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Conserved domains on  [gi|29566788|ref|NP_818352|]
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HNH endonuclease [Mycobacterium phage Omega]

Protein Classification

NUMOD4 motif-containing HNH endonuclease( domain architecture ID 10538565)

NUMOD4 motif-containing HNH endonuclease with an HNH endonuclease domain similar to Escherichia phage T5 endodeoxyribonuclease F-TflII, which cleaves only one strand of asymmetric DNA substrates thereby introducing interruptions into the template or coding strand

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUMOD4 pfam07463
NUMOD4 motif; NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related ...
 37-91 4.19e-11

NUMOD4 motif; NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related proteins.


:

Pssm-ID: 462171  Cd Length: 52  Bit Score: 56.19  E-value: 4.19e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 29566788    37 EEWRPAPGYEGLYEVSSHGRVRSLDRTVptrRHPGGvRKLRGCLLKPSPSKYGHL 91
Cdd:pfam07463   1 EIWKPIPGYEGKYEVSNLGRVRSVDRVT---RSIKG-KILKPTLNKTNGYLRVTL 51
HNH_3 pfam13392
HNH endonuclease; This is a zinc-binding loop of Fold group 7 as found in ...
 104-141 1.20e-08

HNH endonuclease; This is a zinc-binding loop of Fold group 7 as found in endo-deoxy-ribonucleases and HNH nucleases.


:

Pssm-ID: 433169  Cd Length: 46  Bit Score: 49.13  E-value: 1.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 29566788   104 EYIHHLVMLAFSGPRPEGMLVCHNDGDPTNNRLDNLRW 141
Cdd:pfam13392   1 KYAHRVAWELHNGPIPDGMVVDHIDGDRRNNRPENLRL 38
 
Name Accession Description Interval E-value
NUMOD4 pfam07463
NUMOD4 motif; NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related ...
 37-91 4.19e-11

NUMOD4 motif; NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related proteins.


Pssm-ID: 462171  Cd Length: 52  Bit Score: 56.19  E-value: 4.19e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 29566788    37 EEWRPAPGYEGLYEVSSHGRVRSLDRTVptrRHPGGvRKLRGCLLKPSPSKYGHL 91
Cdd:pfam07463   1 EIWKPIPGYEGKYEVSNLGRVRSVDRVT---RSIKG-KILKPTLNKTNGYLRVTL 51
HNH_3 pfam13392
HNH endonuclease; This is a zinc-binding loop of Fold group 7 as found in ...
 104-141 1.20e-08

HNH endonuclease; This is a zinc-binding loop of Fold group 7 as found in endo-deoxy-ribonucleases and HNH nucleases.


Pssm-ID: 433169  Cd Length: 46  Bit Score: 49.13  E-value: 1.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 29566788   104 EYIHHLVMLAFSGPRPEGMLVCHNDGDPTNNRLDNLRW 141
Cdd:pfam13392   1 KYAHRVAWELHNGPIPDGMVVDHIDGDRRNNRPENLRL 38
 
Name Accession Description Interval E-value
NUMOD4 pfam07463
NUMOD4 motif; NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related ...
 37-91 4.19e-11

NUMOD4 motif; NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related proteins.


Pssm-ID: 462171  Cd Length: 52  Bit Score: 56.19  E-value: 4.19e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 29566788    37 EEWRPAPGYEGLYEVSSHGRVRSLDRTVptrRHPGGvRKLRGCLLKPSPSKYGHL 91
Cdd:pfam07463   1 EIWKPIPGYEGKYEVSNLGRVRSVDRVT---RSIKG-KILKPTLNKTNGYLRVTL 51
HNH_3 pfam13392
HNH endonuclease; This is a zinc-binding loop of Fold group 7 as found in ...
 104-141 1.20e-08

HNH endonuclease; This is a zinc-binding loop of Fold group 7 as found in endo-deoxy-ribonucleases and HNH nucleases.


Pssm-ID: 433169  Cd Length: 46  Bit Score: 49.13  E-value: 1.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 29566788   104 EYIHHLVMLAFSGPRPEGMLVCHNDGDPTNNRLDNLRW 141
Cdd:pfam13392   1 KYAHRVAWELHNGPIPDGMVVDHIDGDRRNNRPENLRL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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