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Conserved domains on  [gi|47522862|ref|NP_999185|]
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pro-epidermal growth factor precursor [Sus scrofa]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 634-676 7.91e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 7.91e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     634 QVIASSDLVWPSGITIDYLTDKLYWCDAKQSVIEMSNLDGSRR 676
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 547-589 6.38e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 6.38e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     547 ERLFEEAVDVPEGLAIDWIGRKFYWTDRGRSLIEGSDLNGKYR 589
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-633 1.73e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 1.73e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47522862     590 EIIIKEDISQPRGIAVHPVAKRLFWTDMGTnPRIESSSLQGIGR 633
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 504-546 4.64e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 4.64e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     504 ETLLNQQIGMVLALDHDPVENKVYFAHTALKWIERANMDGSQR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 745-780 2.45e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 2.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47522862    745 CLHQNGGCEHICKESFGTAQCLCHEGFLKAPDGKMC 780
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 331-393 2.48e-07

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 52.77  E-value: 2.48e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47522862  331 GQEP-KSHVCTCAEGYTLSQDGRK-----CEDVNECAFWNHGCTLGCENTPGSYYCTCPAGFVLLPDGK 393
Cdd:cd01475  155 ASEPlADHVFYVEDFSTIEELTKKfqgkiCVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
EGF_CA pfam07645
Calcium-binding EGF domain;
870-902 1.87e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.87e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 47522862    870 DIDECELGTSVCPpTSSECINTEGGHVCRCSEG 902
Cdd:pfam07645    1 DVDECATGTHNCP-ANTVCVNTIGSFECRCPDG 32
PHA03099 super family cl31525
epidermal growth factor-like protein (EGF-like protein); Provisional
 975-1013 2.46e-06

epidermal growth factor-like protein (EGF-like protein); Provisional


The actual alignment was detected with superfamily member PHA03099:

Pssm-ID: 165381  Cd Length: 139  Bit Score: 48.10  E-value: 2.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47522862   975 CPPSHDGYCLHGgVCMYIEAVDSYACNCVFGYVGERCQH 1013
Cdd:PHA03099   45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQH 82
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 916-940 2.47e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 2.47e-06
                           10        20
                   ....*....|....*....|....*
gi 47522862    916 CQLGVHTCGENATCTNTEGNYTCTC 940
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTC 25
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 439-476 6.16e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 6.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47522862    439 CSSpDNGGCSQLCLPlSPVTWECGCFPGYDLQLDKKSC 476
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 677-718 1.91e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.91e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47522862     677 QRLAQNDVGHP--FAVAVFEDHVWFSDWTMPsVIRVNKRTGKNR 718
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 408-436 2.49e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*....
gi 47522862    408 CSHDCVLTSDGPICFCPEDSVLEADGKTC 436
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 151-189 9.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 9.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 47522862     151 RVLLSALKYPANVAVDPVERLMFWSSVVAGSLHRADVTG 189
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
TolB super family cl43285
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 47-194 4.76e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG0823:

Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862   47 FLIFSHGNS-IFRIDLEGTNHEQLVADAGISVLMDFHYNEERIYWV--DLERQLLQRVFLNGTRQEKVCNLEKNVSGMAI 123
Cdd:COG0823    3 FTLSRDGNSdIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSW 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47522862  124 NWINEELIWSNQQEGT--ITVTDMKGNNSRVLLSALKYPanvAVDPVERLMFWSSVVAGS--LHRADVTGVEVRL 194
Cdd:COG0823   83 SPDGKRLAFVSRSDGRfdIYVLDLDGGAPRRLTDGPGSP---SWSPDGRRIVFSSDRGGRpdLYVVDLDGRKRRL 154
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 634-676 7.91e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 7.91e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     634 QVIASSDLVWPSGITIDYLTDKLYWCDAKQSVIEMSNLDGSRR 676
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 547-589 6.38e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 6.38e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     547 ERLFEEAVDVPEGLAIDWIGRKFYWTDRGRSLIEGSDLNGKYR 589
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-633 1.73e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 1.73e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47522862     590 EIIIKEDISQPRGIAVHPVAKRLFWTDMGTnPRIESSSLQGIGR 633
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 504-546 4.64e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 4.64e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     504 ETLLNQQIGMVLALDHDPVENKVYFAHTALKWIERANMDGSQR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 745-780 2.45e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 2.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47522862    745 CLHQNGGCEHICKESFGTAQCLCHEGFLKAPDGKMC 780
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 331-393 2.48e-07

