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Conserved domains on  [gi|18202479|sp|Q02539|]
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RecName: Full=Histone H1.1; AltName: Full=Histone H1a

Protein Classification

histone H1/H5 family protein( domain architecture ID 10049384)

histone H1/H5 family protein similar to a linker histone (H1 or H5), which is a chromatin-associated protein that binds to the exterior of nucleosomes and dramatically stabilizes the highly condensed states of chromatin fibers

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
H15 cd00073
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, ...
41-120 2.18e-12

linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated proteins that bind to the exterior of nucleosomes and dramatically stabilize the highly condensed states of chromatin fibers; stabilization of higher order folding occurs through electrostatic neutralization of the linker DNA segments, through a highly positively charged carboxy- terminal domain known as the AKP helix (Ala, Lys, Pro); thought to be involved in specific protein-protein and protein-DNA interactions and play a role in suppressing core histone tail domain acetylation in the chromatin fiber


:

Pssm-ID: 238028 [Multi-domain]  Cd Length: 88  Bit Score: 60.71  E-value: 2.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18202479  41 PSVSELIVQAASSSKERGGVSLAALKKALAAAGYDV-EKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVET 119
Cdd:cd00073   5 PPYSEMVTEAIKALKERKGSSLQAIKKYIEAKYKVDdENFNKLLKLALKKGVAKGKLVQVKGTGASGSFKLSKKKKKKKK 84

                .
gi 18202479 120 K 120
Cdd:cd00073  85 P 85
 
Name Accession Description Interval E-value
H15 cd00073
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, ...
41-120 2.18e-12

linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated proteins that bind to the exterior of nucleosomes and dramatically stabilize the highly condensed states of chromatin fibers; stabilization of higher order folding occurs through electrostatic neutralization of the linker DNA segments, through a highly positively charged carboxy- terminal domain known as the AKP helix (Ala, Lys, Pro); thought to be involved in specific protein-protein and protein-DNA interactions and play a role in suppressing core histone tail domain acetylation in the chromatin fiber


Pssm-ID: 238028 [Multi-domain]  Cd Length: 88  Bit Score: 60.71  E-value: 2.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18202479  41 PSVSELIVQAASSSKERGGVSLAALKKALAAAGYDV-EKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVET 119
Cdd:cd00073   5 PPYSEMVTEAIKALKERKGSSLQAIKKYIEAKYKVDdENFNKLLKLALKKGVAKGKLVQVKGTGASGSFKLSKKKKKKKK 84

                .
gi 18202479 120 K 120
Cdd:cd00073  85 P 85
Linker_histone pfam00538
linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin ...
41-108 2.62e-12

linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.


Pssm-ID: 459846 [Multi-domain]  Cd Length: 71  Bit Score: 59.85  E-value: 2.62e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18202479    41 PSVSELIVQAASSSKERGGVSLAALKKALAAAGY--DVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSF 108
Cdd:pfam00538   2 PPYSDMIKEAIKALKERKGSSRQAIKKYIKANYKvgDVAKFNSLLKRALKKGVEKGTLVQPKGTGASGSF 71
H15 smart00526
Domain in histone families 1 and 5;
41-101 8.38e-06

Domain in histone families 1 and 5;


Pssm-ID: 197772 [Multi-domain]  Cd Length: 66  Bit Score: 42.18  E-value: 8.38e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18202479     41 PSVSELIVQAASSSKERGGVSLAALKKALAAAgYDVEKNN--SRIKLGIKSLVSKGTLVQTKG 101
Cdd:smart00526   5 PPYSEMIVEAISALKERKGSSLQAIKKYIEAN-YKVLPNNfrKLLKLALKRLVASGKLVQVKG 66
 
Name Accession Description Interval E-value
H15 cd00073
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, ...
41-120 2.18e-12

linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated proteins that bind to the exterior of nucleosomes and dramatically stabilize the highly condensed states of chromatin fibers; stabilization of higher order folding occurs through electrostatic neutralization of the linker DNA segments, through a highly positively charged carboxy- terminal domain known as the AKP helix (Ala, Lys, Pro); thought to be involved in specific protein-protein and protein-DNA interactions and play a role in suppressing core histone tail domain acetylation in the chromatin fiber


Pssm-ID: 238028 [Multi-domain]  Cd Length: 88  Bit Score: 60.71  E-value: 2.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18202479  41 PSVSELIVQAASSSKERGGVSLAALKKALAAAGYDV-EKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVET 119
Cdd:cd00073   5 PPYSEMVTEAIKALKERKGSSLQAIKKYIEAKYKVDdENFNKLLKLALKKGVAKGKLVQVKGTGASGSFKLSKKKKKKKK 84

                .
gi 18202479 120 K 120
Cdd:cd00073  85 P 85
Linker_histone pfam00538
linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin ...
41-108 2.62e-12

linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.


Pssm-ID: 459846 [Multi-domain]  Cd Length: 71  Bit Score: 59.85  E-value: 2.62e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18202479    41 PSVSELIVQAASSSKERGGVSLAALKKALAAAGY--DVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSF 108
Cdd:pfam00538   2 PPYSDMIKEAIKALKERKGSSRQAIKKYIKANYKvgDVAKFNSLLKRALKKGVEKGTLVQPKGTGASGSF 71
H15 smart00526
Domain in histone families 1 and 5;
41-101 8.38e-06

Domain in histone families 1 and 5;


Pssm-ID: 197772 [Multi-domain]  Cd Length: 66  Bit Score: 42.18  E-value: 8.38e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18202479     41 PSVSELIVQAASSSKERGGVSLAALKKALAAAgYDVEKNN--SRIKLGIKSLVSKGTLVQTKG 101
Cdd:smart00526   5 PPYSEMIVEAISALKERKGSSLQAIKKYIEAN-YKVLPNNfrKLLKLALKRLVASGKLVQVKG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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