cd15079 143 PEGFLTSCsfdylTRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAV 191

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

29-218

8.12e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 43.42 E-value: 8.12e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGG 108
Cdd:cd15001   5 VYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFI 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISCevpavlELAC 188
Cdd:cd15001  85 CSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHC------QKAW 158

                       170       180       190
                ....*....|....*....|....*....|
gi 22129389 189 ADTFLFEVYSFTGTILLVLVPFLLILLSYT 218
Cdd:cd15001 159 PSTLYSRLYVVYLAIVIFFIPLIVMTFAYA 188

7tmA_GPR83

cd15389

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...

29-220

8.31e-05

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.

Pssm-ID: 320511 [Multi-domain] Cd Length: 285 Bit Score: 43.48 E-value: 8.31e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGG 108
Cdd:cd15389   6 AYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVY 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVklVVCSWVLGIMtatvsvtwvFSFPFCGPSKINHISCEVpAVLELAC 188
Cdd:cd15389  86 VSTLTLTAIALDRHRVILHPLKPRITPCQGVVV--IAIIWIMASC---------LSLPHAIYQKLVEFEYSN-ERTRSRC 153

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 22129389 189 ADTF-----LFEVYSFTGT-ILLVLVPFLLILLSYTQI 220
Cdd:cd15389 154 LPSFpepsdLFWKYLDLATfILQYVLPLLIIGVAYTRV 191

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

32-297

1.19e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 42.84 E-value: 1.19e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFGGCFAQTYFILLFGGTEC 111
Cdd:cd15070   9 LIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 112 FLLGAMAYDRFAAICYPLTYPMIMS-KRIFVKLVVCsWVLGIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLELACAD 190
Cdd:cd15070  87 MSLLAIAVDRYLRVKLTVRYRIVTTqRRIWLALGLC-WLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRMDYMV 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 191 TFLFEVYsftgtillVLVPFLLILLSYTQILFTVLRM---------PSTTGRQKAFSTCASHLTSVTLFYST-------A 254
Cdd:cd15070 166 YFSFFTW--------ILIPLVIMCALYVDIFYIIRNKlsqnatgfrETGAFYGREFKTAKSLALVLFLFAVCwlplsiiN 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129389 255 CMTYLQPKskySPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMK 297
Cdd:cd15070 238 CVVYFNPK---VPKIALYLGILLSHANSMMNPIVYACKIKKFK 277

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

29-220

1.58e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 42.73 E-value: 1.58e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVveasfSTTVMPEMLVVLTSEKATIS----FGG--CFAQTYF 102
Cdd:cd15392   6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLAL-----SDILMAVFCVPFSFIALLILqywpFGEfmCPVVNYL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 103 ILLFGGTECFLLGAMAYDRFAAICYPLTYPmiMSKRIFVKLVVCSWVLGIMTATVSVTwvfsfpFCGPSKINHISCEVPA 182
Cdd:cd15392  81 QAVSVFVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATALPIAI------TSRLFEDSNASCGQYI 152

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 22129389 183 VLELACADTFLFeVYSFTGTILLVLVPFLLILLSYTQI 220
Cdd:cd15392 153 CTESWPSDTNRY-IYSLVLMILQYFVPLAVLVFTYTRI 189

7tmA_AT1R

cd15192

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...

32-226

1.82e-04

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.

Pssm-ID: 320320 [Multi-domain] Cd Length: 285 Bit Score: 42.42 E-value: 1.82e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVmpEMLVVLTSEKATISFGG--CFAQTYFILLFGGT 109
Cdd:cd15192   9 IIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITL--PLWAAYTAMEYHWPFGNflCKIASALVSFNLYA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPltypmiMSKRIFVKLVVcSWVlgimtaTVSVTWVFSFPFCGPSKINHISCEVPAVLELACA 189
Cdd:cd15192  87 SVFLLTCLSIDRYLAIVHP------MKSRLRRTLVV-ARV------TCIVIWLLAGVASLPAIIHRDVFFIENTNITVCA 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 22129389 190 -------DTFLFeVYSFTGTILLVLVPFLLILLSYTQILFTVLR 226
Cdd:cd15192 154 fhypsqnSTLLV-GLGLMKNLLGFLIPFLIILTCYTLIGKALKK 196

