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Conserved domains on  [gi|2499566|sp|Q92047|]
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RecName: Full=Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Short=PIMT; AltName: Full=L-isoaspartyl protein carboxyl methyltransferase; AltName: Full=Protein L-isoaspartyl/D-aspartyl methyltransferase; AltName: Full=Protein-beta-aspartate methyltransferase

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 12014395)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
8-216 3.94e-107

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


:

Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 306.99  E-value: 3.94e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566      8 ASHAELVNNLRKNGIIKSDRVYEVMLATDRSHFSRC----NPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKAL 83
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPEsfksYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     84 DVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGFTEEAPYDAIHVGAAAP 163
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2499566    164 TVPQALLDQLKPGGRLILPVGPaGGNQMLEQYDKLEDGSTKMKPLMGVIYVPL 216
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
8-216 3.94e-107

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 306.99  E-value: 3.94e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566      8 ASHAELVNNLRKNGIIKSDRVYEVMLATDRSHFSRC----NPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKAL 83
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPEsfksYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     84 DVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGFTEEAPYDAIHVGAAAP 163
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2499566    164 TVPQALLDQLKPGGRLILPVGPaGGNQMLEQYDKLEDGSTKMKPLMGVIYVPL 216
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 12-223 6.11e-70

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 213.15  E-value: 6.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     12 ELVNNLRKNGIIKSDRVYEVMLATDRSHFS----RCNPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKALDVGS 87
Cdd:TIGR00080   9 ALIDKLINEGYIKSKRVIDALLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELLE--LKPGMKVLEIGT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     88 GSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpslITSGRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVPQ 167
Cdd:TIGR00080  87 GSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPE 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2499566    168 ALLDQLKPGGRLILPVGPagGNQMLEQYDKlEDGSTKMKPLMGVIYVPLTDKDKQW 223
Cdd:TIGR00080 162 ALIDQLKEGGILVMPVGE--YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 12-219 7.20e-51

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 164.42  E-value: 7.20e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    12 ELVNNLRKNGIIKSDRVYEVMLATDRSHF----SRCNPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKALDVGS 87
Cdd:PRK13942   8 RVIEELIREGYIKSKKVIDALLKVPRHLFvpeyLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLD--LKEGMKVLEIGT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    88 GSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpslITSGRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVPQ 167
Cdd:PRK13942  86 GSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2499566   168 ALLDQLKPGGRLILPVGPAggNQMLEQYDKLEdGSTKMKPLMGVIYVPLTDK 219
Cdd:PRK13942 161 PLIEQLKDGGIMVIPVGSY--SQELIRVEKDN-GKIIKKKLGEVAFVPLIGK 209
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 14-217 1.84e-49

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 160.25  E-value: 1.84e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   14 VNNLRKNGIiKSDRVYEVMLATDRSHF----SRCNPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKALDVGSGS 89
Cdd:COG2518   1 VQQLRPRGV-TDPRVLDAMRAVPRELFvpeaLRELAYADRALPIGHGQTISQPYIVARMLEALD--LKPGDRVLEIGTGS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   90 GILSVCFSRMVGptgKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVPQAL 169
Cdd:COG2518  78 GYQAAVLARLAG---RVYSVERDPELAERARERLAALGYD-----NVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEAL 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 2499566  170 LDQLKPGGRLILPVGPaGGNQMLEQYDKLEDGSTKmKPLMGVIYVPLT 217
Cdd:COG2518 150 LEQLAPGGRLVAPVGE-GGVQRLVLITRTGDGFER-ESLFEVRFVPLR 195
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 81-183 3.04e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   81 KALDVGSGSGILSVCFSRmvGPTGKVIGIDhikeLVEDSIANVKKDDpSLITSGRIKLIVGDGRMG-FTEEAPYDAI--- 156
Cdd:cd02440   1 RVLDLGCGTGALALALAS--GPGARVTGVD----ISPVALELARKAA-AALLADNVEVLKGDAEELpPEADESFDVIisd 73

