NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|130200|sp|P01832|]
View 

RecName: Full=Polymeric immunoglobulin receptor; Short=PIgR; Short=Poly-Ig receptor; Contains: RecName: Full=Secretory component; Flags: Precursor

Protein Classification

Ig_pIgR_like domain-containing protein( domain architecture ID 10146041)

Ig_pIgR_like domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 460-555 5.22e-28

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 108.25  E-value: 5.22e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   460 SPTIDKFTAVQGEPVEITCHFPCKYFSSEKYWCKWNDHGCEDLPT---KLSSSGDLVKCN-NNLVLTLTLDSVSEDDEGW 535
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSsegVVPGGRISLTDDpDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 130200   536 YWCGAKDGHEFEEVAAVRVE 555
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 351-453 4.56e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 99.78  E-value: 4.56e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   351 SRSPPVLKGFPGGSVTIRCPYNPKrsDSHLQLYLWEGSQTRHLLVDSGEGLVQKdytGRLALFEEPGNGTFSVVLNQLTA 430
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRK 75

                        90       100
                ....*....|....*....|....*
gi 130200   431 EDEGFYWCVSDDDE--SLTTSVKLQ 453
Cdd:cd05716  76 EDAGWYWCGVGDDGdrGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 30-124 5.56e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 91.31  E-value: 5.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200    30 GPGEVNVLEGDSVSITCYYPTTSvtRHSRKFWCREEeSGRCVTLASTGYTSQEysGRGKLTDFPDKGEFVVTVDQLTQND 109
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPKY--ASSRKYWCKWG-SEGCQTLVSSEGVVPG--GRISLTDDPDNGVFTVTLNQLRKED 77

                        90
                ....*....|....*
gi 130200   110 SGSYKCGVGVNGRGL 124
Cdd:cd05716  78 AGWYWCGVGDDGDRG 92
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 245-330 7.63e-11

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05716:

Pssm-ID: 472250  Cd Length: 100  Bit Score: 59.33  E-value: 7.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   245 PGLLYGNLGGSVTFECALDSEDANAVASL-RQVRGG-NVVIDSQGTIDPafeGRILFT-KAENGHFSVVIAGLRKEDTGN 321
Cdd:cd05716   4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWcKWGSEGcQTLVSSEGVVPG---GRISLTdDPDNGVFTVTLNQLRKEDAGW 80


                ....*....
gi 130200   322 YLCGVQSNG 330
Cdd:cd05716  81 YWCGVGDDG 89
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 142-231 9.00e-11

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05716:

Pssm-ID: 472250  Cd Length: 100  Bit Score: 59.33  E-value: 9.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   142 VYKQYESYTVTITCPFTYATRQLKKSFYKVEDGELVLIIDSSSKEAKdprykGRITLQIQsTTAKEFTVTIKHLQLNDAG 221
Cdd:cd05716   6 VVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG-----GRISLTDD-PDNGVFTVTLNQLRKEDAG 79

                        90
                ....*....|
gi 130200   222 QYVCQSGSDP 231
Cdd:cd05716  80 WYWCGVGDDG 89
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 460-555 5.22e-28

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 108.25  E-value: 5.22e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   460 SPTIDKFTAVQGEPVEITCHFPCKYFSSEKYWCKWNDHGCEDLPT---KLSSSGDLVKCN-NNLVLTLTLDSVSEDDEGW 535
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSsegVVPGGRISLTDDpDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 130200   536 YWCGAKDGHEFEEVAAVRVE 555
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 351-453 4.56e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 99.78  E-value: 4.56e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   351 SRSPPVLKGFPGGSVTIRCPYNPKrsDSHLQLYLWEGSQTRHLLVDSGEGLVQKdytGRLALFEEPGNGTFSVVLNQLTA 430
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRK 75

                        90       100
                ....*....|....*....|....*
gi 130200   431 EDEGFYWCVSDDDE--SLTTSVKLQ 453
Cdd:cd05716  76 EDAGWYWCGVGDDGdrGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 30-124 5.56e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 91.31  E-value: 5.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200    30 GPGEVNVLEGDSVSITCYYPTTSvtRHSRKFWCREEeSGRCVTLASTGYTSQEysGRGKLTDFPDKGEFVVTVDQLTQND 109
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPKY--ASSRKYWCKWG-SEGCQTLVSSEGVVPG--GRISLTDDPDNGVFTVTLNQLRKED 77