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

30-150

1.87e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 42.46 E-value: 1.87e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQT-------YF 102
Cdd:cd15350   7 FFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGPFETKlddimdsLF 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129389 103 ILLFGGTeCFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVL 150
Cdd:cd15350  87 CLSLLGS-IFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTF 133

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

24-148

1.88e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 42.34 E-value: 1.88e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVvlTSEKATISFGGCFAQTY-- 101
Cdd:cd15312   1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMV--RSVESCWYFGDLFCKIHss 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129389 102 FILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSW 148
Cdd:cd15312  79 LDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISW 125

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

30-150

1.98e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 42.16 E-value: 1.98e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15978   7 YSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVL 150
Cdd:cd15978  87 STFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCL 127

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

32-220

2.11e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 42.34 E-value: 2.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemlvvltsekatisfggcFAQTYFIL---LFGG 108
Cdd:cd15065   8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMT------------------FAVVNDLLgywLFGE 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFL---------------LGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVtwvfSFPFCGPSKI 173
Cdd:cd15065  70 TFCNIwisfdvmcstasilnLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPI----HLGWHRLSQD 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 22129389 174 NHISCEVPAVLELACADTFLFeVYSFTGTILLVLVPFLLILLSYTQI 220
Cdd:cd15065 146 EIKGLNHASNPKPSCALDLNP-TYAVVSSLISFYIPCLVMLLIYSRL 191

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

32-299

2.60e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 41.80 E-value: 2.60e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFGGCFAQTYFIL--LFGGT 109
Cdd:cd15325   9 GFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP--FSAIFEILGYWAFGRVFCNIWAAVdvLCCTA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMtatVSVTWVFSFPFCGPS--KINHISCEVPAVLela 187
Cdd:cd15325  87 SIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLV---ISIGPLFGWKEPAPEdeTICQITEEPGYAL--- 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 188 cadtflfevYSFTGTILLvlvPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTL-FYSTACMTYLQPKSKyS 266
Cdd:cd15325 161 ---------FSALGSFYL---PLAIILVMYCRVYVVALKFSREKKAAKTLGIVVGCFVLCWLpFFLVMPIGSIFPAYK-P 227

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129389 267 PDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15325 228 SDTVFKITFWLGYFNSCINPIIYPCSSQEFKKA 260

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

32-167

2.61e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 42.24 E-value: 2.61e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKA-TISFGGCFAQTYFILLFGGTE 110
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFCFHA 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPF 167
Cdd:cd15217  89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKF 145

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

30-233

4.57e-04

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 40.97 E-value: 4.57e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15008   6 FGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGV 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPmiMSKRIFVKLVVCSWVLGimTATVSVTwvfsFPFCGPSKINHISCEVPAVLELAca 189
Cdd:cd15008  86 QIYVLLSICVDRFYTIVYPLSFK--VSREKAKKMIAASWLFD--AAFVSPA----LFFYGSNWGPHCNFFLPDSWDGA-- 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 22129389 190 dtflfeVYSFTGTILLVLVPFLLILLSYTQILFTVLRMpSTTGR 233
Cdd:cd15008 156 ------AYAIIHLLVGFLVPSILIILFYQKVIKYIWRI-GTDGR 192

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

26-299

4.68e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 41.03 E-value: 4.68e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVtltGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemlvvLTSEKATIS---FGGCFAQTYF 102
Cdd:cd15326   6 VLGAFILFAIV---GNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP-----FSATLEILGywvFGRIFCDIWA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 103 IL--LFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLgimTATVSVTWVFSFPfcGPSKINHISCEV 180
Cdd:cd15326  78 AVdvLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVL---STVISIGPLLGWK--EPAPPDDKVCEI 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 181 pavlelacADTFLFEVYSFTGTIllvLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQ 260
Cdd:cd15326 153 --------TEEPFYALFSSLGSF---YIPLIVILVMYCRVYIVALKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSL 221

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129389 261 PKSKYSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15326 222 FSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRA 260

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-150

4.84e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 41.10 E-value: 4.84e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILL 105
Cdd:cd15329   3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVL 150
Cdd:cd15329  83 LCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLL 127

