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Conserved domains on  [gi|1026922172|gb|OAF70399|]
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Major facilitator superfamily domain-containing protein 6-like protein [Intoshia linei]

Protein Classification

major facilitator superfamily domain-containing protein 6-like( domain architecture ID 13214178)

major facilitator superfamily domain-containing protein 6-like (MFSD6L)

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 370-733 1.63e-108

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 336.59  E-value: 1.63e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 370 YSSPKHSFVLMLVILILVGLLSPPHNRVVDNAWFEYLDTIEMSESFSNHKIWKLLGYAVVPFITVLIVIASSKCNVIsfw 449
Cdd:cd17479    76 YLLYHQIFLLVLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFLPP--- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 450 yptmnlsstpqfetfpyfyinaserVSSKYLLHFYLYAGFMILSIPLVFLLNPMKRSYSELSSapskktkmyksnvyehl 529
Cdd:cd17479   153 -------------------------KISRILLHFYTYGGFMILTFLLSFFYPIPVPKKEEHSS----------------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 530 pisdedshiipphtpiLVNRGLRMCFGSMTAAVYTITFFIFEMIKSLEQLFLFWSLVDVGGNGLHFSLFISVASVSQILF 609
Cdd:cd17479   191 ----------------KVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIALALLSEILM 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 610 SIILSRKFNtKILKRKIIFIVVLISMIQCVVYSFSFNPWYILIGATLSAFGRPLFKDTLEKLDEFVViNWQMDRSVDLVL 689
Cdd:cd17479   255 SFFGNWLLR-KLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLA-SPGMERSLQLVL 332

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1026922172 690 RGLIAPFGYALGAMMFGYFYEKLGISILFQATTGVLGLWLIFLI 733
Cdd:cd17479   333 RALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 14-91 2.53e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17479:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 376  Bit Score: 105.85  E-value: 2.53e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1026922172  14 MSTYYFASNSANAALMPFLPLFYRAVGLNAFLMGLLYASYKTSTIFGTIFWPSLCRVYCSARSNILVSIMITLVLYMI 91
Cdd:cd17479     1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLL 78
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 370-733 1.63e-108

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 336.59  E-value: 1.63e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 370 YSSPKHSFVLMLVILILVGLLSPPHNRVVDNAWFEYLDTIEMSESFSNHKIWKLLGYAVVPFITVLIVIASSKCNVIsfw 449
Cdd:cd17479    76 YLLYHQIFLLVLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFLPP--- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 450 yptmnlsstpqfetfpyfyinaserVSSKYLLHFYLYAGFMILSIPLVFLLNPMKRSYSELSSapskktkmyksnvyehl 529
Cdd:cd17479   153 -------------------------KISRILLHFYTYGGFMILTFLLSFFYPIPVPKKEEHSS----------------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 530 pisdedshiipphtpiLVNRGLRMCFGSMTAAVYTITFFIFEMIKSLEQLFLFWSLVDVGGNGLHFSLFISVASVSQILF 609
Cdd:cd17479   191 ----------------KVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIALALLSEILM 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 610 SIILSRKFNtKILKRKIIFIVVLISMIQCVVYSFSFNPWYILIGATLSAFGRPLFKDTLEKLDEFVViNWQMDRSVDLVL 689
Cdd:cd17479   255 SFFGNWLLR-KLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLA-SPGMERSLQLVL 332

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1026922172 690 RGLIAPFGYALGAMMFGYFYEKLGISILFQATTGVLGLWLIFLI 733
Cdd:cd17479   333 RALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 14-91 2.53e-24

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 105.85  E-value: 2.53e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1026922172  14 MSTYYFASNSANAALMPFLPLFYRAVGLNAFLMGLLYASYKTSTIFGTIFWPSLCRVYCSARSNILVSIMITLVLYMI 91
Cdd:cd17479     1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLL 78
MFS_1 pfam07690
Major Facilitator Superfamily;
559-736 2.16e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 559 TAAVYTITFFIFEMIKSLEQLFLfwsLVDVGGNGLHFSLFISVASVSQILFSIILSRkFNTKILKRKIIFIVVLISMIQC 638
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLL---AEDLGISPTEIGLLLTLFSLGYALAQPLAGR-LSDRFGRRRVLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 639 VVYSFSFNPWYILIGATLSAFGRPLFKDTLEKLdefvVINW--QMDRSVDLVLRGLIAPFGYALGAMMFGYFYEKLGISI 716
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALAL----IADWfpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152

