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Conserved domains on  [gi|37999785|sp|Q9HAT8|]
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RecName: Full=E3 ubiquitin-protein ligase pellino homolog 2; Short=Pellino-2; AltName: Full=RING-type E3 ubiquitin transferase pellino homolog 2

Protein Classification

E3 ubiquitin-protein ligase pellino family protein( domain architecture ID 10520238)

E3 ubiquitin-protein ligase pellino family protein which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins, and is involved in the TLR and IL-1 signaling pathways; similar to human E3 ubiquitin-protein ligase pellino homolog 1 (pellino-1)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 12-420 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


:

Pssm-ID: 461403  Cd Length: 409  Bit Score: 873.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785    12 PNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVV 91
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785    92 EYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEK 171
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKTGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   172 AAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGA 251
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   252 TLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINR-KEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEA 330
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRgRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   331 NeRECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNC 410
Cdd:pfam04710 321 R-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 37999785   411 IKLIFQGPID 420
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 12-420 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 873.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785    12 PNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVV 91
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785    92 EYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEK 171
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKTGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   172 AAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGA 251
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   252 TLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINR-KEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEA 330
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRgRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   331 NeRECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNC 410
Cdd:pfam04710 321 R-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 37999785   411 IKLIFQGPID 420
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 12-420 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 873.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785    12 PNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVV 91
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785    92 EYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEK 171
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKTGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   172 AAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGA 251
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   252 TLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINR-KEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEA 330
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRgRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37999785   331 NeRECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNC 410
Cdd:pfam04710 321 R-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 37999785   411 IKLIFQGPID 420
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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