NCBI Conserved Domain Search

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 210.49 E-value: 1.99e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYP 352
Cdd:cd20115   1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDLRPEEAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPPPGYP 80

                        90
                ....*....|....
gi 67461585 353 SQDFDWADYLKQCG 366
Cdd:cd20115  81 GQDFDWADYLKQCG 94

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 208.14 E-value: 1.63e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20111   1 QNGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRDK 80

                        90
                ....*....|....
gi 67461585 127 VSDWDEFLRQTLIG 140
Cdd:cd20111  81 LSDWEEFLAQTLTG 94

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 200.04 E-value: 1.44e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 159 LDLIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHL 238
Cdd:cd20113   1 LDLIGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEGSDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIRHL 80

                        90
                ....*....|....*....
gi 67461585 239 KNEAEWQEILAKVKEEEEE 257
Cdd:cd20113  81 KSEAEWQEILKKVKEEEEE 99

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 183.16 E-value: 1.72e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTPRRARVYKQ 461
Cdd:cd20117   1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIPECIVHVESMDIFPVGWCETNGYPLLHPRKARVNKQ 80

                        90
                ....*....|
gi 67461585 462 RKIAVVQPEK 471
Cdd:cd20117  81 RKIAVVQPEK 90

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.

Pssm-ID: 188980 Cd Length: 85 Bit Score: 176.10 E-value: 4.21e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 782 EVAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIKFAFY 861
Cdd:cd09581   1 EEEERLKLDSNPLFWSVDDVVRFIKSTDCAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFY 80


                ....*
gi 67461585 862 EQFAN 866
Cdd:cd09581  81 EQFAN 85

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 172.07 E-value: 1.45e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20093   1 QSGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYEDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKEK 80

                        90
                ....*....|....
gi 67461585 127 VSDWDEFLRQTLIG 140
Cdd:cd20093  81 ELDWAEFLIKELTG 94

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 165.93 E-value: 2.78e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20112   1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEK 80

                        90
                ....*....|....
gi 67461585 127 VSDWDEFLRQTLIG 140
Cdd:cd20112  81 YTDWTEFLIHDLTG 94

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 164.35 E-value: 7.70e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20095   1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLVEIDDLRPEESEKITFVCHANSPGIFPVGWCAKNGLRLTPPPGYPKS 80

                        90
                ....*....|..
gi 67461585 355 DFDWADYLKQCG 366
Cdd:cd20095  81 EFDWDSYLKLCG 92

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.

Pssm-ID: 463469 Cd Length: 112 Bit Score: 163.53 E-value: 2.91e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585   502 CPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKdsvwHGCGEVLKAKYKGK 581
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGN----GGREEIITAKYEGK 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 67461585   582 SYRATVEIVKTADRVTEFCRQTCIKLECCPNLFGPR 617
Cdd:pfam12140  77 THTVKLPIVNSASDVWRFLEKLCEKLGCCENLFSPQ 112

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 156.50 E-value: 6.54e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENhARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYP 352
Cdd:cd20116   1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDLRPEA-SENSMLCHADSLGILPVQWCLKNGVNLTPPKGYS 79

                        90
                ....*....|....
gi 67461585 353 SQDFDWADYLKQCG 366
Cdd:cd20116  80 GQDFDWADYQKQCG 93

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 154.98 E-value: 1.81e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTPRRARVYKQRK 463
Cdd:cd20118   2 FTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVPEYIVDVESMDIFPVGWCEANGYPLTPPHKAVCKKKRK 81


                ....*....
gi 67461585 464 IAVVQPEKQ 472
Cdd:cd20118  82 IAVVQPEKQ 90

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 135.45 E-value: 1.52e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585     23 EDYLEETGSTAVPYGSFKHVDTRLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKA 102
Cdd:smart00561   1 EDYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGW--DDKYDFWCHADSP 78

                           90
                   ....*....|....*...
gi 67461585    103 DLYPIGWCEQNKKTLEAP 120
Cdd:smart00561  79 DIFPVGWCEKNGHPLQPP 96

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 131.21 E-value: 2.19e-36

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTPRRA 456
Cdd:cd20096   1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSPNIIVDVESTDIFPVGWCESNGYPLVTPRKY 73

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 131.20 E-value: 3.60e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 160 DLIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHLK 239
Cdd:cd20094   2 DRIKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDSDSPDFWLFYLSPRLHPLGWAKSNGYTYRPPKSLEKLH 81

                        90
                ....*....|
gi 67461585 240 NEAEWQEILA 249
Cdd:cd20094  82 ATEEWKAILQ 91

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 126.60 E-value: 2.24e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585    360 DYLKQCGAEAAPQRCF--PPLISEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPiPECIVSVESMDI 437
Cdd:smart00561   2 DYLEETGARAAPVELFkqPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDK-YDFWCHADSPDI 80

                           90
                   ....*....|....*.
gi 67461585    438 FPLGWCETNGHPLSTP 453
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 115.42 E-value: 1.71e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585    252 KEEEEEPLPSYLFKDKQVIGIHTFSVNMKLEAVDPWSPFGISPATVVKVFDEkYFLVEMDDLRpenhARRSFVCHADSPG 331
Cdd:smart00561   5 EETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGY-RLLLHFDGWD----DKYDFWCHADSPD 79

                           90
                   ....*....|....*..
gi 67461585    332 IFPVQWSLKNGLHISPP 348
Cdd:smart00561  80 IFPVGWCEKNGHPLQPP 96

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a protein-protein interaction domain. The Polycomb group includes transcriptional repressors which are involved in the regulation of some key regulatory genes during development in many organisms. They are best known for silencing Hox (Homeobox) genes. Polycomb proteins work together in large multimeric and chromatin-associated complexes. They organize chromatin of the target genes and maintain repressed states during many cell divisions. Polycomb proteins are classified based on their common function, but not on conserved domains and/or motifs; however many Polycomb proteins (members of PRC1 class complex) contain SAM domains which are more similar to each other inside of the Polycomb group than to SAM domains outside of it. Most information about structure and function of Polycomb SAM domains comes from studies of Ph (Polyhomeotic) and Scm (Sex comb on midleg) proteins. Polycomb SAM domains usually can be found at the C-terminus of the proteins. Some members of this group contain, in addition to the SAM domain, MTB repeats, Zn finger, and/or DUF3588 domains. Polycomb SAM domains can form homo- and/or heterooligomers through ML and EH surfaces. SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Polycomb proteins are known to be highly expressed in some cells years before their cancer pathology; thus they are attractive markers for early cancer therapy.

Pssm-ID: 188908 Cd Length: 64 Bit Score: 113.34 E-value: 3.33e-30

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 793 PLKWSVADVVRFIRSTD-CAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIER 855
Cdd:cd09509   1 PSKWSVDDVAQFIKSLDgCAEYAEVFREQEIDGQALLLLTEDDLLKGMGLKLGPALKIYNHIVK 64

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 109.70 E-value: 1.60e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLrPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20099   1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLVIGIDGP-SADDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYESK 79

                        90
                ....*....|..
gi 67461585 355 DFDWADYLKQCG 366
Cdd:cd20099  80 PFDWEEYLEETG 91

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 106.35 E-value: 2.47e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 159 LDLIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLEsSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHL 238
Cdd:cd20114   1 VDLITVGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGLE-DESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICDL 79

                        90
                ....*....|....*.
gi 67461585 239 KNEAEWQEILAKVKEE 254
Cdd:cd20114  80 KSASEWKEALEKSLAE 95

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 103.10 E-value: 3.54e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585    131 DEFLRQTliGACSPPVPLLEglRNGRNPLDLIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLEssDNYEHWLY 210
Cdd:smart00561   1 EDYLEET--GARAAPVELFK--QPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWD--DKYDFWCH 74

                           90       100
                   ....*....|....*....|..
gi 67461585    211 YLDPFLHHVGWAAQQGYELQPP 232
Cdd:smart00561  75 ADSPDIFPVGWCEKNGHPLQPP 96

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 100.84 E-value: 2.95e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  52 PGMKLEVAVRTDPE------TYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRD 125
Cdd:cd20097   6 IGVKVEVANRDDDKptdnvkVYWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPPKSIED 85

                        90       100
                ....*....|....*....|
gi 67461585 126 KVSDWDEFLRQTLIGACSPP 145
Cdd:cd20097  86 KENDWKEYIMKRLHGKRTIP 105

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 98.35 E-value: 6.12e-25

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67461585   279 MKLEAVDPWSPFGISPATVVKVFDeKYFLVEMDDLRPENharrSFVCHADSPGIFPVQWSLKNGLHISPPP 349
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLG-GRLRLRFDGWDDSY----DFWCHADSPDIHPVGWCEKNGHPLQPPK 66

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 96.04 E-value: 4.81e-24

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585    54 MKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKADLYPIGWCEQNKKTLEAPE 121
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGW--DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 91.03 E-value: 2.34e-22

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67461585   388 MKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSkKPIPECIVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGW-DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 91.84 E-value: 4.31e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20125   1 FKEGMKLEAVDPLNLSAICVATVMKVLRFGYLMIRIDSYEPDASGSDWFCYHESSPCIFPAGFCEVNNITLTPPNGYDGR 80

                        90       100
                ....*....|....*....|.
gi 67461585 355 DFDWADYLKQCGAEAAPQRCF 375
Cdd:cd20125  81 TFTWEGYLRQTGATAAPQHLF 101

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 89.62 E-value: 7.37e-22

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgEDRRADFWCDIRKADLYPIGWCE 111
Cdd:cd20088   1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGW-DPSRYDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 91.59 E-value: 1.01e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  20 LSWEDYLEETGSTAVPYGSFKHVDTRLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGygEDRRADFWCDI 99
Cdd:cd20105   2 FSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDG--SDNKNDFWRLV 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 67461585 100 RKADLYPIGWCEQNKKTLEAPEGIRDKVSDWDEFLRQTLIGACSPPV 146
Cdd:cd20105  80 DSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPV 126

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 90.20 E-value: 1.36e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  53 GMKLEVAVR-----TDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKV 127
Cdd:cd20119   7 GMKVEVENTdtdliEDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPRTIEHKY 86

                        90
                ....*....|....*...
gi 67461585 128 SDWDEFLRQTLIGACSPP 145
Cdd:cd20119  87 SDWKEFLVKRLTGARTLP 104

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 89.13 E-value: 2.88e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  53 GMKLEVaVRTD----PETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKVS 128
Cdd:cd20121   7 GMKVEV-LNTDavlpSRVYWIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTIHAKFT 85

                        90
                ....*....|....*..
gi 67461585 129 DWDEFLRQTLIGACSPP 145
Cdd:cd20121  86 DWRGYLMKRLVGSRTIP 102

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex comb on midleg) subfamily of Polycomb group is a protein-protein interaction domain. Proteins of this subfamily are transcriptional repressors associated with PRC1 complex. This group includes invertebrate Scm protein and chordate Scm homolog 1 and Scm-like 1, 2, 3 proteins. Most have a SAM domain, two MBT repeats, and a DUF3588 domain, except Scm-like 4 proteins which do not have MBT repeats. Originally the Scm protein was described in Drosophila as a regulator required for proper spatial expression of homeotic genes. It plays a major role during early embryogenesis. SAM domains of Scm proteins can interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with SAM domains of Ph (polyhomeotic) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Mammalian Scmh1 protein is known be indispensible member of PRC1 complex; it plays a regulatory role for the complex during meiotic prophase of male sperm cells, and is particularly involved in regulation of chromatin modification at the XY chromatin domain of the pachytene spermatocytes.

Pssm-ID: 188977 Cd Length: 72 Bit Score: 88.25 E-value: 2.88e-21

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 791 SNPLKWSVADVVRFIRSTD---CAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIK 857
Cdd:cd09578   2 KDPSTWSVEDVVQFIKEADpqaLAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLK 71

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 86.54 E-value: 7.85e-21

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCE 444
Cdd:cd20088   1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSRYDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 87.60 E-value: 1.25e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  51 APGMKLEVaVRTD----PETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20120   5 AEGVRVEV-PNTDcnlpTKVFWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTIQHK 83

                        90
                ....*....|....*....
gi 67461585 127 VSDWDEFLRQTLIGACSPP 145
Cdd:cd20120  84 YTNWKAFLVKRLTGAKTLP 102

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 83.72 E-value: 9.69e-20

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585   167 RLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLEssDNYEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:pfam02820   2 KLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWD--DSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 82.70 E-value: 5.51e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKV--------FD---EKYflvemddlrpenharrSFVCHADSPGIFPVQWSLKN 341
Cdd:cd20101   4 NGFKVGMKLEGIDPKHPSLFCVLSVAEVrgyrlrlhFDgysECY----------------DFWVNADSPDIFPVGWCEKT 67

                        90       100       110
                ....*....|....*....|....*....|....
gi 67461585 342 GLHISPPPGYPSQDFDWADYLKQCGAEAAPQRCF 375
Cdd:cd20101  68 GHKLQPPKGYTSETFSWSAYLKLTKAQAAPKHLF 101

