NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|565830229|sp|P0DM84|]
View 

RecName: Full=Apolipoprotein C-I; Short=Apo-CI; Short=ApoC-I; AltName: Full=Apolipoprotein C1; Contains: RecName: Full=Truncated apolipoprotein C-I; Flags: Precursor

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ApoC-I super family cl04678
Apolipoprotein C-I (ApoC-1); Apolipoprotein C-I (ApoC-1) is a water-soluble protein component ...
 27-71 3.84e-04

Apolipoprotein C-I (ApoC-1); Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolism. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.


The actual alignment was detected with superfamily member pfam04691:

Pssm-ID: 428068  Cd Length: 61  Bit Score: 34.76  E-value: 3.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 565830229  27 APDVASTFRNIPNSLKEFGNNLKD----TFESI-----PEATRKLMTSFAERLK 71
Cdd:pfam04691  1 APDVSSAFERFPDKLKEFGNTLEDkaraAIEHIkqselPAKTRNWFSETFEKVK 54
 
Name Accession Description Interval E-value
ApoC-I pfam04691
Apolipoprotein C-I (ApoC-1); Apolipoprotein C-I (ApoC-1) is a water-soluble protein component ...
 27-71 3.84e-04

Apolipoprotein C-I (ApoC-1); Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolism. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.


Pssm-ID: 428068  Cd Length: 61  Bit Score: 34.76  E-value: 3.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 565830229  27 APDVASTFRNIPNSLKEFGNNLKD----TFESI-----PEATRKLMTSFAERLK 71
Cdd:pfam04691  1 APDVSSAFERFPDKLKEFGNTLEDkaraAIEHIkqselPAKTRNWFSETFEKVK 54
 
Name Accession Description Interval E-value
ApoC-I pfam04691
Apolipoprotein C-I (ApoC-1); Apolipoprotein C-I (ApoC-1) is a water-soluble protein component ...
 27-71 3.84e-04

Apolipoprotein C-I (ApoC-1); Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolism. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.


Pssm-ID: 428068  Cd Length: 61  Bit Score: 34.76  E-value: 3.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 565830229  27 APDVASTFRNIPNSLKEFGNNLKD----TFESI-----PEATRKLMTSFAERLK 71
Cdd:pfam04691  1 APDVSSAFERFPDKLKEFGNTLEDkaraAIEHIkqselPAKTRNWFSETFEKVK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH