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Conserved domains on  [gi|159024811|ref|NP_739592|]
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Membrane glycoprotein [dengue virus type 2]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Flavi_M super family cl03065
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a ...
 2-75 1.13e-26

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a membrane-anchored envelope comprised of 3 proteins called C, M and E. The envelope glycoprotein M is translated as a precursor, called prM. The precursor portion of the protein is the signal peptide for the protein's entry into the membrane. prM is cleaved to form M by the proprotein convertase furin in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


The actual alignment was detected with superfamily member pfam01004:

Pssm-ID: 470726  Cd Length: 74  Bit Score: 92.26  E-value: 1.13e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 159024811   2 VALVPHVGMGLETRTETWMSSEGAWKHVQRIETWILRHPGFTMMAAILAYTIGTTHFQRALIFILLTAVTPSMT 75
Cdd:pfam01004  1 VALPPHVGLGLETRTETWMSSRGAWKQLQKVETWALRNPGFTVIALFIAHLIGSSITQKVIIFILLLLVTPAYS 74
 
Name Accession Description Interval E-value
Flavi_M pfam01004
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions ...
 2-75 1.13e-26

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E. The envelope glycoprotein M is made as a precursor, called prM. The precursor portion of the protein is the signal peptide for the proteins entry into the membrane. prM is cleaved to form M in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 460022  Cd Length: 74  Bit Score: 92.26  E-value: 1.13e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 159024811   2 VALVPHVGMGLETRTETWMSSEGAWKHVQRIETWILRHPGFTMMAAILAYTIGTTHFQRALIFILLTAVTPSMT 75
Cdd:pfam01004  1 VALPPHVGLGLETRTETWMSSRGAWKQLQKVETWALRNPGFTVIALFIAHLIGSSITQKVIIFILLLLVTPAYS 74
Flavi_M cd17038
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a ...
 1-74 3.91e-24

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a membrane-anchored envelope comprised of 3 proteins called C, M and E. The envelope glycoprotein M is translated as a precursor, called prM. The precursor portion of the protein is the signal peptide for the protein's entry into the membrane. prM is cleaved to form M by the proprotein convertase furin in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 341208  Cd Length: 75  Bit Score: 85.76  E-value: 3.91e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 159024811  1 SVALVPHVGMGLETRTETWMSSEGAWKHVQRIETWILRHPGFTMMAAILAYTIGTTHFQRALIFILLTAVTPSM 74
Cdd:cd17038   1 SVAIPPHGTGGLTTRKETWLSTSNGKEHLTRVERWVLRNPGYALAAVALAWMLGSSTTQRVIIIVLLLLVAPAY 74
 
Name Accession Description Interval E-value
Flavi_M pfam01004
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions ...
 2-75 1.13e-26

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E. The envelope glycoprotein M is made as a precursor, called prM. The precursor portion of the protein is the signal peptide for the proteins entry into the membrane. prM is cleaved to form M in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 460022  Cd Length: 74  Bit Score: 92.26  E-value: 1.13e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 159024811   2 VALVPHVGMGLETRTETWMSSEGAWKHVQRIETWILRHPGFTMMAAILAYTIGTTHFQRALIFILLTAVTPSMT 75
Cdd:pfam01004  1 VALPPHVGLGLETRTETWMSSRGAWKQLQKVETWALRNPGFTVIALFIAHLIGSSITQKVIIFILLLLVTPAYS 74
Flavi_M cd17038
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a ...
 1-74 3.91e-24

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a membrane-anchored envelope comprised of 3 proteins called C, M and E. The envelope glycoprotein M is translated as a precursor, called prM. The precursor portion of the protein is the signal peptide for the protein's entry into the membrane. prM is cleaved to form M by the proprotein convertase furin in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 341208  Cd Length: 75  Bit Score: 85.76  E-value: 3.91e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 159024811  1 SVALVPHVGMGLETRTETWMSSEGAWKHVQRIETWILRHPGFTMMAAILAYTIGTTHFQRALIFILLTAVTPSM 74
Cdd:cd17038   1 SVAIPPHGTGGLTTRKETWLSTSNGKEHLTRVERWVLRNPGYALAAVALAWMLGSSTTQRVIIIVLLLLVAPAY 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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