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 82.29 E-value: 5.54e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKV 127
Cdd:cd20102   2 HGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGW--DDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSPGN 79

                        90
                ....*....|
gi 67461585 128 SDWDEFLRQT 137
Cdd:cd20102  80 FSWDKYLEET 89

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 80.75 E-value: 1.89e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVFDEKyFLVEMD------DlrpenharrsFVCHADSPGIFPVQWSLKNGLHIS 346
Cdd:cd20102   2 HGFRVGMKLEAVDRKNPSLICVATVTDVIGNR-FLVHFDgwddsyD----------YWCDPDSPYIHPVGWCEENGKTLQ 70

                        90       100
                ....*....|....*....|
gi 67461585 347 PPPGYPSQDFDWADYLKQCG 366
Cdd:cd20102  71 PPKGYSPGNFSWDKYLEETN 90

SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain of Ph (polyhomeotic) proteins of Polycomb group is a protein-protein interaction domain. Ph1,2,3 proteins are members of PRC1 complex. This complex is involved in transcriptional repression of Hox (Homeobox) cluster genes. It is recruited through methylated H3Lys27 and supports the repression state by mediating monoubiquitination of histone H2A. Proteins of the Ph1,2,3 subfamily contribute to anterior-posterior neural tissue specification during embryogenesis. Additionally, the P2 protein of zebrafish is known to be involved in epiboly and tailbud formation. SAM domains of Ph proteins may interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with the SAM domain of Scm (sex comb on midleg) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome.

Pssm-ID: 188976 Cd Length: 69 Bit Score: 79.37 E-value: 3.16e-18

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 791 SNPLKWSVADVVRFIRS-TDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIK 857
Cdd:cd09577   1 SNPSKWSVEDVYEFIRSlPGCSDYAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICAKINSLK 68

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 78.45 E-value: 5.16e-18

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFdEKYFLVEMDDLRPENHarrSFVCHADSPGIFPVQWS 338
Cdd:cd20088   1 FKVGMKLEAVDPLNPSEICVATVVKVV-GGRLLLHFDGWDPSRY---DFWCDVDSPDIHPVGWC 60

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 78.45 E-value: 5.26e-18

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585 162 IAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSdNYEHWLYYLDPFLHHVGWAA 223
Cdd:cd20088   1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPS-RYDFWCDVDSPDIHPVGWCE 61

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 79.28 E-value: 7.56e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGI--RDKV 127
Cdd:cd20136   5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNW--DDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYpnPEKF 82

                        90
                ....*....|
gi 67461585 128 SdWDEFLRQT 137
Cdd:cd20136  83 S-WTEYLEAT 91

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 77.73 E-value: 2.83e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGygEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20091   7 VNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDG--SDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFRMN 84

                        90
                ....*....|..
gi 67461585 127 VSDWDEFLRQTL 138
Cdd:cd20091  85 PSSWPMFLQKTL 96

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 75.38 E-value: 2.20e-16

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67461585 380 SEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKkpipECI---VSVESMDIFPLGWCETNGHPLSTPRR 455
Cdd:cd20101   2 NKNGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYS----ECYdfwVNADSPDIFPVGWCEKTGHKLQPPKG 76

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 74.82 E-value: 2.41e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENhARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYpSQ 354
Cdd:cd20126   1 FKEGMKLEAIDPLNLSTICVATVRKVLANGYLMIGIDGSEAAD-GSDWFCYHATSPSIFPVGFCEINMIELTPPRGY-KK 78

                        90
                ....*....|..
gi 67461585 355 DFDWADYLKQCG 366
Cdd:cd20126  79 PFKWFDYLRETG 90

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 75.80 E-value: 3.90e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 356 FDWADYLKQCGAEAAPQRCF-----PPLiseHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPiPECIV 430
Cdd:cd20105   2 FSWDKYLKETGAVPAPVHCFkqsytPPV---NEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNK-NDFWR 77

                        90       100
                ....*....|....*....|...
gi 67461585 431 SVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20105  78 LVDSSEIQPIGNCEKNGGMLQPP 100

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 73.76 E-value: 9.78e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20131  11 KNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECH--DFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEE 88

                        90
                ....*....|.
gi 67461585 127 VSDWDEFLRQT 137
Cdd:cd20131  89 EFSWSQYLRST 99

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 72.55 E-value: 1.86e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLrPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20127   1 FEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMIGIDGG-PSTDGSDWFCYHASSHAIFPVGFCQKNDIELTPPKGYDAQ 79

                        90
                ....*....|..
gi 67461585 355 DFDWADYLKQCG 366
Cdd:cd20127  80 TFNWENYLEKTK 91

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 72.30 E-value: 2.93e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  48 NGFAPGMKLEvAVrtDPE---TYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAPEGIR 124
Cdd:cd20101   4 NGFKVGMKLE-GI--DPKhpsLFCVLSVAEVRGYRLRLHFDGYSECY--DFWVNADSPDIFPVGWCEKTGHKLQPPKGYT 78

                        90
                ....*....|...
gi 67461585 125 DKVSDWDEFLRQT 137
Cdd:cd20101  79 SETFSWSAYLKLT 91

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 70.60 E-value: 8.30e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  49 GFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRD-KV 127
Cdd:cd20135   5 GFRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNW--DESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKDpKH 82

                        90
                ....*....|
gi 67461585 128 SDWDEFLRQT 137
Cdd:cd20135  83 FSWEKYLEET 92

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 70.59 E-value: 1.07e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVfdEKYFLVEMDDLRPENHarrSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20133   6 FKVGMRLEGIDPEHPSLFCVLSVAEV--QGYRLRLHFDGYSECY---DFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDG 80

                        90       100
                ....*....|....*....|.
gi 67461585 355 DFDWADYLKQCGAEAAPQRCF 375
Cdd:cd20133  81 EFNWSSYLKTCKAQAAPKNLF 101

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 68.92 E-value: 1.80e-14

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIpECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20092   6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAF-DYWCRYDSRDIFPVGWCKKTGHPLQPP 74

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 68.85 E-value: 1.83e-14

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPEcIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20100   1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQ-WVDCDSPDIYPVGWCELVGYPLQPP 71

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 69.48 E-value: 2.35e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  49 GFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKVS 128
Cdd:cd20134   5 GFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNW--DDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDN 82

                        90
                ....*....|
gi 67461585 129 -DWDEFLRQT 137
Cdd:cd20134  83 fSWEKYLEET 92

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 68.08 E-value: 3.13e-14

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDrrADFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20100   1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDE--FDQWVDCDSPDIYPVGWCELVGYPLQPP 71

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 69.18 E-value: 3.16e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20132   3 KNGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCY--DFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEE 80


                ....*....
gi 67461585 127 VSDWDEFLR 135
Cdd:cd20132  81 EFNWQSYLK 89

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 68.80 E-value: 4.08e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGygEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKV 127
Cdd:cd20106   8 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMNA 85

                        90
                ....*....|...
gi 67461585 128 SDWDEFLRQTLIG 140
Cdd:cd20106  86 SSWPMFLLRTLNG 98

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 68.41 E-value: 6.18e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLveMDDLRPENHarrSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20132   6 FKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRL--HFDGYSDCY---DFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEE 80

                        90       100
                ....*....|....*....|.
gi 67461585 355 DFDWADYLKQCGAEAAPQRCF 375
Cdd:cd20132  81 EFNWQSYLKTCKAQAAPKSLF 101

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 68.28 E-value: 6.38e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEdrRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20133   3 RNGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSE--CYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDG 80


                ....*....
gi 67461585 127 VSDWDEFLR 135
Cdd:cd20133  81 EFNWSSYLK 89

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 67.55 E-value: 1.12e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKyFLVEMDDLRPEnharRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20134   6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSR-FLVHFDNWDDT----YDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDP 80

                        90
                ....*....|...
gi 67461585 355 D-FDWADYLKQCG 366
Cdd:cd20134  81 DnFSWEKYLEETG 93

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 67.33 E-value: 1.37e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 160 DLIAPGSRLECQAFQDSLST------WIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPS 233
Cdd:cd20097   2 EKVKIGVKVEVANRDDDKPTdnvkvyWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPPK 81

                        90
                ....*....|....*..
gi 67461585 234 AIrhLKNEAEWQEILAK 250
Cdd:cd20097  82 SI--EDKENDWKEYIMK 96

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 66.11 E-value: 1.70e-13

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRRaDFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20096   1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSP-NIIVDVESTDIFPVGWCESNGYPLVTP 70

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 65.38 E-value: 2.74e-13

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585  49 GFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20103   4 GFEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIY--DFWVDDDSPDIHPPGWCSKTGHPLEPP 73