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

31-299

5.03e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 41.04 E-value: 5.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKA-TISFGGCFAQTYFILLFGGT 109
Cdd:cd15305   8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFSTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWvlgimtaTVSVTWVFSFPFCGPSKINHISCEVPAVLElaca 189
Cdd:cd15305  88 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------TISIGISMPIPVIGLQDDEKVFVNGTCVLN---- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 dtflFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCAS----HLTSVTLFYSTACMTYLQPKSKY 265
Cdd:cd15305 157 ----DENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIvfflFLIMWCPFFITNILSVLCKEACD 232

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129389 266 SPDTKKLMSLAY--SLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15305 233 QKLMEELLNVFVwvGYVSSGINPLVYTLFNKTYRRA 268

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

30-220

5.30e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 40.88 E-value: 5.30e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLsvveaSFSTTVMPEMLVVLTSEKATISFGGCFAQ--TYFILLFG 107
Cdd:cd15394   7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNL-----AFSDMLMCATCVPLTLAYAFEPRGWVFGRfmCYFVFLMQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 108 GTECFL----LGAMAYDRFAAICYPLtypmimSKRIFVKLvvCSWVLGIMtatvsvtWVFSFPFCGPSKINHISCEVPAv 183
Cdd:cd15394  82 PVTVYVsvftLTAIAVDRYYVTVYPL------RRRISRRT--CAYIVAAI-------WLLSCGLALPAAAHTYYVEFKG- 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 22129389 184 LELACADTFLFE------VYSFTGTILLVLVPFLLILLSYTQI 220
Cdd:cd15394 146 LDFSICEEFWFGqekqrlAYACSTLLITYVLPLLAISLSYLRI 188

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

31-151

6.64e-04

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 40.86 E-value: 6.64e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGTE 110
Cdd:cd15336   8 LIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129389 111 CFLLGAMAYDRFAAICYPLTYPMIMSKR--IFVKLVVCSWVLG 151
Cdd:cd15336  88 MITLLAISLDRYLVITKPLASIRWVSKKraMIIILLVWLYSLA 130

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

32-153

7.02e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 40.57 E-value: 7.02e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGTEC 111
Cdd:cd15979   9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVST 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129389 112 FLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIM 153
Cdd:cd15979  89 FSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGL 130

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

28-226

1.11e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 40.16 E-value: 1.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  28 GAFL-VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLF 106
Cdd:cd15056   4 STFLsLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 107 GGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCsWVLGIMTATVSVTwvfsfpfcgpSKINHISCEVPAVLEL 186
Cdd:cd15056  84 TTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGC-WVIPTFISFLPIM----------QGWNHIGIEDLIAFNC 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 22129389 187 ACADTF-LFEV---YSFTGTILLVLVPFLLILLSYTQILFTVLR 226
Cdd:cd15056 153 ASGSTScVFMVnkpFAIICSTVAFYIPALLMVLAYYRIYVAARE 196

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

26-228

1.52e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 39.56 E-value: 1.52e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFsTTVMPEMLVV-LTSEKATISFGGCFAQTYFIL 104
Cdd:cd14982   3 FPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYyLNGGWWPFGDFLCRLTGLLFY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 105 LFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLgIMTATVSVTWvfsFPFCGPSKINHISCEVPAVL 184
Cdd:cd14982  82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIL-VLVASVPLLL---LRSTIAKENNSTTCFEFLSE 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 22129389 185 ELACAdtflfEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMP 228
Cdd:cd14982 158 WLASA-----APIVLIALVVGFLIPLLIILVCYSLIIRALRRRS 196

