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Conserved domains on  [gi|168986655|ref|NP_919263|]
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leucine-rich repeat-containing protein 74A isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-356 3.39e-45

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 163.81  E-value: 3.39e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655  92 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 171
Cdd:COG5238  167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 172 HLGLEGARIISDFFERNsSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 251
Cdd:COG5238  247 QIGDEGVIALAEALKNN-TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 252 DLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNeS 331
Cdd:COG5238  326 NLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-R 404

                        250       260
                 ....*....|....*....|....*
gi 168986655 332 LRVLKLFLNPINMDGAILLILAIKR 356
Cdd:COG5238  405 LHTLILDGNLIGAEAQQRLEQLLER 429
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-356 3.39e-45

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 163.81  E-value: 3.39e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655  92 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 171
Cdd:COG5238  167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 172 HLGLEGARIISDFFERNsSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 251
Cdd:COG5238  247 QIGDEGVIALAEALKNN-TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 252 DLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNeS 331
Cdd:COG5238  326 NLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-R 404

                        250       260
                 ....*....|....*....|....*
gi 168986655 332 LRVLKLFLNPINMDGAILLILAIKR 356
Cdd:COG5238  405 LHTLILDGNLIGAEAQQRLEQLLER 429
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-368 1.87e-32

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 125.93  E-value: 1.87e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 112 LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVlSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSS 191
Cdd:cd00116   60 LNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPA 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 192 IWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLsWNNFHTR-GAVALCNGL 270
Cdd:cd00116  139 LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDL-NNNGLTDeGASALAETL 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 271 RGNVTLTKLDLSMNGFGNEVALALGEVLR-LNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297

                        250       260
                 ....*....|....*....|.
gi 168986655 350 L--ILAIKRNPKSRMEELDIS 368
Cdd:cd00116  298 LaeSLLEPGNELESLWVKDDS 318
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 188-340 6.63e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 6.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 188 NSSSIWSLELSGndfKEDSAALLCQALSTNYqIKKLDLSHNQFSdvgGEHLGQMLAINVGLTSLDLSWNNFH---TRGAV 264
Cdd:PLN00113  67 NSSRVVSIDLSG---KNISGKISSAIFRLPY-IQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNNFTgsiPRGSI 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 168986655 265 ALcnglrgnvtLTKLDLSMNGFGNEVALALGEVLRLNrclvYLDIGGNDIgnegASKISKGLESNESLRVLKLFLN 340
Cdd:PLN00113 140 PN---------LETLDLSNNMLSGEIPNDIGSFSSLK----VLDLGGNVL----VGKIPNSLTNLTSLEFLTLASN 198
LRR_6 pfam13516
Leucine Rich repeat;
301-323 9.78e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.44  E-value: 9.78e-04
                          10        20
                  ....*....|....*....|...
gi 168986655  301 NRCLVYLDIGGNDIGNEGASKIS 323
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-356 3.39e-45

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 163.81  E-value: 3.39e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655  92 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 171
Cdd:COG5238  167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 172 HLGLEGARIISDFFERNsSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 251
Cdd:COG5238  247 QIGDEGVIALAEALKNN-TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 252 DLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNeS 331
Cdd:COG5238  326 NLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-R 404

                        250       260
                 ....*....|....*....|....*
gi 168986655 332 LRVLKLFLNPINMDGAILLILAIKR 356
Cdd:COG5238  405 LHTLILDGNLIGAEAQQRLEQLLER 429
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 125-368 6.20e-38

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 143.78  E-value: 6.20e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 125 IAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE--NYYLQEMNISNNHLGLEGARIISDFFERNsSSIWSLELSGNDF 202
Cdd:COG5238  142 NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKAlqNNSVETVYLGCNQIGDEGIEELAEALTQN-TTVTTLWLKRNPI 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 203 KEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLS 282
Cdd:COG5238  221 GDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 283 MNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRm 362
Cdd:COG5238  301 VNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLR- 379


                 ....*.
gi 168986655 363 eELDIS 368
Cdd:COG5238  380 -ELNLG 384
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 116-332 1.54e-36

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 139.93  E-value: 1.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 116 GLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSsIWSL 195
Cdd:COG5238  219 PIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTT-LTSL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 196 ELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVT 275
Cdd:COG5238  298 DLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTT 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 168986655 276 LTKLDLSMNGFGNEVALALGEVLRLNRcLVYLDIGGNDIGNEGASKISKGLESNESL 332
Cdd:COG5238  378 LRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIKSV 433
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 171-390 3.12e-34

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 133.38  E-value: 3.12e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 171 NHLGLEGAriISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTS 250
Cdd:COG5238  163 ARLGLLAA--ISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 251 LDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNE 330
Cdd:COG5238  241 LDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 331 SLRVLKLFLNPINMDGAILLILAIKRNPKsrMEELDISNVLVSEQFMKTLDGVYAVHPQL 390
Cdd:COG5238  321 TLHTLNLAYNGIGAQGAIALAKALQENTT--LHSLDLSDNQIGDEGAIALAKYLEGNTTL 378
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-368 1.87e-32

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 125.93  E-value: 1.87e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 112 LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVlSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSS 191
Cdd:cd00116   60 LNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPA 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 192 IWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLsWNNFHTR-GAVALCNGL 270
Cdd:cd00116  139 LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDL-NNNGLTDeGASALAETL 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 271 RGNVTLTKLDLSMNGFGNEVALALGEVLR-LNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297

