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Conserved domains on  [gi|137500|sp|P21089|]
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RecName: Full=Protein OPG200; AltName: Full=Protein B15

Protein Classification

Poxv_Bcl-2-like domain-containing protein( domain architecture ID 10533309)

Poxv_Bcl-2-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Poxv_Bcl-2-like pfam06227
Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins ...
 1-143 4.16e-43

Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins that function as immunomodulators to evade the host innate immune response through the inhibition of apoptosis or blocking the activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-kappaB (NF-kappaB). These proteins have low sequence identity but high structural similarity to the eukaryotic Bcl-2 protein family. They have a Bcl-2 fold which comprises a central hydrophobic alpha-helix that is surrounded by an additional layer of 6-7 amphipathic alpha-helices. Included in this family are proteins B14, A52, A46, C6, K7, N1, and N2. Protein N1 has the unusual dual ability of modulating apoptosis and inflammatory signalling. Protein K7, in addition to its anti-inflammatory activity, forms a complex with RNA helicase DDX3 and antagonizes interferon-beta promoter induction.


:

Pssm-ID: 368802  Cd Length: 145  Bit Score: 139.37  E-value: 4.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137500       1 MTANFSTHVFSPQHCGCDRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVF-IDIRELVKNMPWD- 78
Cdd:pfam06227   2 NNIDFSDYDLSFNYIIADTISDDDSIKDILEEYFRWRGNIGRNRDSAGKLFKELMKFDDDAIKKYgGDLITLIKNLLLDs 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 137500      79 DVKDCTEIIRCYIPDEQKTIREISAIIGLCAYAATYWGGEDhPTSNSLNALFVMLEMLNYVDYNI 143
Cdd:pfam06227  82 DIYNFKLFIKLKINIDNDNIEECKAIIGLCAILSEYWGKED-PTKNSLNILYLFFKNLSDDDLNK 145
 
Name Accession Description Interval E-value
Poxv_Bcl-2-like pfam06227
Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins ...
 1-143 4.16e-43

Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins that function as immunomodulators to evade the host innate immune response through the inhibition of apoptosis or blocking the activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-kappaB (NF-kappaB). These proteins have low sequence identity but high structural similarity to the eukaryotic Bcl-2 protein family. They have a Bcl-2 fold which comprises a central hydrophobic alpha-helix that is surrounded by an additional layer of 6-7 amphipathic alpha-helices. Included in this family are proteins B14, A52, A46, C6, K7, N1, and N2. Protein N1 has the unusual dual ability of modulating apoptosis and inflammatory signalling. Protein K7, in addition to its anti-inflammatory activity, forms a complex with RNA helicase DDX3 and antagonizes interferon-beta promoter induction.


Pssm-ID: 368802  Cd Length: 145  Bit Score: 139.37  E-value: 4.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137500       1 MTANFSTHVFSPQHCGCDRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVF-IDIRELVKNMPWD- 78
Cdd:pfam06227   2 NNIDFSDYDLSFNYIIADTISDDDSIKDILEEYFRWRGNIGRNRDSAGKLFKELMKFDDDAIKKYgGDLITLIKNLLLDs 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 137500      79 DVKDCTEIIRCYIPDEQKTIREISAIIGLCAYAATYWGGEDhPTSNSLNALFVMLEMLNYVDYNI 143
Cdd:pfam06227  82 DIYNFKLFIKLKINIDNDNIEECKAIIGLCAILSEYWGKED-PTKNSLNILYLFFKNLSDDDLNK 145
PHA02861 PHA02861
uncharacterized protein; Provisional
 10-144 2.08e-31

uncharacterized protein; Provisional


Pssm-ID: 165196  Cd Length: 149  Bit Score: 109.71  E-value: 2.08e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137500     10 FSPQHCGCDRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVF-IDIRELVKNMPWDDVKDCTEIIR 88
Cdd:PHA02861   3 FCPGYCLVDCLNRDDDIRQIIVDYIYWSMYSYRSRSPAGKVFQVLKMFRRDSEIVFgENFRHIVKNFKTLGIEDTVQAVK 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 137500     89 CYIPDeQKTIREISAIIGLCAYAATYWGGEDHPTSNSLNALFVMLEMLNYVDYNII 144
Cdd:PHA02861  83 CFTVG-KNALRESVSMVDLCASLAEYWGGEDLPTNDSLQALKLMTILLSDDDYSFI 137
 
