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Conserved domains on  [gi|134034174|sp|Q9BT17|]
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RecName: Full=Mitochondrial ribosome-associated GTPase 1; AltName: Full=GTP-binding protein 7; AltName: Full=Mitochondrial GTPase 1; Flags: Precursor

Protein Classification

YlqF/YawG GTPase family protein( domain architecture ID 10111434)

YlqF/YawG GTPase family protein similar to human mitochondrial ribosome-associated GTPase 1 that plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 30-207 4.71e-77

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


:

Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 233.57  E-value: 4.71e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  30 WFPGHMAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGlKNVI 109
Cdd:cd01856    1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQG-EPVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 110 FTNCVKDENVKQIIPMVTELIGRSHRYHRK--ENLEYCIMVIGVPNVGKSSLINSLRRQhlrkgKATRVGGEPGITRAVM 187
Cdd:cd01856   80 FVNAKNGKGVKKLLKKAKKLLKENEKLKAKglLPRPLRAMVVGIPNVGKSTLINRLRGK-----KVAKVGNKPGVTRGQQ 154

                        170       180
                 ....*....|....*....|
gi 134034174 188 SkIQVSERplMFLLDTPGVL 207
Cdd:cd01856  155 W-IRIGPN--IELLDTPGIL 171
 
Name Accession Description Interval E-value
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 30-207 4.71e-77

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 233.57  E-value: 4.71e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  30 WFPGHMAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGlKNVI 109
Cdd:cd01856    1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQG-EPVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 110 FTNCVKDENVKQIIPMVTELIGRSHRYHRK--ENLEYCIMVIGVPNVGKSSLINSLRRQhlrkgKATRVGGEPGITRAVM 187
Cdd:cd01856   80 FVNAKNGKGVKKLLKKAKKLLKENEKLKAKglLPRPLRAMVVGIPNVGKSTLINRLRGK-----KVAKVGNKPGVTRGQQ 154

                        170       180
                 ....*....|....*....|
gi 134034174 188 SkIQVSERplMFLLDTPGVL 207
Cdd:cd01856  155 W-IRIGPN--IELLDTPGIL 171
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 30-320 2.20e-75

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 233.17  E-value: 2.20e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174   30 WFPGHMAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGlKNVI 109
Cdd:TIGR03596   3 WFPGHMAKARREIKENLKLVDVVIEVLDARIPLSSRNPMIDEIRGNKPRLIVLNKADLADPAVTKQWLKYFEEKG-IKAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  110 FTNCVKDENVKQIIPMVTELIGrshryHRKENLEYC--------IMVIGVPNVGKSSLINslrrqHLRKGKATRVGGEPG 181
Cdd:TIGR03596  82 AVNAKKGAGVKKIIKAAKKLLK-----EKNEKLKAKglknrpirAMIVGIPNVGKSTLIN-----RLAGKKVAKVGNRPG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  182 ITRAvMSKIQVSERplMFLLDTPGVLAPRIESVETGLKLALCGTVLDHLVGEETMADYLLYTLNKHQRFGYVQHYGLGSA 261
Cdd:TIGR03596 152 VTKG-QQWIKLSDN--LELLDTPGILWPKFEDQEVGLKLAATGAIKDEALDLEDVALFLLEYLLEHYPELLKERYKLDEL 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 134034174  262 CDNVERVLKSVAVKLGKTQKvkvltgtGNvniiQPNYPAAARDFLQTFRRGLLGSVMLD 320
Cdd:TIGR03596 229 PEDPVELLEAIAKKRGCLLK-------GG----ELDLDRAAEILLNDFRKGKLGRISLE 276
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
30-320 1.37e-72

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 226.14  E-value: 1.37e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  30 WFPGHMAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGLKnVI 109
Cdd:COG1161    5 WFPGHMAKARRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVGNKPRLLVLNKADLADPSVTKQWLKYFEKQGVD-AL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 110 FTNCVKDENVKQIIPMVTELIGRSHRYHRKENleycIMVIGVPNVGKSSLINslrrqHLRKGKATRVGGEPGITRAvMSK 189
Cdd:COG1161   84 AISAKKGKGIKELIEAIRELAPEKGIKRRPIR----VMIVGIPNVGKSTLIN-----RLAGKKVAKTGNKPGVTKG-QQW 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 190 IQVSERplMFLLDTPGVLAPRIESVETGLKLALCGTVLDHLVGEETMADYLLYTLNKHqrfgYV----QHYGLGSACDNV 265
Cdd:COG1161  154 IKLDDG--LELLDTPGILWPKFEDPEVGYKLAATGAIKDEVLDLEEVALFLLGYLARR----YPellkERYKLDELPRTK 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 134034174 266 ERVLKSVAVKLGktqkvKVLTGtGNVniiqpNYPAAARDFLQTFRRGLLGSVMLD 320
Cdd:COG1161  228 LELLEAIGRKRG-----CLLSG-GEV-----DLEKAAEILLTDFRSGKLGRITLE 271
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 146-207 6.67e-11

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 58.78  E-value: 6.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134034174  146 IMVIGVPNVGKSSLINSLrrqhlrKGKATRVGGEPGITR-AVMSKIQVSERPLMfLLDTPGVL 207
Cdd:pfam01926   2 VALVGRPNVGKSTLINAL------TGAKAIVSDYPGTTRdPNEGRLELKGKQII-LVDTPGLI 57
PRK00098 PRK00098
GTPase RsgA; Reviewed
 71-206 2.91e-07

GTPase RsgA; Reviewed


Pssm-ID: 234631 [Multi-domain]  Cd Length: 298  Bit Score: 51.36  E-value: 2.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  71 ETLGLKPhLLVLNKMDL-ADLTEQQKIMQHLEGEGLKnVIFTNCVKDENVKQIIPM----VTELIGRShryhrkenleyc 145
Cdd:PRK00098 108 EANGIKP-IIVLNKIDLlDDLEEARELLALYRAIGYD-VLELSAKEGEGLDELKPLlagkVTVLAGQS------------ 173

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134034174 146 imviGvpnVGKSSLINSLR----------RQHLRKGKATrvggepgiTRAVmSKIQVSERPlmFLLDTPGV 206
Cdd:PRK00098 174 ----G---VGKSTLLNALApdlelktgeiSEALGRGKHT--------TTHV-ELYDLPGGG--LLIDTPGF 226
 
Name Accession Description Interval E-value
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 30-207 4.71e-77

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 233.57  E-value: 4.71e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  30 WFPGHMAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGlKNVI 109
Cdd:cd01856    1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQG-EPVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 110 FTNCVKDENVKQIIPMVTELIGRSHRYHRK--ENLEYCIMVIGVPNVGKSSLINSLRRQhlrkgKATRVGGEPGITRAVM 187
Cdd:cd01856   80 FVNAKNGKGVKKLLKKAKKLLKENEKLKAKglLPRPLRAMVVGIPNVGKSTLINRLRGK-----KVAKVGNKPGVTRGQQ 154

                        170       180
                 ....*....|....*....|
gi 134034174 188 SkIQVSERplMFLLDTPGVL 207
Cdd:cd01856  155 W-IRIGPN--IELLDTPGIL 171
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 30-320 2.20e-75

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 233.17  E-value: 2.20e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174   30 WFPGHMAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGlKNVI 109
Cdd:TIGR03596   3 WFPGHMAKARREIKENLKLVDVVIEVLDARIPLSSRNPMIDEIRGNKPRLIVLNKADLADPAVTKQWLKYFEEKG-IKAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  110 FTNCVKDENVKQIIPMVTELIGrshryHRKENLEYC--------IMVIGVPNVGKSSLINslrrqHLRKGKATRVGGEPG 181
Cdd:TIGR03596  82 AVNAKKGAGVKKIIKAAKKLLK-----EKNEKLKAKglknrpirAMIVGIPNVGKSTLIN-----RLAGKKVAKVGNRPG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  182 ITRAvMSKIQVSERplMFLLDTPGVLAPRIESVETGLKLALCGTVLDHLVGEETMADYLLYTLNKHQRFGYVQHYGLGSA 261
Cdd:TIGR03596 152 VTKG-QQWIKLSDN--LELLDTPGILWPKFEDQEVGLKLAATGAIKDEALDLEDVALFLLEYLLEHYPELLKERYKLDEL 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 134034174  262 CDNVERVLKSVAVKLGKTQKvkvltgtGNvniiQPNYPAAARDFLQTFRRGLLGSVMLD 320
Cdd:TIGR03596 229 PEDPVELLEAIAKKRGCLLK-------GG----ELDLDRAAEILLNDFRKGKLGRISLE 276
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
30-320 1.37e-72

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 226.14  E-value: 1.37e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  30 WFPGHMAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGLKnVI 109
Cdd:COG1161    5 WFPGHMAKARRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVGNKPRLLVLNKADLADPSVTKQWLKYFEKQGVD-AL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 110 FTNCVKDENVKQIIPMVTELIGRSHRYHRKENleycIMVIGVPNVGKSSLINslrrqHLRKGKATRVGGEPGITRAvMSK 189
Cdd:COG1161   84 AISAKKGKGIKELIEAIRELAPEKGIKRRPIR----VMIVGIPNVGKSTLIN-----RLAGKKVAKTGNKPGVTKG-QQW 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 190 IQVSERplMFLLDTPGVLAPRIESVETGLKLALCGTVLDHLVGEETMADYLLYTLNKHqrfgYV----QHYGLGSACDNV 265
Cdd:COG1161  154 IKLDDG--LELLDTPGILWPKFEDPEVGYKLAATGAIKDEVLDLEEVALFLLGYLARR----YPellkERYKLDELPRTK 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 134034174 266 ERVLKSVAVKLGktqkvKVLTGtGNVniiqpNYPAAARDFLQTFRRGLLGSVMLD 320
Cdd:COG1161  228 LELLEAIGRKRG-----CLLSG-GEV-----DLEKAAEILLTDFRSGKLGRITLE 271
Nucleostemin_like cd04178
A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein ...
 50-206 6.50e-21

A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein that functions as a regulator of cell growth and proliferation in stem cells and in several types of cancer cells, but is not expressed in the differentiated cells of most mammalian adult tissues. NS shuttles between the nucleolus and nucleoplasm bidirectionally at a rate that is fast and independent of cell type. Lowering GTP levels decreases the nucleolar retention of NS, and expression of NS is abruptly down-regulated during differentiation prior to terminal cell division. Found only in eukaryotes, NS consists of an N-terminal basic domain, a coiled-coil domain, a GTP-binding domain, an intermediate domain, and a C-terminal acidic domain. Experimental evidence indicates that NS uses its GTP-binding property as a molecular switch to control the transition between the nucleolus and nucleoplasm, and this process involves interaction between the basic, GTP-binding, and intermediate domains of the protein.


Pssm-ID: 206753 [Multi-domain]  Cd Length: 171  Bit Score: 88.02  E-value: 6.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  50 DCIIEVHDARIPLSGRNPLFQETL----GLKPHLLVLNKMDLADLTEQQKIMQHLEGEgLKNVIFT-----------NCV 114
Cdd:cd04178    1 DVILEVLDARDPLGCRCPQVERAVlvlgPNKKLVLVLNKIDLVPKENVEKWLKYLRNE-FPTVAFKastqqqkknlsRKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 115 KDENVKQIIPMVTELIGRS------HRYHRKENLEYCIMV--IGVPNVGKSSLINSLRRQHlrkgkATRVGGEPGITRaV 186
Cdd:cd04178   80 KKVKASDDLLSSSACLGADallkllKNYARNKGIKTSITVgvVGYPNVGKSSVINSLKRSR-----ACNVGATPGVTK-S 153

                        170       180
                 ....*....|....*....|
gi 134034174 187 MSKIQVSERplMFLLDTPGV 206
Cdd:cd04178  154 MQEVHLDKH--VKLLDSPGV 171
MJ1464 cd01859
An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents ...
 46-206 3.50e-20

An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents archaeal GTPase typified by the protein MJ1464 from Methanococcus jannaschii. The members of this family show a circular permutation of the GTPase signature motifs so that C-terminal strands 5, 6, and 7 (strands 6 contain the NKxD motif) are relocated to the N terminus.


Pssm-ID: 206752 [Multi-domain]  Cd Length: 157  Bit Score: 85.83  E-value: 3.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  46 LKLVDCIIEVHDARIPLSGRNPLFQE---TLGlKPHLLVLNKMDLADLTEQQKIMQHLEGEGLkNVIFTNCVKDENVKQI 122
Cdd:cd01859    9 IKEADVVLEVVDARDPELTRSRKLERmalELG-KKLIIVLNKADLVPREVLEKWKEVFESEGL-PVVYVSARERLGTRIL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 123 IPMVTELIGRSHryhrkenlEYCIMVIGVPNVGKSSLINSLRRQHlrKGKATRVGGEPGITRAvMSKIQVSERplMFLLD 202
Cdd:cd01859   87 RRTIKELAIDGK--------PVIVGVVGYPKVGKSSIINALKGRH--SASTSPIPGSPGYTKG-IQLVRIDSK--IYLID 153


                 ....
gi 134034174 203 TPGV 206
Cdd:cd01859  154 TPGV 157
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 50-206 6.23e-20

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 84.74  E-value: 6.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  50 DCIIEVHDARIPLSGRNP--LFQETLGLKPHLLVLNKMDLADL-TEQQKIMQHLEGEGLKNViFTNCVKDENVKQIIPMV 126
Cdd:cd01849    1 DVVVEVVDARDPLSSRNPdiEVLINEKNKKLIMVLNKADLVPKeVLRKWVAELSELYGTKTF-FISATNGQGILKLKAEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 127 TEligrsHRYHRKENLEYCIMVIGVPNVGKSSLINSlrrqhLRKGKATRVGGEPGITRaVMSKIQVSERplMFLLDTPGV 206
Cdd:cd01849   80 TK-----QKLKLKYKKGIRVGVVGLPNVGKSSFINA-----LLNKFKLKVGSIPGTTK-LQQDVKLDKE--IYLYDTPGI 146
YqeH cd01855
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ...
 46-206 3.21e-13

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.


Pssm-ID: 206748 [Multi-domain]  Cd Length: 191  Bit Score: 67.29  E-value: 3.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  46 LKLVDcIIEVHDARIPLsgrnplFQETLGLKPHLLVLNKMD-LADLTEQQKIMQHL------EGEGLKNVIFTNCVKDEN 118
Cdd:cd01855   38 VHVVD-IFDFPGSLIPG------LAELIGAKPVILVGNKIDlLPKDVKPNRLKQWVkkrlkiGGLKIKDVILVSAKKGWG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 119 VKQIIPMVTELIGRSHRyhrkenleycIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGE------PGITRAVMsKIQV 192
Cdd:cd01855  111 VEELIEEIKKLAKYRGD----------VYVVGATNVGKSTLINALLKSNGGKVQAQALVQRltvspiPGTTLGLI-KIPL 179

                        170
                 ....*....|....
gi 134034174 193 SERPLMFllDTPGV 206
Cdd:cd01855  180 GEGKKLY--DTPGI 191
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
 50-209 4.60e-13

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 65.72  E-value: 4.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  50 DCIIEVHDARIPLSGRNP----LFQETLGLKPHLLVLNKMDLadLTEQQKIM--QHLEGEGLKNVIFTncvkdenvkqii 123
Cdd:cd01857   13 DVVVQIVDARNPLFFRCPdlekYVKEVDPSKENVLLLNKADL--VTEEQRKAwaRYFKKEGIVVLFFS------------ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 124 pmvteligrshryhrkENLEYCIMVIGVPNVGKSSLINSLRRQhlrkgKATRVGGEPGITRAvMSKIQVSerPLMFLLDT 203
Cdd:cd01857   79 ----------------ALNEATIGLVGYPNVGKSSLINALVGS-----KKVSVSSTPGKTKH-FQTIFLE--PGITLCDC 134


                 ....*.
gi 134034174 204 PGVLAP 209
Cdd:cd01857  135 PGLVFP 140
NGP_1 cd01858
A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; ...
 47-206 3.82e-11

A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; Autoantigen NGP-1 (Nucleolar G-protein gene 1) has been shown to localize in the nucleolus and nucleolar organizers in all cell types analyzed, which is indicative of a function in ribosomal assembly. NGP-1 and its homologs show a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with NKXD motif) are relocated to the N terminus.


Pssm-ID: 206751 [Multi-domain]  Cd Length: 157  Bit Score: 60.39  E-value: 3.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  47 KLVDC---IIEVHDARIPLSGRNPLFQETLGL-KPH---LLVLNKMDLADLTEQQKIMQHLEGEgLKNVIF----TNCVK 115
Cdd:cd01858    4 KVIDSsdvIIQVLDARDPMGTRCKHVEKYLRKeKPHkhlIFVLNKCDLVPTWVTKRWVKVLSKE-YPTLAFhasiTNPFG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 116 DENVKQIIPMVTELigrshryhRKENLEYCIMVIGVPNVGKSSLINSLRRQhlrkgKATRVGGEPGITR-----AVMSKI 190
Cdd:cd01858   83 KGALINLLRQFAKL--------HSDKKQISVGFIGYPNVGKSSVINTLRSK-----KVCKVAPIPGETKvwqyiTLMKRI 149

                        170
                 ....*....|....*.
gi 134034174 191 qvserplmFLLDTPGV 206
Cdd:cd01858  150 --------YLIDCPGV 157
GTPase_YqeH TIGR03597
ribosome biogenesis GTPase YqeH; This family describes YqeH, a member of a larger family of ...
 39-207 3.83e-11

ribosome biogenesis GTPase YqeH; This family describes YqeH, a member of a larger family of GTPases involved in ribosome biogenesis. Like YqlF, it shows a cyclical permutation relative to GTPases EngA (in which the GTPase domain is duplicated), Era, and others. Members of this protein family are found in a relatively small number of bacterial species, including Bacillus subtilis but not Escherichia coli. [Protein synthesis, Other]


Pssm-ID: 213834 [Multi-domain]  Cd Length: 360  Bit Score: 63.41  E-value: 3.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174   39 LKKMQSSLKLVDCIIEVHDaripLSG-RNPLFQETLGLKPHLLVLNKMDLadLTEQQK-------IMQHLEGEGLK--NV 108
Cdd:TIGR03597  57 LNSLGDSNALIVYVVDIFD----FEGsLIPELKRFVGGNPVLLVGNKIDL--LPKSVNlskikewMKKRAKELGLKpvDI 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  109 IFTNCVKDENVKQIIPMVTeligrshRYHRKENleycIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGEPGITRAvMS 188
Cdd:TIGR03597 131 ILVSAKKGNGIDELLDKIK-------KARNKKD----VYVVGVTNVGKSSLINKLLKQNNGDKDVITTSPFPGTTLD-LI 198

                         170
                  ....*....|....*....
gi 134034174  189 KIQVSERplMFLLDTPGVL 207
Cdd:TIGR03597 199 EIPLDDG--HSLYDTPGII 215
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 146-207 6.67e-11

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 58.78  E-value: 6.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134034174  146 IMVIGVPNVGKSSLINSLrrqhlrKGKATRVGGEPGITR-AVMSKIQVSERPLMfLLDTPGVL 207
Cdd:pfam01926   2 VALVGRPNVGKSTLINAL------TGAKAIVSDYPGTTRdPNEGRLELKGKQII-LVDTPGLI 57
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 71-206 2.03e-09

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 56.64  E-value: 2.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  71 ETLGLKPhLLVLNKMDLADLTEQQKIMQHLEGEGLKnVIFTNCVKDENVKQIIPMVTE----LIGRShryhrkenleyci 146
Cdd:cd01854   30 EASGIEP-VIVLNKADLVDDEELEELLEIYEKLGYP-VLAVSAKTGEGLDELRELLKGktsvLVGQS------------- 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134034174 147 mviGvpnVGKSSLINSLR----------RQHLRKGKATrvggepgiTRAVMskiqvserpLM------FLLDTPGV 206
Cdd:cd01854   95 ---G---VGKSTLLNALLpelvlatgeiSEKLGRGRHT--------TTHRE---------LFplpgggLIIDTPGF 147
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
 71-206 2.69e-09

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 55.63  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174   71 ETLGLKPhLLVLNKMDLA-DLTEQQKIMQHLEGEGLKnVIFTNCVKDENVKQIIPMVTE----LIGRShryhrkenleyc 145
Cdd:pfam03193  50 EASGIEP-VIVLNKIDLLdEEEELEELLKIYRAIGYP-VLFVSAKTGEGIEALKELLKGkttvLAGQS------------ 115

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134034174  146 imviGVpnvGKSSLINSLR----------RQHLRKGKATrvggepgiTRAV-MSKIQVSErplmFLLDTPGV 206
Cdd:pfam03193 116 ----GV---GKSTLLNALLpeldlrtgeiSEKLGRGRHT--------TTHVeLFPLPGGG----LLIDTPGF 168
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
71-206 7.91e-08

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 52.81  E-value: 7.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  71 ETLGLKPhLLVLNKMDLADLTEQQKIMQHLEGEGLKnVIFTNCVKDENVKQIIPMVTE----LIGRShryhrkenleyci 146
Cdd:COG1162  111 EAAGIEP-VIVLNKADLADDEELEELLAIYEALGYP-VLAVSAKTGEGLDELRELLKGktsvLVGQS------------- 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134034174 147 mviGVpnvGKSSLINSLR----------RQHLRKGKATrvggepgiTRAVMskiqvserplMFLL-------DTPGV 206
Cdd:COG1162  176 ---GV---GKSTLINALLpdadlatgeiSEKLGRGRHT--------TTHAE----------LYPLpgggwliDTPGF 228
PRK00098 PRK00098
GTPase RsgA; Reviewed
 71-206 2.91e-07

GTPase RsgA; Reviewed


Pssm-ID: 234631 [Multi-domain]  Cd Length: 298  Bit Score: 51.36  E-value: 2.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  71 ETLGLKPhLLVLNKMDL-ADLTEQQKIMQHLEGEGLKnVIFTNCVKDENVKQIIPM----VTELIGRShryhrkenleyc 145
Cdd:PRK00098 108 EANGIKP-IIVLNKIDLlDDLEEARELLALYRAIGYD-VLELSAKEGEGLDELKPLlagkVTVLAGQS------------ 173

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134034174 146 imviGvpnVGKSSLINSLR----------RQHLRKGKATrvggepgiTRAVmSKIQVSERPlmFLLDTPGV 206
Cdd:PRK00098 174 ----G---VGKSTLLNALApdlelktgeiSEALGRGKHT--------TTHV-ELYDLPGGG--LLIDTPGF 226
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 146-215 7.01e-06

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 45.89  E-value: 7.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134034174 146 IMVIGVPNVGKSSLINSLRRQhlrkgkaTR--VGGEPGITR-AVMSKIQVSERPLMfLLDTPGV--LAPRIESVE 215
Cdd:cd01895    5 IAIIGRPNVGKSSLLNALLGE-------ERviVSDIAGTTRdSIDVPFEYDGQKYT-LIDTAGIrkKGKVTEGIE 71
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 148-207 1.58e-05

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 44.54  E-value: 1.58e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134034174 148 VIGVPNVGKSSLINSLRRQHLRKgkatrVGGEPGITRAVMSK--IQVSERPLMFlLDTPGVL 207
Cdd:cd00880    2 IFGRPNVGKSSLLNALLGQNVGI-----VSPIPGTTRDPVRKewELLPLGPVVL-IDTPGLD 57
PRK12289 PRK12289
small ribosomal subunit biogenesis GTPase RsgA;
71-205 2.11e-05

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237040 [Multi-domain]  Cd Length: 352  Bit Score: 45.78  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  71 ETLGLkPHLLVLNKMDLADLTEQQKIMQHLEGEGLKnVIFTNCVKDENVKQIIPmvtELIGRshryhrkenleycIMVIG 150
Cdd:PRK12289 117 ESTGL-EIVLCLNKADLVSPTEQQQWQDRLQQWGYQ-PLFISVETGIGLEALLE---QLRNK-------------ITVVA 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134034174 151 VPN-VGKSSLINSLRRQ----------HLRKGKATrvggepgiTRAVmskiQVSERPLMFLL-DTPG 205
Cdd:PRK12289 179 GPSgVGKSSLINRLIPDvelrvgkvsgKLGRGRHT--------TRHV----ELFELPNGGLLaDTPG 233
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 146-223 2.32e-05

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 43.90  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  146 IMVIGVPNVGKSSLINSLRRQHLRKGKATrvggePGITR-AVMSKIQVSERPLMF-LLDTPG---VLAPRIESVETGLKL 220
Cdd:TIGR00231   4 IVIVGHPNVGKSTLLNSLLGNKGSITEYY-----PGTTRnYVTTVIEEDGKTYKFnLLDTAGqedYDAIRRLYYPQVERS 78


                  ...
gi 134034174  221 ALC 223
Cdd:TIGR00231  79 LRV 81
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
148-206 2.88e-05

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 45.40  E-value: 2.88e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134034174 148 VIGVPNVGKSSLINSLrrqhLRKgkaTR--VGGEPGITR-AVMSKIQVSERPLMfLLDTPGV 206
Cdd:COG1160  180 IVGRPNVGKSSLINAL----LGE---ERviVSDIAGTTRdSIDTPFERDGKKYT-LIDTAGI 233
obgE PRK12299
GTPase CgtA; Reviewed
 60-138 7.21e-05

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 43.91  E-value: 7.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  60 IPLSGRNP------------LFQETLGLKPHLLVLNKMDLADL-TEQQKIMQHLEGEGLKNVIFTNCVKDENVKQIIPMV 126
Cdd:PRK12299 244 VDIEAVDPvedyktirneleKYSPELADKPRILVLNKIDLLDEeEEREKRAALELAALGGPVFLISAVTGEGLDELLRAL 323

                         90
                 ....*....|..
gi 134034174 127 TELIGRSHRYHR 138
Cdd:PRK12299 324 WELLEEARREEE 335
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
 143-205 7.24e-05

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 42.50  E-value: 7.24e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134034174 143 EYCIMviGVPNVGKSSLINSLrrqhLRKGKATRVGGEPGITRavmsKI---QVSERplMFLLDTPG 205
Cdd:cd01876    1 EVAFA--GRSNVGKSSLINAL----TNRKKLARTSKTPGRTQ----LInffNVGDK--FRLVDLPG 54
YeeP COG3596
Predicted GTPase [General function prediction only];
146-206 9.95e-05

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 43.60  E-value: 9.95e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134034174 146 IMVIGVPNVGKSSLINSLRRQhlrkgKATRVG-GEP---GITRAVmskIQVSERPLMFLLDTPGV 206
Cdd:COG3596   42 IALVGKTGAGKSSLINALFGA-----EVAEVGvGRPctrEIQRYR---LESDGLPGLVLLDTPGL 98
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 148-206 1.09e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 43.50  E-value: 1.09e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134034174 148 VIGVPNVGKSSLINSLrrqhLRKgkaTR--VGGEPGITR-AVMSKIQVSERPLMfLLDTPGV 206
Cdd:PRK00093 178 IIGRPNVGKSSLINAL----LGE---ERviVSDIAGTTRdSIDTPFERDGQKYT-LIDTAGI 231
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 148-205 1.44e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 41.67  E-value: 1.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134034174 148 VIGVPNVGKSSLINSLRRQHLrkgkaTRVGGEPGITRAVMSK---IQVSERPLMFlLDTPG 205
Cdd:cd00882    2 VVGRGGVGKSSLLNALLGGEV-----GEVSDVPGTTRDPDVYvkeLDKGKVKLVL-VDTPG 56
GTP_EFTU pfam00009
Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in ...
 32-130 3.85e-04

Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.


Pssm-ID: 425418 [Multi-domain]  Cd Length: 187  Bit Score: 40.59  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174   32 PGHmAKGLKKMQSSLKLVDCIIEVHDARiplSGRNP-----LFQ-ETLGLkPHLLVLNKMDLADLTE--------QQKIM 97
Cdd:pfam00009  77 PGH-VDFVKEVIRGLAQADGAILVVDAV---EGVMPqtrehLRLaRQLGV-PIIVFINKMDRVDGAEleevveevSRELL 151

                          90       100       110
                  ....*....|....*....|....*....|....
gi 134034174   98 QHLEGEGLK-NVIFTNCVKDENVKQIIPMVTELI 130
Cdd:pfam00009 152 EKYGEDGEFvPVVPGSALKGEGVQTLLDALDEYL 185
Obg cd01898
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ...
 68-130 4.00e-04

Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.


Pssm-ID: 206685 [Multi-domain]  Cd Length: 170  Bit Score: 40.49  E-value: 4.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 134034174  68 LFQETLGLKPHLLVLNKMDLADLTE-QQKIMQHLEGEGLKNVIFTNCVKDENVKQIIPMVTELI 130
Cdd:cd01898  107 AYNPGLAEKPRIVVLNKIDLLDAEErFEKLKELLKELKGKKVFPISALTGEGLDELLKKLAKLL 170
CDC3 COG5019
Septin family protein [Cell cycle control, cell division, chromosome partitioning, ...
 133-206 4.35e-04

Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 227352 [Multi-domain]  Cd Length: 373  Bit Score: 41.54  E-value: 4.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 133 SHRYHR--KENLEYCIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGEPGITRAVMSKIQ---VSERPLMF---LLDTP 204
Cdd:COG5019   11 NQRHRKlsKKGIDFTIMVVGESGLGKTTFINTLFGTSLVDETEIDDIRAEGTSPTLEIKITkaeLEEDGFHLnltVIDTP 90


                 ..
gi 134034174 205 GV 206
Cdd:COG5019   91 GF 92
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 149-206 4.41e-04

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 40.11  E-value: 4.41e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 134034174 149 IGVPNVGKSSLINSLRRQHlrkgKATrVGGEPGITRAVM-SKIQVSERPLMfLLDTPGV 206
Cdd:cd01894    3 VGRPNVGKSTLFNRLTGRR----DAI-VSDTPGVTRDRKyGEAEWGGREFI-LIDTGGI 55
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
 146-210 5.61e-04

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 40.14  E-value: 5.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134034174 146 IMVIGVPNVGKSSLINSLRRQHL----RKGKATRVggepgITRAVMSK--IQVserplmFLLDTPGVLAPR 210
Cdd:cd04163    6 VAIIGRPNVGKSTLLNALVGQKIsivsPKPQTTRN-----RIRGIYTDddAQI------IFVDTPGIHKPK 65
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
146-205 6.33e-04

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 39.96  E-value: 6.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134034174 146 IMVIGVPNVGKSSLINSLRRQH--LRKGKATRvggepGITRAVmSKIQVSERPLMFLL-DTPG 205
Cdd:COG1100    6 IVVVGTGGVGKTSLVNRLVGDIfsLEKYLSTN-----GVTIDK-KELKLDGLDVDLVIwDTPG 62
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 48-129 9.37e-04

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 39.47  E-value: 9.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  48 LVDCIIEVHDARI----PLSGRNPLFQETLGL--KPHLLVLNKMDLADLTEQQKIMQHLEGEGLKnVIFTNCVKDENVKQ 121
Cdd:cd01897   79 LRAAVLFFIDPSEtcgySIEEQLSLFKEIKPLfnKPVIVVLNKIDLLTEEDLSEIEKELEKEGEE-VIKISTLTEEGVDE 157


                 ....*...
gi 134034174 122 IIPMVTEL 129
Cdd:cd01897  158 LKNKACEL 165
TIGR00157 TIGR00157
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ...
 49-215 1.57e-03

ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors]


Pssm-ID: 272934 [Multi-domain]  Cd Length: 245  Bit Score: 39.32  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174   49 VDCIIEVHDARIPLSGRNPLFQ-----ETLGLKPhLLVLNKMDLADLTEqqkiMQHLEGEGLKN----VIFTNCVKDENV 119
Cdd:TIGR00157  37 IDQIVIVSSAVLPELSLNQLDRflvvaEAQNIEP-IIVLNKIDLLDDED----MEKEQLDIYRNigyqVLMTSSKNQDGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  120 KQIIPMVTELIGrshryhrkenleyciMVIGVPNVGKSSLINSLRRQ----------HLRKGKATrvggepgITRAVMSK 189
Cdd:TIGR00157 112 KELIEALQNRIS---------------VFAGQSGVGKSSLINALDPSvkqqvndissKLGLGKHT-------TTHVELFH 169

                         170       180
                  ....*....|....*....|....*.
gi 134034174  190 IQVSerplmFLLDTPGVLAPRIESVE 215
Cdd:TIGR00157 170 FHGG-----LIADTPGFNEFGLWHLE 190
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
 44-123 1.75e-03

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 38.60  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  44 SSLKLVDCIIEVHDARIPLSGRNPLFQETLG--LKPHLLVLNKMDLadLTEQQKIMQHLE----GEGLKNVIFTNCVKDE 117
Cdd:cd04163   78 SALKDVDLVLFVVDASEWIGEGDEFILELLKksKTPVILVLNKIDL--VKDKEDLLPLLEklkeLHPFAEIFPISALKGE 155


                 ....*.
gi 134034174 118 NVKQII 123
Cdd:cd04163  156 NVDELL 161
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 143-184 1.96e-03

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 38.61  E-value: 1.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 134034174  143 EYCImvIGVPNVGKSSLINSLRRqhlRKGKAtRVGGEPGITR 184
Cdd:TIGR03598  20 EIAF--AGRSNVGKSSLINALTN---RKKLA-RTSKTPGRTQ 55
EngB COG0218
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ...
 153-184 1.98e-03

GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 439988 [Multi-domain]  Cd Length: 194  Bit Score: 38.90  E-value: 1.98e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 134034174 153 NVGKSSLINSLRRqhlRKGKAtRVGGEPGITR 184
Cdd:COG0218   33 NVGKSSLINALTN---RKKLA-RTSKTPGKTQ 60
era TIGR00436
GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other ...
 146-210 2.05e-03

GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other bacteria. It plays a role in ribosome biogenesis. Few bacteria lack this protein. [Protein synthesis, Other]


Pssm-ID: 129528 [Multi-domain]  Cd Length: 270  Bit Score: 39.29  E-value: 2.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134034174  146 IMVIGVPNVGKSSLINSLRRQhlrkgKATRVGGEPGITRAVMSKIQVSERPLMFLLDTPGVLAPR 210
Cdd:TIGR00436   3 VAILGRPNVGKSTLLNQLHGQ-----KISITSPKAQTTRNRISGIHTTGASQIIFIDTPGFHEKK 62
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 117-163 2.53e-03

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 39.27  E-value: 2.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 134034174 117 ENVKQIIPMVTELIGRSHRYHR-KENLEycIMVIGVPNVGKSSLINSL 163
Cdd:COG0486  188 ERLEELREELEALLASARQGELlREGIK--VVIVGRPNVGKSSLLNAL 233
PRK12288 PRK12288
small ribosomal subunit biogenesis GTPase RsgA;
71-163 2.87e-03

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237039 [Multi-domain]  Cd Length: 347  Bit Score: 39.07  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  71 ETLGLKPhLLVLNKMDL------ADLTEQQKIMQHLegeGLKnVIFTNCVKDENVKQIIPMVTELIGrshryhrkenley 144
Cdd:PRK12288 147 ETLGIEP-LIVLNKIDLlddegrAFVNEQLDIYRNI---GYR-VLMVSSHTGEGLEELEAALTGRIS------------- 208

                         90
                 ....*....|....*....
gi 134034174 145 cIMViGVPNVGKSSLINSL 163
Cdd:PRK12288 209 -IFV-GQSGVGKSSLINAL 225
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
31-123 2.88e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 38.04  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174  31 FPGHM--AKGLKKMQSSLKLVDCIIEVHDARIPLSgRNPLFQ-----ETLGLK-PHLLVLNKMDLA---DLTEQQKIMQH 99
Cdd:COG1100   60 TPGQDefRETRQFYARQLTGASLYLFVVDGTREET-LQSLYElleslRRLGKKsPIILVLNKIDLYdeeEIEDEERLKEA 138

                         90       100
                 ....*....|....*....|....
gi 134034174 100 LEGEGLKNVIFTNCVKDENVKQII 123
Cdd:COG1100  139 LSEDNIVEVVATSAKTGEGVEELF 162
PRK04213 PRK04213
GTP-binding protein EngB;
146-205 3.10e-03

GTP-binding protein EngB;


Pssm-ID: 179790 [Multi-domain]  Cd Length: 201  Bit Score: 38.36  E-value: 3.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 146 IMVIGVPNVGKSSLINSLrrqhlrKGKATRVGGEPGITRAVmSKIQVSErplMFLLDTPG 205
Cdd:PRK04213  12 IVFVGRSNVGKSTLVREL------TGKKVRVGKRPGVTRKP-NHYDWGD---FILTDLPG 61
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 148-206 3.81e-03

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 37.44  E-value: 3.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134034174 148 VIGVPNVGKSSLINSLrrqhlrKGKATRVGGEPGIT--RAVmSKIQVSERPLMfLLDTPGV 206
Cdd:cd01879    2 LVGNPNVGKTTLFNAL------TGARQKVGNWPGVTveKKE-GEFKLGGKEIE-IVDLPGT 54
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
148-206 3.86e-03

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 38.85  E-value: 3.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 134034174 148 VIGVPNVGKSSLINSLrrqhLRKGKATrVGGEPGITR-AVMSKIQVSERPLMfLLDTPGV 206
Cdd:COG1160    7 IVGRPNVGKSTLFNRL----TGRRDAI-VDDTPGVTRdRIYGEAEWGGREFT-LIDTGGI 60
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 149-205 8.51e-03

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 37.72  E-value: 8.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 134034174 149 IGVPNVGKSSLINSLrrqhLRKGKATrVGGEPGITR-AVMSKIQVSERPLMfLLDTPG 205
Cdd:PRK00093   7 VGRPNVGKSTLFNRL----TGKRDAI-VADTPGVTRdRIYGEAEWLGREFI-LIDTGG 58
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 149-184 9.17e-03

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 36.32  E-value: 9.17e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 134034174 149 IGVPNVGKSSLINSLrrqhLRKGKATrVGGEPGITR 184
Cdd:cd04164    9 AGKPNVGKSSLLNAL----AGRDRAI-VSDIAGTTR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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