                        90
                ....*....|....*
gi 130200   110 SGSYKCGVGVNGRGL 124
Cdd:cd05716  78 AGWYWCGVGDDGDRG 92
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-132 3.99e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 71.72  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      30 GPGEVNVLEGDSVSITCYYPTTSVTRHSRKFWCREEESGR---CVTLASTGYTSQEYSGRGKLTDFPDKGEFVVTVDQLT 106
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGptfLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 130200     107 QNDSGSYKCGVGVNGRG-LDFGVNVLV 132
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGvFGKGTRLTV 108
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 245-330 7.63e-11

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 59.33  E-value: 7.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   245 PGLLYGNLGGSVTFECALDSEDANAVASL-RQVRGG-NVVIDSQGTIDPafeGRILFT-KAENGHFSVVIAGLRKEDTGN 321
Cdd:cd05716   4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWcKWGSEGcQTLVSSEGVVPG---GRISLTdDPDNGVFTVTLNQLRKEDAGW 80


                ....*....
gi 130200   322 YLCGVQSNG 330
Cdd:cd05716  81 YWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 142-231 9.00e-11

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 59.33  E-value: 9.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   142 VYKQYESYTVTITCPFTYATRQLKKSFYKVEDGELVLIIDSSSKEAKdprykGRITLQIQsTTAKEFTVTIKHLQLNDAG 221
Cdd:cd05716   6 VVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG-----GRISLTDD-PDNGVFTVTLNQLRKEDAG 79

                        90
                ....*....|
gi 130200   222 QYVCQSGSDP 231
Cdd:cd05716  80 WYWCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 353-455 1.25e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     353 SPPVLKGFPGGSVTIRCPYNPKRSDSHLQLYlW----EGSQTRHLLVDSGEGLVQKDYTGRLALFEEPGNGTFSVVLNQL 428
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVY-WyrqpPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 130200     429 TAEDEGFYWC--VSDDDESLTTSVKLQIV 455
Cdd:pfam07686  81 TLSDSGTYTCavIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 467-544 7.78e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.20  E-value: 7.78e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 130200      467 TAVQGEPVEITCHfpckYFSSEKYWCKWNDHGCEDLPTKLSSSGDlvkcNNNLVLTLTLDSVSEDDEGWYWCGAKDGH 544
Cdd:smart00410   5 TVKEGESVTLSCE----ASGSPPPEVTWYKQGGKLLAESGRFSVS----RSGSTSTLTISNVTPEDSGTYTCAATNSS 74
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-132 1.36e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 1.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200       31 PGEVNVLEGDSVSITCYYPTTSvtrHSRKFWCREeesgrcvtlastGYTSQEYSGRGKLTdfPDKGEFVVTVDQLTQNDS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP---PPEVTWYKQ------------GGKLLAESGRFSVS--RSGSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 130200      111 GSYKCGVGVNGRGLDFGVNVLV 132
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 245-340 2.22e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.34  E-value: 2.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      245 PGLLYGNLGGSVTFECALDSeDANAVASLRQvrggnvvidsQGTIDPAFEGRILFTKaENGHFSVVIAGLRKEDTGNYLC 324
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYK----------QGGKLLAESGRFSVSR-SGSTSTLTISNVTPEDSGTYTC 68

                           90
                   ....*....|....*.
gi 130200      325 GVQSNGQSGDGPTQLR 340
Cdd:smart00410  69 AATNSSGSASSGTTLT 84
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 354-454 1.86e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.65  E-value: 1.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      354 PPVLKGFPGGSVTIRCPYNpkrSDSHLQLYLWEGSQTRHLlvdsgeglvqkdYTGRLALFEEPGNGTFsvVLNQLTAEDE 433
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLLA------------ESGRFSVSRSGSTSTL--TISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 130200      434 GFYWC-VSDDDESLTTSVKLQI 454
Cdd:smart00410  64 GTYTCaATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 150-243 1.15e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.06  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     150 TVTITCPFT--YATRQLKKSFYKVEDG----ELVLIIDSSSKEakdPRYKGRITLQiQSTTAKEFTVTIKHLQLNDAGQY 223
Cdd:pfam07686  13 SVTLPCTYSssMSEASTSVYWYRQPPGkgptFLIAYYSNGSEE---GVKKGRFSGR-GDPSNGDGSLTIQNLTLSDSGTY 88

                          90       100
                  ....*....|....*....|.
gi 130200     224 VCQSGSDPTAEEQN-VDLRLL 243
Cdd:pfam07686  89 TCAVIPSGEGVFGKgTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 150-241 2.00e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 2.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      150 TVTITCPFTyATRQLKKSFYKvEDGELVLiidssskeakdprYKGRITLQIQSTTakeFTVTIKHLQLNDAGQYVCQSGS 229
Cdd:smart00410  11 SVTLSCEAS-GSPPPEVTWYK-QGGKLLA-------------ESGRFSVSRSGST---STLTISNVTPEDSGTYTCAATN 72

                           90
                   ....*....|..
gi 130200      230 DPTAEEQNVDLR 241
Cdd:smart00410  73 SSGSASSGTTLT 84
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 244-342 9.81e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 9.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     244 TPGLLYGNLGGSVTFEC---ALDSEDANAVASLRQVRGGN----VVIDSQGTIDPAFEGRILFTKA-ENGHFSVVIAGLR 315
Cdd:pfam07686   2 TPREVTVALGGSVTLPCtysSSMSEASTSVYWYRQPPGKGptflIAYYSNGSEEGVKKGRFSGRGDpSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*...
gi 130200     316 KEDTGNYLCGVQSNGQSGDGP-TQLRQL 342
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVFGKgTRLTVL 109
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 458-541 1.46e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     458 EPSPTidkfTAVQGEPVEITCHfpCKYFSSEKYWckWNDHGcedlpTKLSSSGDLVKCNNNLVLTLTLDSVSEDDEGWYW 537
Cdd:pfam13927   7 SPSSV----TVREGETVTLTCE--ATGSPPPTIT--WYKNG-----EPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYT 73


                  ....
gi 130200     538 CGAK 541
Cdd:pfam13927  74 CVAS 77
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 460-555 5.22e-28

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 108.25  E-value: 5.22e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   460 SPTIDKFTAVQGEPVEITCHFPCKYFSSEKYWCKWNDHGCEDLPT---KLSSSGDLVKCN-NNLVLTLTLDSVSEDDEGW 535
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSsegVVPGGRISLTDDpDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 130200   536 YWCGAKDGHEFEEVAAVRVE 555
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 351-453 4.56e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 99.78  E-value: 4.56e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   351 SRSPPVLKGFPGGSVTIRCPYNPKrsDSHLQLYLWEGSQTRHLLVDSGEGLVQKdytGRLALFEEPGNGTFSVVLNQLTA 430
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRK 75

                        90       100
                ....*....|....*....|....*
gi 130200   431 EDEGFYWCVSDDDE--SLTTSVKLQ 453
Cdd:cd05716  76 EDAGWYWCGVGDDGdrGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 30-124 5.56e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 91.31  E-value: 5.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200    30 GPGEVNVLEGDSVSITCYYPTTSvtRHSRKFWCREEeSGRCVTLASTGYTSQEysGRGKLTDFPDKGEFVVTVDQLTQND 109
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPKY--ASSRKYWCKWG-SEGCQTLVSSEGVVPG--GRISLTDDPDNGVFTVTLNQLRKED 77

                        90
                ....*....|....*
gi 130200   110 SGSYKCGVGVNGRGL 124
Cdd:cd05716  78 AGWYWCGVGDDGDRG 92
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-132 3.99e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 71.72  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      30 GPGEVNVLEGDSVSITCYYPTTSVTRHSRKFWCREEESGR---CVTLASTGYTSQEYSGRGKLTDFPDKGEFVVTVDQLT 106
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGptfLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 130200     107 QNDSGSYKCGVGVNGRG-LDFGVNVLV 132
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGvFGKGTRLTV 108
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 245-330 7.63e-11