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 52.77  E-value: 2.48e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47522862  331 GQEP-KSHVCTCAEGYTLSQDGRK-----CEDVNECAFWNHGCTLGCENTPGSYYCTCPAGFVLLPDGK 393
Cdd:cd01475  155 ASEPlADHVFYVEDFSTIEELTKKfqgkiCVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 611-651 6.09e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 6.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47522862    611 RLFWTDMGTNPRIESSSLQGIGRQVIASSDLVWPSGITIDY 651
Cdd:pfam00058    2 RLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
356-395 9.20e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 9.20e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     356 DVNECAFWN---HGCTlgCENTPGSYYCTCPAGFVllpDGKRC 395
Cdd:smart00179    1 DIDECASGNpcqNGGT--CVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
870-902 1.87e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.87e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 47522862    870 DIDECELGTSVCPpTSSECINTEGGHVCRCSEG 902
Cdd:pfam07645    1 DVDECATGTHNCP-ANTVCVNTIGSFECRCPDG 32
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 975-1013 2.46e-06

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 48.10  E-value: 2.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47522862   975 CPPSHDGYCLHGgVCMYIEAVDSYACNCVFGYVGERCQH 1013
Cdd:PHA03099   45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQH 82
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 916-940 2.47e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 2.47e-06
                           10        20
                   ....*....|....*....|....*
gi 47522862    916 CQLGVHTCGENATCTNTEGNYTCTC 940
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTC 25
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 654-694 3.81e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.84  E-value: 3.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47522862    654 DKLYWCDAKQS-VIEMSNLDGSRRQRLAQNDVGHPFAVAVFE 694
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 439-476 6.16e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 6.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47522862    439 CSSpDNGGCSQLCLPlSPVTWECGCFPGYDLQLDKKSC 476
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 364-395 6.59e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 6.59e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47522862    364 NHGCTLGCENTPGSYYCTCPAGFVLLPDGKRC 395
Cdd:pfam14670    5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-940 1.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.00e-05
                         10        20
                 ....*....|....*....|....*....
gi 47522862  912 DIDECQLGvHTCGENATCTNTEGNYTCTC 940
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
870-910 1.11e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.11e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 47522862     870 DIDECELGtSVCPPtSSECINTEGGHVCRCSEGYQgDGIHC 910
Cdd:smart00179    1 DIDECASG-NPCQN-GGTCVNTVGSYRCECPPGYT-DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-607 1.14e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.30  E-value: 1.14e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47522862    567 RKFYWTDRG-RSLIEGSDLNGKYREIIIKEDISQPRGIAVHP 607
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
912-940 1.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.48e-05
                            10        20
                    ....*....|....*....|....*....
gi 47522862     912 DIDECQLGvHTCGENATCTNTEGNYTCTC 940
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 870-910 9.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 9.13e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 47522862  870 DIDECELGtSVCPPtSSECINTEGGHVCRCSEGYQGDgiHC 910
Cdd:cd00054    1 DIDECASG-NPCQN-GGTCVNTVGSYRCSCPPGYTGR--NC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 677-718 1.91e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.91e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47522862     677 QRLAQNDVGHP--FAVAVFEDHVWFSDWTMPsVIRVNKRTGKNR 718
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 408-436 2.49e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*....
gi 47522862    408 CSHDCVLTSDGPICFCPEDSVLEADGKTC 436
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 524-564 5.72e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 5.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47522862    524 NKVYFAHTALKW-IERANMDGSQRERLFEEAVDVPEGLAIDW 564
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 151-189 9.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 9.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 47522862     151 RVLLSALKYPANVAVDPVERLMFWSSVVAGSLHRADVTG 189
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
512-620 1.46e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  512 GMVLALDHDPVENKVYFAHTALKWIERANMDGSQRERLFEEAVDvPEGLAIDWIGRKFYWTDRGRSLIEGSDL-NGKYRE 590
Cdd:COG3391   68 ADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLYVADSGNGRVSVIDTaTGKVVA 146

