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Conserved domains on  [gi|74754378|sp|O60667|]
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RecName: Full=Immunoglobulin mu Fc receptor; Short=IgM FcR; AltName: Full=Fas apoptotic inhibitory molecule 3; Short=FAIM3; AltName: Full=Regulator of Fas-induced apoptosis Toso; Flags: Precursor

Protein Classification

immunoglobulin domain-containing protein; immunoglobulin domain-containing family protein( domain architecture ID 12944272)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and pattern recognition; immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-121 2.43e-27

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 104.02  E-value: 2.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378  24 KVEGELGGSVTIKCPLPE--MHVRIYLCREmaGSGTCGTVVSTTNFIKaeyKGRVTLKQYPRKNLFLVEVTQLTESDSGV 101
Cdd:cd05716   6 VVTGVEGGSVTIQCPYPPkyASSRKYWCKW--GSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 74754378 102 YACGAGMNTDRGKTQKVTLN 121
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
DUF5434 super family cl38773
Family of unknown function (DUF5434); This is a family of unknown function found in ...
 186-333 5.85e-03

Family of unknown function (DUF5434); This is a family of unknown function found in Varicellovirus.


The actual alignment was detected with superfamily member pfam17502:

Pssm-ID: 340217  Cd Length: 189  Bit Score: 37.53  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378   186 HRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHtrlhRQRALDYGSQSGREGQGfHILIPTILGLFLL 265
Cdd:pfam17502  15 YRRFLERNSRAAAKLAAATTPTHTASSIQQPEAEARPRHRSLSSR----RNSVPHKDPHAGAGGDG-HLALPDMPSGTLG 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378   266 allglVVKRAVERRKALSRRARRLAVRM-RALESSQRPRGSPR-PRSQNNIYSACPRRARGADAAGTGEA 333
Cdd:pfam17502  90 -----ALAMAAQRRKSIGRPDPLVNAAAgNALRSSQRPRGDGRnPRGEGHSSSSSSYTQRGNSHGHRGEA 154
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-121 2.43e-27

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 104.02  E-value: 2.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378  24 KVEGELGGSVTIKCPLPE--MHVRIYLCREmaGSGTCGTVVSTTNFIKaeyKGRVTLKQYPRKNLFLVEVTQLTESDSGV 101
Cdd:cd05716   6 VVTGVEGGSVTIQCPYPPkyASSRKYWCKW--GSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 74754378 102 YACGAGMNTDRGKTQKVTLN 121
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 21-123 3.80e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 65.17  E-value: 3.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378    21 PEVKVEGELGGSVTIKCPLP----EMHVRIYLCREMAGSGT--CGTVVSTTNFIKAEyKGRVTLKQYPRKNLFLVEVTQL 94
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSssmsEASTSVYWYRQPPGKGPtfLIAYYSNGSEEGVK-KGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 74754378    95 TESDSGVYACGAGMNTDRGKTQKVTLNVH 123
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
63-104 4.03e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.90  E-value: 4.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 74754378     63 STTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYAC 104
Cdd:smart00406  38 NGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
DUF5434 pfam17502
Family of unknown function (DUF5434); This is a family of unknown function found in ...
 186-333 5.85e-03

Family of unknown function (DUF5434); This is a family of unknown function found in Varicellovirus.


Pssm-ID: 340217  Cd Length: 189  Bit Score: 37.53  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378   186 HRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHtrlhRQRALDYGSQSGREGQGfHILIPTILGLFLL 265
Cdd:pfam17502  15 YRRFLERNSRAAAKLAAATTPTHTASSIQQPEAEARPRHRSLSSR----RNSVPHKDPHAGAGGDG-HLALPDMPSGTLG 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378   266 allglVVKRAVERRKALSRRARRLAVRM-RALESSQRPRGSPR-PRSQNNIYSACPRRARGADAAGTGEA 333
Cdd:pfam17502  90 -----ALAMAAQRRKSIGRPDPLVNAAAgNALRSSQRPRGDGRnPRGEGHSSSSSSYTQRGNSHGHRGEA 154
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-121 2.43e-27

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 104.02  E-value: 2.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378  24 KVEGELGGSVTIKCPLPE--MHVRIYLCREmaGSGTCGTVVSTTNFIKaeyKGRVTLKQYPRKNLFLVEVTQLTESDSGV 101
Cdd:cd05716   6 VVTGVEGGSVTIQCPYPPkyASSRKYWCKW--GSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 74754378 102 YACGAGMNTDRGKTQKVTLN 121
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 21-123 3.80e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 65.17  E-value: 3.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378    21 PEVKVEGELGGSVTIKCPLP----EMHVRIYLCREMAGSGT--CGTVVSTTNFIKAEyKGRVTLKQYPRKNLFLVEVTQL 94
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSssmsEASTSVYWYRQPPGKGPtfLIAYYSNGSEEGVK-KGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 74754378    95 TESDSGVYACGAGMNTDRGKTQKVTLNVH 123
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
63-104 4.03e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.90  E-value: 4.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 74754378     63 STTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYAC 104
Cdd:smart00406  38 NGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-122 1.12e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378     25 VEGELGGSVTIKCPLP-EMHVRIYLCREmagsgtcgtvvsttNFIKAEYKGRVTLKQYPRkNLFLVeVTQLTESDSGVYA 103
Cdd:smart00410   4 VTVKEGESVTLSCEASgSPPPEVTWYKQ--------------GGKLLAESGRFSVSRSGS-TSTLT-ISNVTPEDSGTYT 67

                           90
                   ....*....|....*....
gi 74754378    104 CGAGmNTDRGKTQKVTLNV 122
Cdd:smart00410  68 CAAT-NSSGSASSGTTLTV 85
DUF5434 pfam17502
Family of unknown function (DUF5434); This is a family of unknown function found in ...
 186-333 5.85e-03

Family of unknown function (DUF5434); This is a family of unknown function found in Varicellovirus.


Pssm-ID: 340217  Cd Length: 189  Bit Score: 37.53  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378   186 HRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHtrlhRQRALDYGSQSGREGQGfHILIPTILGLFLL 265
Cdd:pfam17502  15 YRRFLERNSRAAAKLAAATTPTHTASSIQQPEAEARPRHRSLSSR----RNSVPHKDPHAGAGGDG-HLALPDMPSGTLG 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74754378   266 allglVVKRAVERRKALSRRARRLAVRM-RALESSQRPRGSPR-PRSQNNIYSACPRRARGADAAGTGEA 333
Cdd:pfam17502  90 -----ALAMAAQRRKSIGRPDPLVNAAAgNALRSSQRPRGDGRnPRGEGHSSSSSSYTQRGNSHGHRGEA 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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