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 59.33  E-value: 7.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   245 PGLLYGNLGGSVTFECALDSEDANAVASL-RQVRGG-NVVIDSQGTIDPafeGRILFT-KAENGHFSVVIAGLRKEDTGN 321
Cdd:cd05716   4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWcKWGSEGcQTLVSSEGVVPG---GRISLTdDPDNGVFTVTLNQLRKEDAGW 80


                ....*....
gi 130200   322 YLCGVQSNG 330
Cdd:cd05716  81 YWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 142-231 9.00e-11

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 59.33  E-value: 9.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   142 VYKQYESYTVTITCPFTYATRQLKKSFYKVEDGELVLIIDSSSKEAKdprykGRITLQIQsTTAKEFTVTIKHLQLNDAG 221
Cdd:cd05716   6 VVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG-----GRISLTDD-PDNGVFTVTLNQLRKEDAG 79

                        90
                ....*....|
gi 130200   222 QYVCQSGSDP 231
Cdd:cd05716  80 WYWCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 353-455 1.25e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     353 SPPVLKGFPGGSVTIRCPYNPKRSDSHLQLYlW----EGSQTRHLLVDSGEGLVQKDYTGRLALFEEPGNGTFSVVLNQL 428
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVY-WyrqpPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 130200     429 TAEDEGFYWC--VSDDDESLTTSVKLQIV 455
Cdd:pfam07686  81 TLSDSGTYTCavIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 467-544 7.78e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.20  E-value: 7.78e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 130200      467 TAVQGEPVEITCHfpckYFSSEKYWCKWNDHGCEDLPTKLSSSGDlvkcNNNLVLTLTLDSVSEDDEGWYWCGAKDGH 544
Cdd:smart00410   5 TVKEGESVTLSCE----ASGSPPPEVTWYKQGGKLLAESGRFSVS----RSGSTSTLTISNVTPEDSGTYTCAATNSS 74
IgV_PD1 cd16088
Immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1); The members here are ...
 29-117 1.01e-07

Immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1); The members here are composed of the immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1; also known as CD279/cluster of differentiation 279). PD1 is a cell surface receptor that is expressed on T cells and pro-B cells. The protein's structure includes an extracellular IgV domain followed by a transmembrane region and an intracellular tail. Activation of CD4+ T cells, CD8+ T cells, NKT cells, B cells, and monocytes induces PD-1 expression, immediately after which it binds two distinct ligands, PD-L1 (also known as B7-H1 or CD274/cluster of differentiation 274) and PD-L2, also known as B7-DC. PD-1 plays an important role in down regulating the immune system by preventing the activation of T-cells, reducing autoimmunity and promoting self-tolerance. The inhibitory effect of PD-1 is accomplished by promoting apoptosis in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells. A class of drugs that target PD-1, known as the PD-1 inhibitors, activate the immune system to attack tumors and treat cancer. Comparisons between the mouse PD-1 (mPD-1) and human PD-1 (hPD-1) reveals that unlike the mPD-1 which has a conventional IgSF V-set domain, hPD-1 lacks a C" strand, and instead the C' and D strands are connected by a long and flexible loop. In addition, the BC loop is not stabilized by disulfide bonding to the F strand of the ligand binding beta sheet. These differences result in different binding affinities of human and mouse PD-1 for their ligands.


Pssm-ID: 409509  Cd Length: 112  Bit Score: 50.97  E-value: 1.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200    29 FGPGEVNVLEGDSVSITCYYPTTSvtRHSRKFWCREEESGRCVTLA--STGYTSQEYSGRGKLTDFPDKGEFVVTVDQLT 106
Cdd:cd16088   4 FSPALLVVTEGANATFTCSFSNTS--ESFVLNWYRLSPSNQTDKLAafPEDRSQPGQDWRFRVTQLPNGRDFHMSVVRAR 81

                        90
                ....*....|.
gi 130200   107 QNDSGSYKCGV 117
Cdd:cd16088  82 RNDSGTYLCGA 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-132 1.36e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 1.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200       31 PGEVNVLEGDSVSITCYYPTTSvtrHSRKFWCREeesgrcvtlastGYTSQEYSGRGKLTdfPDKGEFVVTVDQLTQNDS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP---PPEVTWYKQ------------GGKLLAESGRFSVS--RSGSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 130200      111 GSYKCGVGVNGRGLDFGVNVLV 132
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 245-340 2.22e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.34  E-value: 2.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      245 PGLLYGNLGGSVTFECALDSeDANAVASLRQvrggnvvidsQGTIDPAFEGRILFTKaENGHFSVVIAGLRKEDTGNYLC 324
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYK----------QGGKLLAESGRFSVSR-SGSTSTLTISNVTPEDSGTYTC 68

                           90
                   ....*....|....*.
gi 130200      325 GVQSNGQSGDGPTQLR 340
Cdd:smart00410  69 AATNSSGSASSGTTLT 84
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 354-454 1.86e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.65  E-value: 1.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      354 PPVLKGFPGGSVTIRCPYNpkrSDSHLQLYLWEGSQTRHLlvdsgeglvqkdYTGRLALFEEPGNGTFsvVLNQLTAEDE 433
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLLA------------ESGRFSVSRSGSTSTL--TISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 130200      434 GFYWC-VSDDDESLTTSVKLQI 454
Cdd:smart00410  64 GTYTCaATNSSGSASSGTTLTV 85
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 150-236 5.51e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.09  E-value: 5.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   150 TVTITCPFTYATRQLKKSFYKVEDG---ELVLIIDSSSKEAKDpRYKGRITLQIQSTTakEFTVTIKHLQLNDAGQYVCQ 226
Cdd:cd00099  15 SVTLSCEVSSSFSSTYIYWYRQKPGqgpEFLIYLSSSKGKTKG-GVPGRFSGSRDGTS--SFSLTISNLQPEDSGTYYCA 91

                        90
                ....*....|
gi 130200   227 SGSDPTAEEQ 236
Cdd:cd00099  92 VSESGGTDKL 101
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 150-243 1.15e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.06  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     150 TVTITCPFT--YATRQLKKSFYKVEDG----ELVLIIDSSSKEakdPRYKGRITLQiQSTTAKEFTVTIKHLQLNDAGQY 223
Cdd:pfam07686  13 SVTLPCTYSssMSEASTSVYWYRQPPGkgptFLIAYYSNGSEE---GVKKGRFSGR-GDPSNGDGSLTIQNLTLSDSGTY 88

                          90       100
                  ....*....|....*....|.
gi 130200     224 VCQSGSDPTAEEQN-VDLRLL 243
Cdd:pfam07686  89 TCAVIPSGEGVFGKgTRLTVL 109
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 348-454 1.71e-04

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 41.61  E-value: 1.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   348 IDVSRSPPVLKGFPGGSVTIRCPYNPKRSDSHLQLYLWEGSQTRHLLVDSGEGLvqkdYTGRLALFEEPGNGT-FSVVLN 426
Cdd:cd04980   1 IVMTQSPASLSVSPGERVTISCKASQSISSNYLAWYQQKPGQAPKLLIYYASTL----HSGVPSRFSGSGSGTdFTLTIS 76

                        90       100       110
                ....*....|....*....|....*....|
gi 130200   427 QLTAEDEGFYWCVSDDDESLT--TSVKLQI 454
Cdd:cd04980  77 SVEPEDAAVYYCQQGYTFPYTfgGGTKLEI 106
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 353-451 1.82e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 41.03  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     353 SPPVLKGFPGGSVTIRCPYNPKRSDSHlqlYLWEGSQTRHLLVDsgegLVQKDYTGRlalfeepgnGTFSVVLNQLTAED 432
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSASTGSPGPD---VTWSKEGGTLIESL----KVKHDNGRT---------TQSSLLISNVTKED 65

                          90
                  ....*....|....*....
gi 130200     433 EGFYWCVSDDDESLTTSVK 451
Cdd:pfam00047  66 AGTYTCVVNNPGGSATLST 84
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 150-241 2.00e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 2.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      150 TVTITCPFTyATRQLKKSFYKvEDGELVLiidssskeakdprYKGRITLQIQSTTakeFTVTIKHLQLNDAGQYVCQSGS 229
Cdd:smart00410  11 SVTLSCEAS-GSPPPEVTWYK-QGGKLLA-------------ESGRFSVSRSGST---STLTISNVTPEDSGTYTCAATN 72

                           90
                   ....*....|..
gi 130200      230 DPTAEEQNVDLR 241
Cdd:smart00410  73 SSGSASSGTTLT 84
Ig_Aggrecan_like cd05878
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core ...
 28-117 4.26e-04

Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG); The members here are composed of the immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core proteins (CSPGs). Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409462  Cd Length: 125  Bit Score: 40.68  E-value: 4.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200    28 IFGPGEVNVLEGDSVSITCYY------PTTSVTRHS-RKFWCREEESGR-----CVTLASTGY--TSQEYSGRGKLTDFP 93
Cdd:cd05878   1 IPQSSPVRVLLGTSVTLPCYFidpphpVTPSTAPLApRIKWSKVSVDGKkekevVLLVATEGRvrVNSAYQGRVSLPNYP 80

                        90       100
                ....*....|....*....|....*
gi 130200    94 D-KGEFVVTVDQLTQNDSGSYKCGV 117
Cdd:cd05878  81 AiPSDATLEVQSLRASDSGLYRCEV 105
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 253-330 7.21e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.01  E-value: 7.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   253 GGSVTFEC-ALDSEDANAVASLRQVRGGN-----VVIDSQGTIDPAFEGRILFTKAENGHFSVVIAGLRKEDTGNYLCGV 326
Cdd:cd00099  13 GESVTLSCeVSSSFSSTYIYWYRQKPGQGpefliYLSSSKGKTKGGVPGRFSGSRDGTSSFSLTISNLQPEDSGTYYCAV 92


                ....
gi 130200   327 QSNG 330
Cdd:cd00099  93 SESG 96
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 350-454 7.96e-04

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 39.89  E-value: 7.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   350 VSRSPPVlkGFPGGSVTIRCPYNPKRSDSHLQLYL-WEGSQTR---HLLVDSGEGLVQKD--YTGRLALF-EEPGNGTFS 422
Cdd:cd20934   2 VPEDPVV--ALVGTDATLRCSFSPEPGFSLAQLSVfWQLTDTKqlvHSFTESQDQGRDQGsaYANRTALFpDLLAQGNAS 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 130200   423 VVLNQLTAEDEGFYWCVSDDDESLTTSVKLQI 454
Cdd:cd20934  80 LRLQRVRVADEGSYTCFVSVQDFGSAAVSLQV 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 353-442 8.58e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 39.62  E-value: 8.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   353 SPPVLKGFPGGSVTIRCPYNPKRSDSHLQLYLWEGSQTRHLLV------DSGEGLVQKDYTGRLalfeePGNGTFSVVLN 426
Cdd:cd00099   4 SPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQGPEFLIylssskGKTKGGVPGRFSGSR-----DGTSSFSLTIS 78

                        90
                ....*....|....*.
gi 130200   427 QLTAEDEGFYWCVSDD 442
Cdd:cd00099  79 NLQPEDSGTYYCAVSE 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 244-342 9.81e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 9.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     244 TPGLLYGNLGGSVTFEC---ALDSEDANAVASLRQVRGGN----VVIDSQGTIDPAFEGRILFTKA-ENGHFSVVIAGLR 315
Cdd:pfam07686   2 TPREVTVALGGSVTLPCtysSSMSEASTSVYWYRQPPGKGptflIAYYSNGSEEGVKKGRFSGRGDpSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*...
gi 130200     316 KEDTGNYLCGVQSNGQSGDGP-TQLRQL 342
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVFGKgTRLTVL 109
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 458-541 1.46e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     458 EPSPTidkfTAVQGEPVEITCHfpCKYFSSEKYWckWNDHGcedlpTKLSSSGDLVKCNNNLVLTLTLDSVSEDDEGWYW 537
Cdd:pfam13927   7 SPSSV----TVREGETVTLTCE--ATGSPPPTIT--WYKNG-----EPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYT 73


