NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|417817|sp|P32584|]
View 

RecName: Full=Protein-S-isoprenylcysteine O-methyltransferase; Short=ICMT; AltName: Full=Isoprenylcysteine carboxylmethyltransferase; AltName: Full=Prenylated protein carboxyl methyltransferase; Short=PPMT; AltName: Full=Prenylcysteine carboxyl methyltransferase; Short=pcCMT

Protein Classification

protein-S-isoprenylcysteine O-methyltransferase( domain architecture ID 10514227)

protein-S-isoprenylcysteine O-methyltransferase catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 127-219 2.34e-29

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


:

Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 105.90  E-value: 2.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817     127 LLVILGQYTRTIAMHTAGHSFSHIVKTkkESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLL--NPLSLVIFIFVLWK 204
Cdd:pfam04140   3 GLFLFGQILRKWAMVTLGRYWNHRVAI--LPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCnaWYTALVFYALNAWL 80

                          90
                  ....*....|....*
gi 417817     205 FFSDRIRVEEKYLIE 219
Cdd:pfam04140  81 LFSVRIRQEEKALAH 95
 
Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 127-219 2.34e-29

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 105.90  E-value: 2.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817     127 LLVILGQYTRTIAMHTAGHSFSHIVKTkkESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLL--NPLSLVIFIFVLWK 204
Cdd:pfam04140   3 GLFLFGQILRKWAMVTLGRYWNHRVAI--LPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCnaWYTALVFYALNAWL 80

                          90
                  ....*....|....*
gi 417817     205 FFSDRIRVEEKYLIE 219
Cdd:pfam04140  81 LFSVRIRQEEKALAH 95
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 125-239 4.53e-19

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 79.43  E-value: 4.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817   125 GCLLVILGQYTRTIAMHTAGHSFSHIVKTKKesDHVLVKTGVYSWSRHPSYLGFFWWAIGTqLLLLNPLSLVIFIFVLWK 204
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLVPPRK--AHRLVTTGPYRYVRHPMYLGFLLLLLGL-ALLLGSLLALLLALLLLL 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 417817   205 FFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI 239
Cdd:COG2020  79 LYVLRIRREERRLRARFGEEYRAYAARVPRLIPRL 113
isopcys_mtase NF040696
protein-S-isoprenylcysteine O-methyltransferase;
158-239 3.08e-07

protein-S-isoprenylcysteine O-methyltransferase;


Pssm-ID: 468660  Cd Length: 190  Bit Score: 49.17  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817    158 DHVLVKTGVYSWSRHPSYLGFFWWAIGtQLLLLNPLSLVIFIFVLWK-FFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGI 236
Cdd:NF040696 109 GHTLVTSGVYRYIRHPMYAAFWLWAIA-QALLLPNWIAGLAGLVGFGiLYFLRVPREEQMMLETFGDEYRAYMQRTGRLI 187


                 ...
gi 417817    237 PFI 239
Cdd:NF040696 188 PKI 190
 
Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 127-219 2.34e-29

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 105.90  E-value: 2.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817     127 LLVILGQYTRTIAMHTAGHSFSHIVKTkkESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLL--NPLSLVIFIFVLWK 204
Cdd:pfam04140   3 GLFLFGQILRKWAMVTLGRYWNHRVAI--LPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCnaWYTALVFYALNAWL 80

                          90
                  ....*....|....*
gi 417817     205 FFSDRIRVEEKYLIE 219
Cdd:pfam04140  81 LFSVRIRQEEKALAH 95
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 125-239 4.53e-19

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 79.43  E-value: 4.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817   125 GCLLVILGQYTRTIAMHTAGHSFSHIVKTKKesDHVLVKTGVYSWSRHPSYLGFFWWAIGTqLLLLNPLSLVIFIFVLWK 204
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLVPPRK--AHRLVTTGPYRYVRHPMYLGFLLLLLGL-ALLLGSLLALLLALLLLL 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 417817   205 FFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI 239
Cdd:COG2020  79 LYVLRIRREERRLRARFGEEYRAYAARVPRLIPRL 113
isopcys_mtase NF040696
protein-S-isoprenylcysteine O-methyltransferase;
158-239 3.08e-07

protein-S-isoprenylcysteine O-methyltransferase;


Pssm-ID: 468660  Cd Length: 190  Bit Score: 49.17  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817    158 DHVLVKTGVYSWSRHPSYLGFFWWAIGtQLLLLNPLSLVIFIFVLWK-FFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGI 236
Cdd:NF040696 109 GHTLVTSGVYRYIRHPMYAAFWLWAIA-QALLLPNWIAGLAGLVGFGiLYFLRVPREEQMMLETFGDEYRAYMQRTGRLI 187


                 ...
gi 417817    237 PFI 239
Cdd:NF040696 188 PKI 190
PEMT pfam04191
Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) ...
 120-224 4.37e-06

Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids.


Pssm-ID: 461218 [Multi-domain]  Cd Length: 105  Bit Score: 44.09  E-value: 4.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417817     120 LCTVLGCLLVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPSY----LGFFWWAIGTQlllLNPLSL 195
Cdd:pfam04191   1 LRLILGLLLIALGLWLVLSSYRALGIFGTFYGDFFGILMDKLVTGGPYRYLNNPMYvggtLGFLGLALITG---SPAGLL 77

                          90       100
                  ....*....|....*....|....*....
gi 417817     196 VIFIFVLWKFFSdRIRVEEKYLIEFFSAE 224
Cdd:pfam04191  78 LALLVLLVYFIA-LKFVEEPHMAKIYGKR 105
DUF1295 pfam06966
Protein of unknown function (DUF1295); This family contains a number of bacterial and ...
 164-232 7.50e-03

Protein of unknown function (DUF1295); This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.


Pssm-ID: 399743  Cd Length: 235  Bit Score: 36.58  E-value: 7.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 417817     164 TGVYSWSRHPSYLG--FFWW---AIGTQLLLLNPLSLV---IFIFVLWKFFSDrIRVEEKYLIEFF--SAEYIEYKNKV 232
Cdd:pfam06966 158 TGLWRYSRHPNYFGeaLIWWgifLIALNVLSGLEWWTIfgpLVMTLLLVFVSG-IPLTERSADKKYgdREDYRAYQRTT 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH