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Conserved domains on  [gi|223590133|sp|Q9NQX0|]
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RecName: Full=Putative histone-lysine N-methyltransferase PRDM6; AltName: Full=PR domain zinc finger protein 6; AltName: Full=PR domain-containing protein 6

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 244-372 5.22e-88

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


:

Pssm-ID: 380968  Cd Length: 128  Bit Score: 268.58  E-value: 5.22e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKvQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19191    1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEK-QIGAVRNTQHLWEIYDQEGTLQHFIDGGDPSKSSWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFF 372
Cdd:cd19191   80 RYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
zf-H2C2_2 pfam13465
Zinc-finger double domain;
544-568 1.98e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.98e-05
                          10        20
                  ....*....|....*....|....*
gi 223590133  544 LNNHIRTHTGEKPFKCERCERSFTQ 568
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 527-594 8.29e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 8.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223590133 527 RPFkCGYCGRAFAGATTLNNHIRTHTgekpFKCERCERSFTQATQLSRH---------QRMPNeCKPITESPEsIEV 594
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHclqvhketlTKVPN-ALPGRDDPE-IEI 70
 
Name Accession Description Interval E-value
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 244-372 5.22e-88

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 268.58  E-value: 5.22e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKvQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19191    1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEK-QIGAVRNTQHLWEIYDQEGTLQHFIDGGDPSKSSWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFF 372
Cdd:cd19191   80 RYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 260-365 6.44e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 65.62  E-value: 6.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133  260 YGICAAQRIQQGTWIGPFQGVLL-----PPEKVQAGAVRNTQHLWEIY--DQDGTLQHFIDGGEPSKSSWMRYIR--CAR 330
Cdd:pfam00856   2 RGLFATEDIPKGEFIGEYVEVLLitkeeADKRELLYYDKLELRLWGPYlfTLDEDSEYCIDARALYYGNWARFINhsCDP 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 223590133  331 HCgEQNLTVVQYRSNIFYRACIDIPRGTELLVWYN 365
Cdd:pfam00856  82 NC-EVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 248-368 2.56e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 55.42  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133   248 VCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQ------AGAVRNTQHLWEIYDQdgtlqHFIDGGEpsKSS 321
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEerpkayDTDGAKAFYLFDIDSD-----LCIDARR--KGN 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 223590133   322 WMRYIRcarHCGEQNLTVVQYRSNIFYRACI----DIPRGTELLVWYNDSY 368
Cdd:smart00317  74 LARFIN---HSCEPNCELLFVEVNGDDRIVIfalrDIKPGEELTIDYGSDY 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
544-568 1.98e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.98e-05
                          10        20
                  ....*....|....*....|....*
gi 223590133  544 LNNHIRTHTGEKPFKCERCERSFTQ 568
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 527-594 8.29e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 8.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223590133 527 RPFkCGYCGRAFAGATTLNNHIRTHTgekpFKCERCERSFTQATQLSRH---------QRMPNeCKPITESPEsIEV 594
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHclqvhketlTKVPN-ALPGRDDPE-IEI 70
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 529-551 2.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.56e-03
                          10        20
                  ....*....|....*....|...
gi 223590133  529 FKCGYCGRAFAGATTLNNHIRTH 551
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 244-372 5.22e-88

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 268.58  E-value: 5.22e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKvQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19191    1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEK-QIGAVRNTQHLWEIYDQEGTLQHFIDGGDPSKSSWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFF 372
Cdd:cd19191   80 RYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 244-375 9.73e-45

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 154.82  E-value: 9.73e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAgAVRNTQhLWEIYDQDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19196    1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDP-CKNNNL-MWEVFNEDGTVSHFIDASQENHRSWM 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIP 375
Cdd:cd19196   79 TFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 243-376 5.39e-37

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 134.06  E-value: 5.39e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 243 DLPREVCLC-TSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGavRNTQHLWEIYdQDGTLQHFIDGgEPSKSS 321
Cdd:cd19198    2 DLPEGLRVLqTSFGGTPHYGVFCKKTIPKGTRFGPFRGRVVNTSEIKTY--DDNSFMWEIF-EDGKLSHFIDG-RGSTGN 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 223590133 322 WMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPL 376
Cdd:cd19198   78 WMSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFMGIPV 132
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 244-374 7.53e-35

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 128.12  E-value: 7.53e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGvllppEKVQAGAVRNTQHLWEIYDqDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19193    4 LPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEG-----EIVEDEEAADSGYSWQIYK-GGKLSHYIDAKDESKSNWM 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGI 374
Cdd:cd19193   78 RYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELGI 128
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 244-365 9.92e-30

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 111.91  E-value: 9.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLlppekvqagavrntqhlweiydqdgtlqhfidggepsksSWM 323
Cdd:cd10534    1 LPAGLELVLSSIPEGGLGVFARRTIPAGTRFGPLEGVV---------------------------------------NWM 41