                         90       100       110
                 ....*....|....*....|....*....|
gi 47522862  591 IIIKEDisQPRGIAVHPVAKRLFWTDMGTN 620
Cdd:COG3391  147 TIPVGA--GPHGIAVDPDGKRLYVANSGSN 174
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 494-673 4.49e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.26  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  494 RHMHFDGTDYETLLNQQIGmvLALDhdpVENKVYFAHTALKWIERANMDGSQRERLFEEAVDV-PEGLAIDWIGRKFYWT 572
Cdd:cd14962   43 GKVFVIGNAGPNRFVSPIG--VAID---ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALFKrPTGIAVDPAGKRLYVV 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  573 DRGRSLIEGSDLNGKYREIIIK-----EDISQPRGIAVHPvAKRLFWTDMGtNPRI-----ESSSLQGIGRQVIASSDLV 642
Cdd:cd14962  118 DTLAHKVKVFDLDGRLLFDIGKrgsgpGEFNLPTDLAVDR-DGNLYVTDTM-NFRVqifdaDGKFLRSFGERGDGPGSFA 195

                        170       180       190
                 ....*....|....*....|....*....|.
gi 47522862  643 WPSGITIDYlTDKLYWCDAKQSVIEMSNLDG 673
Cdd:cd14962  196 RPKGIAVDS-EGNIYVVDAAFDNVQIFNPEG 225
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 47-194 4.76e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862   47 FLIFSHGNS-IFRIDLEGTNHEQLVADAGISVLMDFHYNEERIYWV--DLERQLLQRVFLNGTRQEKVCNLEKNVSGMAI 123
Cdd:COG0823    3 FTLSRDGNSdIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSW 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47522862  124 NWINEELIWSNQQEGT--ITVTDMKGNNSRVLLSALKYPanvAVDPVERLMFWSSVVAGS--LHRADVTGVEVRL 194
Cdd:COG0823   83 SPDGKRLAFVSRSDGRfdIYVLDLDGGAPRRLTDGPGSP---SWSPDGRRIVFSSDRGGRpdLYVVDLDGRKRRL 154
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 634-676 7.91e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 7.91e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     634 QVIASSDLVWPSGITIDYLTDKLYWCDAKQSVIEMSNLDGSRR 676
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 547-589 6.38e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 6.38e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     547 ERLFEEAVDVPEGLAIDWIGRKFYWTDRGRSLIEGSDLNGKYR 589
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-633 1.73e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 1.73e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47522862     590 EIIIKEDISQPRGIAVHPVAKRLFWTDMGTnPRIESSSLQGIGR 633
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 504-546 4.64e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 4.64e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     504 ETLLNQQIGMVLALDHDPVENKVYFAHTALKWIERANMDGSQR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 745-780 2.45e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 2.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47522862    745 CLHQNGGCEHICKESFGTAQCLCHEGFLKAPDGKMC 780
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 331-393 2.48e-07

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 52.77  E-value: 2.48e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47522862  331 GQEP-KSHVCTCAEGYTLSQDGRK-----CEDVNECAFWNHGCTLGCENTPGSYYCTCPAGFVLLPDGK 393
Cdd:cd01475  155 ASEPlADHVFYVEDFSTIEELTKKfqgkiCVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 611-651 6.09e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 6.09e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47522862    611 RLFWTDMGTNPRIESSSLQGIGRQVIASSDLVWPSGITIDY 651
Cdd:pfam00058    2 RLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
356-395 9.20e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 9.20e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 47522862     356 DVNECAFWN---HGCTlgCENTPGSYYCTCPAGFVllpDGKRC 395
Cdd:smart00179    1 DIDECASGNpcqNGGT--CVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
870-902 1.87e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.87e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 47522862    870 DIDECELGTSVCPpTSSECINTEGGHVCRCSEG 902
Cdd:pfam07645    1 DVDECATGTHNCP-ANTVCVNTIGSFECRCPDG 32
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 975-1013 2.46e-06

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 48.10  E-value: 2.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47522862   975 CPPSHDGYCLHGgVCMYIEAVDSYACNCVFGYVGERCQH 1013
Cdd:PHA03099   45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQH 82
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 916-940 2.47e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 2.47e-06
                           10        20
                   ....*....|....*....|....*
gi 47522862    916 CQLGVHTCGENATCTNTEGNYTCTC 940
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTC 25
EGF_CA pfam07645
Calcium-binding EGF domain;
912-940 2.69e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 44.92  E-value: 2.69e-06
                           10        20
                   ....*....|....*....|....*....
gi 47522862    912 DIDECQLGVHTCGENATCTNTEGNYTCTC 940
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 654-694 3.81e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.84  E-value: 3.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47522862    654 DKLYWCDAKQS-VIEMSNLDGSRRQRLAQNDVGHPFAVAVFE 694
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 439-476 6.16e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 6.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47522862    439 CSSpDNGGCSQLCLPlSPVTWECGCFPGYDLQLDKKSC 476
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 364-395 6.59e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 6.59e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47522862    364 NHGCTLGCENTPGSYYCTCPAGFVLLPDGKRC 395
Cdd:pfam14670    5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 887-910 6.86e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 6.86e-06
                           10        20
                   ....*....|....*....|....
gi 47522862    887 ECINTEGGHVCRCSEGYQGDGIHC 910
Cdd:pfam12947   13 TCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 356-395 7.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.25e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 47522862  356 DVNECAFwNHGCTLG--CENTPGSYYCTCPAGFVllpdGKRC 395
Cdd:cd00054    1 DIDECAS-GNPCQNGgtCVNTVGSYRCSCPPGYT----GRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-940 1.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.00e-05
                         10        20
                 ....*....|....*....|....*....
gi 47522862  912 DIDECQLGvHTCGENATCTNTEGNYTCTC 940
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
870-910 1.11e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.11e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 47522862     870 DIDECELGtSVCPPtSSECINTEGGHVCRCSEGYQgDGIHC 910
Cdd:smart00179    1 DIDECASG-NPCQN-GGTCVNTVGSYRCECPPGYT-DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-607 1.14e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.30  E-value: 1.14e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47522862    567 RKFYWTDRG-RSLIEGSDLNGKYREIIIKEDISQPRGIAVHP 607
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
912-940 1.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.48e-05
                            10        20
                    ....*....|....*....|....*....
gi 47522862     912 DIDECQLGvHTCGENATCTNTEGNYTCTC 940
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCEC 28
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 318-354 2.66e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47522862    318 CKLRKGNCrGSMCGQEPKSHVCTCAEGYTLSQDGRKC 354
Cdd:pfam14670    1 CSVNNGGC-SHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
356-385 3.76e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.84  E-value: 3.76e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47522862    356 DVNECAFWNHGCTLG--CENTPGSYYCTCPAG 385
Cdd:pfam07645    1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 339-359 8.70e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 40.47  E-value: 8.70e-05
                           10        20
                   ....*....|....*....|.
gi 47522862    339 CTCAEGYTLSQDGRKCEDVNE 359
Cdd:pfam12662    2 CSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 870-910 9.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 9.13e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 47522862  870 DIDECELGtSVCPPtSSECINTEGGHVCRCSEGYQGDgiHC 910
Cdd:cd00054    1 DIDECASG-NPCQN-GGTCVNTVGSYRCSCPPGYTGR--NC 37
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 360-395 1.54e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 1.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47522862    360 CAFWNHGCTLG--CENTPGSYYCTCPAGFVLlpDGKRC 395
Cdd:pfam12947    1 CSDNNGGCHPNatCTNTGGSFTCTCNDGYTG--DGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 677-718 1.91e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.91e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47522862     677 QRLAQNDVGHP--FAVAVFEDHVWFSDWTMPsVIRVNKRTGKNR 718
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 408-436 2.49e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*....
gi 47522862    408 CSHDCVLTSDGPICFCPEDSVLEADGKTC 436
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 524-564 5.72e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 5.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47522862    524 NKVYFAHTALKW-IERANMDGSQRERLFEEAVDVPEGLAIDW 564
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 151-189 9.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 9.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 47522862     151 RVLLSALKYPANVAVDPVERLMFWSSVVAGSLHRADVTG 189
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
512-620 1.46e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  512 GMVLALDHDPVENKVYFAHTALKWIERANMDGSQRERLFEEAVDvPEGLAIDWIGRKFYWTDRGRSLIEGSDL-NGKYRE 590
Cdd:COG3391   68 ADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLYVADSGNGRVSVIDTaTGKVVA 146