                        90       100       110
                ....*....|....*....|....*....|.
gi 2499566  157 HVGAAAPTVPQALLDQ----LKPGGRLILPV 183
Cdd:cd02440  74 PPLHHLVEDLARFLEEarrlLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
8-216 3.94e-107

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 306.99  E-value: 3.94e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566      8 ASHAELVNNLRKNGIIKSDRVYEVMLATDRSHFSRC----NPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKAL 83
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPEsfksYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     84 DVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGFTEEAPYDAIHVGAAAP 163
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2499566    164 TVPQALLDQLKPGGRLILPVGPaGGNQMLEQYDKLEDGSTKMKPLMGVIYVPL 216
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 12-223 6.11e-70

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 213.15  E-value: 6.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     12 ELVNNLRKNGIIKSDRVYEVMLATDRSHFS----RCNPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKALDVGS 87
Cdd:TIGR00080   9 ALIDKLINEGYIKSKRVIDALLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELLE--LKPGMKVLEIGT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     88 GSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpslITSGRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVPQ 167
Cdd:TIGR00080  87 GSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPE 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2499566    168 ALLDQLKPGGRLILPVGPagGNQMLEQYDKlEDGSTKMKPLMGVIYVPLTDKDKQW 223
Cdd:TIGR00080 162 ALIDQLKEGGILVMPVGE--YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 12-219 7.20e-51

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 164.42  E-value: 7.20e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    12 ELVNNLRKNGIIKSDRVYEVMLATDRSHF----SRCNPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKALDVGS 87
Cdd:PRK13942   8 RVIEELIREGYIKSKKVIDALLKVPRHLFvpeyLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLD--LKEGMKVLEIGT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    88 GSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpslITSGRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVPQ 167
Cdd:PRK13942  86 GSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2499566   168 ALLDQLKPGGRLILPVGPAggNQMLEQYDKLEdGSTKMKPLMGVIYVPLTDK 219
Cdd:PRK13942 161 PLIEQLKDGGIMVIPVGSY--SQELIRVEKDN-GKIIKKKLGEVAFVPLIGK 209
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 14-217 1.84e-49

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 160.25  E-value: 1.84e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   14 VNNLRKNGIiKSDRVYEVMLATDRSHF----SRCNPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKALDVGSGS 89
Cdd:COG2518   1 VQQLRPRGV-TDPRVLDAMRAVPRELFvpeaLRELAYADRALPIGHGQTISQPYIVARMLEALD--LKPGDRVLEIGTGS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   90 GILSVCFSRMVGptgKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVPQAL 169
Cdd:COG2518  78 GYQAAVLARLAG---RVYSVERDPELAERARERLAALGYD-----NVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEAL 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 2499566  170 LDQLKPGGRLILPVGPaGGNQMLEQYDKLEDGSTKmKPLMGVIYVPLT 217
Cdd:COG2518 150 LEQLAPGGRLVAPVGE-GGVQRLVLITRTGDGFER-ESLFEVRFVPLR 195
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
11-218 1.62e-44

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 148.04  E-value: 1.62e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    11 AELVNNLRKNGIiKSDRVYEVMLATDRSHFS----RCNPYMDSPQSIGYQATISAPHMHAYALELLHdhLYEGAKALDVG 86
Cdd:PRK00312  10 ARLVLRLRAEGI-LDERVLEAIEATPRELFVpeafKHKAYENRALPIGCGQTISQPYMVARMTELLE--LKPGDRVLEIG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    87 SGSGILSVCFSRMVGptgKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVP 166
Cdd:PRK00312  87 TGSGYQAAVLAHLVR---RVFSVERIKTLQWEAKRRLKQLGLH-----NVSVRHGDGWKGWPAYAPFDRILVTAAAPEIP 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2499566   167 QALLDQLKPGGRLILPVGpaGGNQMLEQYDKLEDGSTKMKPLMGVIYVPLTD 218
Cdd:PRK00312 159 RALLEQLKEGGILVAPVG--GEEQQLLTRVRKRGGRFEREVLEEVRFVPLVK 208
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 11-216 3.21e-35