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

41-298

1.70e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 39.38 E-value: 1.70e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  41 NATIVTVIFLDHSLHIPMYLFLQNLSVveASFSTTVMPEMLVVLTSEKATISFG--GCFAQTYFILLFGGTECFLLGAMA 118
Cdd:cd15075  18 NATVIIVTLRHKQLRQPLNYALVNLAV--ADLGTTVFGGLLSVVTNAVGYFNLGrvGCVLEGFAVAFFGIAALCTVAVIA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 119 YDRFAAICYPLTYPMIMSKRIFvklvvcswvlgimtATVSVTWVFSFPFCGPSKINHISCEVPAVLELACADTFLFEVYS 198
Cdd:cd15075  96 VDRLFVVCKPLGTLTFQTRHAL--------------AGIASSWLWSLIWNTPPLFGWGSYQLEGVMTSCAPDWYSRDPVN 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 199 FTGTILLVLV----PFLLILLSYTQILFTV----LRMPSTTGRQKAFSTCASHLTSVTLF--------YSTACMTYL-QP 261
Cdd:cd15075 162 VSYILCYFSFcfaiPFAIILVSYGYLLWTLrqvaKLGVAEGGSTAKAEVQVARMVVVMVMafllcwlpYAAFALTVVsKP 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129389 262 KSKYSPDTKKL-MSLAYSllTPLLNPLIYSLRNKEMKR 298
Cdd:cd15075 242 DVYINPLIATVpMYLAKS--STVYNPIIYIFMNKQFRD 277

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-226

1.87e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 39.46 E-value: 1.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTsekATISFGG---CFAQTYF 102
Cdd:cd15055   3 LYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSI---ETCWYFGdtfCKLHSSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 103 ILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIfVKLVVCswvlgimtatvsVTWVFSFPFCGPSKINHISceVPA 182
Cdd:cd15055  80 DYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRR-VKICIC------------LCWFVSALYSSVLLYDNLN--QPG 144

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129389 183 VLEL-ACADTFLFEVYSFTGTILLVL---VPFLLILLSYTQILFTVLR 226
Cdd:cd15055 145 LIRYnSCYGECVVVVNFIWGVVDLVLtfiLPCTVMIVLYMRIFVVARS 192

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

30-220

2.00e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 39.20 E-value: 2.00e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVlTSEKATISFGG--CFAQTYFILLFG 107
Cdd:cd14997   7 YGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVE-TWAREPWLLGEfmCKLVPFVELTVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 108 GTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTA--TVSVTWVFSFPFCGPSKInhISCEVPavle 185
Cdd:cd14997  86 HASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSspVLFITEFKEEDFNDGTPV--AVCRTP---- 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 22129389 186 lacADTFLFEVYSFTGTILLVLVPFLLILLSYTQI 220
Cdd:cd14997 160 ---ADTFWKVAYILSTIVVFFVVPLAILSGLYSVI 191

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

32-171

2.04e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 39.02 E-value: 2.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPeMLVVLTSEKATIsFGGCFAQTYFIL-LFGGTE 110
Cdd:cd15063   9 FLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLP-FSAVNEVLDVWI-FGHTWCQIWLAVdVWMCTA 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129389 111 CFL-LGAMAYDRFAAICYPLTYPMIMSKRifvklvvcswvlgIMTATVSVTWVFSFPFCGPS 171
Cdd:cd15063  87 SILnLCAISLDRYLAITRPIRYPSLMSTK-------------RAKCLIAGVWVLSFVICFPP 135

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

30-161

2.29e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 39.10 E-value: 2.29e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQ-------TYF 102
Cdd:cd15352   7 FLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQhmdnvfdSMI 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22129389 103 ILLFGGTECFLLgAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTW 161
Cdd:cd15352  87 CISLVASICNLL-AIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVY 144

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

28-220

2.35e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 39.22 E-value: 2.35e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  28 GAFL-VIYLVTLTGNATI-VTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVvltSEKATISFGGCFAQTY--FI 103
Cdd:cd15320   5 GCFLsVLILSTLLGNTLVcAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAV---AEIAGFWPFGSFCNIWvaFD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTA--TVSVTWVFSFPfCGPSKINHISCEVP 181
Cdd:cd15320  82 IMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfiPVQLNWHKAKP-TSFLDLNASLRDLT 160

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 22129389 182 avleLACADTFLFEVYSFTGTILLVLVPFLLILLSYTQI 220
Cdd:cd15320 161 ----MDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRI 195

7tmA_CysLTR1

cd15158

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...

32-249

2.75e-03

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320286 [Multi-domain] Cd Length: 285 Bit Score: 38.96 E-value: 2.75e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVmpEMLVVLTSEKATISFGG--CFAQTYFILLFGGT 109
Cdd:cd15158   9 VITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTL--PLRVVYYVHKGQWLFGDflCRISSYALYVNLYC 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATvsvtwvfSFPFCGPSKI--NHISCEVPAvlELA 187
Cdd:cd15158  87 SIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSS-------PFLMSGSHDTetNKTKCFEPP--QSN 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129389 188 CADTFLFeVYSFTGTILLVLVPFLLILLSYTQILFTVLRMPSTTGRQKAFSTCASHLTSVTL 249
Cdd:cd15158 158 QQLTKLL-VLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARKQQSSRKKAIRMIIIVL 218

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

29-156

2.84e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 38.81 E-value: 2.84e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGG 108
Cdd:cd15390   6 VFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPmiMSKRIFVKLVVCSWVLGIMTAT 156
Cdd:cd15390  86 ASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLAL 131

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-222

3.02e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 38.76 E-value: 3.02e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  26 MFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPM-YLFLqNLSVVEASFSTTVMP-EMLVVLTSekaTISFGGCFAQTY-- 101
Cdd:cd15314   3 LYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTnYLIL-SLAVADLLVGGLVMPpSMVRSVET---CWYFGDLFCKIHss 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 102 FILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLgimTATVSVTWVFSFPFCGPSKINHISCEVP 181
Cdd:cd15314  79 FDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSV---SALVGFGIIFLELNIKGIYYNHVACEGG 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22129389 182 AVLelacadtFLFEVYSFTGTILLVLVPFLLILLSYTQILF 222
Cdd:cd15314 156 CLV-------FFSKVSSVVGSVFSFYIPAVIMLCIYLKIFL 189

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

30-170

3.12e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 38.65 E-value: 3.12e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLD-HSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGG 108
Cdd:cd15097   7 FSLIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMY 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVklvvcswvlgimtATVSVTWVFSFPFCGP 170
Cdd:cd15097  87 ASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAV-------------AAIALIWGLSLLFAGP 135

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

28-150

3.22e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 38.49 E-value: 3.22e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  28 GAFL-VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPeMLVVLTSEKATISFGGCFAQTY--FIL 104
Cdd:cd15067   3 GVVLsLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP-FSILHEMTGGYWLFGRDWCDVWhsFDV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 105 LFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVL 150
Cdd:cd15067  82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWIC 127

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

33-299

3.42e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 38.56 E-value: 3.42e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  33 IYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGTECF 112
Cdd:cd15050  10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 113 LLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGiMTATVSVTWVFSFPFCGPSKINHISCEvpavlelacADTF 192
Cdd:cd15050  90 SLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLS-FLWVIPILGWHHFARGGERVVLEDKCE---------TDFH 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 193 LFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRmPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLqPKSKYSPDTKKL 272
Cdd:cd15050 160 DVTWFKVLTAILNFYIPSLLMLWFYAKIFKAVNR-ERKAAKQLGFIMAAFILCWIPYFILFMVIAFC-KNCCNENLHMFT 237

                       250       260
                ....*....|....*....|....*..
gi 22129389 273 MSLAYslLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15050 238 IWLGY--INSTLNPFIYPLCNENFKKT 262

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

32-299

3.43e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 38.39 E-value: 3.43e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVvlTSEKATISFGGCFAQTYFIL--LFGGT 109
Cdd:cd15322   9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLA--NEVMGYWYFGKVWCEIYLALdvLFCTS 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVlgimtatvsVTWVFSFPfcgPSKINHISCEVPAVLELACA 189
Cdd:cd15322  87 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWV---------ISAVISFP---PLITIEKKSGQPEGPICKIN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILLVLVPFLLILLSYTQIlftvlrmpsTTGRQKAFSTCASHLTSVTL-----FYSTACMTYLQpkSK 264
Cdd:cd15322 155 DEKWYIISSCIGSFFAPCLIMVLVYIRIYQI---------AKNREKRFTFVLAVVIGVFVicwfpFFFTYTLTAVC--DC 223

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 265 YSPDTKKLMSLAYSLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15322 224 SVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 258

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

32-224

3.56e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 38.29 E-value: 3.56e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPemLVVLTSEKATISFGGCFAQTYFILLFGGTEC 111
Cdd:cd15071   9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 112 FLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMtatVSVTWVFSFPFCGPSKINH----------ISCEVP 181
Cdd:cd15071  87 LALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFL---VGLTPMFGWNNLNAVERAWaanssmgelvIKCQFE 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 22129389 182 AVLELACADTFLFEVYsftgtillVLVPFLLILLSYTQILFTV 224
Cdd:cd15071 164 TVISMEYMVYFNFFVW--------VLPPLLLMLLIYLEVFYLI 198

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

112-227

4.03e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 38.15 E-value: 4.03e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 112 FLLGAMAYDRFAAICYPLTypmIMSKRIFVKLVVCswvlgimtatvsVTWVFSFPFCGPSKINH----ISCEVPAVLEla 187
Cdd:cd15195  89 FMLVVIALDRVFAILSPLS---ANQARKRVKIMLT------------VAWVLSALCSIPQSFIFsvlrKMPEQPGFHQ-- 151

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 188 CADTFLF------EVYSFTGTILLVLVPFLLILLSYTQILFTVLRM 227
Cdd:cd15195 152 CVDFGSAptkkqeRLYYFFTMILSFVIPLIITVTCYLLILFEISKM 197

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

30-148

4.06e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 38.38 E-value: 4.06e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQ-------TYF 102
Cdd:cd15354   7 FLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRhidnvfdSLI 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 103 ILLFGGTECFLLgAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSW 148
Cdd:cd15354  87 CISVVASMCSLL-AIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

30-227

5.15e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 38.11 E-value: 5.15e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMP-EMLVVLTSEKATISFGGCFAQTYFILLFGG 108
Cdd:cd14979   7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPvELYNFWWQYPWAFGDGGCKLYYFLFEACTY 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMtatVSVTWVFSFPFCGPSKINHISCEVPAVLELAC 188
Cdd:cd14979  87 ATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSIL---CAIPILFLMGIQYLNGPLPGPVPDSAVCTLVV 163

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 22129389 189 ADTFLFEVYSFTGTILLVLVPFLLILLsYTQILFTVLRM 227
Cdd:cd14979 164 DRSTFKYVFQVSTFIFFVLPMFVISIL-YFRIGVKLRSM 201

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

30-221

5.49e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 37.82 E-value: 5.49e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTvMPEMLVVLTSEKATIsFGGCFAQTYFIL----L 105
Cdd:cd15088   7 FGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLG-MPFLIHQFAIDGQWY-FGEVMCKIITALdannQ 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTecFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATvsVTWVFS--FPFCGPSKINHISCEVPav 183
Cdd:cd15088  85 FTST--YILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSIL--PVWVYSslIYFPDGTTFCYVSLPSP-- 158

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 22129389 184 lelacADTFLFEVYSFtgtILLVLVPFLLILLSYTQIL 221
Cdd:cd15088 159 -----DDLYWFTIYHF---ILGFAVPLVVITVCYILIL 188

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

31-226

5.56e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 37.71 E-value: 5.56e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVvlTSEKATISFGGCFAQTYFIL--LFGG 108
Cdd:cd15059   8 SVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLV--NELMGYWYFGSVWCEIWLALdvLFCT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWvlgIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLElac 188
Cdd:cd15059  86 ASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVW---IISAVISLPPLFGWKDEQPWHGAEPQCELSDDPG--- 159

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 22129389 189 adtflfevYSFTGTILLVLVPFLLILLSYTQILFTVLR 226
Cdd:cd15059 160 --------YVLFSSIGSFYIPLLIMIIVYARIYRAAKR 189

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

30-299

5.60e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 37.79 E-value: 5.60e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEAsFSTTVMPEMLVVLTsekatisfggcFAQTYFILLFG-G 108
Cdd:cd15000   6 FLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADL-LTLLVCPWMFLVHD-----------FFQNYVLGSVGcK 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 109 TECFL-----------LGAMAYDRFAAICYPLTYPmiMSKRIFVKLVVCSWVLGIMTATvsvtwvfsfPFCgpSKINHIS 177
Cdd:cd15000  74 LEGFLegslllasvlaLCAVSYDRLTAIVLPSEAR--LTKRGAKIVIVITWIVGLLLAL---------PLA--IYRSYRE 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 178 CEVPAVLELACA-DTFLFEVYSFTGTILLVLVPFLLILLSYTQILF-------TVLRM--PSTTG-RQKAFSTCASHL-T 245
Cdd:cd15000 141 RQWKNFLETYCAeNTQVLPIYWHVIITVLVWLPLGIMLICYSAIFWkldkyerRVLRRehPSVVRyKKKAAKTLFIVLiT 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129389 246 SVTLFYSTACMTYLQPKSKYSPDTKKLMSLAYSL----------LTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15000 221 FVVCRIPFTALIFYRYKLVPNDNTQNSVSGSFHIlwfaskylmfLNAAVNPLIYGFTNENFRKA 284

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

32-299

5.68e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 37.62 E-value: 5.68e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEkaTISFGGCFAQTYFILLFGGTEC 111
Cdd:cd15334   9 ILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKE--TWIMGQVVCDIWLSVDITCCTC 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 112 FLL--GAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWvfsfpfcgpsKINHISCEVPAVLElacA 189
Cdd:cd15334  87 SILhlSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFW----------RHQTTSREDECIIK---H 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 190 DTFLFEVYSFTGTILlvlVPFLLILLSYTQIlftvlrMPSTTGRQKAFSTCASHLTSVTL----FYSTACMTYLQPKSKY 265
Cdd:cd15334 154 DHIVFTIYSTFGAFY---IPLALILILYYKI------YRAATRERKAATTLGLILGAFVIcwlpFFVKEVIVNTCDSCYI 224

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129389 266 SPDTKKLMS-LAYslLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15334 225 SEEMSNFLTwLGY--INSLINPLIYTIFNEDFKKA 257

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-235

5.86e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 37.81 E-value: 5.86e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFST-TVMPEMLVVLTSEKAtisFGGCFAQTYFIL--L 105
Cdd:cd15012   5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIfCVLQNLSIYLIPSWP---FGEVLCRMYQFVhsL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 106 FGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWvlgIMTATVSVTWVFSFPFCGPSKINHISCEVPAVLE 185
Cdd:cd15012  82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVW---LTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLD 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 22129389 186 LACADTFLFEVYSFtgtILLVLVPFLLILLSYTQILFTVLRMPSTTGRQK 235
Cdd:cd15012 159 REMFNSKLYDTINF---IVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

30-148

5.98e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 37.58 E-value: 5.98e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  30 FLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVV-------LTSEKATISFGGCFAQTYF 102
Cdd:cd15353   7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVItllngndTDAQSFTVNIDNVIDSVIC 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129389 103 ILLFGGTeCFLLgAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSW 148
Cdd:cd15353  87 SSLLASI-CSLL-SIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

29-150

6.31e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 37.74 E-value: 6.31e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  29 AFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGG 108
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129389 109 TECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVL 150
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWIS 126

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

32-170

6.34e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 37.87 E-value: 6.34e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSV---VEASFSttVMPEMLVVLTSEKATISF----------GGCFA 98
Cdd:cd15387   9 LILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIadlVVAVFQ--VLPQLIWDITFRFYGPDFlcrlvkylqvVGMFA 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129389  99 QTYFILLfggtecfllgaMAYDRFAAICYPLTYPMIMSKRIFvklVVCSWVLGIMtATVSVTWVFSFPFCGP 170
Cdd:cd15387  87 STYMLLL-----------MSIDRCLAICQPLRSLHRRSDRVY---VLFSWLLSLV-FSIPQVHIFSLREVGN 143

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

31-152

6.75e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 37.60 E-value: 6.75e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  31 LVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMP-EMLVVLTSEKATISFGGCFAQTYFILLFGGT 109
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTA 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129389 110 ECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGI 152
Cdd:cd15304  88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISV 130

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

32-299

7.04e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 37.37 E-value: 7.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  32 VIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFSTTVMPEMLVVLTSEKATISFGGCFAQTYFILLFGGTEC 111
Cdd:cd15206   9 VIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVST 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 112 FLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKinhiscevpavleLACADT 191
Cdd:cd15206  89 FTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGG-------------HKCREV 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 192 FLFEVYSFTGTILLVL----VPFLLILLSYTQILFTvLRMPSTTGRQKAFSTCASHLTSVTLFYSTACMTYLQPKSKYSP 267
Cdd:cd15206 156 WPNEIAEQAWYVFLDLmllvIPGLVMSVAYGLISWT-LLEAKKRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPSAARY 234

