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Conserved domains on  [gi|28875793|ref|NP_789861|]
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thrombospondin-2 precursor [Bos taurus]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641979)

thrombospondin type-1 domain-containing protein similar to Plasmodium circumsporozoite protein that is an essential sporozoite protein required for development of malaria sporozoites in mosquitoes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 1.50e-121

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 372.35  E-value: 1.50e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793    972 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793   1052 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 28875793   1132 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 20-215 1.10e-55

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 191.42  E-value: 1.10e-55
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793      20 DQDEDTAFDLFSISNINRKTIGAKqfrgpdPSVPAYRFVRfdyiPPVSAEHLGRITEaMRRKEGFFLTASMKQDRRSRGT 99
Cdd:smart00210    1 GQDLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793     100 LLALEGPgATHRQFEIVSNGPADTLDLTY-WVDGTQHVISLEDVGLADSQWKNVTVQVTGETYSLYVGCDLMDSFALDEP 178
Cdd:smart00210   70 LFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 28875793     179 FYEHLQTERSRMYVTKGAAREsHFRGLLQNVYLVFEN 215
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 320-374 3.30e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 76.69  E-value: 3.30e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 28875793    320 CWQDGRFFAENETWVVDSCTKCTCKKFKTVCHQISCPPATCADPW--FVEGECCPSC 374
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 5.74e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.70  E-value: 5.74e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     495 WSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGGAKEQQMCNRKSCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 2.63e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 73.78  E-value: 2.63e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     438 WSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRSCKGSGRETKACQGPPCP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.43e-11

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 60.12  E-value: 1.43e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 28875793    383 SPWAEWTECSATCGSGTQQRGRSCDVT---SNTCLGPSIQTRACSLGRC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 845-882 2.16e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.91  E-value: 2.16e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 28875793    845 TDVDNDLVGDQCDNneDIDEDGHQNNQDNCPHIPNANQ 882
Cdd:pfam02412    1 TDSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-949 2.54e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.83  E-value: 2.54e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 28875793    919 EDSDGDRRGDACKDDFDNDSIPDIDDVCPEN 949
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 787-821 6.01e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.67  E-value: 6.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 28875793    787 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 821
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 4.21e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 4.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 28875793    650 CKDKTHSCHRHAECIYlghfSDPMYKCECQTGYAGDGLIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 1.50e-121

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 372.35  E-value: 1.50e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793    972 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793   1052 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 28875793   1132 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 20-215 1.10e-55

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 191.42  E-value: 1.10e-55
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793      20 DQDEDTAFDLFSISNINRKTIGAKqfrgpdPSVPAYRFVRfdyiPPVSAEHLGRITEaMRRKEGFFLTASMKQDRRSRGT 99
Cdd:smart00210    1 GQDLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793     100 LLALEGPgATHRQFEIVSNGPADTLDLTY-WVDGTQHVISLEDVGLADSQWKNVTVQVTGETYSLYVGCDLMDSFALDEP 178
Cdd:smart00210   70 LFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 28875793     179 FYEHLQTERSRMYVTKGAAREsHFRGLLQNVYLVFEN 215
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 320-374 3.30e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 76.69  E-value: 3.30e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 28875793    320 CWQDGRFFAENETWVVDSCTKCTCKKFKTVCHQISCPPATCADPW--FVEGECCPSC 374
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 5.74e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.70  E-value: 5.74e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     495 WSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGGAKEQQMCNRKSCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 2.63e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 73.78  E-value: 2.63e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     438 WSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRSCKGSGRETKACQGPPCP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
320-374 1.81e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 68.70  E-value: 1.81e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 28875793     320 CWQDGRFFAENETWVVDSCTKCTCKKFKTV-CHQISCPPAT-CADPW--FVEGECCPSC 374
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 2.40e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.21  E-value: 2.40e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28875793    439 SHWSPWSSCSVTCGVGNVTRIRLCNSPVPqmGGRSCKGSGRETKACQGPPC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 1.00e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 66.29  E-value: 1.00e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28875793    496 SPWSPWSACTVTCAGGIRERTRVCNSPEPqhGGKDCVGGAKEQQMCNRKSC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.43e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 60.12  E-value: 1.43e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 28875793    383 SPWAEWTECSATCGSGTQQRGRSCDVT---SNTCLGPSIQTRACSLGRC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 2.89e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 59.52  E-value: 2.89e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     382 WSPWAEWTECSATCGSGTQQRGRSCDVTSNT-----CLGPSIQTRACSLGRCD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 845-882 2.16e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.91  E-value: 2.16e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 28875793    845 TDVDNDLVGDQCDNneDIDEDGHQNNQDNCPHIPNANQ 882
Cdd:pfam02412    1 TDSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-949 2.54e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.83  E-value: 2.54e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 28875793    919 EDSDGDRRGDACKDDFDNDSIPDIDDVCPEN 949
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 787-821 6.01e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.67  E-value: 6.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 28875793    787 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 821
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 4.21e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 4.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 28875793    650 CKDKTHSCHRHAECIYlghfSDPMYKCECQTGYAGDGLIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 94-211 8.89e-04