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 124.15  E-value: 3.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    11 AELVNNLRKNGIIKSDRVYEVMLATDRSHFS----RCNPYMDSPQSIGYQATISAPHMHAYALELLHDHlyEGAKALDVG 86
Cdd:PRK13944   3 KRLVEELVREGIIKSERVKKAMLSVPREEFVmpeyRMMAYEDRPLPLFAGATISAPHMVAMMCELIEPR--PGMKILEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    87 SGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpsLITSGRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVP 166
Cdd:PRK13944  81 TGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIER----LGYWGVVEVYHGDGKRGLEKHAPFDAIIVTAAASTIP 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 2499566   167 QALLDQLKPGGRLILPVGPAGGnQMLEQYDKLEDGSTKmKPLMGVIYVPL 216
Cdd:PRK13944 157 SALVRQLKDGGVLVIPVEEGVG-QVLYKVVKRGEKVEK-RAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 11-183 7.13e-22

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 92.43  E-value: 7.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     11 AELVNNLRKNGIIKSDRVYEVMLATDRSHFSrcnPymDSPQSIGYQA----------------TISAPHMHAYALELLHd 74
Cdd:TIGR04364   6 AALVDELREDGVIRSPRVEAAFRTVPRHLFA---P--GAPLEKAYAAnravvtkrdedgralsSVSAPHIQAMMLEQAG- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     75 hLYEGAKALDVGSGsGILSVCFSRMVGPTGKVIGIDHIKELVEDSIAnvkkddpSLITSG--RIKLIVGDGRMGFTEEAP 152
Cdd:TIGR04364  80 -VEPGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTDRARA-------CLAAAGypQVTVVLADAEAGVPELAP 150

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2499566    153 YDAIHVGAAAPTVPQALLDQLKPGGRLILPV 183
Cdd:TIGR04364 151 YDRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 12-183 1.48e-19

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 85.28  E-value: 1.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    12 ELVNNLRKNGIikSDRVYEVMLATDRSHFSRcnpyMDSPQSIGYQ-------------ATISAPHMHAYALELLHdhLYE 78
Cdd:PRK13943   9 KLFWILKKYGI--SDHIAKAFLEVPREEFLT----KSYPLSYVYEdivlvsyddgeeySTSSQPSLMALFMEWVG--LDK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    79 GAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpslITSGRIKLIVGDGRMGFTEEAPYDAIHV 158
Cdd:PRK13943  81 GMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRR-----LGIENVIFVCGDGYYGVPEFAPYDVIFV 155

                        170       180
                 ....*....|....*....|....*
gi 2499566   159 GAAAPTVPQALLDQLKPGGRLILPV 183
Cdd:PRK13943 156 TVGVDEVPETWFTQLKEGGRVIVPI 180
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 76-180 8.58e-12

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 62.48  E-value: 8.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   76 LYEGAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpsLITSGRIKLIVGDGRMGFtEEAPYDA 155
Cdd:COG2519  89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLER----FGLPDNVELKLGDIREGI-DEGDVDA 163

                        90       100
                ....*....|....*....|....*..
gi 2499566  156 IHVGAAAP--TVPQAlLDQLKPGGRLI 180
Cdd:COG2519 164 VFLDMPDPweALEAV-AKALKPGGVLV 189
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
69-181 4.44e-10

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 58.26  E-value: 4.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   69 LELLHDHLYEGAKALDVGSGSGILSVcFSRMVGPtGKVIGIDhIKEL-VEDSIANVKKDDpsliTSGRIKLIVGDGRmgf 147
Cdd:COG2264 139 LEALEKLLKPGKTVLDVGCGSGILAI-AAAKLGA-KRVLAVD-IDPVaVEAARENAELNG----VEDRIEVVLGDLL--- 208