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYN 365
Cdd:cd10534   42 RFVRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 244-375 2.80e-24

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 98.59  E-value: 2.80e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPpekvqagAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19200   10 IPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVGVQRS-------SVKDPTYAWEIVDEFGKVKFWIDASEPGTGNWM 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIP 375
Cdd:cd19200   83 KYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMKAAVYPHETMP 134
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 244-364 3.55e-23

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 95.09  E-value: 3.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAvrNTQHLWEIYDqDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19187    3 LPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGA--NRKYFWRIYS-NGEFYHYIDGFDPSKSNWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWY 364
Cdd:cd19187   80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWY 120
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 241-365 9.38e-22

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 90.96  E-value: 9.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 241 LRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGvllppEKVQAGAVRNTQHLWEIYDqdGTLQHF-IDGGEPSK 319
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVG-----EKKKRSQVKNNVYMWEIYG--PKRGWMcVDASDPTK 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223590133 320 SSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYN 365
Cdd:cd19188   74 GNWLRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYN 119
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 244-363 2.71e-19

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 84.99  E-value: 2.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPpekvqagAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19214   30 IPSEFELRESNIPGTGLGIWTKRKIEVGEKFGPYVGEQRS-------NLKDPSYGWEVLDEFGNVKFCIDASQPDVGSWL 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVW 363
Cdd:cd19214  103 KYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLF 142
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 236-366 1.01e-17

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 80.69  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 236 ELPEWLRD---LPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVllppekvQAGAVRNTQHLWEIYDQD------- 305
Cdd:cd19213    9 EAPVYIPDdipIPSDFELRESSIPGAGLGVWAKRKIEAGERFGPYTGV-------QRSTLKDTNFGWEQILNDvevssqe 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223590133 306 ----------GTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYND 366
Cdd:cd19213   82 gcitkivddlGNEKFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVYVKD 152
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 237-367 1.13e-17

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 79.31  E-value: 1.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 237 LPEWLRDLPRevclctSTVPGLAYGICAAQRIQQGTWIGPFQGVL----LPPEKVqagavrntqhlWEIYDQDGTLQHFI 312
Cdd:cd19201    3 LPGELELRKP------SQDAGRSGGVWAKQPLPEGTRFGPYPGKLvkepLDPSYE-----------WKVEAQGSKGGEGL 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 223590133 313 DGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDS 367
Cdd:cd19201   66 LLLTEDSGTWLKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREP 120
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 263-368 2.15e-16

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 75.66  E-value: 2.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 263 CAAQRIQQGTWIGPFQGVLLPPEKvQAGAVRntqhlWEIYDQDGTLQhFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQY 342
Cdd:cd19195   23 CVDEVIPKGHIFGPYEGQICTQDK-SSGFFS-----WLIVDKNNRYK-SIDGSDETKANWMRYVVISREEREQNLLAFQH 95

                         90       100
                 ....*....|....*....|....*.
gi 223590133 343 RSNIFYRACIDIPRGTELLVWYNDSY 368
Cdd:cd19195   96 SEQIYFRACRDIRPGEKLRVWYSEDY 121
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 244-373 1.84e-15

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 73.27  E-value: 1.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 244 LPREVCLcTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYdQDGTLQHFIDGGEPSKSSWM 323
Cdd:cd19189    6 LPRQLYL-RQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIY-HNDVLEFCIITTDENECNWM 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 223590133 324 RYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFG 373
Cdd:cd19189   84 MFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 261-367 1.11e-14

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 70.78  E-value: 1.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 261 GICAAQRIQQGTWIGPFQGVLLPPEKVQAGAvrNTQHLWEIYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVV 340
Cdd:cd19190   21 GLYTARRVKKGEKFGPFAGEKRMPNELDESM--DPRLMWEVRGSKGEVLYILDASNPRHSNWLRFVHEAPSQEQKNLAAI 98

                         90       100
                 ....*....|....*....|....*..
gi 223590133 341 QYRSNIFYRACIDIPRGTELLVWYNDS 367
Cdd:cd19190   99 QEGENIFYLAVDDIETDTELLIGYLDS 125
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 306-372 2.00e-13

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 66.38  E-value: 2.00e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223590133 306 GTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSN--IFYRACIDIPRGTELLVWYNDSYTSFF 372
Cdd:cd19197   35 VRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIADLPGgqIFYRALRDIQPGEELTVWYSNSLAQWF 103
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 259-368 5.82e-13

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 65.90  E-value: 5.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 259 AYGICAAQRIQQGTWIGPF--QGVLLPPEKVQAGAvrntqhlwEIYDQDGTLQHFiDGGEPSKSSWMRYIRCARHCGEQN 336
Cdd:cd19199   20 SEGVFALVPLVKRTQFGPFeaKRVARLDGFAVFPL--------KVFEKDGSVVYL-DTSNEDDCNWMMFVRPATDVEHQN 90

