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Conserved domains on  [gi|34610123|ref|NP_919037|]
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B2 protein [Macrobrachium rosenbergii nodavirus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
B2 super family cl12995
RNA binding protein B2; B2 is expressed by the insect Flock House virus (FHV) as a ...
 14-87 2.25e-03

RNA binding protein B2; B2 is expressed by the insect Flock House virus (FHV) as a counter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cleavage of it by Dicer. B2 blocks cleavage of the FHV genome by Dicer and also the incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.


The actual alignment was detected with superfamily member pfam11473:

Pssm-ID: 314404  Cd Length: 72  Bit Score: 34.66  E-value: 2.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34610123    14 QSTYELVQQFPrclSQVCQAVKTAIDSLPTCQDPKVAKDLSSYKACLSKMEATAFNATDNLLSKPRVVATLKGE 87
Cdd:pfam11473   2 PSKLALIQELP---DRIQTAVEAAMGMSYQDAPNNVRRDLDNLHACLNKAKLTVNRMVTSLLEKPSVVAYLEGK 72
 
Name Accession Description Interval E-value
B2 pfam11473
RNA binding protein B2; B2 is expressed by the insect Flock House virus (FHV) as a ...
 14-87 2.25e-03

RNA binding protein B2; B2 is expressed by the insect Flock House virus (FHV) as a counter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cleavage of it by Dicer. B2 blocks cleavage of the FHV genome by Dicer and also the incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.


Pssm-ID: 314404  Cd Length: 72  Bit Score: 34.66  E-value: 2.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34610123    14 QSTYELVQQFPrclSQVCQAVKTAIDSLPTCQDPKVAKDLSSYKACLSKMEATAFNATDNLLSKPRVVATLKGE 87
Cdd:pfam11473   2 PSKLALIQELP---DRIQTAVEAAMGMSYQDAPNNVRRDLDNLHACLNKAKLTVNRMVTSLLEKPSVVAYLEGK 72
 
Name Accession Description Interval E-value
B2 pfam11473
RNA binding protein B2; B2 is expressed by the insect Flock House virus (FHV) as a ...
 14-87 2.25e-03

RNA binding protein B2; B2 is expressed by the insect Flock House virus (FHV) as a counter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cleavage of it by Dicer. B2 blocks cleavage of the FHV genome by Dicer and also the incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.


Pssm-ID: 314404  Cd Length: 72  Bit Score: 34.66  E-value: 2.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34610123    14 QSTYELVQQFPrclSQVCQAVKTAIDSLPTCQDPKVAKDLSSYKACLSKMEATAFNATDNLLSKPRVVATLKGE 87
Cdd:pfam11473   2 PSKLALIQELP---DRIQTAVEAAMGMSYQDAPNNVRRDLDNLHACLNKAKLTVNRMVTSLLEKPSVVAYLEGK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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