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Conserved domains on  [gi|46094060|ref|NP_996798|]
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protein BEX3 isoform b [Homo sapiens]

Protein Classification

BEX domain-containing protein( domain architecture ID 10517751)

BEX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 1-107 9.31e-20

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


:

Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 76.91  E-value: 9.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094060     1 MANIHQENEEMEQ---PMQNGEEDRPLGGGEGHQPAGN-RRGQARRLAPNFRWAIPNRQI-NDGMGGDGDDMEIFMEEMR 75
Cdd:pfam04538   1 MEKACQENEGKPEeqgKVENEEEPEDLEGGEPRKPRGNtRRGRVRQSVPNFREDIPNRHLsPEEMMREGDDMERFGEEMR 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 46094060    76 EIRRKLRELQLRNclrilmgelSNHHDHHDEF 107
Cdd:pfam04538  81 ELRQKLREQQWRQ---------RPHRDHHYPF 103
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 1-107 9.31e-20

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 76.91  E-value: 9.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094060     1 MANIHQENEEMEQ---PMQNGEEDRPLGGGEGHQPAGN-RRGQARRLAPNFRWAIPNRQI-NDGMGGDGDDMEIFMEEMR 75
Cdd:pfam04538   1 MEKACQENEGKPEeqgKVENEEEPEDLEGGEPRKPRGNtRRGRVRQSVPNFREDIPNRHLsPEEMMREGDDMERFGEEMR 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 46094060    76 EIRRKLRELQLRNclrilmgelSNHHDHHDEF 107
Cdd:pfam04538  81 ELRQKLREQQWRQ---------RPHRDHHYPF 103
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 1-107 9.31e-20

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 76.91  E-value: 9.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094060     1 MANIHQENEEMEQ---PMQNGEEDRPLGGGEGHQPAGN-RRGQARRLAPNFRWAIPNRQI-NDGMGGDGDDMEIFMEEMR 75
Cdd:pfam04538   1 MEKACQENEGKPEeqgKVENEEEPEDLEGGEPRKPRGNtRRGRVRQSVPNFREDIPNRHLsPEEMMREGDDMERFGEEMR 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 46094060    76 EIRRKLRELQLRNclrilmgelSNHHDHHDEF 107
Cdd:pfam04538  81 ELRQKLREQQWRQ---------RPHRDHHYPF 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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