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Conserved domains on  [gi|90110651|sp|Q2QL84|]
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RecName: Full=Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; AltName: Full=Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein

Protein Classification

ANKYR and SAM_ASZ1 domain-containing protein( domain architecture ID 12789531)

ANKYR and SAM_ASZ1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-250 2.01e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.33  E-value: 2.01e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  53 ALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGA--NASfDKDKQTILITACsARGSEEqilk 130
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAdvNAQ-DNDGNTPLHLAA-ANGNLE---- 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651 131 CVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKML 210
Cdd:COG0666 168 IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 90110651 211 QTKDGKIPSEIAKRNKHLEIFNFLSLTLNPLEGNLKQLTK 250
Cdd:COG0666 248 KDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
SAM_ASZ1 cd09521
SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine ...
 272-333 1.22e-22

SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine Zipper) also known as GASZ (Germ cell-specific Ankyrin, SAM, leucine Zipper) subfamily is a potential protein-protein interaction domain. Proteins of this group are involved in the repression of transposable elements during spermatogenesis, oogenesis, and preimplantation embryogenesis. They support synthesis of PIWI-interacting RNA via association with some PIWI proteins, such as MILI and MIWI. This association is required for initiation and maintenance of retrotransposon repression during the meiosis. In mice lacking ASZ1, DNA damage and delayed germ cell maturation was observed due to retrotransposons releasing from their repressed state.


:

Pssm-ID: 188920  Cd Length: 64  Bit Score: 90.81  E-value: 1.22e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90110651 272 SYTAFGDLEIFLHGLGLEHMTDLLKEKDITLRHLLTMRKDEFTKNGITN-KDQQKILSALKEL 333
Cdd:cd09521   1 SYSKLDDLELFLHGLELGHLTPLFKEHDVTFSQLLKMTEEDLEKIGITQpGDQKKILDAIKEV 63
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-250 2.01e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.33  E-value: 2.01e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  53 ALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGA--NASfDKDKQTILITACsARGSEEqilk 130
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAdvNAQ-DNDGNTPLHLAA-ANGNLE---- 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651 131 CVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKML 210
Cdd:COG0666 168 IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 90110651 211 QTKDGKIPSEIAKRNKHLEIFNFLSLTLNPLEGNLKQLTK 250
Cdd:COG0666 248 KDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
SAM_ASZ1 cd09521
SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine ...
 272-333 1.22e-22

SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine Zipper) also known as GASZ (Germ cell-specific Ankyrin, SAM, leucine Zipper) subfamily is a potential protein-protein interaction domain. Proteins of this group are involved in the repression of transposable elements during spermatogenesis, oogenesis, and preimplantation embryogenesis. They support synthesis of PIWI-interacting RNA via association with some PIWI proteins, such as MILI and MIWI. This association is required for initiation and maintenance of retrotransposon repression during the meiosis. In mice lacking ASZ1, DNA damage and delayed germ cell maturation was observed due to retrotransposons releasing from their repressed state.


Pssm-ID: 188920  Cd Length: 64  Bit Score: 90.81  E-value: 1.22e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90110651 272 SYTAFGDLEIFLHGLGLEHMTDLLKEKDITLRHLLTMRKDEFTKNGITN-KDQQKILSALKEL 333
Cdd:cd09521   1 SYSKLDDLELFLHGLELGHLTPLFKEHDVTFSQLLKMTEEDLEKIGITQpGDQKKILDAIKEV 63
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-234 1.22e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 84.72  E-value: 1.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   59 ISLVQELLDSGISVDSSFRYGWTPLMYAASI-----ANVELVRVLLDRGA--NASFDKDKQTILITACSARGSeeqiLKC 131
Cdd:PHA03100  48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIkynltDVKEIVKLLLEYGAnvNAPDNNGITPLLYAISKKSNS----YSI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  132 VELLLSRNADPNVACRRLMTPIMYAARDGHP--QVVAVLVAHGAEVN----------------TQDENGYTALTWAARQG 193
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHYAVYNN 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 90110651  194 HKNVVLKLLELGANKMLQTKDGKIPSEIAKRNKHLEIFNFL 234
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
129-211 5.00e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.92  E-value: 5.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHgAEVNTQDeNGYTALTWAARQGHKNVVLKLLELGANK 208
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87


                  ...
gi 90110651   209 MLQ 211
Cdd:pfam12796  88 NVK 90
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
272-334 1.71e-06

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 45.34  E-value: 1.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90110651   272 SYTAFGDLEIFLHGLGLEHMTDLLKEKDIT-LRHLLTMRKDEFTKNGITNK-DQQKILSALKELE 334
Cdd:pfam07647   2 ESWSLESVADWLRSIGLEQYTDNFRDQGITgAELLLRLTLEDLKRLGITSVgHRRKILKKIQELK 66
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 53-169 7.53e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 7.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  53 ALTTGDISLVQELLDSGISVDSS------FR--------YGWTPLMYAASIANVELVRVLLDRGANA----SFDKDKQTI 114
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSPratgtfFRpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIraqdSLGNTVLHI 175

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90110651 115 LITACSARGSEEQIlkcvELLLSRNADPNVAC------RRLMTPIMYAARDGHPQVVAVLV 169
Cdd:cd22192 176 LVLQPNKTFACQMY----DLILSYDKEDDLQPldlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 78-104 1.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 1.53e-04
                           10        20
                   ....*....|....*....|....*..
gi 90110651     78 YGWTPLMYAASIANVELVRVLLDRGAN 104
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-250 2.01e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.33  E-value: 2.01e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  53 ALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGA--NASfDKDKQTILITACsARGSEEqilk 130
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAdvNAQ-DNDGNTPLHLAA-ANGNLE---- 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651 131 CVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKML 210
Cdd:COG0666 168 IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 90110651 211 QTKDGKIPSEIAKRNKHLEIFNFLSLTLNPLEGNLKQLTK 250
Cdd:COG0666 248 KDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-234 1.35e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 1.35e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  47 NETFKKALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGAN-ASFDKDKQTILITACsARGSE 125
Cdd:COG0666  55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADvNARDKDGETPLHLAA-YNGNL 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651 126 EqilkCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELG 205
Cdd:COG0666 134 E----IVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209

                       170       180
                ....*....|....*....|....*....
gi 90110651 206 ANKMLQTKDGKIPSEIAKRNKHLEIFNFL 234
Cdd:COG0666 210 ADVNAKDNDGKTALDLAAENGNLEIVKLL 238
SAM_ASZ1 cd09521
SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine ...
 272-333 1.22e-22

SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine Zipper) also known as GASZ (Germ cell-specific Ankyrin, SAM, leucine Zipper) subfamily is a potential protein-protein interaction domain. Proteins of this group are involved in the repression of transposable elements during spermatogenesis, oogenesis, and preimplantation embryogenesis. They support synthesis of PIWI-interacting RNA via association with some PIWI proteins, such as MILI and MIWI. This association is required for initiation and maintenance of retrotransposon repression during the meiosis. In mice lacking ASZ1, DNA damage and delayed germ cell maturation was observed due to retrotransposons releasing from their repressed state.


Pssm-ID: 188920  Cd Length: 64  Bit Score: 90.81  E-value: 1.22e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90110651 272 SYTAFGDLEIFLHGLGLEHMTDLLKEKDITLRHLLTMRKDEFTKNGITN-KDQQKILSALKEL 333
Cdd:cd09521   1 SYSKLDDLELFLHGLELGHLTPLFKEHDVTFSQLLKMTEEDLEKIGITQpGDQKKILDAIKEV 63
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
59-234 7.12e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 7.12e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  59 ISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASFDKDKQTILITACSARGSEEQILkcveLLLSR 138
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVAL----LLLAA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651 139 NADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKDGKIP 218
Cdd:COG0666  77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                       170
                ....*....|....*.
gi 90110651 219 SEIAKRNKHLEIFNFL 234
Cdd:COG0666 157 LHLAAANGNLEIVKLL 172
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-234 1.22e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 84.72  E-value: 1.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   59 ISLVQELLDSGISVDSSFRYGWTPLMYAASI-----ANVELVRVLLDRGA--NASFDKDKQTILITACSARGSeeqiLKC 131
Cdd:PHA03100  48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIkynltDVKEIVKLLLEYGAnvNAPDNNGITPLLYAISKKSNS----YSI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  132 VELLLSRNADPNVACRRLMTPIMYAARDGHP--QVVAVLVAHGAEVN----------------TQDENGYTALTWAARQG 193
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHYAVYNN 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 90110651  194 HKNVVLKLLELGANKMLQTKDGKIPSEIAKRNKHLEIFNFL 234
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
129-211 5.00e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.92  E-value: 5.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHgAEVNTQDeNGYTALTWAARQGHKNVVLKLLELGANK 208
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87


                  ...
gi 90110651   209 MLQ 211
Cdd:pfam12796  88 NVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-179 7.00e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 7.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651    83 LMYAASIANVELVRVLLDRGANASF-DKDKQTILITACSaRGSEEqilkCVELLLSrNADPNVACRRlMTPIMYAARDGH 161
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLqDKNGRTALHLAAK-NGHLE----IVKLLLE-HADVNLKDNG-RTALHYAARSGH 73

                          90
                  ....*....|....*...
gi 90110651   162 PQVVAVLVAHGAEVNTQD 179
Cdd:pfam12796  74 LEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
57-144 8.51e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 8.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651    57 GDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRgANASFDKDKQTILITACSARgseeqILKCVELLL 136
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSG-----HLEIVKLLL 81


                  ....*...
gi 90110651   137 SRNADPNV 144
Cdd:pfam12796  82 EKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 65-240 2.99e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.59  E-value: 2.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   65 LLDSGISVDSSFRYGWTPLmyAASI----ANVELVRVLLDRGANAsFDKD--KQTIL-ITACSARGSEeqilKCVELLLS 137
Cdd:PHA03095 138 LLRKGADVNALDLYGMTPL--AVLLksrnANVELLRLLIDAGADV-YAVDdrFRSLLhHHLQSFKPRA----RIVRELIR 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  138 RNADPNVACRRLMTPIMYAARDGHPQ--VVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKDG 215
Cdd:PHA03095 211 AGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDG 290

                        170       180
                 ....*....|....*....|....*.
gi 90110651  216 KIPSEIAKRNKHLEIFN-FLSLTLNP 240
Cdd:PHA03095 291 NTPLSLMVRNNNGRAVRaALAKNPSA 316
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-234 1.65e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   153 IMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMlqTKDGKIPSEIAKRNKHLEIFN 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                  ..
gi 90110651   233 FL 234
Cdd:pfam12796  79 LL 80
Ank_4 pfam13637
Ankyrin repeats (many copies);
150-202 2.05e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 58.83  E-value: 2.05e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90110651   150 MTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLL 202
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-218 1.16e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.44  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   41 LPVEEKNETFKKALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASfdkdkqtILITACS 120
Cdd:PHA02874  30 ISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS-------ILPIPCI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  121 ARGSEEQILKCvelllsrNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLK 200
Cdd:PHA02874 103 EKDMIKTILDC-------GIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175

                        170
                 ....*....|....*...
gi 90110651  201 LLELGANKMLQTKDGKIP 218
Cdd:PHA02874 176 LLEKGAYANVKDNNGESP 193
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 53-207 2.51e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 62.32  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   53 ALTTGDISLVQELLDSGISVDSSF-RYGWTPLMYAASIANVELVRVLLDRGANASF-DKDKQTILITACSARGseeqiLK 130
Cdd:PHA02875  75 AVEEGDVKAVEELLDLGKFADDVFyKDGMTPLHLATILKKLDIMKLLIARGADPDIpNTDKFSPLHLAVMMGD-----IK 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90110651  131 CVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENG-YTALTWAARQGHKNVVLKLLELGAN 207
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGAD 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 62-234 1.54e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 1.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   62 VQELLDSGISVDSSFRYGWTPLMYAASIANVE-LVRVLLDRGA--NASFDKDKQTILITACSARGSEeqilKCVELLLSR 138
Cdd:PHA03095  66 VRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAGAdvNAKDKVGRTPLHVYLSGFNINP----KVIRLLLRK 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  139 NADPNVACRRLMTP--IMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKN--VVLKLLELGANKMLQTKD 214
Cdd:PHA03095 142 GADVNALDLYGMTPlaVLLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPRarIVRELIRAGCDPAATDML 221

                        170       180
                 ....*....|....*....|...
gi 90110651  215 GKIPSEIAK---RNKHLEIFNFL 234
Cdd:PHA03095 222 GNTPLHSMAtgsSCKRSLVLPLL 244
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 53-207 1.66e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.62  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   53 ALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGA----------------------------- 103
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipdvkypdieselhdaveegdvkaveell 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  104 ------NASFDKDKQTILITAcsargSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNT 177
Cdd:PHA02875  89 dlgkfaDDVFYKDGMTPLHLA-----TILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170       180       190
                 ....*....|....*....|....*....|
gi 90110651  178 QDENGYTALTWAARQGHKNVVLKLLELGAN 207
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 41-154 5.98e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.08  E-value: 5.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   41 LPVEEKNETFKKALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASFdKDKQTILITACS 120
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY-FGKNGCVAALCY 208

                         90       100       110
                 ....*....|....*....|....*....|....
gi 90110651  121 ArgSEEQILKCVELLLSRNADPNVacrrlMTPIM 154
Cdd:PHA02875 209 A--IENNKIDIVRLFIKRGADCNI-----MFMIE 235
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 52-207 8.54e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 8.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   52 KALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANV-ELVRVLLDRGA--NASFDKDKQTILITACSARGSEEqi 128
Cdd:PHA02876 246 KAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGAdvNAKNIKGETPLYLMAKNGYDTEN-- 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  129 lkcVELLLSRNADPNVACRRLMTPIMYAAR-DGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGAN 207
Cdd:PHA02876 324 ---IRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
Ank_5 pfam13857
Ankyrin repeats (many copies);
134-186 1.53e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.81  E-value: 1.53e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90110651   134 LLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTAL 186
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 141-235 3.83e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.67  E-value: 3.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  141 DPNVAcRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKDGKIPSE 220
Cdd:PTZ00322  75 DPVVA-HMLTVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLE 153

                         90
                 ....*....|....*
gi 90110651  221 IAKRNKHLEIFNFLS 235
Cdd:PTZ00322 154 LAEENGFREVVQLLS 168
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 55-207 4.15e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 4.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   55 TTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASF-DKDKQTILITACSARgsEEQILKcVE 133
Cdd:PLN03192 534 STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIrDANGNTALWNAISAK--HHKIFR-IL 610

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90110651  134 LLLSRNADPNVACRRLMTpimyAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGAN 207
Cdd:PLN03192 611 YHFASISDPHAAGDLLCT----AAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-234 8.47e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.20  E-value: 8.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   56 TGDISLVQELLDS-----GISVDSSFrygwTPLMYAASIANVELVRVLLDRGANASFDKDK-QTILITACSARGSeeqil 129
Cdd:PHA02874  11 SGDIEAIEKIIKNkgnciNISVDETT----TPLIDAIRSGDAKIVELFIKHGADINHINTKiPHPLLTAIKIGAH----- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  130 KCVELLLSRNADPNVacrrLMTPimyaarDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKM 209
Cdd:PHA02874  82 DIIKLLIDNGVDTSI----LPIP------CIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVN 151

                        170       180
                 ....*....|....*....|....*
gi 90110651  210 LQTKDGKIPSEIAKRNKHLEIFNFL 234
Cdd:PHA02874 152 IEDDNGCYPIHIAIKHNFFDIIKLL 176
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 278-332 2.23e-07

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 47.62  E-value: 2.23e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 90110651 278 DLEIFLHGLGLEHMTDLLKEKDITLRHLLTMRKDEFTKNGITNK-DQQKILSALKE 332
Cdd:cd09487   1 DVAEWLESLGLEQYADLFRKNEIDGDALLLLTDEDLKELGITSPgHRKKILRAIQR 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 73-207 2.34e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.10  E-value: 2.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   73 DSSFRYgwtplMYAASIANVELVRVLLDRGANASFDKDKQTILITACsARGSEEQILKCVELLLSRNADPNVACRRLMTP 152
Cdd:PHA03095  13 AALYDY-----LLNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLY-LHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 90110651  153 IMYAARDGH-PQVVAVLVAHGAEVNTQDENGYTAL-TWAARQG-HKNVVLKLLELGAN 207
Cdd:PHA03095  87 LHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLhVYLSGFNiNPKVIRLLLRKGAD 144
Ank_5 pfam13857
Ankyrin repeats (many copies);
168-222 3.73e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 3.73e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 90110651   168 LVAHG-AEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKDGKIPSEIA 222
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
47-99 6.04e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 6.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90110651    47 NETFKKALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLL 99
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 132-234 6.50e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 52.18  E-value: 6.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  132 VELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALtW----------------------- 188
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL-Wnaisakhhkifrilyhfasisdp 619

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 90110651  189 ---------AARQGHKNVVLKLLELGANKMLQTKDGKIPSEIAKRNKHLEIFNFL 234
Cdd:PLN03192 620 haagdllctAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
272-334 1.71e-06

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 45.34  E-value: 1.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90110651   272 SYTAFGDLEIFLHGLGLEHMTDLLKEKDIT-LRHLLTMRKDEFTKNGITNK-DQQKILSALKELE 334
Cdd:pfam07647   2 ESWSLESVADWLRSIGLEQYTDNFRDQGITgAELLLRLTLEDLKRLGITSVgHRRKILKKIQELK 66
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 61-218 1.81e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   61 LVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASFDKDKQTILITACSARGSEEQIlkcvELLLSRNA 140
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDII----KLLLEKGA 181

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90110651  141 DPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTALTWAARqgHKNVVLKLLELGANKMLQTKDGKIP 218
Cdd:PHA02874 182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTP 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-234 3.64e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   45 EKNETFKKALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASF--------------DKD 110
Cdd:PHA02876 144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIialddlsvlecavdSKN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  111 KQTI----------------LITACSARGSEEQIL-----------------------------KCVELLLSRNADPNVA 145
Cdd:PHA02876 224 IDTIkaiidnrsninkndlsLLKAIRNEDLETSLLlydagfsvnsiddckntplhhasqapslsRLVPKLLERGADVNAK 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  146 CRRLMTPIMYAARDGH-PQVVAVLVAHGAEVNTQDENGYTALTWAAR-QGHKNVVLKLLELGANKMLQTKDGKIPSEIAK 223
Cdd:PHA02876 304 NIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAA 383

                        250
                 ....*....|.
gi 90110651  224 RNKHLEIFNFL 234
Cdd:PHA02876 384 VRNNVVIINTL 394
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 61-199 4.80e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.29  E-value: 4.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   61 LVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGAN-ASFDKDKQTILITACSARGSeeqiLKCVELLLSRN 139
Cdd:PHA02876 357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADiEALSQKIGTALHFALCGTNP----YMSVKTLIDRG 432

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90110651  140 ADPNVACRRLMTPIMYAARDG-HPQVVAVLVAHGAEVNTQD-ENGYTALTWAARQGHKNVVL 199
Cdd:PHA02876 433 ANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINiQNQYPLLIALEYHGIVNILL 494
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-222 6.61e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 6.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   31 DRVSQKLKVPLPVEEKNETFKK----ALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANAS 106
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTflhyAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  107 F-DKDKQTILITAcsargSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARdgHPQVVAVLVAHGAEVNTQDENGYTA 185
Cdd:PHA02874 185 VkDNNGESPLHNA-----AEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTP 257

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 90110651  186 LTWAARQG-HKNVVLKLLELGANKMLQTKDGKIPSEIA 222
Cdd:PHA02874 258 LHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 61-218 1.59e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   61 LVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASFD-KDKQTILITACSARGSeeqilkCVELLLSrN 139
Cdd:PHA02874 172 IIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAIIHNRS------AIELLIN-N 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  140 ADPNVACRRLMTPIMYAARdgHP---QVVAVLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKllELGANKMLQTKDGK 216
Cdd:PHA02874 245 ASINDQDIDGSTPLHHAIN--PPcdiDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK--DIIANAVLIKEADK 320


                 ..
gi 90110651  217 IP 218
Cdd:PHA02874 321 LK 322
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 282-333 3.94e-05

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 41.49  E-value: 3.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90110651   282 FLHGLGLEHMTDLLKEKDITLRHLLTMRKDEFTKNGITNK-DQQKILSALKEL 333
Cdd:pfam00536  11 WLESIGLGQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLgHRKKILYAIQRL 63
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 53-169 7.53e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 7.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  53 ALTTGDISLVQELLDSGISVDSS------FR--------YGWTPLMYAASIANVELVRVLLDRGANA----SFDKDKQTI 114
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSPratgtfFRpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIraqdSLGNTVLHI 175

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90110651 115 LITACSARGSEEQIlkcvELLLSRNADPNVAC------RRLMTPIMYAARDGHPQVVAVLV 169
Cdd:cd22192 176 LVLQPNKTFACQMY----DLILSYDKEDDLQPldlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 91-222 7.83e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   91 NVELVRVLLdrganASFDKDKQTILITACSARGSEEQI-LKCVELLLSRNADPNVACR-RLMTPIMYAARDGHPQVVAVL 168
Cdd:PHA02878 113 NVEIFKIIL-----TNRYKNIQTIDLVYIDKKSKDDIIeAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELL 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 90110651  169 VAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMLQTKDGKIPSEIA 222
Cdd:PHA02878 188 LSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 78-104 1.03e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.16  E-value: 1.03e-04
                          10        20
                  ....*....|....*....|....*..
gi 90110651    78 YGWTPLMYAASIANVELVRVLLDRGAN 104
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 102-207 1.03e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.05  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  102 GANASFDKDKQTILITACSARGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDEN 181
Cdd:PHA02876 131 GNDIHYDKINESIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD 210

                         90       100
                 ....*....|....*....|....*.
gi 90110651  182 GYTALTWAARQGHKNVVLKLLELGAN 207
Cdd:PHA02876 211 DLSVLECAVDSKNIDTIKAIIDNRSN 236
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 38-158 1.46e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.10  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   38 KVPLPVEEKNETFKKALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAAS-IANVELVRVLLDRGANASFdkdKQTIL- 115
Cdd:PHA02878 193 NVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGyCKDYDILKLLLEHGVDVNA---KSYILg 269

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 90110651  116 ITACSARGSEEQILKcveLLLSRNADPNVACRRLMTPIMYAAR 158
Cdd:PHA02878 270 LTALHSSIKSERKLK---LLLEYGADINSLNSYKLTPLSSAVK 309
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 78-104 1.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 1.53e-04
                           10        20
                   ....*....|....*....|....*..
gi 90110651     78 YGWTPLMYAASIANVELVRVLLDRGAN 104
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 78-104 3.66e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 3.66e-04
                          10        20
                  ....*....|....*....|....*...
gi 90110651    78 YGWTPLMYAASIA-NVELVRVLLDRGAN 104
Cdd:pfam00023   1 DGNTPLHLAAGRRgNLEIVKLLLSKGAD 28
PHA03095 PHA03095
ankyrin-like protein; Provisional
 60-106 5.61e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 5.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 90110651   60 SLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANAS 106
Cdd:PHA03095 238 SLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284
PHA02946 PHA02946
ankyin-like protein; Provisional
 58-262 1.07e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   58 DISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANA-SFDKDKQTILITacsARGSEEQILKCVELLL 136
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPnACDKQHKTPLYY---LSGTDDEVIERINLLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  137 SRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGAEVNTQDENGYTAL--TWAARQGHKNVVLKLLELGANKMLQTKD 214
Cdd:PHA02946 128 QYGAKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHD 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  215 GKIPSEI--AKRNKHLEIFNFL--SLTLN--------PLEGNLKQLTKEETICKLLTTDS 262
Cdd:PHA02946 208 GNTPLHIvcSKTVKNVDIINLLlpSTDVNkqnkfgdsPLTLLIKTLSPAHLINKLLSTSN 267
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 95-182 1.49e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   95 VRVLLDRGANA-SFDKDKQTILITACsARGSeeqiLKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLVAHGA 173
Cdd:PTZ00322  98 ARILLTGGADPnCRDYDGRTPLHIAC-ANGH----VQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172


                 ....*....
gi 90110651  174 EVNTQDENG 182
Cdd:PTZ00322 173 CHFELGANA 181
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 181-207 1.55e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.55e-03
                           10        20
                   ....*....|....*....|....*..
gi 90110651    181 NGYTALTWAARQGHKNVVLKLLELGAN 207
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
Ank_4 pfam13637
Ankyrin repeats (many copies);
129-169 2.78e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 2.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 90110651   129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQVVAVLV 169
Cdd:pfam13637  14 LELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 46-202 4.12e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   46 KNETFKKALTTGDIS-LVQELLDSGISVDSSFRYGWTPL-MYAASIANVELVRVLLDRGAN---------------ASFD 108
Cdd:PHA02876 273 KNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADvnaadrlyitplhqaSTLD 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651  109 KDKQTILI-----TACSARGSEEQI----------LKCVELLLSRNADPNVACRRLMTPIMYAARDGHPQV-VAVLVAHG 172
Cdd:PHA02876 353 RNKDIVITllelgANVNARDYCDKTpihyaavrnnVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMsVKTLIDRG 432

                        170       180       190
                 ....*....|....*....|....*....|
gi 90110651  173 AEVNTQDENGYTALTWAARQGHKNVVLKLL 202
Cdd:PHA02876 433 ANVNSKNKDLSTPLHYACKKNCKLDVIEML 462
SAM_ANKS3 cd09519
SAM domain of ANKS3 subfamily; SAM (sterile alpha motif) domain of ANKS3 subfamily is a ...
 273-319 4.30e-03

SAM domain of ANKS3 subfamily; SAM (sterile alpha motif) domain of ANKS3 subfamily is a potential protein-protein interaction domain. Proteins of this subfamily have N-terminal ankyrin repeats and a C-terminal SAM domain. SAM is a widespread domain in signaling proteins. In many cases it mediates homo-dimerization/oligomerization.


Pssm-ID: 188918  Cd Length: 64  Bit Score: 35.55  E-value: 4.30e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 90110651 273 YTAFGDLEIFLHGLGLEHMTDLLKEKDITLRHLLTMRKDEFTKNGIT 319
Cdd:cd09519   1 YTGPKDLSELLEQIGCSKYLPIFEEQDIDLRIFLTLTESDLKEIGIT 47
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 150-177 4.68e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*...
gi 90110651   150 MTPIMYAARDGHPQVVAVLVAHGAEVNT 177
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
79-136 5.82e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 5.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 90110651    79 GWTPLMYAASIANVELVRVLLDRGANAS-FDKDKQTILITACSaRGSEEqilkCVELLL 136
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAAS-NGNVE----VLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 56-137 5.94e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.11  E-value: 5.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   56 TGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANAS-FDKDKQTILITAcsargSEEQILKCVEL 134
Cdd:PTZ00322  92 SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELA-----EENGFREVVQL 166


                 ...
gi 90110651  135 LLS 137
Cdd:PTZ00322 167 LSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 150-176 6.33e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 6.33e-03
                           10        20
                   ....*....|....*....|....*..
gi 90110651    150 MTPIMYAARDGHPQVVAVLVAHGAEVN 176
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 53-192 7.06e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.71  E-value: 7.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90110651   53 ALTTGDISLVQELLDSGISVDSSFRYGWTPLMYAASIANVELVRVLLDRGANASFDKDKQTILITACSARGSEEQILKcv 132
Cdd:PHA02878 175 ATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDILK-- 252

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90110651  133 eLLLSRNADPNVACRRL-MTPIMYAARDghPQVVAVLVAHGAEVNTQDENGYTALTWAARQ 192
Cdd:PHA02878 253 -LLLEHGVDVNAKSYILgLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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