                         170       180
                  ....*....|....*....|
gi 1026922172 717 LFQATTGVLGLWLIFLIVFE 736
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPR 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
545-734 1.92e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 545 ILVNRGLRMCFGSMtaAVYTITFFIFEmiksleQLFLFWSLVDVGGNGLHFSLFISVASVSQILFSII---LSRKFNtki 621
Cdd:COG2211   224 LLKNRPFLLLLLAY--LLFFLALALVA------ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLwprLAKRFG--- 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 622 lKRKIIFIVVLISMIQCVVYSFSF--NPWYILIGATLSAFGR--------PLFKDTLEkLDEfvVINWQMDRSVDLVLRG 691
Cdd:COG2211   293 -KKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLgailvlpwAMLADVVD-YDE--WKTGRRREGLYFGIFT 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1026922172 692 LIAPFGYALGAMMFGYFYEKLG-ISILFQATTGVLGLWLIFLIV 734
Cdd:COG2211   369 FAIKLGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFLL 412
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 370-733 1.63e-108

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 336.59  E-value: 1.63e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 370 YSSPKHSFVLMLVILILVGLLSPPHNRVVDNAWFEYLDTIEMSESFSNHKIWKLLGYAVVPFITVLIVIASSKCNVIsfw 449
Cdd:cd17479    76 YLLYHQIFLLVLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFLPP--- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 450 yptmnlsstpqfetfpyfyinaserVSSKYLLHFYLYAGFMILSIPLVFLLNPMKRSYSELSSapskktkmyksnvyehl 529
Cdd:cd17479   153 -------------------------KISRILLHFYTYGGFMILTFLLSFFYPIPVPKKEEHSS----------------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 530 pisdedshiipphtpiLVNRGLRMCFGSMTAAVYTITFFIFEMIKSLEQLFLFWSLVDVGGNGLHFSLFISVASVSQILF 609
Cdd:cd17479   191 ----------------KVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIALALLSEILM 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 610 SIILSRKFNtKILKRKIIFIVVLISMIQCVVYSFSFNPWYILIGATLSAFGRPLFKDTLEKLDEFVViNWQMDRSVDLVL 689
Cdd:cd17479   255 SFFGNWLLR-KLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLA-SPGMERSLQLVL 332

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1026922172 690 RGLIAPFGYALGAMMFGYFYEKLGISILFQATTGVLGLWLIFLI 733
Cdd:cd17479   333 RALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 14-91 2.53e-24

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 105.85  E-value: 2.53e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1026922172  14 MSTYYFASNSANAALMPFLPLFYRAVGLNAFLMGLLYASYKTSTIFGTIFWPSLCRVYCSARSNILVSIMITLVLYMI 91
Cdd:cd17479     1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLL 78
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 479-735 1.05e-08

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 57.98  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 479 YLLHFYLYAGFMILSIPLVFLLNPMkrsyselssapskktkmyksnvYEHLPISDEDSHIIPphtpILVNRGLRMCFGSM 558
Cdd:cd17335   154 YTIAFYVFAVLMLLALLLALKFPFR----------------------PKHPEPNENTGGLLA----LLRNPRVLAFLLVA 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 559 taavytitfFIFEMIKSLEQLFLFWSLVDVGGNGLHFSLFISVASVSQILFSIILSRKFNtKILKRKIIFIVVLISMIQC 638
Cdd:cd17335   208 ---------FLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQ-RFGHVGLLYLGLLAYVVRW 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 639 VVYSFSFNPWYILI-----GATLSAFgrplfkdtlekldefvvinW-------------QMDRSVDLVLRGLIAPFGYAL 700
Cdd:cd17335   278 LLYSFLENPWLVLPiellhGLTFALV-------------------WaaavsyasaaappGLRATAQGLLQGLYFGLGGGL 338

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1026922172 701 GAMMFGYFYEKLGISILFQ--ATTGVLGLWLIFLIVF 735
Cdd:cd17335   339 GSLIGGYLYEAFGARTTFRffAIAALAGLLAFFLIQR 375
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 565-734 6.68e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 55.28  E-value: 6.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 565 ITFFIFEMIKSLEQLFLFWSLVDVGGNGLHFSLFISVASVSQILFSIILSRKFNTKILKRKIIFIVVLISMIQCVVYSFS 644
Cdd:cd17330   182 VYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 645 FNPWYILIGATLSAFGRPLFKDTLekldeFVVINwqmdRSVDLVLRGLIA-------PFGYALGAMMFGYFYEKLGISIL 717
Cdd:cd17330   262 SSVPLLVLAAAILAFGTGIVFPAL-----SALLS----KSVPSKEQGKAQgiiqslqSLARIIGPLLAGPLYSFLGPGVP 332

                         170
                  ....*....|....*..
gi 1026922172 718 FQATTGVLGLWLIFLIV 734
Cdd:cd17330   333 FLLAAGLLLIALFLLSL 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 483-735 2.77e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 2.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 483 FYLYAGFMILSIPLVFLL--NPMKRSYSELSSAPSKKTKMYKsnvyehlpisdedshiipphtpILVNRGLRMCFGSMTa 560
Cdd:cd17325   153 FLVCAALALLALVLALLLlpEPRPPPNKRAVSAARLRSGLRL----------------------LLRDRRLLALFLAIF- 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 561 avytITFFIFEMIKSLeqLFLFwsLVDVGG-NGLHFSLFISVASVSQILFSIILSRKFNtKILKRKIIFIVVLISMIQCV 639
Cdd:cd17325   210 ----VLAFAFGALEPF--LPLY--AAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPLILIGLLLSAVALL 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 640 VYSFSFNPWYILIGATLSAFGRPLFkdtlekldeFVVINWQMDRSVDLVLRGL-------IAPFGYALGAMMFGYFYEKL 712
Cdd:cd17325   281 LLPLATSFWLLLLLLALLGLGLGLV---------FPATLALLADIVPPEGRGTamglfntAFSLGMVLGPLLGGFLYDAF 351

                         250       260
                  ....*....|....*....|...
gi 1026922172 713 GISILFQATTGVLGLWLIFLIVF 735
Cdd:cd17325   352 GFATPFLAAAALLLLAAVLFLLL 374
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 587-664 4.22e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 49.85  E-value: 4.22e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1026922172 587 DVGGNGLHFSLFISVASVSQILFSIILSRKFNTKILKRKIIFIVVLISMIQCVVYSFSFNPW-YILIGATLSAFGRPLF 664
Cdd:cd17471    26 ELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWvLLLVGVVLLSLGAAAF 104
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 14-99 1.86e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 47.58  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172  14 MSTYYFASNSANAALMPFLPLFYRAVGLNAFLMGLLYASYKTSTIFGTIFWPSLCRVYCSARSNILVSIMITLVLYMIMT 93
Cdd:cd17335     2 LKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLF 81


                  ....*.
gi 1026922172  94 TVPLKF 99
Cdd:cd17335    82 FVAQIF 87
MFS_1 pfam07690
Major Facilitator Superfamily;
559-736 2.16e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 559 TAAVYTITFFIFEMIKSLEQLFLfwsLVDVGGNGLHFSLFISVASVSQILFSIILSRkFNTKILKRKIIFIVVLISMIQC 638
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLL---AEDLGISPTEIGLLLTLFSLGYALAQPLAGR-LSDRFGRRRVLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 639 VVYSFSFNPWYILIGATLSAFGRPLFKDTLEKLdefvVINW--QMDRSVDLVLRGLIAPFGYALGAMMFGYFYEKLGISI 716
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALAL----IADWfpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152

                         170       180
                  ....*....|....*....|
gi 1026922172 717 LFQATTGVLGLWLIFLIVFE 736
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPR 172
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 559-735 3.16e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.18  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 559 TAAVYTITFFifemiksleqLFLFWsLVDVGGNGLHFS-----LFISVASVSQILFSIILSRKFNTKILKRKIIFIVVLI 633
Cdd:cd17474   206 SAFLYFFLYF----------AFLTY-LPFLLELLYGISpiiigLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 634 SMIQCVVYSFSFNPWYILIGATLSAFGR----PLFKDTLEKLDEFVVinwqmdRSVDLVLRGLIAPFGYALGAMMFGYFY 709
Cdd:cd17474   275 YALSLLLLGFVPSLALLLIAIVLFGLGLglnlPLLTTLVTELAPEEE------RGTASSLYNFVRFLGQAVGPLLFGLLL 348