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 2499566  148 tEEAPYD--------AIHVgAAAPTVPQAlldqLKPGGRLIL 181
Cdd:COG2264 209 -EDGPYDlvvanilaNPLI-ELAPDLAAL----LKPGGYLIL 244
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 70-181 4.94e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 55.41  E-value: 4.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   70 ELLHDHLYEGAKALDVGSGSGILSVCFSRMvgptG-KVIGIDhikeLVEDSIANVKKDDPSLitsgRIKLIVGDGR-MGF 147
Cdd:COG2227  16 ALLARLLPAGGRVLDVGCGTGRLALALARR----GaDVTGVD----ISPEALEIARERAAEL----NVDFVQGDLEdLPL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 2499566  148 tEEAPYDAI-------HVGAAAPTVpQALLDQLKPGGRLIL 181
Cdd:COG2227  84 -EDGSFDLVicsevleHLPDPAALL-RELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
78-181 1.57e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 53.29  E-value: 1.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   78 EGAKALDVGSGSGILSVCFSRMVgPTGKVIGIDhikeLVEDSIANVKKDDPslitsgRIKLIVGDGRmGFTEEAPYDAIH 157
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERF-PGARVTGVD----LSPEMLARARARLP------NVRFVVADLR-DLDPPEPFDLVV 68

                        90       100       110
                ....*....|....*....|....*....|
gi 2499566  158 VGAA------APTVPQALLDQLKPGGRLIL 181
Cdd:COG4106  69 SNAAlhwlpdHAALLARLAAALAPGGVLAV 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 68-181 1.96e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 54.55  E-value: 1.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   68 ALELLHDHLY--EGAKALDVGSGSGILSVCFSRMVGptGKVIGIDhikeLVEDSIANVKKDDPSLITSGRIKLIVGDGRm 145
Cdd:COG2230  39 KLDLILRKLGlkPGMRVLDIGCGWGGLALYLARRYG--VRVTGVT----LSPEQLEYARERAAEAGLADRVEVRLADYR- 111

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 2499566  146 GFTEEAPYDAI-------HVGAAA-PTVPQALLDQLKPGGRLIL 181
Cdd:COG2230 112 DLPADGQFDAIvsigmfeHVGPENyPAYFAKVARLLKPGGRLLL 155
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 68-211 6.71e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.77  E-value: 6.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   68 ALELLHDHLYEGAKALDVGSGSGILSVCFSRMVGptGKVIGIDHIKELVEDSIANVKKDDPslitsGRIKLIVGD-GRMG 146
Cdd:COG0500  16 ALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAKAGL-----GNVEFLVADlAELD 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2499566  147 FTEEAPYDAI-------HVGAAAPT-VPQALLDQLKPGGRLILPVGPAGGNQMLEQYDKLEDGSTKMKPLMGV 211
Cdd:COG0500  89 PLPAESFDLVvafgvlhHLPPEEREaLLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLR 161
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 83-177 6.79e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.80  E-value: 6.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     83 LDVGSGSGILSVCFSRMVGptGKVIGIDHIKELVEDSIANVKKDDPslitsgRIKLIVGDGR-MGFtEEAPYDAIHVGAA 161
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAGL------NVEFVQGDAEdLPF-PDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 2499566    162 ----APTVPQALLDQ----LKPGG 177
Cdd:pfam13649  73 lhhlPDPDLEAALREiarvLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-181 1.53e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 51.92  E-value: 1.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   65 HAYALELLHDHlyEGAKALDVGSGSGILSVCFSRMvgpTGKVIGIDHIKELVEDSIANVKKDDPslitsgRIKLIVGDG- 143
Cdd:COG2226  11 REALLAALGLR--PGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGL------NVEFVVGDAe 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 2499566  144 RMGFtEEAPYDAIHVGAAAPTVP--QALLDQ----LKPGGRLIL 181
Cdd:COG2226  80 DLPF-PDGSFDLVISSFVLHHLPdpERALAEiarvLKPGGRLVV 122
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 68-183 1.07e-07

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 50.57  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    68 ALELLHDHLYEGAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKddpsLITSGRIKLIVGDG-RMG 146
Cdd:PRK00377  30 ALALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEK----FGVLNNIVLIKGEApEIL 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 2499566   147 FTEEAPYDAIHVGAAAPTVP---QALLDQLKPGGRLILPV 183
Cdd:PRK00377 106 FTINEKFDRIFIGGGSEKLKeiiSASWEIIKKGGRIVIDA 145
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 138-188 3.44e-07

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 50.05  E-value: 3.44e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2499566    138 LIVGDGRMGFTEEAPYDAIHVGAAAPTVPQALLDQLKPGGRLILPVG---PAGG 188
Cdd:TIGR04188 160 VVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSgwlYGGG 213
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 79-181 5.06e-07

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 49.00  E-value: 5.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    79 GAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEdsIAnvKKDDPSLITSGRIKLIVGDGrmgftEEAPYDAIHV 158
Cdd:PRK00216  52 GDKVLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLA--VG--REKLRDLGLSGNVEFVQGDA-----EALPFPDNSF 122

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 2499566   159 GAAA--------PTVPQALldQ-----LKPGGRL-IL 181
Cdd:PRK00216 123 DAVTiafglrnvPDIDKAL--RemyrvLKPGGRLvIL 157
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 78-181 2.24e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.87  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     78 EGAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGD-GRMGFT-EEAPYDA 155
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFD-----NVEFEQGDiEELPELlEDDKFDV 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2499566    156 IHVGAAAPTVP------QALLDQLKPGGRLIL 181
Cdd:pfam13847  78 VISNCVLNHIPdpdkvlQEILRVLKPGGRLII 109
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 70-181 2.40e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 46.34  E-value: 2.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   70 ELLHDHL--YEGAKALDVGSGSGILSVCFSRMvGPTGKVIGIDhIKEL-VEDSIANVKKDDPSlitsgRIKLIVGDGRMG 146
Cdd:COG2813  39 RLLLEHLpePLGGRVLDLGCGYGVIGLALAKR-NPEARVTLVD-VNARaVELARANAAANGLE-----NVEVLWSDGLSG 111

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 2499566  147 FtEEAPYDAI------HVGAAA-PTVPQALLDQ----LKPGGRLIL 181
Cdd:COG2813 112 V-PDGSFDLIlsnppfHAGRAVdKEVAHALIADaarhLRPGGELWL 156
PRK08317 PRK08317
hypothetical protein; Provisional
 66-181 2.60e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 46.85  E-value: 2.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    66 AYALELLHdhLYEGAKALDVGSGSGILSVCFSRMVGPTGKVIGIDhikeLVEDSIANVKKDDPSLItsGRIKLIVGDG-R 144
Cdd:PRK08317   9 ARTFELLA--VQPGDRVLDVGCGPGNDARELARRVGPEGRVVGID----RSEAMLALAKERAAGLG--PNVEFVRGDAdG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 2499566   145 MGFTEEApYDAI-------HVgaaaPTVPQALLDQ---LKPGGRLIL 181
Cdd:PRK08317  81 LPFPDGS-FDAVrsdrvlqHL----EDPARALAEIarvLRPGGRVVV 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 81-183 3.04e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   81 KALDVGSGSGILSVCFSRmvGPTGKVIGIDhikeLVEDSIANVKKDDpSLITSGRIKLIVGDGRMG-FTEEAPYDAI--- 156
Cdd:cd02440   1 RVLDLGCGTGALALALAS--GPGARVTGVD----ISPVALELARKAA-AALLADNVEVLKGDAEELpPEADESFDVIisd 73

                        90       100       110
                ....*....|....*....|....*....|.
gi 2499566  157 HVGAAAPTVPQALLDQ----LKPGGRLILPV 183
Cdd:cd02440  74 PPLHHLVEDLARFLEEarrlLKPGGVLVLTL 104
arsM PRK11873
arsenite methyltransferase;
76-125 3.09e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 46.87  E-value: 3.09e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 2499566    76 LYEGAKALDVGSGSGIlsVCF--SRMVGPTGKVIGIDHIKELVEDSIANVKK 125
Cdd:PRK11873  75 LKPGETVLDLGSGGGF--DCFlaARRVGPTGKVIGVDMTPEMLAKARANARK 124
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
78-180 1.48e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 44.35  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     78 EGAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGFTEEAPYDAIH 157
Cdd:pfam01209  42 RGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEEGKY-----NIEFLQGNAEELPFEDDSFDIVT 116

                          90       100
                  ....*....|....*....|....*....
gi 2499566    158 VG------AAAPTVPQALLDQLKPGGRLI 180
Cdd:pfam01209 117 ISfglrnfPDYLKVLKEAFRVLKPGGRVV 145
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 79-181 1.84e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 43.63  E-value: 1.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   79 GAK-ALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKDDpsliTSGRIKLIVGDGR--MGFTEEAPYDA 155
Cdd:COG4122  16 GAKrILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAG----LADRIRLILGDALevLPRLADGPFDL 91

                        90       100
                ....*....|....*....|....*....
gi 2499566  156 IHVGAAAPTVP---QALLDQLKPGGrLIL 181
Cdd:COG4122  92 VFIDADKSNYPdylELALPLLRPGG-LIV 119
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 83-181 2.02e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.88  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     83 LDVGSGSGILSVCFSRMVgptGKVIGIDHIKELVEDSIANVKKDDpslitsgrIKLIVGDG-RMGFTEEApYDAIHVGAA 161
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG---ARVTGVDISPEMLELAREKAPREG--------LTFVVGDAeDLPFPDNS-FDLVLSSEV 68

                          90       100
                  ....*....|....*....|....*.
gi 2499566    162 APTV--PQALLDQ----LKPGGRLIL 181
Cdd:pfam08241  69 LHHVedPERALREiarvLKPGGILII 94
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
69-181 2.32e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.99  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    69 LELLHDHLYEGAKALDVGSGSGILSVcFSRMVGPTgKVIGIDhIKEL-VEDSIANVKKDDpslitsGRIKLIVGDGrmgf 147
Cdd:PRK00517 110 LEALEKLVLPGKTVLDVGCGSGILAI-AAAKLGAK-KVLAVD-IDPQaVEAARENAELNG------VELNVYLPQG---- 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 2499566   148 teEAPYD--------AIHVgAAAPTVPQAlldqLKPGGRLIL 181
Cdd:PRK00517 177 --DLKADvivanilaNPLL-ELAPDLARL----LKPGGRLIL 211
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 66-181 4.24e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 43.62  E-value: 4.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   66 AYALELLHdhLYEGAKALDVGSGSGILSVCFSRMvGPTGKVIGIDHIKELVEDSIANVKK---DDpslitsgrIKLIVGD 142
Cdd:COG2242 237 ALTLAKLA--LRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARRfgvPN--------VEVVEGE 305

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 2499566  143 GRMGFTEEAPYDAIHVGAAAPTVP---QALLDQLKPGGRLIL 181
Cdd:COG2242 306 APEALADLPDPDAVFIGGSGGNLPeilEACWARLRPGGRLVA 347
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 59-183 8.83e-05

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 40.78  E-value: 8.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     59 ISAPHMHAYALELLHdhLYEGAKALDVGSGSGILSVCFSRMVGPtGKVIGIDHIKELVEdsianvkkddpsLITSGRIKL 138
Cdd:TIGR02469   2 MTKREVRALTLAKLR--LRPGDVLWDIGAGTGSVTIEAARLVPN-GRVYAIERNPEALD------------LIERNLRRF 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2499566    139 IVGDGRMgFTEEAPY---------DAIHVGAAApTVPQALLD----QLKPGGRLILPV 183
Cdd:TIGR02469  67 GVSNIVI-VEGDAPEapeallpdpDAVFVGGSG-GLLQEILEaverRLRPGGRIVLNA 122
PRK14968 PRK14968
putative methyltransferase; Provisional
 70-110 1.91e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.04  E-value: 1.91e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 2499566    70 ELLHDHLYE--GAKALDVGSGSGILSVCFSRMvgpTGKVIGID 110
Cdd:PRK14968  13 FLLAENAVDkkGDRVLEVGTGSGIVAIVAAKN---GKKVVGVD 52
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 69-181 4.53e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.33  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     69 LELLHDHLYEGAKALDVGSGSGILSVCFSRMvGPtGKVIGIDhIKEL-VEDSIANVKKDDpsliTSGRIKLIVGDGRMgf 147
Cdd:pfam06325 152 LEALERLVKPGESVLDVGCGSGILAIAALKL-GA-KKVVGVD-IDPVaVRAAKENAELNG----VEARLEVYLPGDLP-- 222

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2499566    148 teEAPYDAIHVGAAAPTVpQALLDQ----LKPGGRLIL 181
Cdd:pfam06325 223 --KEKADVVVANILADPL-IELAPDiyalVKPGGYLIL 257
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 79-178 1.24e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 39.10  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    79 GAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEdsIANVKKDDPSLITSGRIKLIVGDG-RMGFTeEAPYDAIH 157
Cdd:PLN02233  74 GDRVLDLCCGSGDLAFLLSEKVGSDGKVMGLDFSSEQLA--VAASRQELKAKSCYKNIEWIEGDAtDLPFD-DCYFDAIT 150

                         90       100
                 ....*....|....*....|....*..
gi 2499566   158 VGAAAPTV------PQALLDQLKPGGR 178
Cdd:PLN02233 151 MGYGLRNVvdrlkaMQEMYRVLKPGSR 177
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
63-181 2.26e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 37.67  E-value: 2.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566   63 HMHAYALELLHDHlyEGAKALDVGSGSGILSVCFSRMVgptGKVIGIDHIKELVEdsIANVKKDDpslitsgrIKLIVGD 142
Cdd:COG4976  33 LLAEELLARLPPG--PFGRVLDLGCGTGLLGEALRPRG---YRLTGVDLSEEMLA--KAREKGVY--------DRLLVAD 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 2499566  143 GRMGFTEEAPYDAI-------HVGAAAPTVpQALLDQLKPGGRLIL 181
Cdd:COG4976  98 LADLAEPDGRFDLIvaadvltYLGDLAAVF-AGVARALKPGGLFIF 142
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 70-181 4.23e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.80  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566     70 ELLHDHLYE--GAKALDVGSGSGILSVCFSRMvGPTGKVIGIDHIKELVEDSIANVKKDDPSlitsgRIKLIVGDGRMGf 147
Cdd:pfam05175  21 RLLLEHLPKdlSGKVLDLGCGAGVLGAALAKE-SPDAELTMVDINARALESARENLAANGLE-----NGEVVASDVYSG- 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2499566    148 TEEAPYDAI------HVG-AAAPTVPQALL----DQLKPGGRLIL 181
Cdd:pfam05175  94 VEDGKFDLIisnppfHAGlATTYNVAQRFIadakRHLRPGGELWI 138
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
66-181 4.29e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 36.90  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2499566    66 AYALELLHdhLYEGAKALDVGSGSGILSV----CFsrmvgPTGKVIGIDHIKELVEDSIANVKKddpslITSGRIKLIVG 141
Cdd:PRK08287  21 ALALSKLE--LHRAKHLIDVGAGTGSVSIeaalQF-----PSLQVTAIERNPDALRLIKENRQR-----FGCGNIDIIPG 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 2499566   142 DGRMGFTEEApyDAIHVGAAAPTVpQALLD----QLKPGGRLIL 181
Cdd:PRK08287  89 EAPIELPGKA--DAIFIGGSGGNL-TAIIDwslaHLHPGGRLVL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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