NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|33301343|sp|Q8N729|]
View 

RecName: Full=Neuropeptide W; AltName: Full=Preproprotein L8; Short=hPPL8; Contains: RecName: Full=Neuropeptide W-23; Short=NPW23; Short=hL8; Contains: RecName: Full=Neuropeptide W-30; Short=NPW30; Short=hL8C; Flags: Precursor

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NPBW super family cl21045
Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, ...
 30-104 4.08e-24

Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.


The actual alignment was detected with superfamily member pfam15180:

Pssm-ID: 464547  Cd Length: 118  Bit Score: 90.53  E-value: 4.08e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33301343    30 SGAWYKHVASPRYHTVGRAAGLLMGLRRSPYLWRRALRAAAGPLARDTLSPEPAAREAPLLLPSWVQELWETRRR 104
Cdd:pfam15180  16 AEAWYKQAAGPSYYSVGRASGLLSGIRRSPYARRSEPEGAAGPLEGAGAAPEPRQRSSLRSLAVCVKDVSPNLQS 90
 
Name Accession Description Interval E-value
NPBW pfam15180
Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, ...
 30-104 4.08e-24

Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.


Pssm-ID: 464547  Cd Length: 118  Bit Score: 90.53  E-value: 4.08e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33301343    30 SGAWYKHVASPRYHTVGRAAGLLMGLRRSPYLWRRALRAAAGPLARDTLSPEPAAREAPLLLPSWVQELWETRRR 104
Cdd:pfam15180  16 AEAWYKQAAGPSYYSVGRASGLLSGIRRSPYARRSEPEGAAGPLEGAGAAPEPRQRSSLRSLAVCVKDVSPNLQS 90
 
Name Accession Description Interval E-value
NPBW pfam15180
Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, ...
 30-104 4.08e-24

Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.


Pssm-ID: 464547  Cd Length: 118  Bit Score: 90.53  E-value: 4.08e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33301343    30 SGAWYKHVASPRYHTVGRAAGLLMGLRRSPYLWRRALRAAAGPLARDTLSPEPAAREAPLLLPSWVQELWETRRR 104
Cdd:pfam15180  16 AEAWYKQAAGPSYYSVGRASGLLSGIRRSPYARRSEPEGAAGPLEGAGAAPEPRQRSSLRSLAVCVKDVSPNLQS 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH