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Conserved domains on  [gi|110347495|ref|NP_796067|]
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leucine-rich repeat-containing protein 58 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-242 5.06e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 5.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  60 GGFPHLQLLDVSGNsltalgPELLTLSGLRTLLARNNRLGgpgSLPKGLAQsplCRSLQVLNLSGNCFQELPASLLELRA 139
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLT---DLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 140 LQTLSLGGNQLQSIPAEIENLRSLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSVPPQLSQLHSLRSLSLHNNLL 219
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180
                 ....*....|....*....|...
gi 110347495 220 TYLPrEILNLIHLEELSLRGNPL 242
Cdd:COG4886  241 TDLP-ELGNLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-242 5.06e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 5.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  60 GGFPHLQLLDVSGNsltalgPELLTLSGLRTLLARNNRLGgpgSLPKGLAQsplCRSLQVLNLSGNCFQELPASLLELRA 139
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLT---DLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 140 LQTLSLGGNQLQSIPAEIENLRSLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSVPPQLSQLHSLRSLSLHNNLL 219
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180
                 ....*....|....*....|...
gi 110347495 220 TYLPrEILNLIHLEELSLRGNPL 242
Cdd:COG4886  241 TDLP-ELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-242 6.40e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 88.37  E-value: 6.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  61 GFPHLQLLDVSGNSLTALGPE--LLTLSGLRTLLARNNRLGGP---GSLP--------------KGLAQSPLCRSLQVLN 121
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGSiprGSIPnletldlsnnmlsgEIPNDIGSFSSLKVLD 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 122 LSGNCFQ-ELPASLLELRALQTLSLGGNQLQ-SIPAEIENLRSLECLYLG-GNFIKEIPPELANLPSLNYLVLC-DNKIQ 197
Cdd:PLN00113 171 LGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHLDLVyNNLTG 250

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 110347495 198 SVPPQLSQLHSLRSLSLHNNLLT-YLPREILNLIHLEELSLRGNPL 242
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-242 4.30e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 4.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 113 LCRSLQVLNLSGNCFQELPaSLLELRALQTLSLGGNQLQSIPaEIENLRSLECLYLGGNFIKEI---------------- 176
Cdd:cd21340   22 LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVeglenltnleelhien 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 177 ---PPE---------LANL-PSLNYLVLCDNKIQSVPPqLSQLHSLRSLSLHNNLLTYLpREILNLI----HLEELSLRG 239
Cdd:cd21340  100 qrlPPGekltfdprsLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL-EELLDLLsswpSLRELDLTG 177


                 ...
gi 110347495 240 NPL 242
Cdd:cd21340  178 NPV 180
LRR_8 pfam13855
Leucine rich repeat;
161-219 1.18e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110347495  161 RSLECLYLGGNFIKEIPPE-LANLPSLNYLVLCDNKIQSVPPQ-LSQLHSLRSLSLHNNLL 219
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-242 5.06e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 5.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  60 GGFPHLQLLDVSGNsltalgPELLTLSGLRTLLARNNRLGgpgSLPKGLAQsplCRSLQVLNLSGNCFQELPASLLELRA 139
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLT---DLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 140 LQTLSLGGNQLQSIPAEIENLRSLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSVPPQLSQLHSLRSLSLHNNLL 219
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180
                 ....*....|....*....|...
gi 110347495 220 TYLPrEILNLIHLEELSLRGNPL 242
Cdd:COG4886  241 TDLP-ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-290 1.54e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 1.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  48 YNRLTSLPRALGGgFPHLQLLDVSGNSLTALGPELLTLSGLRTLLARNNRLGgpgSLPKGLAQsplCRSLQVLNLSGNCF 127
Cdd:COG4886  122 GNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT---DLPEELGN---LTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 128 QELPASLLELRALQTLSLGGNQLQSIPAEIENLRSLECLYLGGNFIKEIPpELANLPSLNYLVLCDNKIQSVPPqLSQLH 207
Cdd:COG4886  195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLT 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 208 SLRSLSLHNNLLTylpreILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRSISYTPYDLPGNLLRYLGS 287
Cdd:COG4886  273 NLKTLDLSNNQLT-----DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347


                 ...
gi 110347495 288 ASN 290
Cdd:COG4886  348 ALL 350
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-242 1.43e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 1.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 120 LNLSGNCFQELPASLLELRALQTLSLGGNQlqsipaEIENLRSLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSV 199
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 110347495 200 PPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 242
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-242 6.40e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 88.37  E-value: 6.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  61 GFPHLQLLDVSGNSLTALGPE--LLTLSGLRTLLARNNRLGGP---GSLP--------------KGLAQSPLCRSLQVLN 121
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGSiprGSIPnletldlsnnmlsgEIPNDIGSFSSLKVLD 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 122 LSGNCFQ-ELPASLLELRALQTLSLGGNQLQ-SIPAEIENLRSLECLYLG-GNFIKEIPPELANLPSLNYLVLC-DNKIQ 197
Cdd:PLN00113 171 LGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHLDLVyNNLTG 250

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 110347495 198 SVPPQLSQLHSLRSLSLHNNLLT-YLPREILNLIHLEELSLRGNPL 242
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-242 2.31e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.66  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  62 FPHLQLLDVSGNSLTA-LGPELLTLSGLRTLLARNNRLGGPgsLPKGLaqSPLCRSLQVLNLSGNCFQ-ELPASLLELra 139
Cdd:PLN00113  68 SSRVVSIDLSGKNISGkISSAIFRLPYIQTINLSNNQLSGP--IPDDI--FTTSSSLRYLNLSNNNFTgSIPRGSIPN-- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 140 LQTLSLGGNQLQ-SIPAEIENLRSLECLYLGGNFIK-EIPPELANLPSLNYLVLCDNK-IQSVPPQLSQLHSLRSLSL-H 215
Cdd:PLN00113 142 LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLgY 221

                        170       180
                 ....*....|....*....|....*..
gi 110347495 216 NNLLTYLPREILNLIHLEELSLRGNPL 242
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNL 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-242 4.30e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 4.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 113 LCRSLQVLNLSGNCFQELPaSLLELRALQTLSLGGNQLQSIPaEIENLRSLECLYLGGNFIKEI---------------- 176
Cdd:cd21340   22 LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVeglenltnleelhien 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 177 ---PPE---------LANL-PSLNYLVLCDNKIQSVPPqLSQLHSLRSLSLHNNLLTYLpREILNLI----HLEELSLRG 239
Cdd:cd21340  100 qrlPPGekltfdprsLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL-EELLDLLsswpSLRELDLTG 177


                 ...
gi 110347495 240 NPL 242
Cdd:cd21340  178 NPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
49-290 1.77e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.57  E-value: 1.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  49 NRLTSLPRALGGgfpHLQLLDVSGNSLTALgPELLTLSGLRTLLARNNRLGGPGSLPKglaqsplcrSLQVLNLSGNCFQ 128
Cdd:PRK15370 209 NELKSLPENLQG---NIKTLYANSNQLTSI-PATLPDTIQEMELSINRITELPERLPS---------ALQSLDLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 129 ELPASLLElrALQTLSLGGNQLQSIPAEIENlrSLECLYLGGNFIKEIPPELAnlPSLNYLVLCDNKIQSVPPQLSQlhS 208
Cdd:PRK15370 276 CLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLPP--E 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 209 LRSLSLHNNLLTYLPREIlnlihleelslrgnplvvrfvrdltydPPTLLELaarTIKIRSISYTPYDLPGnLLRYLGSA 288
Cdd:PRK15370 348 LQVLDVSKNQITVLPETL---------------------------PPTITTL---DVSRNALTNLPENLPA-ALQIMQAS 396


                 ..
gi 110347495 289 SN 290
Cdd:PRK15370 397 RN 398
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
49-254 2.93e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 67.88  E-value: 2.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  49 NRLTSLPRALgggfPHLQLLDVSGNSLTALgPELLtlSGLRTLLARNNRLGGPGSLPKGLaqsplcrslQVLNLSGNCFQ 128
Cdd:PRK15387 292 NQLTSLPVLP----PGLQELSVSDNQLASL-PALP--SELCKLWAYNNQLTSLPTLPSGL---------QELSVSDNQLA 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 129 ELPASLLELRALQTLSlggNQLQSIPAEIENLRSLeclYLGGNFIKEIPPelanLPS-LNYLVLCDNKIQSVPPQLSqlh 207
Cdd:PRK15387 356 SLPTLPSELYKLWAYN---NRLTSLPALPSGLKEL---IVSGNRLTSLPV----LPSeLKELMVSGNRLTSLPMLPS--- 422

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 110347495 208 SLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL---VVRFVRDLTYDP 254
Cdd:PRK15387 423 GLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLserTLQALREITSAP 472
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-267 3.80e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 3.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  48 YNRLTSLPRALGGgFPHLQLLDVSGNSLTALGPELLTLSGLRTLLARNNRLGgpgSLPkGLAQSPlcrSLQVLNLSGNCF 127
Cdd:COG4886  191 NNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT---DLP-ELGNLT---NLEELDLSNNQL 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 128 QELPaSLLELRALQTLSLGGNQLQSIpaEIENLRSLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSVPPQLSQLH 207
Cdd:COG4886  263 TDLP-PLANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 208 SLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKI 267
Cdd:COG4886  340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
48-208 1.01e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.18  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  48 YNRLTSLPRALGGGfphLQLLDVSGNSLTALgPELLTlSGLRTLLARNNRLGG-PGSLPKGlaqsplcrsLQVLNLSGNC 126
Cdd:PRK15370 271 HNKISCLPENLPEE---LRYLSVYDNSIRTL-PAHLP-SGITHLNVQSNSLTAlPETLPPG---------LKTLEAGENA 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 127 FQELPASLLElrALQTLSLGGNQLQSIPAEIENlrSLECLYLGGNFIKEIPpelANLP-SLNYLVLCDNKIQSVPPQLSQ 205
Cdd:PRK15370 337 LTSLPASLPP--ELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLP---ENLPaALQIMQASRNNLVRLPESLPH 409


                 ...
gi 110347495 206 LHS 208
Cdd:PRK15370 410 FRG 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 51-242 4.35e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 4.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  51 LTSLPR---------ALGGGFP-------HLQLLDVSGNSLTALGPELLTLSG-LRTLLARNNRLggPGSLPKGLAQspl 113
Cdd:PLN00113 328 LTSLPRlqvlqlwsnKFSGEIPknlgkhnNLTVLDLSTNNLTGEIPEGLCSSGnLFKLILFSNSL--EGEIPKSLGA--- 402

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 114 CRSLQVLNLSGNCFQ-ELPASLLELRALQTLSLGGNQLQ-SIPAEIENLRSLECLYLGGN-------------------- 171
Cdd:PLN00113 403 CRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNkffgglpdsfgskrlenldl 482

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110347495 172 ----FIKEIPPELANLPSLNYLVLCDNKIQSV-PPQLSQLHSLRSLSL-HNNLLTYLPREILNLIHLEELSLRGNPL 242
Cdd:PLN00113 483 srnqFSGAVPRKLGSLSELMQLKLSENKLSGEiPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 68-237 3.06e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 55.65  E-value: 3.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495   68 LDVSGNSLTALGPELLTLSGLRTLLARnnrlggpGSlpKGLAQSP---LCRSLQVLNLSgNC--FQELPASLLELRALQT 142
Cdd:PLN03210  616 LQMQGSKLEKLWDGVHSLTGLRNIDLR-------GS--KNLKEIPdlsMATNLETLKLS-DCssLVELPSSIQYLNKLED 685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  143 LSLGG-NQLQSIPAEIeNLRSLECL---------------------YLGGNFIKEIPPELaNLPSLNYLVLCDNK----- 195
Cdd:PLN03210  686 LDMSRcENLEILPTGI-NLKSLYRLnlsgcsrlksfpdistniswlDLDETAIEEFPSNL-RLENLDELILCEMKseklw 763

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 110347495  196 --IQSVPPQLSQL-HSLRSLSLHNN-LLTYLPREILNLIHLEELSL 237
Cdd:PLN03210  764 erVQPLTPLMTMLsPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEI 809
PLN03150 PLN03150
hypothetical protein; Provisional
 153-220 4.37e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.82  E-value: 4.37e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 153 IPAEIENLRSLECLYLGGNFIK-EIPPELANLPSLNYLVLCDNKIQ-SVPPQLSQLHSLRSLSLHNNLLT 220
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-242 5.31e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 5.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  48 YNRLT-SLPRALGGgFPHLQLLDVSGNSLTA-LGPELLTLSGLRTLLARNNRLGGPgslpkglaqsplcrslqvlnlsgn 125
Cdd:PLN00113 221 YNNLSgEIPYEIGG-LTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSGP------------------------ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 126 cfqeLPASLLELRALQTLSLGGNQLQ-SIPAEIENLRSLECLYL-GGNFIKEIPPELANLPSLNYLVLCDNKIQ-SVPPQ 202
Cdd:PLN00113 276 ----IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKN 351

