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Conserved domains on  [gi|18266882|sp|P49196|]
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RecName: Full=Small ribosomal subunit protein eS12; AltName: Full=40S ribosomal protein S12

Protein Classification

ribosomal L7Ae/L30e/S12e/Gadd45 family protein( domain architecture ID 10472466)

ribosomal L7Ae/L30e/S12e/Gadd45 family protein belongs to a family of K-turn-binding proteins that are important in ribosome structure, the site-specific modification of RNA, and spliceosome assembly

CATH:  3.30.1330.30
Gene Ontology:  GO:0003735|GO:0042274
PubMed:  24149842|24524803|7622064

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 25-119 4.10e-30

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


:

Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 104.21  E-value: 4.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18266882    25 ALRAVLRAAHHADGLAKGLHETCKALDKREAHFCVLAENCDEPQYVKLVETLCAEHQIPLIKVADKKIIGEYCGLCKyDK 104
Cdd:pfam01248   2 AIYEVLKKALKTGKLVLGLKEVTKALERGEAKLVIIAEDCDPEEKVKLIPALCKEKNVPYVKVPSKKELGEACGKKR-PV 80

                          90
                  ....*....|....*
gi 18266882   105 EGKARKVVGCSSAVV 119
Cdd:pfam01248  81 SALAIKDEGDSKILV 95
 
Name Accession Description Interval E-value
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 25-119 4.10e-30

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 104.21  E-value: 4.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18266882    25 ALRAVLRAAHHADGLAKGLHETCKALDKREAHFCVLAENCDEPQYVKLVETLCAEHQIPLIKVADKKIIGEYCGLCKyDK 104
Cdd:pfam01248   2 AIYEVLKKALKTGKLVLGLKEVTKALERGEAKLVIIAEDCDPEEKVKLIPALCKEKNVPYVKVPSKKELGEACGKKR-PV 80

                          90
                  ....*....|....*
gi 18266882   105 EGKARKVVGCSSAVV 119
Cdd:pfam01248  81 SALAIKDEGDSKILV 95
Rpl7Ae COG1358
Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure ...
 30-98 2.32e-06

Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure and biogenesis]; Ribosomal protein L7Ae or related RNA K-turn-binding protein is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440969 [Multi-domain]  Cd Length: 98  Bit Score: 43.22  E-value: 2.32e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18266882  30 LRAAHHADGLAKGLHETCKALDKREAHFCVLAENCDEPQyVKLVETLCAEHQIPLIKVADKKIIGEYCG 98
Cdd:COG1358   7 LGLARRAGKLVSGEEQVLKAIRKGKAKLVIIAEDASENT-KKKLLDLCEEYGVPVVEVGTKEELGKAIG 74
PTZ00222 PTZ00222
60S ribosomal protein L7a; Provisional
 42-140 9.63e-06

60S ribosomal protein L7a; Provisional


Pssm-ID: 140249  Cd Length: 263  Bit Score: 43.53  E-value: 9.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18266882   42 GLHETCKALDKREAHFCVLAENCDEPQYVKLVETLCAEHQIPLIKVADKKIIGEYCGlckydkegkaRKVVGCssAVVTN 121
Cdd:PTZ00222 136 GLQEVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANKIPYAIVKDMARLGDAIG----------RKTATC--VAITD 203

                         90
                 ....*....|....*....
gi 18266882  122 WGNEEQgrAILTDYFASKN 140
Cdd:PTZ00222 204 VNAEDE--AALKNLIRSVN 220
SNU13 cd21104
U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, ...
 11-125 1.99e-04

U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, also known as NHP2-like protein 1 or U4/U6.U5 tri-snRNP 15.5 kDa protein, is a component of the spliceosome B complex, involved in pre-mRNA splicing. It binds to the 5'-stem-loop of U4 snRNA.


Pssm-ID: 411046  Cd Length: 122  Bit Score: 38.46  E-value: 1.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18266882  11 APAAVAQGPMDkegalraVLRAAHHADGLAKGLHETCKALDKREAHFCVLAENCdEPQYVKL-VETLCAEHQIPLIKVAD 89
Cdd:cd21104   8 ADAQLTQTILD-------LVQQAANYKQLKKGANEATKTLNRGIAEFIVMAADA-EPLEILLhLPLLCEDKNVPYVFVPS 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18266882  90 KKIIGEYCGLckydkegkARKVVGCSsaVVTNWGNE 125
Cdd:cd21104  80 KQALGRACGV--------SRPVIACS--VTTNEGSQ 105
 
Name Accession Description Interval E-value
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 25-119 4.10e-30

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 104.21  E-value: 4.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18266882    25 ALRAVLRAAHHADGLAKGLHETCKALDKREAHFCVLAENCDEPQYVKLVETLCAEHQIPLIKVADKKIIGEYCGLCKyDK 104
Cdd:pfam01248   2 AIYEVLKKALKTGKLVLGLKEVTKALERGEAKLVIIAEDCDPEEKVKLIPALCKEKNVPYVKVPSKKELGEACGKKR-PV 80

                          90
                  ....*....|....*
gi 18266882   105 EGKARKVVGCSSAVV 119
Cdd:pfam01248  81 SALAIKDEGDSKILV 95
Rpl7Ae COG1358
Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure ...
 30-98 2.32e-06

Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure and biogenesis]; Ribosomal protein L7Ae or related RNA K-turn-binding protein is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440969 [Multi-domain]  Cd Length: 98  Bit Score: 43.22  E-value: 2.32e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18266882  30 LRAAHHADGLAKGLHETCKALDKREAHFCVLAENCDEPQyVKLVETLCAEHQIPLIKVADKKIIGEYCG 98
Cdd:COG1358   7 LGLARRAGKLVSGEEQVLKAIRKGKAKLVIIAEDASENT-KKKLLDLCEEYGVPVVEVGTKEELGKAIG 74
PTZ00222 PTZ00222
60S ribosomal protein L7a; Provisional
 42-140 9.63e-06

60S ribosomal protein L7a; Provisional


Pssm-ID: 140249  Cd Length: 263  Bit Score: 43.53  E-value: 9.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18266882   42 GLHETCKALDKREAHFCVLAENCDEPQYVKLVETLCAEHQIPLIKVADKKIIGEYCGlckydkegkaRKVVGCssAVVTN 121
Cdd:PTZ00222 136 GLQEVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANKIPYAIVKDMARLGDAIG----------RKTATC--VAITD 203

                         90
                 ....*....|....*....
gi 18266882  122 WGNEEQgrAILTDYFASKN 140
Cdd:PTZ00222 204 VNAEDE--AALKNLIRSVN 220
SNU13 cd21104
U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, ...
 11-125 1.99e-04

U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13, also known as NHP2-like protein 1 or U4/U6.U5 tri-snRNP 15.5 kDa protein, is a component of the spliceosome B complex, involved in pre-mRNA splicing. It binds to the 5'-stem-loop of U4 snRNA.


Pssm-ID: 411046  Cd Length: 122  Bit Score: 38.46  E-value: 1.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18266882  11 APAAVAQGPMDkegalraVLRAAHHADGLAKGLHETCKALDKREAHFCVLAENCdEPQYVKL-VETLCAEHQIPLIKVAD 89
Cdd:cd21104   8 ADAQLTQTILD-------LVQQAANYKQLKKGANEATKTLNRGIAEFIVMAADA-EPLEILLhLPLLCEDKNVPYVFVPS 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18266882  90 KKIIGEYCGLckydkegkARKVVGCSsaVVTNWGNE 125
Cdd:cd21104  80 KQALGRACGV--------SRPVIACS--VTTNEGSQ 105
PRK13602 PRK13602
50S ribosomal protein L7ae-like protein;
42-99 5.73e-04

50S ribosomal protein L7ae-like protein;


Pssm-ID: 184174 [Multi-domain]  Cd Length: 82  Bit Score: 36.68  E-value: 5.73e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 18266882   42 GLHETCKALDKREAHFCVLAENCDePQYVKLVETLCAEHQIPLIKVADKKIIGEYCGL 99
Cdd:PRK13602  15 GTKQTVKALKRGSVKEVVVAEDAD-PRLTEKVEALANEKGVPVSKVDSMKKLGKACGI 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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