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Conserved domains on  [gi|146330986|sp|Q32ZZ4|]
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RecName: Full=NADH-ubiquinone oxidoreductase chain 2; AltName: Full=NADH dehydrogenase subunit 2

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-336 3.98e-166

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 467.02  E-value: 3.98e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330
                 ....*....|....*.
gi 146330986 321 KSTALLSPLTILSTMI 336
Cdd:MTH00105 321 KPMTLLPTLIILSTML 336
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-336 3.98e-166

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 467.02  E-value: 3.98e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330
                 ....*....|....*.
gi 146330986 321 KSTALLSPLTILSTMI 336
Cdd:MTH00105 321 KPMTLLPTLIILSTML 336
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-276 1.11e-24

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 101.62  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   23 SSHWLTMWIGFEMNMLAIIP-ILMKKYNPRSMEASTKYFLTQATASMLLMLAVTI-----------NLVHSGQWSTTNPL 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   91 NPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILL-TWQKLAP-----MSVLYQISPMINLDLMFTMSILSIAI 164
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  165 GGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIIL---------TTTTFLTFMTNSTTTTLSLSHLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLThglfsaglfLCAGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 146330986  236 KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSI 276
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWI 281
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-298 6.96e-24

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 101.73  E-value: 6.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   6 FSIITFTMMLGtGIVMTSS-HWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------T 75
Cdd:COG1007  104 FYALLLFATLG-MMLMASAnDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGIsllygatgS 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  76 INLVHSGQWSTTNPLNP---AASIILTLA-MAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQI------ 145
Cdd:COG1007  183 LNLAGIAAALAAGGANSpllLLGLVLVLAgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafp 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 146 SPMINLDLMFT-MSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNST 224
Cdd:COG1007  263 GLAADWQLLLAvLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMNLGAFAVIL 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 225 TTTLSLSHLWN---------KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMR 295
Cdd:COG1007  343 LLSRKGGEAEEiedlaglarRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLR 422


                 ...
gi 146330986 296 LIY 298
Cdd:COG1007  423 VVK 425
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-297 8.61e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 92.70  E-value: 8.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   15 LGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWS 85
Cdd:TIGR01770 113 LGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgSLNFEDLLLFL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   86 TTNPLNP---AASIILTL-AMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMI-------NLDLM 154
Cdd:TIGR01770 193 SNGMLNIsllLLGIVLILvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfseaWQIFL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  155 FTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW------------MTAILAYNPTMALLNLTIYIILTTTTFLTFMTN 222
Cdd:TIGR01770 273 AIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligllagtlegIKAVLFYIFIYALMSLGAFGVLSLLRSYKDEWI 352

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146330986  223 STTTTLSLSHLWNkePLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:TIGR01770 353 EYISDFAGLFKTN--PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-336 3.98e-166

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 467.02  E-value: 3.98e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330
                 ....*....|....*.
gi 146330986 321 KSTALLSPLTILSTMI 336
Cdd:MTH00105 321 KPMTLLPTLIILSTML 336
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-336 2.19e-115

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 337.95  E-value: 2.19e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320

                        330
                 ....*....|....*.
gi 146330986 321 KSTaLLSPLTILSTMI 336
Cdd:MTH00112 321 KNT-LTATLTTLSTLL 335
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-335 2.34e-115

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 337.93  E-value: 2.34e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMiNLDLMFTMSIL 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330
                 ....*....|....*
gi 146330986 321 KSTALLSPLTILSTM 335
Cdd:MTH00135 320 QLTLPLAISTTATLM 334
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-336 2.23e-108

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 320.33  E-value: 2.23e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNqT 320
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFK-N 319

                        330
                 ....*....|....*.
gi 146330986 321 KSTALLSPLTILSTMI 336
Cdd:MTH00070 320 KTNNLLSLTIILSLML 335
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-336 6.42e-86

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 262.94  E-value: 6.42e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGN 320

                        330       340
                 ....*....|....*....|.
gi 146330986 321 KS-----TALLSPLTILSTMI 336
Cdd:MTH00041 321 ITvygviLSILSSISILGLLL 341
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-336 1.09e-82

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 254.89  E-value: 1.09e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVH 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSIL 160
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320

                        330
                 ....*....|....*.
gi 146330986 321 KSTaLLSPLTILSTMI 336
Cdd:MTH00200 321 SNL-LVGLLLLLSILG 335
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-336 6.77e-52

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 175.01  E-value: 6.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   1 MNPLIFSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLvh 80
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNM-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 sgqwSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQispMINLDLMFTMSIL 160
Cdd:MTH00160  80 ----LNLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSY---LINNNFIIIIIIL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLI 240
Cdd:MTH00160 153 SAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 241 TTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQT 320
Cdd:MTH00160 233 KFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFS 312

                        330
                 ....*....|....*.
gi 146330986 321 KSTALLSPLTILSTMI 336
Cdd:MTH00160 313 LILNFLSFISLFGLIL 328
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 11-336 6.30e-49

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 166.99  E-value: 6.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  11 FTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVHSGQWSTtnpl 90
Cdd:MTH00144  11 FLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS---- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  91 npaaSIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINL-DLMFTMSILSIAIGGWGG 169
Cdd:MTH00144  87 ----MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVISVLSALVGSIGG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 170 LNQTQLRKVMAYSSIAHMGWMTAILAYNPtMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTML 249
Cdd:MTH00144 163 LNQTQVRALLAYSSISHTGWMLVAILHGS-WLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 250 SLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQTKSTALLSPL 329
Cdd:MTH00144 242 SLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLLGGL 321


                 ....*..
gi 146330986 330 TILSTMI 336
Cdd:MTH00144 322 LFLLLYL 328
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 12-300 4.62e-45

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 156.86  E-value: 4.62e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  12 TMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTInlvhsgQWSTTNPLN 91
Cdd:MTH00011  14 TMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTM------MWSFPSLLK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  92 PAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMSILSIAIGGWGGLN 171
Cdd:MTH00011  88 NITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGLGGMN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 172 QTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSL 251
Cdd:MTH00011 168 QTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSL 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 146330986 252 GGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSS 300
Cdd:MTH00011 248 GGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNF 296
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 11-332 9.30e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 137.50  E-value: 9.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  11 FTMMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLvhsgqwsTTNPL 90
Cdd:MTH00197   5 FIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSF-------SNLYL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  91 NPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPmiNLDLMFTMSILSIAIGGWGGL 170
Cdd:MTH00197  78 SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSS--SFMGLLICSVLSSLIGGIGGM 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 171 NQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLS 250
Cdd:MTH00197 156 NQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 251 LGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYSSALTLFPSMNNTVMKWQLNQTKSTALLSPLT 330
Cdd:MTH00197 236 LGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLMMMLP 315


                 ..
gi 146330986 331 IL 332
Cdd:MTH00197 316 LL 317
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 15-314 4.38e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 103.96  E-value: 4.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  15 LGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAVT-------------INLVH 80
Cdd:MTH00196   4 LGILCLISSSNWLSVYLAIELQTLSLfILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCAllcgttgglhlsyINLVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  81 SGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTmsIL 160
Cdd:MTH00196  84 NSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGG--LF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMAL------LNLTIYIILTTTTFLTFMTNSTTTTLSLSHLW 234
Cdd:MTH00196 162 SLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFESIqaslvyLFIYIIMSICVFSIILALNVYKNLIIEFSGLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 235 NKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRL---IYSSALTLFPSMNNT 311
Cdd:MTH00196 242 RRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIvkiLFFQANSFLLISTKI 321


                 ...
gi 146330986 312 VMK 314
Cdd:MTH00196 322 LKK 324
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-276 1.11e-24

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 101.62  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   23 SSHWLTMWIGFEMNMLAIIP-ILMKKYNPRSMEASTKYFLTQATASMLLMLAVTI-----------NLVHSGQWSTTNPL 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   91 NPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILL-TWQKLAP-----MSVLYQISPMINLDLMFTMSILSIAI 164
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  165 GGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIIL---------TTTTFLTFMTNSTTTTLSLSHLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLThglfsaglfLCAGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 146330986  236 KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSI 276
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWI 281
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-298 6.96e-24

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 101.73  E-value: 6.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   6 FSIITFTMMLGtGIVMTSS-HWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------T 75
Cdd:COG1007  104 FYALLLFATLG-MMLMASAnDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGIsllygatgS 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  76 INLVHSGQWSTTNPLNP---AASIILTLA-MAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQI------ 145
Cdd:COG1007  183 LNLAGIAAALAAGGANSpllLLGLVLVLAgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafp 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 146 SPMINLDLMFT-MSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNST 224
Cdd:COG1007  263 GLAADWQLLLAvLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMNLGAFAVIL 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 225 TTTLSLSHLWN---------KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMR 295
Cdd:COG1007  343 LLSRKGGEAEEiedlaglarRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLR 422


                 ...
gi 146330986 296 LIY 298
Cdd:COG1007  423 VVK 425
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-297 8.61e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 92.70  E-value: 8.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   15 LGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWS 85
Cdd:TIGR01770 113 LGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgSLNFEDLLLFL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   86 TTNPLNP---AASIILTL-AMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMI-------NLDLM 154
Cdd:TIGR01770 193 SNGMLNIsllLLGIVLILvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfseaWQIFL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  155 FTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW------------MTAILAYNPTMALLNLTIYIILTTTTFLTFMTN 222
Cdd:TIGR01770 273 AIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligllagtlegIKAVLFYIFIYALMSLGAFGVLSLLRSYKDEWI 352

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146330986  223 STTTTLSLSHLWNkePLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:TIGR01770 353 EYISDFAGLFKTN--PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 6-267 3.03e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 91.23  E-value: 3.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   6 FSIITFTMMLGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTINLVHSGQW 84
Cdd:MTH00199  99 SPILILIVALGSLLLVSSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGET 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  85 ST----TNPLNPAASIILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMftMSIL 160
Cdd:MTH00199 179 SIqginSILTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLI--CAVL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 161 SIAIGGWGGLNQTQLRKVMAYSSIAHMG---WMTAILAYNPTMALLNLTIYIILTTT---TFLTFMTNSTTTTLSLSHLW 234
Cdd:MTH00199 257 SIIYGAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESIQASLIYMIIYVIMSIcsfSIILSLKLTKGLIVEVSGLS 336

                        250       260       270
                 ....*....|....*....|....*....|...
gi 146330986 235 NKEPLITTIILVTMLSLGGLPPLSGFLPKWMII 267
Cdd:MTH00199 337 RKNPVIALTLALTFLSIAGIPPLAGFLSKWLIL 369
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
13-297 5.55e-19

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 87.57  E-value: 5.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  13 MMLGTGIVMTSSHWLTMWIGFEMNMLAI-IPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQ 83
Cdd:PRK05777 112 ALLGMMVMVSANDLLTLFLGLELLSLPLyALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMsllygatgSLSFAGIAK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  84 WSTTNPLNP---AASIILTLA-MAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLYQI-------SPMINLD 152
Cdd:PRK05777 192 ALADGSGNSlllLFGLVFLLVgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvafggLSEDWQQ 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 153 LMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSH 232
Cdd:PRK05777 272 VLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMTLGAFGVISLLRRKGGE 351

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146330986 233 LWN---------KEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:PRK05777 352 AESisdfaglskRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVI 425
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 13-298 2.14e-17

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 82.50  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  13 MMLGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQW 84
Cdd:COG0651  116 LLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVgllygatgTLNMADLAAR 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  85 STT--NPLNPAASIILTLAMAMKLGLSPFHFWVPE-----------VTQGVHLPSGL--ILLTWQKLAPMSVLYQISPmi 149
Cdd:COG0651  196 LAEldPGLLLAAFALLLVGFGIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVyaILRVLTLLFGADPALFLGT-- 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 150 nldLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMTAILAYNPTMALL--------NLTIYIILTTTTFLTFMT 221
Cdd:COG0651  274 ---LLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAgalfhllnHALAKALLFLAAGAIERA 350

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146330986 222 NSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIY 298
Cdd:COG0651  351 TGTRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFG 427
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 15-267 3.52e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 67.19  E-value: 3.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  15 LGTGIVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSM---------EASTKYFLTQATASMLLMLAV----------- 74
Cdd:MTH00198 199 LGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCalyfgftgneg 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  75 TINLVHSGQWSTTNPLNPAASI---ILTLAMAMKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLAPMSVLyqISPMINL 151
Cdd:MTH00198 279 MLGTILSATLETTNIELRQGSLgylFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILL--TSLVITS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 152 DLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMG-----------------WMTAILAYNPTMALLNL--------T 206
Cdd:MTH00198 357 KLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGfiligvsagtyeslqasWTYAVTYLVSALASFTVictleefgT 436

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146330986 207 IYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGFLPKWMII 267
Cdd:MTH00198 437 RTPTSRQRDGSFGNYNLVRRLVDLTILSRGQPYIAFSLAIVFLSLAGIPPLLGFLGKWFIL 497
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 50-298 1.61e-09

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 58.80  E-value: 1.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   50 PRSMEASTKYFLTQATASmLLMLAVTINLVHSGQWST------TNPLNPAASIILTL----AMAMKLGLSPFHFWVPEV- 118
Cdd:TIGR01972 152 PNRIYAAMKFFLYTLAGS-LLMLLAILGLYFLGGGTFdllellNLPLPFGVQTWLFLaffiAFAVKVPLFPLHTWLPDAh 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  119 ----TQGVHLPSGLILltwqKLAPMSVLYQISPM------INLDLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMG 188
Cdd:TIGR01972 231 veapTAGSVILAGVLL----KMGTYGFLRFNLPLfpdaslYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  189 WMT-AILAYNPT-------MALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGF 260
Cdd:TIGR01972 307 FVLlGIFSFNELgisgavfQMISHGLITAALFLLVGVLYERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGF 386

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 146330986  261 LPKWMIIQELTKNN---SIIAPTTMAITALLNLFFYMRLIY 298
Cdd:TIGR01972 387 VGEFLILLGSFKVNpvvAFLAALGIVLAAAYMLTLYKRVFF 427
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-335 4.37e-09

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 51.87  E-value: 4.37e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 146330986  291 FFYMRLIYSSALTLFPSMNNTVMKWQLNQTKSTALLSPLTILSTM 335
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSIL 45
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 50-199 2.00e-08

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 55.47  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  50 PRSMEASTKYFLTQATASMLLMLAVTINLVHSGQWS------TTNPLNPAASIILTLAM----AMKLGLSPFHFWVPEV- 118
Cdd:COG1008  157 ERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTfdiaelAAAPLPLTAQLLLFLAFfiafAVKVPMFPFHTWLPDAh 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 119 ----TQGVHLPSGLIL----------------LTWQKLAPmsvlyqispminldLMFTMSILSIAIGGWGGLNQTQLRKV 178
Cdd:COG1008  237 veapTAGSVLLAGVLLkmggygllrfalplfpEASAYFAP--------------LLAALGVIGIIYGALVALAQTDLKRL 302

                        170       180
                 ....*....|....*....|..
gi 146330986 179 MAYSSIAHMGWMT-AILAYNPT 199
Cdd:COG1008  303 IAYSSVSHMGFVLlGIFALNPL 324
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
6-263 2.37e-08

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 55.44  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   6 FSIITFTMMLGTGIVMTSSHWLTMWIGFEMnmLAIIPILMKKY---NPRSMEASTKYFLTQATASMLLMLAVTI------ 76
Cdd:PRK02504 112 FAAILLTATLGGMFLSGATELVMIFISLET--LSIASYLLTGYmkrDPRSNEAALKYLLIGAASSAIFLYGSSLlyglsg 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  77 ---NLVHSGQWSTTNPlNPAASIILTLAMA---MKLGLSPFHFWVPEVTQGVHLPSGLILLTWQKLA----PMSVLYQIS 146
Cdd:PRK02504 190 gstQLSAIALALITSP-SLGLALALVFVIAgiaFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAF 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 147 PMINLD--LMFT-MSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWM------------TAILAYNPTMALLNltiyIIL 211
Cdd:PRK02504 269 PSFDEQwkLLFTaLAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVmiglvagteagyASMVFYLLAYLFMN----LGA 344

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 146330986 212 TTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLPPLSGFLPK 263
Cdd:PRK02504 345 FACVILFSLRTGTDQISDYAGLYQKDPLLTLGLSLCLLSLGGIPPLAGFFGK 396
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 49-298 2.67e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 52.19  E-value: 2.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  49 NPRSMEASTKYFLTQATASMLLMLAV--------TINL-VHSGQWSTTNPLNpAASIILTLAMAMKLGLSPFHFWVPE-- 117
Cdd:PRK08375 151 DRRALAAARKYLIVGLIGSTFLLIGVgllygvtgTLNMaDLAGALAENPTVV-TAFGFVLLALALKAAVFPLHTWLPRay 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 118 ---------------VTQGVHlpsGLILLtwqklapMSVLYQISPMINLDLMF---TMSILSIAIGGWGGLNQTQLRKVM 179
Cdd:PRK08375 230 paappvvtallsglvTKVAVY---ALIRI-------YFTVFGGDFRFALGLGWllaVLALLSMLVGSLAALGQDDVKRVL 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 180 AYSSIAHMGWMTAILAYN----PTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWN----KEPLITTIILVTMLSL 251
Cdd:PRK08375 300 AYSTVSQMGYILLGLALLtplaLAAGLLHLLHHALMKGALFLAAGAIEVTYGTRRLSELSglgrRMPLTAAAFAVASLSL 379

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 146330986 252 GGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIY 298
Cdd:PRK08375 380 IGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWY 426
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 47-299 3.27e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 51.90  E-value: 3.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  47 KYNPRSMEASTKYFLTQATASMLLMLAV--------TINL------VHSGQWSTTNPL--NPAASIILTLAMAM-----K 105
Cdd:PRK12667 157 RDRGDAVEAAIKYALIGAVGTTLYFLALaflyatfgTLNMadlsakIRGLSFPLTGGLagNPPLALGVALALALwaftiK 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 106 LGLSPFHFWVPEVTQGVHLP-----SGLILLTwQKLAPMSVLYQI--SPMINLDLMFTMSIL-------SIAIGGWGGLN 171
Cdd:PRK12667 237 AAIFPNHFWLPDAHPAAPSPvsamlSGLVVNV-GAYAIIRFLYTIfgISPSLIDFRAALSPIliilgavSAIIGALMMVV 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 172 QTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSH--------LWNKEPLITTI 243
Cdd:PRK12667 316 QKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASGVFIHAAGTrdidelagLGRKMPIASFA 395

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 146330986 244 ILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLIYS 299
Cdd:PRK12667 396 FLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYS 451
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
33-296 1.28e-06

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 49.95  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  33 FEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAV--------TINLVH----SGQWSTTNPLnPAASIILTL 100
Cdd:PRK12663 137 FEVMLIASFVLITLGQEREQLRGAIKYVVLNLIGSWLFLLGIgllygtfgTLNMAHiamrLNDMGDTATL-TTIALLFLL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 101 AMAMKLGLSPFhFWVPevtQGVHLPSGLI------LLT----WQKLAPMSVLYQISPMINLDLMFTMSILSIAIGGWGGL 170
Cdd:PRK12663 216 AFGMKAALFPF-MWLP---AAYHTPNTEVaalfaaLLTkvgiYALIRVFTLLFPQERELLHPLLATMAAITMVIGALGAL 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 171 NQTQLRKVMAYSSIAHMGWMTAILAYNPTM--------ALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITT 242
Cdd:PRK12663 292 AYKDIRRIAGYQVISSIGFILLGLALGTPAgingaifyLVHDMVVKTALFLIAGSLVRLTGYRSLQYLGGLYRKEPLFGA 371

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 146330986 243 IILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRL 296
Cdd:PRK12663 372 LFLILIFAIGGLPPFSGFWGKVLLVQGALDNGAYILLALMLITSLITMYSLFRI 425
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 48-299 2.07e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 49.33  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  48 YNPRSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWSTTNP--LNPAASIILTLAMAMKLGLSPFHFWVPE 117
Cdd:PRK08376 166 DTWEAIEAGIKYMFVGSLASSMVLLGIallygqygTLNMAYLAVKMSENPtvVAKIALALFIAGLAMKSGAVPVHMWLPD 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 118 VTQGVhlPSGL-ILLTWQKLAPMSVLYQIS-----PMINLD----LMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHM 187
Cdd:PRK08376 246 AYPAA--PSSIsAMLLVIKQAGLYALARVLfsiygPAINLAtvgwVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQI 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 188 GWM-----TAILAYNPT------MALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWN---------KEPLITTIILVT 247
Cdd:PRK08376 324 GYMllglgVGLAALGDPamasygEIALAGGIYHIVNHALYKALLFLTAGAVIYETGTRNlnelgglarTMPKTTIAFLIG 403

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 146330986 248 MLSLGGLPPLSGFLPKWMIIQELTKNNSIIAPTTMaITALLNLFFYMRLIYS 299
Cdd:PRK08376 404 AAAIVGLPPFNGFASKWLIYESSALFNPILGVIAM-IGSVLTLASFVKVFHT 454
ndhB CHL00049
NADH dehydrogenase subunit 2
 51-297 3.26e-06

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 48.46  E-value: 3.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  51 RSMEASTKYFLTQATASMLLMLAVTINLVHSG----------QWSTTNPLNPAAS----IILTLAMAMKLGLSPFHFWVP 116
Cdd:CHL00049 159 RSNEATMKYLLMGGASSSILVYGFSWLYGLSGgeielqeivnGLINTQMYNSPGIsialIFITVGIGFKLSLAPFHQWTP 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 117 EVTQGVHLPSGLILLTWQKLAPMSVLYQIspminLDLMFT------------MSILSIAIGGWGGLNQTQLRKVMAYSSI 184
Cdd:CHL00049 239 DVYEGSPTPVVAFLSVTSKVAASALATRI-----FDIPFYfssnewhllleiLAILSMILGNLIAITQTSMKRMLAYSSI 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 185 AHMGW-MTAILAYNP--------TMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNKEPLITTIILVTMLSLGGLP 255
Cdd:CHL00049 314 GQIGYvIIGIIVGDSndgyasmiTYMLFYIFMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGIP 393

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 146330986 256 PLSGFLPKWMIIQELTKNNSIIAPTTMAITALLNLFFYMRLI 297
Cdd:CHL00049 394 PLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVISIYYYLKII 435
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 50-191 1.69e-05

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 46.35  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  50 PRSMEASTKYFLTQATASMLLMLAV-TINLVHSGQWSTTN-------PLNPAASIILTLAM----AMKLGLSPFHFWVPE 117
Cdd:PRK05846 157 KNRIYAATKFFLYTLLGSLLMLVAIiYLVVVYYNATGTFDiadllnlPLPPGVQYWLFLAFfiafAVKMPMFPLHTWLPD 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 118 V-----TQGVHLPSGLILltwqKLAP---MSVLYQISPMINLD---LMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAH 186
Cdd:PRK05846 237 AhvqapTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEfapIIITLGVIAIIYGALVALAQTDIKKLIAYSSISH 312


                 ....*
gi 146330986 187 MGWMT 191
Cdd:PRK05846 313 MGFVT 317
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 6-291 3.31e-05

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 45.76  E-value: 3.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   6 FSIITFTMMLGtgiVMTSSHWLTMWIGFEMNMLA--IIPILMKKYNprsMEASTKYFLTQATASMLLMLAV--------T 75
Cdd:PRK08668 103 FALMSLAGVLG---VFLANDLLTLYIFWEIMTFSsfMMVPMGKKES---RKASLKYFVLSAIGAYAMLYAIfliyaktgT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  76 INLVHSGQWSTTNPLNPAASIILTLAMAM---KLGLSPFHFWVPE-----------VTQGVHLPSG-------LILLTWQ 134
Cdd:PRK08668 177 FDFADISQGLINDTSTGFALIVFLFLLAFgvaKAGIFPLHVWAPDayseapqsfsaVLSGQLSKLGaygfllvLYVLPGT 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 135 KLAPMSVLYQISPMINLDLMFtMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW-------MTAILAYNPTMALLNLTI 207
Cdd:PRK08668 257 KLFSEFGTYRGVPLFNYILAW-LGNISIIVGTLMAILQEDIKKLIAYSSVANGGYilvglglGTSLGFAGGLFHVFNHAL 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 208 YIILTTTTFLTFMTNSTTTTLSLS-HLWNKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNNsiiapttMAITA 286
Cdd:PRK08668 336 FKGLFFLIFAAVIYRTGTTKISEMgGLIEKMPFTFAMYLVAIISLAGIPPMSGFASKWLIFEALISKG-------MPITA 408


                 ....*
gi 146330986 287 LLNLF 291
Cdd:PRK08668 409 FMAFF 413
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 110-298 3.40e-05

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 45.53  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 110 PFHFWVPE-----------------VTQGVHLpsglilltwqkLAPMSVLYQISPMInLDLMFTMSILSIAIGGWGGLNQ 172
Cdd:COG1009  229 PLHFWLPDamegptpvsallhaatmVKAGVYL-----------LARLSPLFALSPVW-LTVVAIIGAITALFAALIALAQ 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 173 TQLRKVMAYSSIAHMGWMTAIL---AYNPTMALLnltiyiilttttfltfmtnsttttlslshL---------------- 233
Cdd:COG1009  297 TDIKRVLAYSTVSQLGYMFLALgvgAYVAALFHL-----------------------------Lthaffkallflgagsv 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 234 ---------------WNKEPLITTIILVTMLSLGGLPPLSGFLPKWMIIQEL--TKNNSIIAPTTMAITALLNLFFYMRL 296
Cdd:COG1009  348 ihatgtrdirkmgglRKKMPITAITFLIGALSLAGIPPFAGFFSKEAILEAAleAGGLGPLLLAVALLGAFLTAFYSFRL 427


                 ..
gi 146330986 297 IY 298
Cdd:COG1009  428 FF 429
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 100-304 1.11e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 43.76  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 100 LAMAMKLGLSPFHFWVPEV-----TQGVHLPSGlILLTWQKLAPMSVLYQISPMINLDL---MFTMSILSIAIGGWGGLN 171
Cdd:MTH00226 238 LAMAVKIPIFPFHIWLPKAhveapVAGSVLLAG-ILLKLGGYGLVRLSWPILPLGAQNLapaVIAMGIVGIVYGSFATCR 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 172 QTQLRKVMAYSSIAHMGWMTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTTTLSLSHLWNK--------EPLITTI 243
Cdd:MTH00226 317 QIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRLIKyyrglsitMPIWGTI 396

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146330986 244 ILVTMLSLGGLPPLSGFLPKWMIIQELTKNNSIIAP---TTMAITALLNLFFYMRLIYSSALTL 304
Cdd:MTH00226 397 MIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVfvcSGVILSAVYSFYFANRVTFGAPGNL 460
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 100-191 2.12e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 43.12  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 100 LAMAMKLGLSPFHFWVPE-----------VTQGVHLP---SGLILLTWqKLAPMSVLYqISPMInldlmFTMSILSIAIG 165
Cdd:MTH00217 214 LSLAIKIPKIPFHIWLPQahveapvagsvILAGVLLKlggYGFIRFSW-PLLPEASEY-FSPLI-----QTLSLLAIIYG 286

                         90       100
                 ....*....|....*....|....*.
gi 146330986 166 GWGGLNQTQLRKVMAYSSIAHMGWMT 191
Cdd:MTH00217 287 SLTTCRQVDLKRIIAYSSVAHMGLVT 312
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 55-188 5.53e-04

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 41.56  E-value: 5.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  55 ASTKYFLTQATASMLLMLA----------VTINLVHSGQWSTTNPLNPAASIILTLAMAMKLGLSPFHFWVPE------- 117
Cdd:PRK12561 138 AATKFILYTALASIFILVAglalalsgdtFTFDLAELGAKSYPLALELLLYAGFLIAFGVKLPIFPLHTWLPDahgeasa 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146330986 118 ----VTQGVHLPSG---LILLTWQKLAPMSVlyQISPminldLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMG 188
Cdd:PRK12561 218 pvsmILAGVLLKMGgyaLIRFNVQMLPDAHV--YFAP-----ALAILGVVNIIYGALNAFAQDNVKRRLAYSSVSHMG 288
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 11-299 6.60e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 41.34  E-value: 6.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  11 FTMMLGTGIVMtSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFLTQATASMLLMLAVTI---NLVHSGQWSTT 87
Cdd:PRK06589 124 LTILIGVLIAL-SSDLFTMFVCYELLTISTAFLIGHTRNNISLSGGYKYLKILMISALLLFLPAVIliyTKTGNLDFVSG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  88 NPLNPAASIILTLAMAMKLG---LSPFHFWVPEV----TQGVHLPSGLILLTWQKLAPMSVLYQISPMINLDLMFTMS-- 158
Cdd:PRK06589 203 GLFSKNQSIILLLMFIYGIAktaIFPVHSWLPAAmvahYPVSALLHAVIVVKTGLFCIYKILLYIFGLSYLQRIFAEFnw 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 159 -----ILSIAIGGWGGLNQTQLRKVMAYSSIAHMGW-------MTAILAYNPTMALLNLTIYIILTTTTFLTFMTNSTTT 226
Cdd:PRK06589 283 lifipIVSIFYSSLKALKTDNIKKILAYSTISQLSLallsafiLTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKED 362

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146330986 227 TLSLSHLWNKE-PLITTIILVTMLSLGGLPPLSGFLPKWMIIQELTKNN----SIIAPTTMAITALLNLFFYMRLIYS 299
Cdd:PRK06589 363 QVDKLHGTSKSfPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNqpwlSIIVMLVVIASSILSALYLLKILSS 440
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 6-191 1.71e-03

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 39.91  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986   6 FSIITFTMMLgtgiVMTSSHWLTMWIGFEMNMLAIIPILMKKYNPRSMEASTKYFL------TQATASMLLMLAVTINLV 79
Cdd:PRK06458 114 YQLFLFTMLL----ALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIicsvgvAFALFGTILVYANAATVM 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  80 HSGQ----WSTTNPLNPAA-SIILTLAMAM-------KLGLSPFHFWVPE-----------VTQGVHLPSGL-ILLTWQK 135
Cdd:PRK06458 190 GDGEmailWTELLKHASLLdPTLMKLAFVFlligfgtKVGLFPMHAWLPDahseapspvsaLLSGVLLNVALyAVLRYYI 269

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 146330986 136 LAPMSVLYQISPMinldLMFTMSILSIAIGGWGGLNQTQLRKVMAYSSIAHMGWMT 191
Cdd:PRK06458 270 LIDAAIGSDFPGR----LLLIFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLIA 321
ND5 MTH00210
NADH dehydrogenase subunit 5; Provisional
 238-333 7.60e-03

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 177253 [Multi-domain]  Cd Length: 616  Bit Score: 38.07  E-value: 7.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 238 PLITTIILVTMLSLGGLPPLSGFLPKWMIIqELTKNNSIIAPTTM--AITALLNLFFYMRLIYssaLTLFPSMNNTVMKW 315
Cdd:MTH00210 368 PFTYVMILIGSLSLMGFPYLTGFYSKDLIL-ELTYDKYYIAFAYWlgSFSALLTAFYSIRLIY---LTFITNTNSKKEVF 443

                         90
                 ....*....|....*...
gi 146330986 316 QLNQTKSTALLSPLTILS 333
Cdd:MTH00210 444 IGVHESSWNITFPLLLLA 461
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 35-195 8.44e-03

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 37.82  E-value: 8.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986  35 MNMLAIIPILMKKYNP--RSMEASTKYFLTQATASMLLMLAV--------TINLVHSGQWSTTnpLNPAASII----LTL 100
Cdd:PRK08377 137 MEITAITAYALTAYNKtgEAAEASMKYIVLGGIGSSFFLIGValiygatgTLNMAHIAQLAGT--IDPTVAQVglalLIF 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330986 101 AMAMKLGLSPFHFWVPEVTQGVHLPsglILLTWQKLAPMSVLYQISPMIN-----------LDLMFTMSILSIAIGGWGG 169
Cdd:PRK08377 215 GLAVEAELFPLNAWAPDAYQAAPHP---ITVMFSAFVVKAGLYAMARILYlmqnangwssvLKLVIIMATLTVFFAELSA 291

                        170       180
                 ....*....|....*....|....*.
gi 146330986 170 LNQTQLRKVMAYSSIAHMGWMTAILA 195
Cdd:PRK08377 292 LRQKNVKRMIAYSSIGQVGMIALALA 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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