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129389 268 DTKKLMSLAY--SLLTPLLNPLIYSLRNKEMKRA 299
Cdd:cd15206 235 VSSTTISLIQllAYISSCVNPITYCFMNKRFRQA 268

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

27-173

7.17e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 37.40 E-value: 7.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  27 FGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMYLFLQNLSVVEASFS-TTVMPEMLVVLTSEKATISFGgCFAQTYF--I 103
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTDIIWRITVEWRAGDFA-CKVIRYLqvV 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 104 LLFGGTecFLLGAMAYDRFAAICYPLTYpmiMSKRIFVKLVVCswvlgimtatvsVTWVFSFPFCGPSKI 173
Cdd:cd15197  83 VTYAST--YVLVALSIDRYDAICHPMNF---SQSGRQARVLIC------------VAWILSALFSIPMLI 135

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

24-223

7.34e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 37.41 E-value: 7.34e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNaTIVTVIFLDH-SLHIPMYLFLQNLSVVEASFSTTVMP-EMLVVLTSEKATISFGgCFAQTY 101
Cdd:cd14992   1 IILGVALVVIILVSVVGN-FIVIAALARHkNLRGATNYFIASLAISDLLMALFCTPfNFTYVVSLSWEYGHFL-CKIVNY 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389 102 FILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPF---CGPSKINHisC 178
Cdd:cd14992  79 LRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLfsvKNQEKIFC--C 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 22129389 179 EVPAVlelacADTFLFEVYSFTGTILLVLVPFLLILLSYTQILFT 223
Cdd:cd14992 157 QIPPV-----DNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRE 196

7tmA_MCHR1

cd15338

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...

24-230

9.25e-03

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320460 [Multi-domain] Cd Length: 282 Bit Score: 37.10 E-value: 9.25e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  24 VHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIPMY---LFLQNLSVVEASFSTTvMPEMLVVLTSEKATiSFGG--CFA 98
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRCQQTvpdIFIFNLSIVDLLFLLG-MPFLIHQLLGNGVW-HFGEtmCTL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  99 QTYFILLFGGTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTATVSVTWVFSFPFCGPSKINHISC 178
Cdd:cd15338  79 ITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLL 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129389 179 EVPAvlelacADTFLFEVYSFtgtILLVLVPFLLILLSYTQILftvLRMPST 230
Cdd:cd15338 159 PNPE------TDTYWFTLYQF---FLAFALPLVVICVVYFKIL---QNMAST 198

PHA02638

CC chemokine receptor-like protein; Provisional

19-255

9.48e-03

CC chemokine receptor-like protein; Provisional

Pssm-ID: 165021 [Multi-domain] Cd Length: 417 Bit Score: 37.30 E-value: 9.48e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   19 FPELQVHMFGAFLVIYLVTLTGNATIVTVIFLDHSLHIP-MYLFlqNLSVVEASFsttvMPEMLVVLTSEKATISFGG-- 95
Cdd:PHA02638  94 YPSISEYIKIFYIIIFILGLFGNAAIIMILFCKKIKTITdIYIF--NLAISDLIF----VIDFPFIIYNEFDQWIFGDfm 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389   96 --CFAQTYFILLFggTECFLLGAMAYDRFAAICYPLTYPMIMSKRIFVKLVVCSWVLGIMTaTVSVTWVF---SFPFCGP 170
Cdd:PHA02638 168 ckVISASYYIGFF--SNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLII-TSPAYFIFeasNIIFSAQ 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129389  171 SKINHISCEVPAVLELACAD--TFLFEVYSFTGTILLVLVPFLLILLSYTQILFTVLRMpsttgrQKAFSTCASHLTSVT 248
Cdd:PHA02638 245 DSNETISNYQCTLIEDNEKNniSFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKQL------KKSKKTKSIIIVSII 318


                 ....*..
gi 22129389  249 LFYSTAC 255
Cdd:PHA02638 319 IICSLIC 325

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01