Name Accession Description Interval E-value
Poxv_Bcl-2-like pfam06227
Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins ...
 1-143 4.16e-43

Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins that function as immunomodulators to evade the host innate immune response through the inhibition of apoptosis or blocking the activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-kappaB (NF-kappaB). These proteins have low sequence identity but high structural similarity to the eukaryotic Bcl-2 protein family. They have a Bcl-2 fold which comprises a central hydrophobic alpha-helix that is surrounded by an additional layer of 6-7 amphipathic alpha-helices. Included in this family are proteins B14, A52, A46, C6, K7, N1, and N2. Protein N1 has the unusual dual ability of modulating apoptosis and inflammatory signalling. Protein K7, in addition to its anti-inflammatory activity, forms a complex with RNA helicase DDX3 and antagonizes interferon-beta promoter induction.


Pssm-ID: 368802  Cd Length: 145  Bit Score: 139.37  E-value: 4.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137500       1 MTANFSTHVFSPQHCGCDRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVF-IDIRELVKNMPWD- 78
Cdd:pfam06227   2 NNIDFSDYDLSFNYIIADTISDDDSIKDILEEYFRWRGNIGRNRDSAGKLFKELMKFDDDAIKKYgGDLITLIKNLLLDs 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 137500      79 DVKDCTEIIRCYIPDEQKTIREISAIIGLCAYAATYWGGEDhPTSNSLNALFVMLEMLNYVDYNI 143
Cdd:pfam06227  82 DIYNFKLFIKLKINIDNDNIEECKAIIGLCAILSEYWGKED-PTKNSLNILYLFFKNLSDDDLNK 145
PHA02861 PHA02861
uncharacterized protein; Provisional
 10-144 2.08e-31

uncharacterized protein; Provisional


Pssm-ID: 165196  Cd Length: 149  Bit Score: 109.71  E-value: 2.08e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137500     10 FSPQHCGCDRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVF-IDIRELVKNMPWDDVKDCTEIIR 88
Cdd:PHA02861   3 FCPGYCLVDCLNRDDDIRQIIVDYIYWSMYSYRSRSPAGKVFQVLKMFRRDSEIVFgENFRHIVKNFKTLGIEDTVQAVK 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 137500     89 CYIPDeQKTIREISAIIGLCAYAATYWGGEDHPTSNSLNALFVMLEMLNYVDYNII 144
Cdd:PHA02861  83 CFTVG-KNALRESVSMVDLCASLAEYWGGEDLPTNDSLQALKLMTILLSDDDYSFI 137
PHA02922 PHA02922
hypothetical protein; Provisional
 10-141 6.24e-26

hypothetical protein; Provisional


Pssm-ID: 165234  Cd Length: 153  Bit Score: 95.86  E-value: 6.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137500     10 FSPQHCGC--DRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDA-ELVFIDIRELVKNMPWDDVKDCTEI 86
Cdd:PHA02922   8 FSPCHCHAtkDSLNTVADVRHCLTEYILWVSHRWTHRESAGSLYRLLISFRTDAtELFGSELKEFSDSLPWDNIDNCVEI 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 137500     87 IRCYIPDEQ-KTIREISAIIGLCAYAATYWGGEDHptSNSLNALFVMLEMLNYVDY 141
Cdd:PHA02922  88 IKCFIRNDSmKTAKELRAIIGLCTQSAIVSGRVFN--DKYIDILLMLRKILNENDY 141
PHA02827 PHA02827
hypothetical protein; Provisional
 17-147 1.03e-24

hypothetical protein; Provisional


Pssm-ID: 177492  Cd Length: 150  Bit Score: 92.57  E-value: 1.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137500     17 CDRLTSIDDVKQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVF-IDIRELVKNMPWDDVK--DCTEIIRCYIPD 93
Cdd:PHA02827   9 RNNFSDDDDITTAVQDYLYWSSLPFRSREPAGNVFAVFESFKRDASIVFgDDLTWFVKCMFLDSKEgfDHSKSMIRAMLK 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 137500     94 EQKTIREISAIIGLCAYAATYWGGEDHPTSNSLNALFVMLEMLNyvDYNIIFRR 147
Cdd:PHA02827  89 KENYIREACAVIGLLARAAEYWGGESSPTPASAKVLELLMELLT--DNDISHVK 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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