                         170       180
                  ....*....|....*....|....*.
gi 1026922172 710 EKLGISILFqATTGVLGLWLIFLIVF 735
Cdd:cd17474   349 EIFGLSAPF-LVGAAIALAAAVLLAL 373
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 581-734 4.07e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 4.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 581 LFWSLVDVGgnglhfsLFISVASVSQILFSII---LSRKFNtkilKRKIIFIVVLISMIQCVVYSFSFNPWYILIGATLS 657
Cdd:cd17329    30 LGLSASIVG-------LVLALSAVAGIVASLIggrLADRFG----RKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLT 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1026922172 658 AFGRPLFKDTLEKLDEFVVINWQmdRSVDLVLRGLIAPFGYALGAMMFGYFYEkLGISILFQATTGVLGLWLIFLIV 734
Cdd:cd17329    99 GFGGGLFEPASEAMIADVTTPEN--RTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLF 172
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 579-735 8.67e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 45.68  E-value: 8.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 579 LFLFWSLVDVGGNGLHFSLFISVASVSQILFSIILSRkFNTKILKRKIIFIVVLISMIQCVVYSFSFNPWYILIGATLSA 658
Cdd:cd06173   230 LLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGR-LSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLG 308

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1026922172 659 FGRPLFKDTLEKLDEFVVINWQMDR--SVDLVLRGLIAPFGYALGammfGYFYEKLGISILFqATTGVLGLwLIFLIVF 735
Cdd:cd06173   309 LAGGLFNVPLNTLLQLRVPDELRGRvfSVYNALNSGAMPLGALLA----GLLADALGLSAVF-LLAGALLL-LAALLLL 381
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
545-734 1.92e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 545 ILVNRGLRMCFGSMtaAVYTITFFIFEmiksleQLFLFWSLVDVGGNGLHFSLFISVASVSQILFSII---LSRKFNtki 621
Cdd:COG2211   224 LLKNRPFLLLLLAY--LLFFLALALVA------ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLwprLAKRFG--- 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 622 lKRKIIFIVVLISMIQCVVYSFSF--NPWYILIGATLSAFGR--------PLFKDTLEkLDEfvVINWQMDRSVDLVLRG 691
Cdd:COG2211   293 -KKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLgailvlpwAMLADVVD-YDE--WKTGRRREGLYFGIFT 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1026922172 692 LIAPFGYALGAMMFGYFYEKLG-ISILFQATTGVLGLWLIFLIV 734
Cdd:COG2211   369 FAIKLGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFLL 412
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
483-660 2.46e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 483 FYLYAGFMILSIPLVFLLNPmkrsyselSSAPSKKTKMYKSnvyehlpisdedshiippHTPILVNRGLRMCFgsMTAAV 562
Cdd:COG2814   167 FLVNAVLALLALLLLLRLLP--------ESRPAARARLRGS------------------LRELLRRPRLLLLL--LLAFL 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 563 YTITFFIFemiksleQLFLFWSLVDVGG-NGLHFSLFISVASVSQILFSIILSRkFNTKILKRKIIFIVVLISMIQCVVY 641
Cdd:COG2814   219 LGFGFFAL-------FTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGR-LADRFGRRRLLLIGLLLLALGLLLL 290

                         170
                  ....*....|....*....
gi 1026922172 642 SFSFNPWYILIGATLSAFG 660
Cdd:COG2814   291 ALAGSLWLLLLALFLLGFG 309
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 581-736 9.01e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 9.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 581 LFWSLVDVGGNGLHFSLFISVASVSQILFSII---LSRKFNtkilKRKIIFIVVLISMIQCVV-----YSFSFNPWYILI 652
Cdd:cd06173    22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFagvLADRFD----RRRLLILADLLRALLAAVlallaLLGSLSLWLLLV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 653 GATLSAFGRPLF--------KDTLEKlDEFVVINwqmdrSVDLVLRGLIAPFGYALGAMMFGYFYekLGISILFQATTGV 724
Cdd:cd06173    98 LAFLLGIASAFFgparqallPELVPK-EQLVRAN-----ALNSLATQLARIIGPALGGLLVALLG--PGGAFAINALSFL 169

