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Conserved domains on  [gi|12230337|sp|O88425|]
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RecName: Full=Nucleoside diphosphate kinase 6; Short=NDK 6; Short=NDP kinase 6; AltName: Full=nm23-M6

Protein Classification

nucleoside diphosphate kinase 6( domain architecture ID 10138302)

nucleoside diphosphate kinase 6 plays a major role in the synthesis of nucleoside triphosphates other than ATP

CATH:  3.30.70.141
EC:  2.7.4.6
Gene Ontology:  GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183
SCOP:  4001261

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 12-146 2.38e-89

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


:

Pssm-ID: 239877  Cd Length: 135  Bit Score: 257.71  E-value: 2.38e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  12 QLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:cd04414   1 QLTLALIKPDAVAHPLALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337  92 IQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFP 146
Cdd:cd04414  81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
 
Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 12-146 2.38e-89

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 257.71  E-value: 2.38e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  12 QLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:cd04414   1 QLTLALIKPDAVAHPLALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337  92 IQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFP 146
Cdd:cd04414  81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 12-149 1.84e-64

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 194.69  E-value: 1.84e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337     12 QLTLALIKPDAVAHPLILEAVHQqILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISR-FERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 12230337     92 IQLWRTLMGPTrvfRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDFS 149
Cdd:smart00562  80 VKTWRTLMGPT---DPREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDK pfam00334
Nucleoside diphosphate kinase;
14-148 2.68e-49

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 156.11  E-value: 2.68e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337    14 TLALIKPDAVAHPLIlEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQ 93
Cdd:pfam00334   3 TLAIIKPDAVQRGLI-GEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337    94 LWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDF 148
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 10-147 3.52e-40

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 133.27  E-value: 3.52e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  10 ALQLTLALIKPDAVAHPLILEavhqqILS----NKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYI 85
Cdd:COG0105   1 AMERTLVIIKPDAVQRGLIGE-----IISrferKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMV 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12230337  86 LAHKDAIQLWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPD 147
Cdd:COG0105  76 LEGENAVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFSE 134
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 14-147 7.89e-39

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 129.46  E-value: 7.89e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   14 TLALIKPDAVAHPLILEavhqqILS---NK-FLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHK 89
Cdd:PRK00668   4 TFSIIKPDAVQRGLIGE-----IISrfeKKgLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGE 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 12230337   90 DAIQLWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPD 147
Cdd:PRK00668  79 NAIAKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSE 133
 
Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 12-146 2.38e-89

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 257.71  E-value: 2.38e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  12 QLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:cd04414   1 QLTLALIKPDAVAHPLALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337  92 IQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFP 146
Cdd:cd04414  81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 12-145 3.32e-66

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 199.12  E-value: 3.32e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  12 QLTLALIKPDAVAHpLILEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:cd00595   1 ERTLALIKPDAVAE-GLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12230337  92 IQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:cd00595  80 VGEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 12-149 1.84e-64

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 194.69  E-value: 1.84e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337     12 QLTLALIKPDAVAHPLILEAVHQqILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISR-FERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 12230337     92 IQLWRTLMGPTrvfRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDFS 149
Cdd:smart00562  80 VKTWRTLMGPT---DPREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDK pfam00334
Nucleoside diphosphate kinase;
14-148 2.68e-49

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 156.11  E-value: 2.68e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337    14 TLALIKPDAVAHPLIlEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQ 93
Cdd:pfam00334   3 TLAIIKPDAVQRGLI-GEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337    94 LWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDF 148
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 14-146 4.13e-43

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 140.27  E-value: 4.13e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  14 TLALIKPDAVAHPlilEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQ 93
Cdd:cd04418   3 TLAIIKPDAVHKA---EEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAIS 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 12230337  94 LWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFP 146
Cdd:cd04418  80 YWKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 10-147 3.52e-40

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 133.27  E-value: 3.52e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  10 ALQLTLALIKPDAVAHPLILEavhqqILS----NKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYI 85
Cdd:COG0105   1 AMERTLVIIKPDAVQRGLIGE-----IISrferKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMV 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12230337  86 LAHKDAIQLWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPD 147
Cdd:COG0105  76 LEGENAVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFSE 134
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 14-145 1.30e-39

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 131.41  E-value: 1.30e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  14 TLALIKPDAVAH--PLIleavhQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:cd04415   3 TLALIKPDAYSKigKII-----QIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDA 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12230337  92 IQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:cd04415  78 ISEWRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 14-145 1.89e-39

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 131.05  E-value: 1.89e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  14 TLALIKPDAVAHPLILEAVhQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQ 93
Cdd:cd04413   3 TLVIIKPDGVQRGLIGEII-SRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAVK 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 12230337  94 LWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:cd04413  82 TVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 14-147 7.89e-39

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 129.46  E-value: 7.89e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   14 TLALIKPDAVAHPLILEavhqqILS---NK-FLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHK 89
Cdd:PRK00668   4 TFSIIKPDAVQRGLIGE-----IISrfeKKgLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGE 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 12230337   90 DAIQLWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPD 147
Cdd:PRK00668  79 NAIAKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSE 133
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 14-149 1.58e-36

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 124.94  E-value: 1.58e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   14 TLALIKPDAVAHPLIlEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQ 93
Cdd:PLN02931  32 TLAMIKPDGLSGNYT-ERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAVS 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 12230337   94 LWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDFS 149
Cdd:PLN02931 111 DWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFFGDVS 166
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 12-145 8.45e-36

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 121.93  E-value: 8.45e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  12 QLTLALIKPDAVAHPLilEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDA 91
Cdd:cd04416   1 EYTLALIKPDAVAEKK--DEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12230337  92 IQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:cd04416  79 VEEWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 11-145 1.23e-27

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 101.05  E-value: 1.23e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   11 LQLTLALIKPDAVAHPLILEAVhQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKD 90
Cdd:PRK14540   2 KERTFVALKPDAVERKLIGKII-QRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGEN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337   91 AIQLWRTLMGPTRVFRARyiaPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:PRK14540  81 AISTVRKMIGKTNPAEAE---PGTIRGDFGLYTPANIIHASDSKESAEREIKLFF 132
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 14-145 5.33e-24

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 92.09  E-value: 5.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   14 TLALIKPDAVAHPLILEAVHQ------QILSNKFLiVRTRELqwkledCRRFYREHEGRFFYQRLVEFMTSGPIRAYILA 87
Cdd:PTZ00093   5 TFIMVKPDGVQRGLVGEIIKRfekkgyKLVALKML-QPTPEI------AEEHYKEHKGKPFFPGLVKYISSGPVVCMVWE 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 12230337   88 HKDAIQLWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:PTZ00093  78 GKNVVKQGRKLLGATNPLES---APGTIRGDFCVDVGRNVIHGSDSVESAKREIALWF 132
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 11-145 5.37e-22

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 86.65  E-value: 5.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   11 LQLTLALIKPDAVAHPLILEaVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKD 90
Cdd:PRK14542   1 MSRTFIMIKPDGVKNKHVGN-ILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDN 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337   91 AIQLWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:PRK14542  80 AVLHWREVIGATDPKEA---AAGTIRALYAESKEANAVHGSDSDANAALEISFFF 131
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 14-145 6.21e-22

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 86.50  E-value: 6.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   14 TLALIKPDAVAHPLIlEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQ 93
Cdd:PRK14545   6 TFTMIKPDAVENGHI-GGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 12230337   94 LWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:PRK14545  85 DFRTLIGATNPADA---AEGTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 12-145 5.35e-20

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 81.14  E-value: 5.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337  12 QLTLALIKPDAVAHPLILEAVhQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRF-FYQRLVEFMTSGPIRAYILAHKD 90
Cdd:cd04412   1 NCTVCIIKPHAVSHGLLGEIL-QQILDEGFEITALQMFNLTRANAEEFLEVYKGVVpELPAMVDELTSGPCIALEIAGEN 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337  91 AIQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:cd04412  80 AVKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 11-145 2.00e-19

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 79.99  E-value: 2.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   11 LQLTLALIKPDAVAHPLIlEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKD 90
Cdd:PRK14541   1 MERTLTILKPDCVRKQLI-GAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKEN 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 12230337   91 AIQLWRTLMGPTRVFRAryiAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:PRK14541  80 AVADFRTLIGATDPAEA---AEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 10-158 5.91e-14

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 66.76  E-value: 5.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   10 ALQLTLALIKPDAVAHPLILEAVhQQILSNKFLIVRTRELQWKLEDCRRFYREHE------------------------- 64
Cdd:PRK14544   2 PIERTLVILKPDAVKRGLVGEII-SRFEKAGLKIVAMKMVKATPEQIERFYPSSEewyrsvgnkllkayqelgidprarl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   65 --------GRFFYQRLVEFMTSGPIRAYILAHKDAIQLWRTLMGPTRVFRAryiAPDSIRGSLGlTDT-----------R 125
Cdd:PRK14544  81 gtddpvevGKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYS-IDSpdlaaeegrvvY 156

                        170       180       190
                 ....*....|....*....|....*....|...
gi 12230337  126 NTTHGSDSVVSASREIaaffpdfseQRWYEEEE 158
Cdd:PRK14544 157 NLVHASDSPEEAEREI---------KFWFREEE 180
PLN02619 PLN02619
nucleoside-diphosphate kinase
 11-145 1.11e-10

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 58.71  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   11 LQLTLALIKPDAVAHPLILEavhqqILS----NKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYIL 86
Cdd:PLN02619  88 MERTFIAIKPDGVQRGLISE-----IISrferKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVW 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 12230337   87 AHKDAIQLWRTLMGPTRVFRARyiaPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFF 145
Cdd:PLN02619 163 EGEGVIKYGRKLIGATDPQKSE---PGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWF 218
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 11-147 3.04e-10

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 56.44  E-value: 3.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12230337   11 LQLTLALIKPDAVAHPLI------LEAVHQQILSNKFLIVRTrelqwKLEDCRRFYRE---HEGRFFYQRLVEFMTSGPI 81
Cdd:PRK14543   5 IQKTLCIIKPDGVRRGLIgnvvsrFERVGLKIVAAKMLLVDR-----SMAEKHYLYDDiavRHGEAVWKSLIKFISSSPV 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12230337   82 RAYILAHKDAIQLWRTLMGPTRvfrARYIAPDSIRG-----SLGLTDTR-----NTTHGSDSVVSASREIAAFFPD 147
Cdd:PRK14543  80 FVFVVEGVESVEVVRKFCGSTE---PKLAIPGTIRGdfsyhSFNYANEKgfsvyNVIHASANEDDALREIPIWFKD 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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