                         90       100       110
                 ....*....|....*....|....*....|..
gi 223590133 337 LTVVQYRSNIFYRACIDIPRGTELLVWYNDSY 368
Cdd:cd19199   91 LTAYQQGEDIYFTTSRDIQPGAELRVWYAAFY 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 260-365 6.44e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 65.62  E-value: 6.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133  260 YGICAAQRIQQGTWIGPFQGVLL-----PPEKVQAGAVRNTQHLWEIY--DQDGTLQHFIDGGEPSKSSWMRYIR--CAR 330
Cdd:pfam00856   2 RGLFATEDIPKGEFIGEYVEVLLitkeeADKRELLYYDKLELRLWGPYlfTLDEDSEYCIDARALYYGNWARFINhsCDP 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 223590133  331 HCgEQNLTVVQYRSNIFYRACIDIPRGTELLVWYN 365
Cdd:pfam00856  82 NC-EVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 261-373 5.76e-12

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 63.14  E-value: 5.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 261 GICAAQRIQQGTWIGPFQGVLLPpekvQAGAVRNTQH-LWEIYDQDGTLqhFIDGGEPSKSSWMRYIRCARHCGEQNLTV 339
Cdd:cd19194   21 GVFAKRRIPKRTQFGPLEGPLVK----KSELKDNKIHpLELEEDDGEDL--YFDLSDENKCNWMMFVRPAQNHLEQNLVA 94

                         90       100       110
                 ....*....|....*....|....*....|....
gi 223590133 340 VQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFG 373
Cdd:cd19194   95 YQYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 252-368 9.22e-10

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 56.58  E-value: 9.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 252 TSTVPGLA---YGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQDGTLqhFIDGGEpsKSSWMRYIRc 328
Cdd:cd10522    4 ISMIPNLShngLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDPLYPFDLNGDIL--VIDAGK--KGNLTRFIN- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 223590133 329 arHCGEQNLTVVQYRSN----IFYRACIDIPRGTELLVWYNDSY 368
Cdd:cd10522   79 --HSDQPNLELIVRTLKgeqhIGFVAIRDIKPGEELFISYGPKY 120
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 241-367 1.87e-09

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 55.89  E-value: 1.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 241 LRDLPREVCLCTSTVPGLAYGI-CAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTqhlweiydqdgTLQHFIDGGEPSK 319
Cdd:cd10520    2 LRSLPPGLALGPSLAQEERLGVwCVGDALQKGTFLGPLEEELESHDLTEGGSPRQE-----------ESGQSGDVLACEQ 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223590133 320 SS-WMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDS 367
Cdd:cd10520   71 SSkWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEEN 119
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 248-368 2.56e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 55.42  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133   248 VCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQ------AGAVRNTQHLWEIYDQdgtlqHFIDGGEpsKSS 321
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEerpkayDTDGAKAFYLFDIDSD-----LCIDARR--KGN 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 223590133   322 WMRYIRcarHCGEQNLTVVQYRSNIFYRACI----DIPRGTELLVWYNDSY 368
Cdd:smart00317  74 LARFIN---HSCEPNCELLFVEVNGDDRIVIfalrDIKPGEELTIDYGSDY 121
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 313-370 2.84e-09

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 55.51  E-value: 2.84e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223590133 313 DGGEPSKSSWMRYIRCARHCGEQNLTVvqYRSN---IFYRACIDIPRGTELLVWYNDSYTS 370
Cdd:cd19192   71 CNGSSEPSDWLRLVQPARDRHEQNLEA--FRKNegqVYFRTLRRIRKGEELLVWYSDELAE 129
zf-H2C2_2 pfam13465
Zinc-finger double domain;
544-568 1.98e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.98e-05
                          10        20
                  ....*....|....*....|....*
gi 223590133  544 LNNHIRTHTGEKPFKCERCERSFTQ 568
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 260-381 2.53e-04

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 41.47  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590133 260 YGICAAQRIQQGTWIGPFQGVLLPP----EKVQAGAVRNTQHLWEIYDQDGTlqhFIDGGEpsKSSWMRYIRcarHCGEQ 335
Cdd:cd10531   12 WGVKAKEDIQKGEFIIEYVGEVIDKkefkERLDEYEELGKSNFYILSLSDDV---VIDATR--KGNLSRFIN---HSCEP 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 223590133 336 NLTVVQYRSNIFYR----ACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQ 381
Cdd:cd10531   84 NCETQKWIVNGEYRigifALRDIPAGEELTFDYNFVNYNEAKQVCLCGAQ 133
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 527-594 8.29e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 8.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223590133 527 RPFkCGYCGRAFAGATTLNNHIRTHTgekpFKCERCERSFTQATQLSRH---------QRMPNeCKPITESPEsIEV 594
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHclqvhketlTKVPN-ALPGRDDPE-IEI 70
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 529-551 2.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.56e-03
                          10        20
                  ....*....|....*....|...
gi 223590133  529 FKCGYCGRAFAGATTLNNHIRTH 551
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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