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 40.48  E-value: 8.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793     94 RRSRGTLLALEGPGATHRQFEIVsNGpadTLDLTYWVDGTQHVISLEDVGLADSQWKNVTVQVTGETYSLYVgCDLMDSF 173
Cdd:pfam02210    4 RQPNGLLLYAGGGGSDFLALELV-NG---RLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV-DGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 28875793    174 ALDEPFYEHLQTERSrMYV--------TKGAARESHFRGLLQNVYL 211
Cdd:pfam02210   79 SLPPGESLLLNLNGP-LYLgglpplllLPALPVRAGFVGCIRDVRV 123
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 497-549 4.09e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.10  E-value: 4.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 28875793   497 PWSPWSACTVTCAGGIRERTRvcnspEPQHGGkdCVGGAKEQqmCNRKSCPID 549
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR-----PILHEG--CTTHMVEE--CEEEECPVE 285
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 384-404 6.05e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.72  E-value: 6.05e-03
                          10        20
                  ....*....|....*....|.
gi 28875793   384 PWAEWTECSATCGSGTQQRGR 404
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR 262
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 1.50e-121

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 372.35  E-value: 1.50e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793    972 QIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793   1052 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 28875793   1132 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 20-215 1.10e-55

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 191.42  E-value: 1.10e-55
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793      20 DQDEDTAFDLFSISNINRKTIGAKqfrgpdPSVPAYRFVRfdyiPPVSAEHLGRITEaMRRKEGFFLTASMKQDRRSRGT 99
Cdd:smart00210    1 GQDLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGV 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793     100 LLALEGPgATHRQFEIVSNGPADTLDLTY-WVDGTQHVISLEDVGLADSQWKNVTVQVTGETYSLYVGCDLMDSFALDEP 178
Cdd:smart00210   70 LFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 28875793     179 FYEHLQTERSRMYVTKGAAREsHFRGLLQNVYLVFEN 215
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 320-374 3.30e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 76.69  E-value: 3.30e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 28875793    320 CWQDGRFFAENETWVVDSCTKCTCKKFKTVCHQISCPPATCADPW--FVEGECCPSC 374
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 5.74e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.70  E-value: 5.74e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     495 WSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGGAKEQQMCNRKSCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 2.63e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 73.78  E-value: 2.63e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     438 WSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRSCKGSGRETKACQGPPCP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
320-374 1.81e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 68.70  E-value: 1.81e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 28875793     320 CWQDGRFFAENETWVVDSCTKCTCKKFKTV-CHQISCPPAT-CADPW--FVEGECCPSC 374
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 2.40e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.21  E-value: 2.40e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28875793    439 SHWSPWSSCSVTCGVGNVTRIRLCNSPVPqmGGRSCKGSGRETKACQGPPC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 1.00e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 66.29  E-value: 1.00e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28875793    496 SPWSPWSACTVTCAGGIRERTRVCNSPEPqhGGKDCVGGAKEQQMCNRKSC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.43e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 60.12  E-value: 1.43e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 28875793    383 SPWAEWTECSATCGSGTQQRGRSCDVT---SNTCLGPSIQTRACSLGRC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 2.89e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 59.52  E-value: 2.89e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 28875793     382 WSPWAEWTECSATCGSGTQQRGRSCDVTSNT-----CLGPSIQTRACSLGRCD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 439-489 9.25e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 55.36  E-value: 9.25e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28875793    439 SHWSPWSSCSVTCGVGNVTRIRLCNSPvPQMGGRSCkGSGRETKACQGPPC 489
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 496-546 1.71e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 54.59  E-value: 1.71e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 28875793    496 SPWSPWSACTVTCAGGIRERTRVCNSPePQHGGKDCvgGAKEQQM-CNRKSC 546
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC--PELLERRpCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 845-882 2.16e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.91  E-value: 2.16e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 28875793    845 TDVDNDLVGDQCDNneDIDEDGHQNNQDNCPHIPNANQ 882
Cdd:pfam02412    1 TDSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-949 2.54e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 50.83  E-value: 2.54e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 28875793    919 EDSDGDRRGDACKDDFDNDSIPDIDDVCPEN 949
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 787-821 6.01e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.67  E-value: 6.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 28875793    787 DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQ 821
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 383-428 6.12e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 47.27  E-value: 6.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 28875793    383 SPWAEWTECSATCGSGTQQR-----------GRSCdvtsntclGPSIQTRACSLGRC 428
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPC--------PELLERRPCNLPPC 52
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 4.21e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 4.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 28875793    650 CKDKTHSCHRHAECIYlghfSDPMYKCECQTGYAGDGLIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 500-546 1.64e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.51  E-value: 1.64e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28875793    500 PWSACTVTCAGGIRERTRVCNSPEPQ--HGGKDCVGGAK--EQQMCNRKSC 546
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 443-489 1.90e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.51  E-value: 1.90e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28875793    443 PWSSCSVTCGVGNVTRIRLCNSPVPQ--MGGRSCKGSGR--ETKACQGPPC 489
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 94-211 8.89e-04

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 40.48  E-value: 8.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28875793     94 RRSRGTLLALEGPGATHRQFEIVsNGpadTLDLTYWVDGTQHVISLEDVGLADSQWKNVTVQVTGETYSLYVgCDLMDSF 173
Cdd:pfam02210    4 RQPNGLLLYAGGGGSDFLALELV-NG---RLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV-DGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 28875793    174 ALDEPFYEHLQTERSrMYV--------TKGAARESHFRGLLQNVYL 211
Cdd:pfam02210   79 SLPPGESLLLNLNGP-LYLgglpplllLPALPVRAGFVGCIRDVRV 123
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 442-489 2.68e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 36.93  E-value: 2.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 28875793    442 SPWSSCSVTCGVGNVTRIRLCNspvpqmggRSCKgSGRETKACQGPPC 489
Cdd:pfam19035    6 TEWSPCSKTCGMGVSTRVSNDN--------AECK-LVTETRLCQLRPC 44
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 497-549 4.09e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.10  E-value: 4.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 28875793   497 PWSPWSACTVTCAGGIRERTRvcnspEPQHGGkdCVGGAKEQqmCNRKSCPID 549
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR-----PILHEG--CTTHMVEE--CEEEECPVE 285
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 384-404 6.05e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.72  E-value: 6.05e-03
                          10        20
                  ....*....|....*....|.
gi 28875793   384 PWAEWTECSATCGSGTQQRGR 404
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSR 262
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 388-428 6.79e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.89  E-value: 6.79e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 28875793    388 WTECSATCGSGTQQR--------------GRSCDVTSNtclgPSIqTRACSLGRC 428
Cdd:pfam19030    6 WGECSVTCGGGVQTRlvqcvqkgggsivpDSECSAQKK----PPE-TQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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