                         90       100       110
                 ....*....|....*....|....*....|
gi 47522862  591 IIIKEDisQPRGIAVHPVAKRLFWTDMGTN 620
Cdd:COG3391  147 TIPVGA--GPHGIAVDPDGKRLYVANSGSN 174
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
515-733 2.95e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  515 LALDHDpveNKVYFAHTALKWIERANMDGSQRERLFEEAVDVPEGLAID-----WIgrkfywTDRGRSLIEGSDL-NGKY 588
Cdd:COG4257   22 VAVDPD---GAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDpdgnlWF------TDNGNNRIGRIDPkTGEI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  589 REIIIKEDISQPRGIAVHPvAKRLFWTDMGTNP--RIESSSlqGIGRQVIASSDLVWPSGITID---------YLTDKLY 657
Cdd:COG4257   93 TTFALPGGGSNPHGIAFDP-DGNLWFTDQGGNRigRLDPAT--GEVTEFPLPTGGAGPYGIAVDpdgnlwvtdFGANAIG 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47522862  658 WCDAKQSVIEMSNLdgsrrqrlaQNDVGHPFAVAV-FEDHVWFSDWTMPSVIRVNKRTGK-NRVRLRGSMLKPSSLVV 733
Cdd:COG4257  170 RIDPDTGTLTEYAL---------PTPGAGPRGLAVdPDGNLWVADTGSGRIGRFDPKTGTvTEYPLPGGGARPYGVAV 238
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 494-673 4.49e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.26  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  494 RHMHFDGTDYETLLNQQIGmvLALDhdpVENKVYFAHTALKWIERANMDGSQRERLFEEAVDV-PEGLAIDWIGRKFYWT 572
Cdd:cd14962   43 GKVFVIGNAGPNRFVSPIG--VAID---ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALFKrPTGIAVDPAGKRLYVV 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  573 DRGRSLIEGSDLNGKYREIIIK-----EDISQPRGIAVHPvAKRLFWTDMGtNPRI-----ESSSLQGIGRQVIASSDLV 642
Cdd:cd14962  118 DTLAHKVKVFDLDGRLLFDIGKrgsgpGEFNLPTDLAVDR-DGNLYVTDTM-NFRVqifdaDGKFLRSFGERGDGPGSFA 195

                        170       180       190
                 ....*....|....*....|....*....|.
gi 47522862  643 WPSGITIDYlTDKLYWCDAKQSVIEMSNLDG 673
Cdd:cd14962  196 RPKGIAVDS-EGNIYVVDAAFDNVQIFNPEG 225
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 47-194 4.76e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862   47 FLIFSHGNS-IFRIDLEGTNHEQLVADAGISVLMDFHYNEERIYWV--DLERQLLQRVFLNGTRQEKVCNLEKNVSGMAI 123
Cdd:COG0823    3 FTLSRDGNSdIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSW 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47522862  124 NWINEELIWSNQQEGT--ITVTDMKGNNSRVLLSALKYPanvAVDPVERLMFWSSVVAGS--LHRADVTGVEVRL 194
Cdd:COG0823   83 SPDGKRLAFVSRSDGRfdIYVLDLDGGAPRRLTDGPGSP---SWSPDGRRIVFSSDRGGRpdLYVVDLDGRKRRL 154
PHA02887 PHA02887
EGF-like protein; Provisional
 966-1012 5.56e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 38.37  E-value: 5.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 47522862   966 YSVRNS--YSECPPSHDGYCLHGgVCMYIEAVDSYACNCVFGYVGERCQ 1012
Cdd:PHA02887   75 FKRKNSmfFEKCKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 557-666 6.28e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.99  E-value: 6.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47522862  557 PEGLAIDWIGrKFYWTDRGRSLIEGSDLNGKY-----REIIIKEDISQPRGIAVHPvAKRLFWTDMGTNpRI-----ESS 626
Cdd:cd05819  151 PTGVAVDSDG-NIYVADTGNHRIQVFDPDGNFlttfgSTGTGPGQFNYPTGIAVDS-DGNIYVADSGNN-RVqvfdpDGA 227

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 47522862  627 SLQGIGRQVIASSDLVWPSGITIDyLTDKLYWCDAKQSVI 666
Cdd:cd05819  228 GFGGNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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