                        250       260
                 ....*....|....*....|.
gi 168986655 350 L--ILAIKRNPKSRMEELDIS 368
Cdd:cd00116  298 LaeSLLEPGNELESLWVKDDS 318
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 102-368 1.59e-30

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 120.54  E-value: 1.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 102 IRNMEEsyVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCI--MEEGVLSLVEMLQENYYLQEMNISNNHLGLEGAR 179
Cdd:cd00116   22 LLCLQV--LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 180 IISDFfeRNSSSIWSLELSGNDFKEDSAALLCQAL-STNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNF 258
Cdd:cd00116  100 VLESL--LRSSSLQELKLNNNGLGDRGLRLLAKGLkDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 259 HTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLES-NESLRVLKL 337
Cdd:cd00116  178 GDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSL 257

                        250       260       270
                 ....*....|....*....|....*....|.
gi 168986655 338 FLNPINMDGAILLILAIKRNPksRMEELDIS 368
Cdd:cd00116  258 SCNDITDDGAKDLAEVLAEKE--SLLELDLR 286
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 101-243 1.04e-17

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 83.94  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 101 FIRNMEEsyVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI 180
Cdd:cd00116  163 ANRDLKE--LNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAA 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168986655 181 ISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLA 243
Cdd:cd00116  241 LASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
172-369 9.91e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 9.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 172 HLGLEGARIISDFfernsSSIWSLELSGNDFKEdsaalLCQALSTNYQIKKLDLSHNQFSDVGGEhLGQMlainVGLTSL 251
Cdd:COG4886  100 ELDLSGNEELSNL-----TNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEP-LGNL----TNLKSL 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 252 DLSWNNFHTrgavaLCNGLRGNVTLTKLDLSMNGFgNEVALALGEvlrLNRcLVYLDIGGNDIgnegaSKISKGLESNES 331
Cdd:COG4886  165 DLSNNQLTD-----LPEELGNLTNLKELDLSNNQI-TDLPEPLGN---LTN-LEELDLSGNQL-----TDLPEPLANLTN 229

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 168986655 332 LRVLKLFLNPINmdgailLILAIKRNPKsrMEELDISN 369
Cdd:COG4886  230 LETLDLSNNQLT------DLPELGNLTN--LEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-342 1.11e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 106 EESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIisdff 185
Cdd:COG4886   58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEEL----- 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 186 eRNSSSIWSLELSGNDFKEdsaalLCQALSTNYQIKKLDLSHNQFSDVgGEHLGQMlainVGLTSLDLSWNNFHTrgava 265
Cdd:COG4886  133 -ANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTDL-PEELGNL----TNLKELDLSNNQITD----- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 266 LCNGLRGNVTLTKLDLSMNGFgNEVALALG-----EVLRLNRC-------------LVYLDIGGNDIgnegaSKISKgLE 327
Cdd:COG4886  197 LPEPLGNLTNLEELDLSGNQL-TDLPEPLAnltnlETLDLSNNqltdlpelgnltnLEELDLSNNQL-----TDLPP-LA 269

                        250
                 ....*....|....*
gi 168986655 328 SNESLRVLKLFLNPI 342
Cdd:COG4886  270 NLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 188-340 6.63e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 6.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 188 NSSSIWSLELSGndfKEDSAALLCQALSTNYqIKKLDLSHNQFSdvgGEHLGQMLAINVGLTSLDLSWNNFH---TRGAV 264
Cdd:PLN00113  67 NSSRVVSIDLSG---KNISGKISSAIFRLPY-IQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNNFTgsiPRGSI 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 168986655 265 ALcnglrgnvtLTKLDLSMNGFGNEVALALGEVLRLNrclvYLDIGGNDIgnegASKISKGLESNESLRVLKLFLN 340
Cdd:PLN00113 140 PN---------LETLDLSNNMLSGEIPNDIGSFSSLK----VLDLGGNVL----VGKIPNSLTNLTSLEFLTLASN 198
LRR_6 pfam13516
Leucine Rich repeat;
301-323 9.78e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.44  E-value: 9.78e-04
                          10        20
                  ....*....|....*....|...
gi 168986655  301 NRCLVYLDIGGNDIGNEGASKIS 323
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-358 2.91e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 136 TKLELEDNCIMEegvlsLVEMLQENYYLQEMNISNNHLglegaRIISDFFErNSSSIWSLELSGNDFKEdsaallCQALS 215
Cdd:COG4886  185 KELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQL-----TDLPEPLA-NLTNLETLDLSNNQLTD------LPELG 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 216 TNYQIKKLDLSHNQFSDVGgeHLGQMlainVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALG 295
Cdd:COG4886  248 NLTNLEELDLSNNQLTDLP--PLANL----TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168986655 296 EVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNP 358
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-284 3.45e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168986655 136 TKLELEDNCImeegvlSLVEMLQENYYLQEMNISNNHLGlEGARIISDffernsssiwslelsgndfkEDSAALLCQALs 215
Cdd:cd21340   71 KKLYLGGNRI------SVVEGLENLTNLEELHIENQRLP-PGEKLTFD--------------------PRSLAALSNSL- 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 168986655 216 tnyqiKKLDLSHNQFSDVggehlgQMLAINVGLTSLDLSWNNFHtrGAVALCNGLRGNVTLTKLDLSMN 284
Cdd:cd21340  123 -----RVLNISGNNIDSL------EPLAPLRNLEQLDASNNQIS--DLEELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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