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Conserved domains on  [gi|38348384|ref|NP_940951|]
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mitoguardin 1 isoform 1 [Homo sapiens]

Protein Classification

Miga domain-containing protein( domain architecture ID 10563164)

Miga domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Miga pfam10265
Mitoguardin; Mitoguardin (Miga) was first identified in flies as a mitochondrial ...
59-603 0e+00

Mitoguardin; Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein that promotes mitochondrial fusion. Later, the mammalian Miga homologs, Miga1 and Miga2, were identified. They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.


:

Pssm-ID: 463034  Cd Length: 532  Bit Score: 908.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384    59 WYYSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRAASDKGSSCSSSRQNLTLS 138
Cdd:pfam10265   1 GQSSLSQLRLSPGTKKVVFATAAGAVSLALLARYLKRRRGKKKQQKLPWKQEGVPKEVLRTPRSGRRVRSSSSRQNDTLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   139 LSSTKDkgsqvcnyangglFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFE 218
Cdd:pfam10265  81 LISSKA-------------PSKHSGSSHSLASVQSVNSSSSCACANSNSWDKAGEESGRLVNIPVTTPENLYLMGMELFE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   219 EALRRWEQALTFRNRQAEDEA-CGSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGAsDPNSLADD 297
Cdd:pfam10265 148 EALRRWEQALTFRSRQAEDEAsCSSVKLGAGDAIAEESVEDSISAEFIHKLESLLHRAYRLQEEFELLLGD-PPDSLLND 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   298 IDKDTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHLVEEGKIYSRVLRTEMLE 377
Cdd:pfam10265 227 IEKSTDFPVRESGDDLCLDDTLSIASTDSFVSAAELSDHREDRVTEALGSLCHYPLYEEALQLVEEGKVSCRTLRTEMLE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   378 CLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAAR 457
Cdd:pfam10265 307 CYSDTDFLAKLHCVRQAFQVLLKDEANRVFLAETGRQILSDLIVKARKSPKKFLESYEEMLEFLENTENWETTEMELEGR 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   458 GVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEHI 537
Cdd:pfam10265 387 GVKCMNFYDIVLDFILMDAFEDLENPPSSVQAVVNNRWLSSSFKETALATACWSVLKAKRRLLKVPDGFIAHFYAISEHV 466
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348384   538 SPVLAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTELLMAYL 603
Cdd:pfam10265 467 SPVLAWGFLGPKESLSDLCCFFKDQVVQFLKDIFDLDKVRYTSVEELAEDILQLLRRRSELLLAYL 532
 
Name Accession Description Interval E-value
Miga pfam10265
Mitoguardin; Mitoguardin (Miga) was first identified in flies as a mitochondrial ...
59-603 0e+00

Mitoguardin; Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein that promotes mitochondrial fusion. Later, the mammalian Miga homologs, Miga1 and Miga2, were identified. They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.


Pssm-ID: 463034  Cd Length: 532  Bit Score: 908.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384    59 WYYSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRAASDKGSSCSSSRQNLTLS 138
Cdd:pfam10265   1 GQSSLSQLRLSPGTKKVVFATAAGAVSLALLARYLKRRRGKKKQQKLPWKQEGVPKEVLRTPRSGRRVRSSSSRQNDTLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   139 LSSTKDkgsqvcnyangglFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFE 218
Cdd:pfam10265  81 LISSKA-------------PSKHSGSSHSLASVQSVNSSSSCACANSNSWDKAGEESGRLVNIPVTTPENLYLMGMELFE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   219 EALRRWEQALTFRNRQAEDEA-CGSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGAsDPNSLADD 297
Cdd:pfam10265 148 EALRRWEQALTFRSRQAEDEAsCSSVKLGAGDAIAEESVEDSISAEFIHKLESLLHRAYRLQEEFELLLGD-PPDSLLND 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   298 IDKDTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHLVEEGKIYSRVLRTEMLE 377
Cdd:pfam10265 227 IEKSTDFPVRESGDDLCLDDTLSIASTDSFVSAAELSDHREDRVTEALGSLCHYPLYEEALQLVEEGKVSCRTLRTEMLE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   378 CLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAAR 457
Cdd:pfam10265 307 CYSDTDFLAKLHCVRQAFQVLLKDEANRVFLAETGRQILSDLIVKARKSPKKFLESYEEMLEFLENTENWETTEMELEGR 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   458 GVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEHI 537
Cdd:pfam10265 387 GVKCMNFYDIVLDFILMDAFEDLENPPSSVQAVVNNRWLSSSFKETALATACWSVLKAKRRLLKVPDGFIAHFYAISEHV 466
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348384   538 SPVLAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTELLMAYL 603
Cdd:pfam10265 467 SPVLAWGFLGPKESLSDLCCFFKDQVVQFLKDIFDLDKVRYTSVEELAEDILQLLRRRSELLLAYL 532
 
Name Accession Description Interval E-value
Miga pfam10265
Mitoguardin; Mitoguardin (Miga) was first identified in flies as a mitochondrial ...
59-603 0e+00

Mitoguardin; Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein that promotes mitochondrial fusion. Later, the mammalian Miga homologs, Miga1 and Miga2, were identified. They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.


Pssm-ID: 463034  Cd Length: 532  Bit Score: 908.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384    59 WYYSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRAASDKGSSCSSSRQNLTLS 138
Cdd:pfam10265   1 GQSSLSQLRLSPGTKKVVFATAAGAVSLALLARYLKRRRGKKKQQKLPWKQEGVPKEVLRTPRSGRRVRSSSSRQNDTLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   139 LSSTKDkgsqvcnyangglFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFE 218
Cdd:pfam10265  81 LISSKA-------------PSKHSGSSHSLASVQSVNSSSSCACANSNSWDKAGEESGRLVNIPVTTPENLYLMGMELFE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   219 EALRRWEQALTFRNRQAEDEA-CGSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGAsDPNSLADD 297
Cdd:pfam10265 148 EALRRWEQALTFRSRQAEDEAsCSSVKLGAGDAIAEESVEDSISAEFIHKLESLLHRAYRLQEEFELLLGD-PPDSLLND 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   298 IDKDTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHLVEEGKIYSRVLRTEMLE 377
Cdd:pfam10265 227 IEKSTDFPVRESGDDLCLDDTLSIASTDSFVSAAELSDHREDRVTEALGSLCHYPLYEEALQLVEEGKVSCRTLRTEMLE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   378 CLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAAR 457
Cdd:pfam10265 307 CYSDTDFLAKLHCVRQAFQVLLKDEANRVFLAETGRQILSDLIVKARKSPKKFLESYEEMLEFLENTENWETTEMELEGR 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348384   458 GVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEHI 537
Cdd:pfam10265 387 GVKCMNFYDIVLDFILMDAFEDLENPPSSVQAVVNNRWLSSSFKETALATACWSVLKAKRRLLKVPDGFIAHFYAISEHV 466
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348384   538 SPVLAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTELLMAYL 603
Cdd:pfam10265 467 SPVLAWGFLGPKESLSDLCCFFKDQVVQFLKDIFDLDKVRYTSVEELAEDILQLLRRRSELLLAYL 532
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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