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 110347495 203 LSQLHSLRSLSLHNNLLT-YLPREILNLIHLEELSLRGNPL 242
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSL 392
LRR_8 pfam13855
Leucine rich repeat;
161-219 1.18e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110347495  161 RSLECLYLGGNFIKEIPPE-LANLPSLNYLVLCDNKIQSVPPQ-LSQLHSLRSLSLHNNLL 219
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
184-242 2.29e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.29e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110347495  184 PSLNYLVLCDNKIQSVPPQ-LSQLHSLRSLSLHNNLLTYL-PREILNLIHLEELSLRGNPL 242
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 115-184 4.01e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.66  E-value: 4.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110347495 115 RSLQVLNLSGNCFQ-ELPASLLELRALQTLSLGGNQLQ-SIPAEIENLRSLECLYLGGNFIK-EIPPELANLP 184
Cdd:PLN03150 442 RHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
LRR_8 pfam13855
Leucine rich repeat;
138-196 2.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110347495  138 RALQTLSLGGNQLQSIPAEI-ENLRSLECLYLGGNFIKEIPPE-LANLPSLNYLVLCDNKI 196
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 64-134 6.75e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 6.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110347495  64 HLQLLDVSGNSLT-ALGPELLTLSGLRTLLARNNRLGgpGSLPKGLAQsplCRSLQVLNLSGNCFQ-ELPASL 134
Cdd:PLN03150 443 HLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN--GSIPESLGQ---LTSLRILNLNGNSLSgRVPAAL 510
LRR_8 pfam13855
Leucine rich repeat;
115-171 1.65e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 110347495  115 RSLQVLNLSGNCFQELPASLLE-LRALQTLSLGGNQLQSI-PAEIENLRSLECLYLGGN 171
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 54-206 3.06e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  54 LPRALGGGFPHLQLLDVSGNSLT-----ALGPELLTLSGLRTLLARNNRLGGPG--SLPKGLAQSPlcrSLQVLNLSGNC 126
Cdd:cd00116  128 LAKGLKDLPPALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGIGDAGirALAEGLKANC---NLEVLDLNNNG 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 127 FQELPASLLE-----LRALQTLSLGGNQLQSI------PAEIENLRSLECLYLGGNFIKEIPPE-----LANLPSLNYLV 190
Cdd:cd00116  205 LTDEGASALAetlasLKSLEVLNLGDNNLTDAgaaalaSALLSPNISLLTLSLSCNDITDDGAKdlaevLAEKESLLELD 284

                        170
                 ....*....|....*.
gi 110347495 191 LCDNKIQSVPPQLSQL 206
Cdd:cd00116  285 LRGNKFGEEGAQLLAE 300
LRR_8 pfam13855
Leucine rich repeat;
48-98 3.62e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 110347495   48 YNRLTSLPRALGGGFPHLQLLDVSGNSLTALGPELLT-LSGLRTLLARNNRL 98
Cdd:pfam13855  10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-163 1.36e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  60 GGFP------HLQLLDVSGNSLTALGPE-LLTLSGLRTLLARNNRLGGpgSLPKGLAQsplCRSLQVLNLSGNCFQ-ELP 131
Cdd:PLN00113 466 GGLPdsfgskRLENLDLSRNQFSGAVPRkLGSLSELMQLKLSENKLSG--EIPDELSS---CKKLVSLDLSHNQLSgQIP 540

                         90       100       110
                 ....*....|....*....|....*....|...
gi 110347495 132 ASLLELRALQTLSLGGNQLQ-SIPAEIENLRSL 163
Cdd:PLN00113 541 ASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
63-150 1.38e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495   63 PHLQLLDVSGNSLTALGPEllTLSGLrtllarnnrlggpgslpkglaqsplcRSLQVLNLSGNCFQEL-PASLLELRALQ 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG--AFKGL--------------------------SNLKVLDLSNNLLTTLsPGAFSGLPSLR 52


                  ....*....
gi 110347495  142 TLSLGGNQL 150
Cdd:pfam13855  53 YLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-217 1.84e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495  49 NRLTSLPRALGGGFPHLQLLDVSGNSLTALG-PELLTLSGLRTLLARNNRLGGPG--SLPKGLAQSPLCRSLQvlnLSGN 125
Cdd:COG5238  142 NLIQVLKDPLGGNAVHLLGLAARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGieELAEALTQNTTVTTLW---LKRN 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347495 126 CFQELPAS-----LLELRALQTLSLGGNQL--QSIPAEIENL---RSLECLYLGGNFIKE-----IPPELANLPSLNYLV 190
Cdd:COG5238  219 PIGDEGAEilaeaLKGNKSLTTLDLSNNQIgdEGVIALAEALknnTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLD 298

                        170       180       190
                 ....*....|....*....|....*....|..
gi 110347495 191 LCDNKI-----QSVPPQLSQLHSLRSLSLHNN 217
Cdd:COG5238  299 LSVNRIgdegaIALAEGLQGNKTLHTLNLAYN 330
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 184-217 9.73e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 9.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 110347495  184 PSLNYLVLCDNKIQSVPPqLSQLHSLRSLSLHNN 217
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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