                         170
                  ....*....|..
gi 1026922172 725 LGLWLIFLIVFE 736
Cdd:cd06173   170 LSALLLLFIRRP 181
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
548-735 9.46e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.16  E-value: 9.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 548 NRGLRMCFGSMTAAV------YTITFFIFEMIKSLeqlflFWSLVDVGgngLHFSLFISVASVSQILFSIILSRkFNTki 621
Cdd:COG2271     6 RYRWRILALLFLAYFlnyldrSNLSVAAPPLQADL-----GLSAAQLG---LLASAFFLGYALGQIPAGLLADR-FGR-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 622 lkRKIIFIVVLISMIQCVVYSFSFNPW-----YILIGATLSAFGRPLFKdtlekldefVVINW--QMDRSVDLVLRGLIA 694
Cdd:COG2271    75 --RRVLAIGLLLWGLATLLFGFATSFWqllllRFLLGLGEAGFFPAALK---------LIAEWfpPKERGRALGIFNAGG 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1026922172 695 PFGYALGAMMFGYFYEKLG------ISILFQATTGVLGLWLIFLIVF 735
Cdd:COG2271   144 PLGGALAPPLLGWLLAAFGwraaflILGLPGLLLALLRFWLLALAYF 190
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 585-735 1.97e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.26  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 585 LVDVGGNGLHFSLFISVASVSQILFSIILSRkFNTKILKRKIIFIVVLISMIQCVVYSFSFNPWYILIGATLSAFGRPLF 664
Cdd:cd06174    23 LQSFGLSASQLGLLFALFSLGYALLQPLAGL-LADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLI 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1026922172 665 KDTLEKLDEFVVinWQMDRSVDLVLRGLIAPFGYALGAMMFGYFYEKLGISilFQATTGVLGLWLIFLIVF 735
Cdd:cd06174   102 DPAVLALIADLF--PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG--WRAVFLIAAALALLAAIL 168
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 483-734 3.39e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 483 FYLYAgFMILSIPLV--FLLNPMKRSYSELSSAPSKktkmyksnvyehlpisdEDSHIIPPHTPILvnrglrmcfgsMTA 560
Cdd:cd17473   156 FLVYL-LALPVLILVllFLPEPARKSKSAASPGAAT-----------------AAALPWKRVLPIY-----------FLA 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 561 AVYTITFFIFEMiksleQLFLFwsLVDVG-GNGLHFSLFISVASVSQILFSIILSRKFNtKILKRKIIFIVVLISMIQCV 639
Cdd:cd17473   207 FLAMLLFYVIPI-----QLPFL--LQERGgGSAALIGLALAIASLAGAIGALLFGRLKR-RLGKRRLLAIGFALMALGFL 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 640 VYSFSFNPWYILIGATLSAFGRPLFKDTLekldefvvINWQMDRsVDLVLRGLIApfGYALGAMMFGYFYEKLGISILFQ 719
Cdd:cd17473   279 LLALASGLWVVLLGAILAGLGFGLLLPTL--------NSWAMSL-VPPELRGRAM--GIVTSAFFLGQFLSPLVLGPLVN 347

                         250
                  ....*....|....*
gi 1026922172 720 ATTGVLGLWLIFLIV 734
Cdd:cd17473   348 LTGGLSGAFLILGVL 362
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 562-735 3.82e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 562 VYTITFFIFEMIKSLEQLFLFWSLvDVGGNGLHFSLFISVASVSQILFSIILSRKFNtKILKRKIIFIVVLISMIQCVVY 641
Cdd:cd17370   204 LYLLAVALFALGNFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSD-RIGRKKLLILGYLSLALAYLGF 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026922172 642 SFSFNPWYILIGATLSAFGRPLFkDTLEKldeFVVinwqmdrsVDLV---LRG-------LIAPFGYALGAMMFGYFYEK 711
Cdd:cd17370   282 ALGSSLWLLLLGFILWGLYMGAQ-ESIER---AAV--------ADLVpaeLRGtayglfnTVVGIGWLLASLIAGYLWDL 349

                         170       180
                  ....*....|....*....|....
gi 1026922172 712 LGISILFqATTGVLGlwLIFLIVF 735
Cdd:cd17370   350 ISPSAAF-LFSAVLA--LIALLLL 370
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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