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RecName: Full=Apoptosis regulatory protein Siva; AltName: Full=CD27-binding protein; Short=CD27BP
Siva domain-containing protein( domain architecture ID 10527203)
Siva domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
Siva | pfam05458 | Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology ... |
1-175 | 8.59e-93 | ||||
Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1. : Pssm-ID: 283184 Cd Length: 173 Bit Score: 267.18 E-value: 8.59e-93
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Name | Accession | Description | Interval | E-value | ||||
Siva | pfam05458 | Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology ... |
1-175 | 8.59e-93 | ||||
Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1. Pssm-ID: 283184 Cd Length: 173 Bit Score: 267.18 E-value: 8.59e-93
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Name | Accession | Description | Interval | E-value | ||||
Siva | pfam05458 | Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology ... |
1-175 | 8.59e-93 | ||||
Cd27 binding protein (Siva); Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1. Pssm-ID: 283184 Cd Length: 173 Bit Score: 267.18 E-value: 8.59e-93
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Blast search parameters | ||||
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