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Conserved domains on  [gi|44887815|sp|Q9JM58|]
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RecName: Full=Cytokine receptor-like factor 1; AltName: Full=Cytokine receptor-like molecule 3; Short=CRLM-3; AltName: Full=Cytokine-like factor 1; Short=CLF-1; AltName: Full=Novel cytokine receptor 6; Short=NR6; Flags: Precursor

Protein Classification

Lep_receptor_Ig and FN3 domain-containing protein( domain architecture ID 10272913)

Lep_receptor_Ig and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 136-231 4.43e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 79.00  E-value: 4.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   136 LPPEKPFNISCWSRNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLALF 207
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 44887815   208 TPYEIWVEATNRLGSARSDVLTLD 231
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 239-341 1.01e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 1.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 239 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 317
Cdd:cd00063   2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                        90       100
                ....*....|....*....|....
gi 44887815 318 pfgiygsKKAGIWSEWSHPTAAST 341
Cdd:cd00063  77 -------VNGGGESPPSESVTVTT 93
Lep_receptor_Ig super family cl05692
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 44-132 7.71e-03

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


The actual alignment was detected with superfamily member pfam06328:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 35.30  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815    44 AVISPQDPTLLIGSSLQATCSIHGDTP---GATAEGLYWTLNGRRLPSELSRLLNTSTLALALANLNGSRQQsgdnLVCh 120
Cdd:pfam06328   4 GHISPSPPVVRLGSNVTASCILKENCCshlGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRAL----LTC- 78

                          90
                  ....*....|..
gi 44887815   121 ardgSILAGSCL 132
Cdd:pfam06328  79 ----CLLWGGQL 86
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 136-231 4.43e-18

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 79.00  E-value: 4.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   136 LPPEKPFNISCWSRNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLALF 207
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 44887815   208 TPYEIWVEATNRLGSARSDVLTLD 231
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 239-341 1.01e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 1.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 239 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 317
Cdd:cd00063   2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                        90       100
                ....*....|....*....|....
gi 44887815 318 pfgiygsKKAGIWSEWSHPTAAST 341
Cdd:cd00063  77 -------VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 239-321 3.76e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 3.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815    239 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-N 317
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAvN 78


                   ....
gi 44887815    318 PFGI 321
Cdd:smart00060  79 GAGE 82
fn3 pfam00041
Fibronectin type III domain;
239-334 1.17e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   239 DPPPDVHVSRVGglEDQLSVRWVSPPALK-DFLfqaKYQIRYRVEDSVD-WKVVDDVSNQTSCRLAGLKPGTVYFVQVRc 316
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNgPIT---GYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQ- 74

                          90
                  ....*....|....*...
gi 44887815   317 npfgiygSKKAGIWSEWS 334
Cdd:pfam00041  75 -------AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
202-364 1.11e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.77  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 202 KDLALFTPYEIWVEATNRLG--SARSDVLTLdVLDVVTTDPPPDVHVSRVGGleDQLSVRWvSPPALKDFlfqAKYQIRY 279
Cdd:COG3401 290 TGLTNGTTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGS--SSITLSW-TASSDADV---TGYNVYR 362

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 280 RVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-NpfgiygskKAGIWSEWSHP------TAASTPRSERPGPGGG 352
Cdd:COG3401 363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvD--------AAGNESAPSEEvsattaSAASGESLTASVDAVP 434

                       170
                ....*....|..
gi 44887815 353 VCEPRGGEPSSG 364
Cdd:COG3401 435 LTDVAGATAAAS 446
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 138-222 1.88e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815    138 PEKPFNISCWSRNMKDLTCRWTPGAHGEtflHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEAT 217
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG---ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 44887815    218 NRLGS 222
Cdd:smart00060  78 NGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 138-229 5.76e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 5.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 138 PEKPFNISCWSRNMKDLTCRWTPGAHGETFLhTNYSLKYKLRWYGQDNTCEEyHTVGPHSCHIpKDLALFTPYEIWVEAT 217
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEV-TPGSETSYTL-TGLKPGTEYEFRVRAV 77

                        90
                ....*....|...
gi 44887815 218 NRLG-SARSDVLT 229
Cdd:cd00063  78 NGGGeSPPSESVT 90
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 44-132 7.71e-03

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 35.30  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815    44 AVISPQDPTLLIGSSLQATCSIHGDTP---GATAEGLYWTLNGRRLPSELSRLLNTSTLALALANLNGSRQQsgdnLVCh 120
Cdd:pfam06328   4 GHISPSPPVVRLGSNVTASCILKENCCshlGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRAL----LTC- 78

                          90
                  ....*....|..
gi 44887815   121 ardgSILAGSCL 132
Cdd:pfam06328  79 ----CLLWGGQL 86
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 136-231 4.43e-18

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 79.00  E-value: 4.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   136 LPPEKPFNISCWSRNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLALF 207
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 44887815   208 TPYEIWVEATNRLGSARSDVLTLD 231
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 239-341 1.01e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 1.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 239 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 317
Cdd:cd00063   2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                        90       100
                ....*....|....*....|....
gi 44887815 318 pfgiygsKKAGIWSEWSHPTAAST 341
Cdd:cd00063  77 -------VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 239-321 3.76e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 3.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815    239 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-N 317
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAvN 78


                   ....
gi 44887815    318 PFGI 321
Cdd:smart00060  79 GAGE 82
fn3 pfam00041
Fibronectin type III domain;
239-334 1.17e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   239 DPPPDVHVSRVGglEDQLSVRWVSPPALK-DFLfqaKYQIRYRVEDSVD-WKVVDDVSNQTSCRLAGLKPGTVYFVQVRc 316
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNgPIT---GYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQ- 74

                          90
                  ....*....|....*...
gi 44887815   317 npfgiygSKKAGIWSEWS 334
Cdd:pfam00041  75 -------AVNGGGEGPPS 85
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 241-335 1.23e-07

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 49.33  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   241 PPDVHVSrVGGLEDQLSVRWVSPPALKDflfqakYQIRYRVEDSVDWKVV-----------DDVSNQTSCRLAGLKPGTV 309
Cdd:pfam16656   1 PEQVHLS-LTGDSTSMTVSWVTPSAVTS------PVVQYGTSSSALTSTAtatsstyttgdGGTGYIHRATLTGLEPGTT 73

                          90       100
                  ....*....|....*....|....*.
gi 44887815   310 YFVQVRCnpfgiygskKAGIWSEWSH 335
Cdd:pfam16656  74 YYYRVGD---------DNGGWSEVYS 90
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
202-364 1.11e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.77  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 202 KDLALFTPYEIWVEATNRLG--SARSDVLTLdVLDVVTTDPPPDVHVSRVGGleDQLSVRWvSPPALKDFlfqAKYQIRY 279
Cdd:COG3401 290 TGLTNGTTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGS--SSITLSW-TASSDADV---TGYNVYR 362

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 280 RVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-NpfgiygskKAGIWSEWSHP------TAASTPRSERPGPGGG 352
Cdd:COG3401 363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvD--------AAGNESAPSEEvsattaSAASGESLTASVDAVP 434

                       170
                ....*....|..
gi 44887815 353 VCEPRGGEPSSG 364
Cdd:COG3401 435 LTDVAGATAAAS 446
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 143-225 1.51e-06

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 46.57  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   143 NISCWSR-NMKDLTCRWTPgahgeTFLHTNYSLKYKLRWYGQDNTCEEYHTVGP----------------HSCHIPKdLA 205
Cdd:pfam18589   3 NISCETNgDLDLMTCRWNT-----TKWSLLADSKVNLRYRRSELSCEDRSTSSLkggsmvkecdcqgpgfYECTIQP-LY 76

                          90       100
                  ....*....|....*....|
gi 44887815   206 LFTPYEIWVEATNRLGSARS 225
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQS 96
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 241-333 7.85e-06

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 44.26  E-value: 7.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815   241 PPDVHVSRVGgleDQLSVRwVSPPA--------LKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFV 312
Cdd:pfam09294   5 PPEVELEVEG---GSLNVT-VKDPEtregknlsLRDLYGSLQYRVSYW-KNSSNGEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|.
gi 44887815   313 QVRcnpFGIYGSKKAGIWSEW 333
Cdd:pfam09294  80 SVQ---AFSPLDNKSSQRSPP 97
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 138-222 1.88e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815    138 PEKPFNISCWSRNMKDLTCRWTPGAHGEtflHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEAT 217
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG---ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 44887815    218 NRLGS 222
Cdd:smart00060  78 NGAGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
210-323 7.66e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.85  E-value: 7.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 210 YEIWVEATNRLGSARSDVLTLDVLDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPAlkdfLFQAKYQIRYRVEDsvDW-- 287
Cdd:COG4733 599 YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLTATGGLGGITLSWSFPVD----ADTLRTEIRYSTTG--DWas 672

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 44887815 288 -KVVDDVSNQTSCRLAGLKPGTVYFVQVRC-NPFGIYG 323
Cdd:COG4733 673 aTVAQALYPGNTYTLAGLKAGQTYYYRARAvDRSGNVS 710
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
203-349 2.77e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.99  E-value: 2.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 203 DLALFTPYEIWVEATNRLG-SARSDVLTLDVldvVTTDPPPDVHVSRVGGLEDQLSVRWvSPPALKDFlfqAKYQIRYRV 281
Cdd:COG3401 198 DIEPGTTYYYRVAATDTGGeSAPSNEVSVTT---PTTPPSAPTGLTATADTPGSVTLSW-DPVTESDA---TGYRVYRSN 270

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 44887815 282 EDSVDWKVVDDVsNQTSCRLAGLKPGTVYFVQVRCnpfgiygSKKAGIWSEWShPTAASTPRSERPGP 349
Cdd:COG3401 271 SGDGPFTKVATV-TTTSYTDTGLTNGTTYYYRVTA-------VDAAGNESAPS-NVVSVTTDLTPPAA 329
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 138-229 5.76e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 5.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815 138 PEKPFNISCWSRNMKDLTCRWTPGAHGETFLhTNYSLKYKLRWYGQDNTCEEyHTVGPHSCHIpKDLALFTPYEIWVEAT 217
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEV-TPGSETSYTL-TGLKPGTEYEFRVRAV 77

                        90
                ....*....|...
gi 44887815 218 NRLG-SARSDVLT 229
Cdd:cd00063  78 NGGGeSPPSESVT 90
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 44-132 7.71e-03

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 35.30  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44887815    44 AVISPQDPTLLIGSSLQATCSIHGDTP---GATAEGLYWTLNGRRLPSELSRLLNTSTLALALANLNGSRQQsgdnLVCh 120
Cdd:pfam06328   4 GHISPSPPVVRLGSNVTASCILKENCCshlGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRAL----LTC- 78

                          90
                  ....*....|..
gi 44887815   121 ardgSILAGSCL 132
Cdd:pfam06328  79 ----CLLWGGQL 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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