                  ....
gi 130200     538 CGAK 541
Cdd:pfam13927  74 CVAS 77
IGv smart00406
Immunoglobulin V-Type;
364-438 1.69e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.13  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      364 SVTIRCPYNPKRSdSHLQLYlW----EGSQTRHLLVDSGEGLVQKD--YTGRLALFEEPGNGTFSVVLNQLTAEDEGFYW 437
Cdd:smart00406   1 SVTLSCKFSGSTF-SSYYVS-WvrqpPGKGLEWLGYIGSNGSSYYQesYKGRFTISKDTSKNDVSLTISNLRVEDTGTYY 78


                   .
gi 130200      438 C 438
Cdd:smart00406  79 C 79
IGv smart00406
Immunoglobulin V-Type;
150-226 1.88e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.75  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200      150 TVTITC---PFTYATRQLkkSFYKVEDG---ELVLIIDSSSKEAKDPRYKGRITLQiQSTTAKEFTVTIKHLQLNDAGQY 223
Cdd:smart00406   1 SVTLSCkfsGSTFSSYYV--SWVRQPPGkglEWLGYIGSNGSSYYQESYKGRFTIS-KDTSKNDVSLTISNLRVEDTGTY 77


                   ...
gi 130200      224 VCQ 226
Cdd:smart00406  78 YCA 80
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 240-324 2.00e-03

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 38.71  E-value: 2.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   240 LRLLTPGLLYGNLGGSVTFECALDSEDANAVASL----RQVRGGNVVI--DSQGTIDPAFEgRILFTKAENG----HFSV 309
Cdd:cd20989   1 VRVQVPPEVRGFLGGSVTLPCHLLPPNMVTHVSQvtwqRHDEHGSVAVfhPKQGPSFPESE-RLSFVAARLGaelrNASL 79

                        90
                ....*....|....*
gi 130200   310 VIAGLRKEDTGNYLC 324
Cdd:cd20989  80 AMFGLRVEDEGNYTC 94
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 354-438 2.48e-03

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 38.28  E-value: 2.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   354 PPVLKGFPGGSVTIRCPYNPKRSDSHlQLYLWEGSQTRH----LLVD-SGEGLVQKDYTGRLALFEEPgNGTFSVVLNQL 428
Cdd:cd16089   6 PESITGPWKGSVNLPCTYVPEEGYTQ-VLVKWLVQRDSDpvtiFLRDsSGDHIQQAKYRGRLEVSKDT-PGDVSLQLDTL 83

                        90
                ....*....|
gi 130200   429 TAEDEGFYWC 438
Cdd:cd16089  84 EMDDRGHYTC 93
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 359-453 5.13e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 37.69  E-value: 5.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   359 GFPGGSVTIRCPYNPKRSDSHLQLYL--W-----EGSQTRHLLVDSGegLVQK---DYTGRLALfEEPGNGTFSVVLNQL 428
Cdd:cd05877   9 SHRGGNVTLPCRYHYEPELSAPRKIRvkWtklevDYAKEEDVLVAIG--TRHKsygSYQGRVFL-RRADDLDASLVITDL 85

                        90       100
                ....*....|....*....|....*...
gi 130200   429 TAEDEGFYWC-VSDD--DESLTTSVKLQ 453
Cdd:cd05877  86 RLEDYGRYRCeVIDGleDESVVVALRLR 113
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 467-539 5.73e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.05  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200     467 TAVQGEPVEITCHFPCKYF--SSEKYWCKWNDHGCEDLPTKLSSSGD----------LVKCNNNLVLTLTLDSVSEDDEG 534
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKGPTFLIAYYSNGSeegvkkgrfsGRGDPSNGDGSLTIQNLTLSDSG 86


                  ....*
gi 130200     535 WYWCG 539
Cdd:pfam07686  87 TYTCA 91
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 244-326 7.06e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 37.30  E-value: 7.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130200   244 TPGLLYGNLGGSVTFECALDSEdaNAVASLRQVR-----------GGNVVIDSQGTIDPAF---EGRILFTKAENGHFSV 309
Cdd:cd05877   3 VQAKVFSHRGGNVTLPCRYHYE--PELSAPRKIRvkwtklevdyaKEEDVLVAIGTRHKSYgsyQGRVFLRRADDLDASL 80

                        90
                ....*....|....*..
gi 130200   310 VIAGLRKEDTGNYLCGV 326
Cdd:cd05877  81 VITDLRLEDYGRYRCEV 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH