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Conserved domains on  [gi|116248529|sp|Q5VUJ6|]
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RecName: Full=Leucine-rich repeat and calponin homology domain-containing protein 2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 643-753 1.63e-72

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409120  Cd Length: 111  Bit Score: 231.36  E-value: 1.63e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 643 REEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKL 722
Cdd:cd21271    1 REELELIEQLRENIESRLKVILPEDLGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 116248529 723 GVSQERLCLPHHILEERGLVKVGVTVQALLE 753
Cdd:cd21271   81 GVPEDKLCLPHHILEEKGLVKVSVTVQALLD 111
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-282 1.13e-39

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 151.62  E-value: 1.13e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 108 YDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVV 186
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 187 SNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPdELGDLP-LVKLDFSCNKVTEIPVC 265
Cdd:COG4886  190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                        170
                 ....*....|....*..
gi 116248529 266 YrKLHHLQVIILDNNPL 282
Cdd:COG4886  269 A-NLTNLKTLDLSNNQL 284
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 434-539 5.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  434 KEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHSTSVMRNKP--------KQTV 505
Cdd:pfam17380 535 RREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTIKPiyrpriseYQPP 614

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 116248529  506 ECEKSVSADEVNSPL----SPLTWQPLENQKDQIDEQP 539
Cdd:pfam17380 615 DVESHMIRFTTQSPEwatpSPATWNPEWNTVTAEEETP 652
 
Name Accession Description Interval E-value
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 643-753 1.63e-72

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409120  Cd Length: 111  Bit Score: 231.36  E-value: 1.63e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 643 REEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKL 722
Cdd:cd21271    1 REELELIEQLRENIESRLKVILPEDLGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 116248529 723 GVSQERLCLPHHILEERGLVKVGVTVQALLE 753
Cdd:cd21271   81 GVPEDKLCLPHHILEEKGLVKVSVTVQALLD 111
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-282 1.13e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 151.62  E-value: 1.13e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 108 YDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVV 186
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 187 SNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPdELGDLP-LVKLDFSCNKVTEIPVC 265
Cdd:COG4886  190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                        170
                 ....*....|....*..
gi 116248529 266 YrKLHHLQVIILDNNPL 282
Cdd:COG4886  269 A-NLTNLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-282 7.53e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 85.13  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  68 PGSLQPQHTVRSLDR----ALEEAGSSGILSLSGR--KLRDFPGSgydLTDTTQ-ADLSRNRFTEIPSDvwLFAPLETLN 140
Cdd:PRK15370 194 PACIPEQITTLILDNnelkSLPENLQGNIKTLYANsnQLTSIPAT---LPDTIQeMELSINRITELPER--LPSALQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 141 LYHNCIKTIPEAIKnlQMLTYLNISRNLLSTLPKYL------------------FDLP--LKVLVVSNNKLVSIPEEIGk 200
Cdd:PRK15370 269 LFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLpsgithlnvqsnsltalpETLPpgLKTLEAGENALTSLPASLP- 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 201 lKDLMELDISCNEIQVLPQQMGKlhSLRELNIRRNNLHVLPDelgDLP--LVKLDFSCNKVTEIPvcyRKLHHLQV---- 274
Cdd:PRK15370 346 -PELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPE---NLPaaLQIMQASRNNLVRLP---ESLPHFRGegpq 416

                        250
                 ....*....|.
gi 116248529 275 ---IILDNNPL 282
Cdd:PRK15370 417 ptrIIVEYNPF 427
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 650-739 1.06e-11

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 61.95  E-value: 1.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529   650 RQLRNNLESRLKVILPDDIG---AALMDGVVLCHLANHIRPRSVASIHVPspavPKLSMAKCRRNVENFLDACKKLGVSQ 726
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTnfsSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLGGKV 76

                           90
                   ....*....|...
gi 116248529   727 ErLCLPHHILEER 739
Cdd:smart00033  77 V-LFEPEDLVEGP 88
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-235 1.20e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 136 LETLNLYHNCIKTIpEAIKNLQMLTYLNISRNLLSTLPKYLFDlP---------LKVLVVSNNKLVSIpEEIGKLKDLME 206
Cdd:cd21340   70 LKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPGEKLTFD-PrslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                         90       100       110
                 ....*....|....*....|....*....|..
gi 116248529 207 LDISCNEIQ---VLPQQMGKLHSLRELNIRRN 235
Cdd:cd21340  147 LDASNNQISdleELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
181-237 1.13e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.13e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 116248529  181 LKVLVVSNNKLVSIPEEIGK-LKDLMELDISCNEIQVL-PQQMGKLHSLRELNIRRNNL 237
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 644-726 8.69e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 48.05  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  644 EEREQIRQ-LRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVasihvpSPAVPKLSMAKCRRNVENFLD-ACKK 721
Cdd:pfam00307   2 ELEKELLRwINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLV------DKKKLNKSEFDKLENINLALDvAEKK 75


                  ....*
gi 116248529  722 LGVSQ 726
Cdd:pfam00307  76 LGVPK 80
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 434-539 5.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  434 KEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHSTSVMRNKP--------KQTV 505
Cdd:pfam17380 535 RREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTIKPiyrpriseYQPP 614

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 116248529  506 ECEKSVSADEVNSPL----SPLTWQPLENQKDQIDEQP 539
Cdd:pfam17380 615 DVESHMIRFTTQSPEwatpSPATWNPEWNTVTAEEETP 652
 
Name Accession Description Interval E-value
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 643-753 1.63e-72

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409120  Cd Length: 111  Bit Score: 231.36  E-value: 1.63e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 643 REEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKL 722
Cdd:cd21271    1 REELELIEQLRENIESRLKVILPEDLGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 116248529 723 GVSQERLCLPHHILEERGLVKVGVTVQALLE 753
Cdd:cd21271   81 GVPEDKLCLPHHILEEKGLVKVSVTVQALLD 111
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 647-753 6.91e-65

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 211.01  E-value: 6.91e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 647 EQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQ 726
Cdd:cd21205    1 EQIEQLRKSIESRLKVTLPDDLGEALMDGVVLCHLANHVRPRSVPSIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 80

                         90       100
                 ....*....|....*....|....*..
gi 116248529 727 ERLCLPHHILEERGLVKVGVTVQALLE 753
Cdd:cd21205   81 ERLCSPGDILEEKGLVRVAVTVQALLQ 107
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 647-754 1.69e-61

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 201.76  E-value: 1.69e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 647 EQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQ 726
Cdd:cd21272    1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                         90       100
                 ....*....|....*....|....*...
gi 116248529 727 ERLCLPHHILEERGLVKVGVTVQALLEL 754
Cdd:cd21272   81 EQLCLPLHILEEKGLSQVAVTVQALLEL 108
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 644-755 1.98e-52

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409119  Cd Length: 112  Bit Score: 177.35  E-value: 1.98e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 644 EEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLG 723
Cdd:cd21270    1 EERELTEQLRENIETRLKVSLPEDLGAALMDGVVLCHLVNHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 116248529 724 VSQERLCLPHHILeERGLVKVGVTVQALLELP 755
Cdd:cd21270   81 VPEADLCSPYDIL-QLNLRGIRKTVETLLALG 111
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-282 1.13e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 151.62  E-value: 1.13e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 108 YDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVV 186
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 187 SNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPdELGDLP-LVKLDFSCNKVTEIPVC 265
Cdd:COG4886  190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                        170
                 ....*....|....*..
gi 116248529 266 YrKLHHLQVIILDNNPL 282
Cdd:COG4886  269 A-NLTNLKTLDLSNNQL 284
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 644-736 5.11e-39

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 140.04  E-value: 5.11e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 644 EEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLG 723
Cdd:cd21273    1 DEKELRAQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMG 80

                         90
                 ....*....|...
gi 116248529 724 VSQERLCLPHHIL 736
Cdd:cd21273   81 VPEVDLCSPSDVL 93
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-283 3.29e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 3.29e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLST 171
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 172 LPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPqQMGKLHSLRELNIRRNNLHVLPDELGDLPLV 250
Cdd:COG4886  197 LPEPLGNLTnLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLK 275

                        170       180       190
                 ....*....|....*....|....*....|...
gi 116248529 251 KLDFSCNKVTEIpvcyrKLHHLQVIILDNNPLQ 283
Cdd:COG4886  276 TLDLSNNQLTDL-----KLKELELLLGLNSLLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-292 1.64e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 1.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 109 DLTDTTQADLSRNRfteipsDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVS 187
Cdd:COG4886   94 DLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 188 NNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVcY 266
Cdd:COG4886  168 NNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTnLETLDLSNNQLTDLPE-L 246

                        170       180
                 ....*....|....*....|....*.
gi 116248529 267 RKLHHLQVIILDNNPLQVPPAQICLK 292
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLPPLANLT 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-286 1.55e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 1.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 108 YDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNciktipEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVV 186
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTnLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 187 SNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVC 265
Cdd:COG4886  144 SNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTnLEELDLSGNQLTDLPEP 223

                        170       180
                 ....*....|....*....|.
gi 116248529 266 YRKLHHLQVIILDNNPLQVPP 286
Cdd:COG4886  224 LANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-289 3.41e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 3.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 109 DLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNL-LSTLPKylfdlpLKVLVVS 187
Cdd:COG4886   48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTN------LESLDLS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 188 NNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCY 266
Cdd:COG4886  122 GNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDLPEPL 201

                        170       180
                 ....*....|....*....|...
gi 116248529 267 RKLHHLQVIILDNNPLQVPPAQI 289
Cdd:COG4886  202 GNLTNLEELDLSGNQLTDLPEPL 224
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
110-290 1.80e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 1.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 110 LTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSN 188
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTnLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 189 NklvsipEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYR 267
Cdd:COG4886  106 N------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLSNNQLTDLPEELG 179

                        170       180
                 ....*....|....*....|...
gi 116248529 268 KLHHLQVIILDNNPLQVPPAQIC 290
Cdd:COG4886  180 NLTNLKELDLSNNQITDLPEPLG 202
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 656-751 1.37e-17

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 78.53  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 656 LESRLKVILPDDIG---AALMDGVVLCHLANHIRPRSVASIHVPSpavpkLSMAKCRRNVENFLDACKKLGVSQERLCLP 732
Cdd:cd00014    8 INEVLGEELPVSITdlfESLRDGVLLCKLINKLSPGSIPKINKKP-----KSPFKKRENINLFLNACKKLGLPELDLFEP 82

                         90
                 ....*....|....*....
gi 116248529 733 HHILEERGLVKVGVTVQAL 751
Cdd:cd00014   83 EDLYEKGNLKKVLGTLWAL 101
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-282 7.53e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 85.13  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  68 PGSLQPQHTVRSLDR----ALEEAGSSGILSLSGR--KLRDFPGSgydLTDTTQ-ADLSRNRFTEIPSDvwLFAPLETLN 140
Cdd:PRK15370 194 PACIPEQITTLILDNnelkSLPENLQGNIKTLYANsnQLTSIPAT---LPDTIQeMELSINRITELPER--LPSALQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 141 LYHNCIKTIPEAIKnlQMLTYLNISRNLLSTLPKYL------------------FDLP--LKVLVVSNNKLVSIPEEIGk 200
Cdd:PRK15370 269 LFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLpsgithlnvqsnsltalpETLPpgLKTLEAGENALTSLPASLP- 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 201 lKDLMELDISCNEIQVLPQQMGKlhSLRELNIRRNNLHVLPDelgDLP--LVKLDFSCNKVTEIPvcyRKLHHLQV---- 274
Cdd:PRK15370 346 -PELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPE---NLPaaLQIMQASRNNLVRLP---ESLPHFRGegpq 416

                        250
                 ....*....|.
gi 116248529 275 ---IILDNNPL 282
Cdd:PRK15370 417 ptrIIVEYNPF 427
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 650-739 1.06e-11

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 61.95  E-value: 1.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529   650 RQLRNNLESRLKVILPDDIG---AALMDGVVLCHLANHIRPRSVASIHVPspavPKLSMAKCRRNVENFLDACKKLGVSQ 726
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTnfsSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLGGKV 76

                           90
                   ....*....|...
gi 116248529   727 ErLCLPHHILEER 739
Cdd:smart00033  77 V-LFEPEDLVEGP 88
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-235 1.20e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 136 LETLNLYHNCIKTIpEAIKNLQMLTYLNISRNLLSTLPKYLFDlP---------LKVLVVSNNKLVSIpEEIGKLKDLME 206
Cdd:cd21340   70 LKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPGEKLTFD-PrslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                         90       100       110
                 ....*....|....*....|....*....|..
gi 116248529 207 LDISCNEIQ---VLPQQMGKLHSLRELNIRRN 235
Cdd:cd21340  147 LDASNNQISdleELLDLLSSWPSLRELDLTGN 178
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 659-744 1.83e-10

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 58.81  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 659 RLKVILPD-----------DIGAALMDGVVLCHLANHIRPRSVaSIHVPSPAvPKLSMAKCRRNVENFLDACK-KLGVSQ 726
Cdd:cd21201   12 RCGVLPPDhratqpnatvfDLAQALRDGVLLCQLLNRLSPGSV-DDREINLR-PQMSQFLCLKNIRTFLQACRtVFGLRS 89

                         90
                 ....*....|....*...
gi 116248529 727 ERLCLPHHILEERGLVKV 744
Cdd:cd21201   90 ADLFEPEDLYDVTNFGKV 107
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-282 6.58e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 6.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 117 DLSRNRFT-EIPSDVWLFAPLETLNLYHNCIK-TIPEAIKNLQMLTYLNISRN-LLSTLPKYLFDL-PLKVLVVSNNKLV 192
Cdd:PLN00113 146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNqLVGQIPRELGQMkSLKWIYLGYNNLS 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 193 -SIPEEIGKLKDLMELDISCNEIQ-VLPQQMGKLHSLRELNIRRNNLH-VLPDELGDLP-LVKLDFSCNKVT-EIPVCYR 267
Cdd:PLN00113 226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQkLISLDLSDNSLSgEIPELVI 305

                        170
                 ....*....|....*
gi 116248529 268 KLHHLQVIILDNNPL 282
Cdd:PLN00113 306 QLQNLEILHLFSNNF 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-282 1.88e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 110 LTDTTQADLSRNRFTEIPsDVWLFAPLETLNLYHNCIKTIpEAIKNLQMLTYLNISRNLLSTLPkYLFDLP-LKVLVVSN 188
Cdd:cd21340    1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIE-NLENLVnLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 189 NKLVSIpEEIGKLKDLMELDISCneiQVLPQQMgKL-----------HSLRELNIRRNNLhvlpDELGDLP----LVKLD 253
Cdd:cd21340   78 NRISVV-EGLENLTNLEELHIEN---QRLPPGE-KLtfdprslaalsNSLRVLNISGNNI----DSLEPLAplrnLEQLD 148

                        170       180       190
                 ....*....|....*....|....*....|..
gi 116248529 254 FSCNKVTEI-PVC--YRKLHHLQVIILDNNPL 282
Cdd:cd21340  149 ASNNQISDLeELLdlLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 108-248 2.45e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 2.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 108 YDLTDTTQADLSRNRFT-EIPsDVWLFAPLETLNLYHNCIK-TIPEAIKNLQMLTYLNISRNLLS-TLPKYLFDLP-LKV 183
Cdd:PLN00113 449 WDMPSLQMLSLARNKFFgGLP-DSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKkLVS 527

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116248529 184 LVVSNNKLV-SIPEEIGKLKDLMELDISCNEIQ-VLPQQMGKLHSLRELNIRRNNLHvlpdelGDLP 248
Cdd:PLN00113 528 LDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLH------GSLP 588
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
146-287 7.23e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 7.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 146 IKTIPEAIKnlQMLTYLNISRNLLSTLPKYLfDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDI---------------- 209
Cdd:PRK15370 190 LTTIPACIP--EQITTLILDNNELKSLPENL-QGNIKTLYANSNQLTSIPATLPDTIQEMELSInritelperlpsalqs 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 210 ---SCNEIQVLPQQMGKlhSLRELNIRRNNLHVLPDELGDlPLVKLDFSCNKVTEIPVCYRKlhHLQVIILDNN-----P 281
Cdd:PRK15370 267 ldlFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTALPETLPP--GLKTLEAGENaltslP 341


                 ....*.
gi 116248529 282 LQVPPA 287
Cdd:PRK15370 342 ASLPPE 347
LRR_8 pfam13855
Leucine rich repeat;
181-237 1.13e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.13e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 116248529  181 LKVLVVSNNKLVSIPEEIGK-LKDLMELDISCNEIQVL-PQQMGKLHSLRELNIRRNNL 237
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-263 4.16e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 4.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 117 DLSRNrFTEIPsdVWLFAPLETLNLYHNcIKTIPEAIKNLQMLtylNISRN-LLSTLPKYLFDLPLKVLVVSNNKLV-SI 194
Cdd:PLN00113 419 ELPSE-FTKLP--LVYFLDISNNNLQGR-INSRKWDMPSLQML---SLARNkFFGGLPDSFGSKRLENLDLSRNQFSgAV 491

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116248529 195 PEEIGKLKDLMELDISCNEIQ-VLPQQMGKLHSLRELNIRRNNLH-VLPDELGDLP-LVKLDFSCNKVT-EIP 263
Cdd:PLN00113 492 PRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPvLSQLDLSQNQLSgEIP 564
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 125-287 9.36e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 9.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 125 EIPSDVWLFAPLETLNL-YHNCIKTIPEAIKNLQMLTYLNISRNLLS-TLPKYLFDLP-LKVLVVSNNKLV-SIPEEIGK 200
Cdd:PLN00113 227 EIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQkLISLDLSDNSLSgEIPELVIQ 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 201 LKDLMELDISCNEIQ-VLPQQMGKLHSLRELNIRRNNLH-VLPDELGDL-PLVKLDFSCNKVT-EIPVCYRKLHHLQVII 276
Cdd:PLN00113 307 LQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI 386

                        170
                 ....*....|...
gi 116248529 277 LDNNPL--QVPPA 287
Cdd:PLN00113 387 LFSNSLegEIPKS 399
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 665-724 2.17e-07

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 49.62  E-value: 2.17e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116248529 665 PDDIGAALMDGVVLCHLANHIRPRSVASIHVPspavpklSMA-KCRRNVENFLDACKKLGV 724
Cdd:cd21207   25 GKDYEDVLKDGVILCKLINILKPGSVKKINTS-------KMAfKLMENIENFLTACKGYGV 78
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 648-751 4.01e-07

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 48.90  E-value: 4.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 648 QIRQLRNNLESRL-KVILPDDIGAALMDGVVLCHLANHIRPRSVASIHvpSPAVPKLSMakcrRNVENFLDACKKLGVSQ 726
Cdd:cd21210    1 AEQEAREWIEEVLgEKLAQGDLLDALKDGVVLCKLANRILPADIRKYK--ESKMPFVQM----ENISAFLNAARKLGVPE 74

                         90       100
                 ....*....|....*....|....*
gi 116248529 727 ERLCLPHHILEERGLVKVGVTVQAL 751
Cdd:cd21210   75 NDLFQTVDLFERKNPAQVLQCLHAL 99
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 644-726 8.69e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 48.05  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  644 EEREQIRQ-LRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVasihvpSPAVPKLSMAKCRRNVENFLD-ACKK 721
Cdd:pfam00307   2 ELEKELLRwINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLV------DKKKLNKSEFDKLENINLALDvAEKK 75


                  ....*
gi 116248529  722 LGVSQ 726
Cdd:pfam00307  76 LGVPK 80
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 647-742 1.27e-06

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 48.03  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 647 EQIRQLRNNLESRLKVILPDDIGA-----ALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSM-AKC-----------R 709
Cdd:cd21204    2 EALLPMKEDLAEWLNDLLGDDLTPdnfldELRNGVVLCQLAQKIQEAAEKAREAGKKNGPPPSYkLKCnenakpgsffaR 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 116248529 710 RNVENFLDACKKLGVSQERLclphhiLEERGLV 742
Cdd:cd21204   82 DNVANFLRWCRKLGVDEVLL------FESEDLV 108
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
 640-758 1.35e-06

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 47.69  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 640 EHLREEreqirQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLsmakcrRNVENFLDAC 719
Cdd:cd21211    1 DHQKEA-----ELRTWIEGVTGLSIGPNFQKGLKDGIILCELINKLQPGSVKKINESMQNWHQL------ENIGNFIKAI 69

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 116248529 720 KKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTK 758
Cdd:cd21211   70 VSYGMKPHDIFEANDLFENGNMTQVQVTLLALAGKAKTK 108
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 665-729 1.90e-06

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 47.33  E-value: 1.90e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116248529 665 PDDIGAALMDGVVLCHLANHIRPRSVASI-HVPSPAVpklsmakCRRNVENFLDACKKLGVSQERL 729
Cdd:cd21208   19 SDDFRESLEDGILLCELINAIKPGSIKKInRLPTPIA-------GLDNLNLFLKACEDLGLKDSQL 77
LRR_8 pfam13855
Leucine rich repeat;
226-282 2.09e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.09e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  226 SLRELNIRRNNLHVLPDE-LGDLP-LVKLDFSCNKVTEI-PVCYRKLHHLQVIILDNNPL 282
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSnLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
CH_PIX cd21202
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ...
 670-751 2.28e-06

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409051 [Multi-domain]  Cd Length: 114  Bit Score: 47.14  E-value: 2.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 670 AALMDGVVLCHLANHIRPRSVASIHvPSPavpkLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQ 749
Cdd:cd21202   32 ESLKNGVVLCRLVNRLKPGTVEKIY-DEP----TTEEECLYNFESFLKACQELGILAEEIFDPNDLYSGGNFQKVLSTLE 106


                 ..
gi 116248529 750 AL 751
Cdd:cd21202  107 RL 108
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
 638-758 3.58e-06

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 46.44  E-value: 3.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 638 KMEHLREEreqirQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLsmakcrRNVENFLD 717
Cdd:cd21284    1 KYDPQKEE-----ELRNWIEEVTGMSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQL------ENIGNFIK 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116248529 718 ACKKLGVSqerlclPHHILE-----ERG-LVKVGVTVQALLELPTTK 758
Cdd:cd21284   70 AIQAYGMK------PHDIFEandlfENGnMTQVQTTLLALAGLAKTK 110
LRR_8 pfam13855
Leucine rich repeat;
136-191 4.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 4.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 116248529  136 LETLNLYHNCIKTI-PEAIKNLQMLTYLNISRNLLSTLPKYLF-DLP-LKVLVVSNNKL 191
Cdd:pfam13855   3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFsGLPsLRYLDLSGNRL 61
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 662-723 5.45e-06

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 45.87  E-value: 5.45e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116248529 662 VILPD----DIGAALMDGVVLCHLANHIRPRSVASI--HVPSPAVPKLSMAKCRRNVENFLDACKKLG 723
Cdd:cd21203   16 LVLPDpseeEFRLCLRDGVVLCKLLNKLQPGAVPKVveSPDDPDGAAGSAFQYFENVRNFLVAIEEMG 83
CH_VAV1 cd21262
calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the ...
 667-755 1.63e-05

calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein.


Pssm-ID: 409111  Cd Length: 120  Bit Score: 44.93  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 667 DIGAALMDGVVLCHLANHIRPRSVASIHVpsPAVPKLSMAKCRRNVENFLDAC-KKLGVSQERLCLPHHILEERGLVKVG 745
Cdd:cd21262   31 DLAQALRDGVLLCQLLNNLLPHAVNLREI--NLRPQMSQFLCLKNIRTFLSTCcEKFGLRKSELFEAFDLFDVRDFGKVI 108

                         90
                 ....*....|
gi 116248529 746 VTVQALLELP 755
Cdd:cd21262  109 DTLSILSWTP 118
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
93-274 2.35e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.85  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  93 LSLSGRKLRDFPGSGYDLTDTTqadLSRNRFTEIPSdvwLFAPLETLNLYHNCIKTIPEAIKNLQMLTylnISRNLLSTL 172
Cdd:PRK15387 247 LEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLPA---LPSGLCKLWIFGNQLTSLPVLPPGLQELS---VSDNQLASL 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 173 PKylfdLPLKV--LVVSNNKLVSIPEEIGKLKdlmELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLv 250
Cdd:PRK15387 318 PA----LPSELckLWAYNNQLTSLPTLPSGLQ---ELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIV- 389

                        170       180
                 ....*....|....*....|....
gi 116248529 251 kldfSCNKVTEIPVCYRKLHHLQV 274
Cdd:PRK15387 390 ----SGNRLTSLPVLPSELKELMV 409
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 650-758 3.12e-05

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 43.71  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 650 RQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLsmakcrRNVENFLDACKKLGVSqerl 729
Cdd:cd21282    6 EELRVWIEGVTGRRIGDNFMDGLKDGVILCELINKLQPGSVRKINESTQNWHKL------ENIGNFIKAIMHYGVK---- 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 116248529 730 clPHHILEERGL------VKVGVTVQALLELPTTK 758
Cdd:cd21282   76 --PHDIFEANDLfentnhTQVQSTLIALASMAKTK 108
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
93-244 5.11e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 46.69  E-value: 5.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  93 LSLSGRKLRDFPGSGYDLTDTTQADlsrNRFTEIPSdvwLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNisrNLLSTL 172
Cdd:PRK15387 307 LSVSDNQLASLPALPSELCKLWAYN---NQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSL 377

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116248529 173 PKylfdLP--LKVLVVSNNKLVSIPEEIGKLKDLMeldISCNEIQVLPQQMGKLHSlreLNIRRNNLHVLPDEL 244
Cdd:PRK15387 378 PA----LPsgLKELIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSGLLS---LSVYRNQLTRLPESL 441
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 651-758 5.66e-05

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 43.00  E-value: 5.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 651 QLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLsmakcrRNVENFLDACKKLGVSQERLC 730
Cdd:cd21283    7 ELRTWIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQL------ENLSNFIKAMVSYGMKPVDLF 80

                         90       100
                 ....*....|....*....|....*...
gi 116248529 731 LPHHILEERGLVKVGVTVQALLELPTTK 758
Cdd:cd21283   81 EANDLFESGNMTQVQVSLLALAGMAKTK 108
CH_VAV3 cd21264
calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously ...
 667-751 1.02e-04

calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1. Its function has been implicated in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV3 protein.


Pssm-ID: 409113  Cd Length: 117  Bit Score: 42.26  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 667 DIGAALMDGVVLCHLANHIRPRSV--ASIHVPspavPKLSMAKCRRNVENFLDA-CKKLGVSQERLCLPHHILEERGLVK 743
Cdd:cd21264   31 DLAQTLRDGVLLCQLLNNLRPHSInlKEINLR----PQMSQFLCLKNIRTFLSAcCETFGMRKSELFEAFDLFDVRDFGK 106


                 ....*...
gi 116248529 744 VGVTVQAL 751
Cdd:cd21264  107 VIETLSKL 114
CH_PLS_FIM_rpt1 cd21217
first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
 660-725 2.52e-04

first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409066 [Multi-domain]  Cd Length: 114  Bit Score: 41.02  E-value: 2.52e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116248529 660 LKVILP-----DDIGAALMDGVVLCHLANHIRPRSVA--SIHVPSPavpkLSMAKCRRNVENFLDACKKLGVS 725
Cdd:cd21217   20 LKHLLPidpdgDDLFEALRDGVLLCKLINKIVPGTIDerKLNKKKP----KNIFEATENLNLALNAAKKIGCK 88
PLN03150 PLN03150
hypothetical protein; Provisional
 149-249 5.91e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 5.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 149 IPEAIKNLQMLTYLNISRNLLSTlpkylfdlplkvlvvsnnklvSIPEEIGKLKDLMELDISCNEIQ-VLPQQMGKLHSL 227
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG---------------------NIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSL 492

                         90       100
                 ....*....|....*....|...
gi 116248529 228 RELNIRRNNLH-VLPDELGDLPL 249
Cdd:PLN03150 493 RILNLNGNSLSgRVPAALGGRLL 515
CH_TAGLN3 cd21281
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ...
 672-758 6.45e-04

calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409130 [Multi-domain]  Cd Length: 119  Bit Score: 40.33  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 672 LMDGVVLCHLANHIRPRSvasiHVPSPAVPKLSMA-KCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQA 750
Cdd:cd21281   34 LMDGTILCRLINSLYPPG----KEPIKKISETKMAfKQMEKISQFLQAAEAYGVITTDIFQTVDLWEGKDMAAVQRTLMA 109


                 ....*...
gi 116248529 751 LLELPTTK 758
Cdd:cd21281  110 LGSVAVTK 117
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 667-732 9.77e-04

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 39.43  E-value: 9.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116248529 667 DIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSmakcrrNVENFLDACKKLGVSQERLCLP 732
Cdd:cd21277   21 DFRSALENGVLLCDLINKIKPGIIKKINRLSTPIAGLD------NINVFLKACEKLGLKEAQLFHP 80
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 136-261 1.64e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 136 LETLNLYHNCI-----KTIPEAIKNLQMLTYLNISRN---------LLSTL--PKYLFDLPLKVLVVSNNKLVSIPEEIG 199
Cdd:COG5238  266 VETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNrigdegaiaLAEGLqgNKTLHTLNLAYNGIGAQGAIALAKALQ 345

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116248529 200 KLKDLMELDISCNEI-----QVLPQQMGKLHSLRELNIRRNNLHV-----LPDELGDLPLVKLDFSCNKVTE 261
Cdd:COG5238  346 ENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKqgaeaLIDALQTNRLHTLILDGNLIGA 417
CH_alphaPIX cd21265
calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak ...
 656-724 1.87e-03

calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak Interactive eXchange factor (alpha-PIX), also called PAK-interacting exchange factor alpha, Rho guanine nucleotide exchange factor 6 (ARHGEF6), Rac/Cdc42 guanine nucleotide exchange factor 6, or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Alpha-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409114  Cd Length: 117  Bit Score: 38.65  E-value: 1.87e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116248529 656 LESRLKVIL-PDD-IGAALMDGVVLCHLANHIRPRSVASiHVPSPAvpklSMAKCRRNVENFLDACKKLGV 724
Cdd:cd21265   17 LNSPKKTISdPEEfLKSSLKDGVVLCKLIERLLPGSVEK-YCLEPK----TEADCIGNIKEFLKGCAALKV 82
PLN03150 PLN03150
hypothetical protein; Provisional
 216-287 2.06e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 2.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116248529 216 VLPQQMGKLHSLRELNIRRNNLH-VLPDELGDLP-LVKLDFSCNKVT-EIPVCYRKLHHLQVIILDNNPL--QVPPA 287
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITsLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLsgRVPAA 509
CH_betaPIX cd21266
calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak ...
 656-724 2.85e-03

calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409115  Cd Length: 112  Bit Score: 37.98  E-value: 2.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116248529 656 LESRLKVILPDD--IGAALMDGVVLCHLANHIRPRSVASIHvPSPAvpklSMAKCRRNVENFLDACKKLGV 724
Cdd:cd21266   15 LESPKKTISDPEgfLQASLKDGVVLCRLLERLLPGSIDKVY-PEPR----TESECLSNIREFLRGCGALRL 80
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 672-758 4.43e-03

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 38.32  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 672 LMDGVVLCHLANHIRPRSVAsihvPSPAVPKLSMA-KCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQA 750
Cdd:cd21280   39 LKDGTVLCHLINSLYPKGQA----PVKKIQASTMAfKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMASVQRTLMN 114


                 ....*...
gi 116248529 751 LLELPTTK 758
Cdd:cd21280  115 LGGLAVTR 122
CH_VAV2 cd21263
calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely ...
 667-744 4.55e-03

calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV2 protein.


Pssm-ID: 409112  Cd Length: 119  Bit Score: 37.63  E-value: 4.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116248529 667 DIGAALMDGVVLCHLANHIRPRSVASIHVPSPavPKLSMAKCRRNVENFLDAC-KKLGVSQERLCLPHHILEERGLVKV 744
Cdd:cd21263   31 DLAQALRDGVLLCQLLHNLSPGSIDLKDINFR--PQMSQFLCLKNIRTFLKVChDKFGLRNSELFDPFDLFDVRDFGKV 107
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 434-539 5.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529  434 KEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHSTSVMRNKP--------KQTV 505
Cdd:pfam17380 535 RREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTIKPiyrpriseYQPP 614

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 116248529  506 ECEKSVSADEVNSPL----SPLTWQPLENQKDQIDEQP 539
Cdd:pfam17380 615 DVESHMIRFTTQSPEwatpSPATWNPEWNTVTAEEETP 652
CH_TAGLN-like cd21209
calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family ...
 672-758 8.92e-03

calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family includes transgelin, transgelin-2 and transgelin-3. Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. It may participate in the development and progression of multiple cancers. Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409058 [Multi-domain]  Cd Length: 119  Bit Score: 36.72  E-value: 8.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116248529 672 LMDGVVLCHLANHIRPRSVASIHVPSPAvpklSMA-KCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQA 750
Cdd:cd21209   34 LKDGTVLCKLINSLYPEGSKPVKKIQSS----KMAfKQMEQISQFLKAAEDYGVRTTDIFQTVDLWEGKDMAAVQRTLMA 109


                 ....*...
gi 116248529 751 LLELPTTK 758
Cdd:cd21209  110 LGSLAVTK 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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