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 66.83 E-value: 2.88e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 264 FKDKQVIGIH--TFSVNMKLEAVDPWSPFGISPATVVKVFDekYFLVEMDDLRPENHarrSFVCHADSPGIFPVQWSLKN 341
Cdd:cd20131   1 FQDSQAVTHNknGFKLGMKLEGIDPQHPSMYFILTVAEVCG--YRLRLHFDGYSECH---DFWVNANSPDIHPAGWFEKT 75

                        90       100       110
                ....*....|....*....|....*....|....
gi 67461585 342 GLHISPPPGYPSQDFDWADYLKQCGAEAAPQRCF 375
Cdd:cd20131  76 GHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLF 109

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-3MBT3,4 (Sex comb on midleg, Malignant brain tumor) subfamily proteins (also known as L3mbtl3,4 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are predicted transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain three MBT repeats and Zn finger domain. Murine L3mbtl3 protein of this subfamily is essential for maturation of myeloid progenitor cells during differentiation. Human L3mbtl4 is a potential tumor suppressor gene in breast cancer, while deregulation of L3MBTL3 is associated with neuroblastoma.

Pssm-ID: 188981 Cd Length: 66 Bit Score: 64.60 E-value: 4.54e-13

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 793 PLKWSVADVVRFIRS-TDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIK 857
Cdd:cd09582   1 VLRWSVDEVAEFVQSlPGCEEHAKVFRDEQIDGEAFLLLTQSDLVKILGIKLGPALKIYNSILMLR 66

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 65.74 E-value: 4.65e-13

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWL----QLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20095   1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLveidDLRPEESEKITFVCHANSPGIFPVGWCAKNGLRLTPP 74

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 65.72 E-value: 5.54e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGygEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20107   7 KNEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDG--SDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMN 84

                        90
                ....*....|....*
gi 67461585 127 VSDWDEFLRQTLIGA 141
Cdd:cd20107  85 ASSWPMFLLKTLNNA 99

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin and Atherin-like subfamily proteins is a putative protein-protein and/or protein-lipid interaction domain. In addition to the C-terminal SAM domain, the majority of proteins belonging to this group also have PHD (or Zn finger) domain. As potential members of the polycomb group, these proteins may be involved in regulation of some key regulatory genes during development. Atherin can be recruited by Ruk/CIN85 kinase-binding proteins via its SH3 domains thus participating in the signal transferring kinase cascades. Also, atherin was found associated with low density lipids (LDL) in atherosclerotic lesions in human. It was suggested that atherin plays an essential role in atherogenesis via immobilization of LDL in the arterial wall. SAM domains of atherins are predicted to form polymers. Inhibition of polymer formation could be a potential antiatherosclerotic therapy.

Pssm-ID: 188982 Cd Length: 69 Bit Score: 63.83 E-value: 8.71e-13

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67461585 793 PLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHI 853
Cdd:cd09583   1 PSNWSVEDVVQYFKTAGFPEEANAFKEQEIDGKSLLLLTRSDVLTGLSLKLGPALKIYEHV 61

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 63.73 E-value: 1.61e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  45 RLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIR 124
Cdd:cd20139   4 RPPHGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGW--DHNYDFWVDADSPDIHPVGWCDKTGHALQVPLGAS 81


                .
gi 67461585 125 D 125
Cdd:cd20139  82 D 82

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a protein-protein interaction domain. Phylogenetic analysis suggests that proteins of this subfamily are most closely related to SAM-Ph1,2,3 subfamily of Polycomb group. They are predicted transcriptional repressors in photoreceptor cells and pinealocytes of vertebrates. SAM domain containing protein 11 is also known as Mr-s (major retinal SAM) protein. In mouse, it is predominantly expressed in developing retinal photoreceptors and in adult pineal gland. The SAM domain is involved in homooligomerization of whole proteins (it was shown based on immunoprecipitation assay and mutagenesis), however its repression activity is not due to SAM/SAM interactions but to the C-terminal region.

Pssm-ID: 188978 Cd Length: 68 Bit Score: 62.85 E-value: 1.93e-12

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 794 LKWSVADVVRFIRSTD-CAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERI 856
Cdd:cd09579   2 RKWTVDDVCSFIGSLPgCAEYAQVFREHSIDGETLPLLTEEHLLNTMGLKLGPALKIRSQVAKR 65

SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT (Sex comb on midleg like, Malignant Brain Tumor) subfamily proteins of the polycomb group is a putative protein-protein interaction domain. Additionally to the SAM domain, most of the proteins of this subfamily have 4 MBT repeats. In Drosophila SAM-Scm-like-4MBT protein (known as dSfmbt) is a member of Pho repressive complex (PhoRC). Additionally to dSfmbt, the PhoRC complex includes Pho or Pho-like proteins. This complex is responsible for HOX (Homeobox) gene silencing: Pho or Pho-like proteins bind DNA and dSmbt binds methylated histones. dSmbt can interact with mono- and di-methylated histones H3 and H4 (however this activity has been shown for the MBT repeats, while exact function of the SAM domain is unclear). Besides interaction with histones, dSmbt can interact with Scm (a member of PRC complex), but this interaction also seems to be SAM domain independent.

Pssm-ID: 188979 Cd Length: 67 Bit Score: 62.77 E-value: 2.37e-12

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67461585 793 PLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIK 857
Cdd:cd09580   1 PSTWGVKDVSQFLRENDCGAYCECFCRQNIDGKRLLSLTKEQIMTLTGMKVGPSLKIYDLIQQLK 65

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 63.67 E-value: 2.63e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKyFLVEMDDLRpENHarrSFVCHADSPGIFPVQWSLKNGLHISPPPGYP-S 353
Cdd:cd20135   6 FRVGMKLEAVDKKNPSFICVATITDMVDNR-LLIHFDNWD-ESY---DYWCDASSPYIHPVGYCQEHGRTLTTPPGYKdP 80

                        90
                ....*....|...
gi 67461585 354 QDFDWADYLKQCG 366
Cdd:cd20135  81 KHFSWEKYLEETN 93

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 63.47 E-value: 2.81e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 376 PPlisEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGS--KKPIPECivsVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20091   5 PP---VNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSdnKNDFWRL---VDSSDIHPVGWCEKNGGLLQPP 78

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 61.87 E-value: 9.48e-12

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 381 EHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSkkpipECI----VSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20102   1 PHGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGW-----DDSydywCDPDSPYIHPVGWCEENGKTLQPPK 73

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 61.56 E-value: 1.11e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKyFLVEMDDLRPEnharRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQ 354
Cdd:cd20136   5 FQVGMKLEAVDRKNPSLVCVATIADIVEDR-LLVHFDNWDDS----YDYWCDVNSPYIQPVGWCQENGRTLVAPQGYPNP 79

                        90
                ....*....|
gi 67461585 355 D-FDWADYLK 363
Cdd:cd20136  80 EkFSWTEYLE 89

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 60.75 E-value: 1.22e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 380 SEHEFKENMKLEAV---NPILpeeVCVATITAVRGSYLWLQLEGskkpIPECI---VSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20103   1 PPHGFEVGMKLEAVdkrNPRL---IRVATVADVEDYRVKLHFDG----WPDIYdfwVDDDSPDIHPPGWCSKTGHPLEPP 73

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 61.35 E-value: 1.84e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 380 SEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGskkpIPECI---VSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20133   2 SRNGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDG----YSECYdfwVNADSPDIHPVGWCEKTGHKLLPPK 75

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 59.22 E-value: 4.25e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECiVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20129   1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQW-VDCESPDLYPVGWCQLTGYQLQPP 71

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 59.23 E-value: 5.08e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgeDRRADFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20130   4 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGW--DSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 58.91 E-value: 6.69e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67461585 274 TFSVNMKLEAVDPWSPFGISPATVVKVfDEKYFLVEMDDLRPENharrSFVCHADSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20092   5 MFKVGMKLEAVDRKNPQLICPATVGDV-DGDEIHISFDGWRGAF----DYWCRYDSRDIFPVGWCKKTGHPLQPP 74

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 59.77 E-value: 7.85e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 160 DLIAPGSRLE-----CQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSA 234
Cdd:cd20119   2 DNITVGMKVEventdTDLIEDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPRT 81

                        90
                ....*....|....*.
gi 67461585 235 IRHlkNEAEWQEILAK 250
Cdd:cd20119  82 IEH--KYSDWKEFLVK 95

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 58.62 E-value: 8.99e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 380 SEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIpECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20110   2 ESNLFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAF-DYWCRYDSRDIFPVGWCARSGHPLQPP 74

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 58.45 E-value: 9.12e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20129   1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEY--DQWVDCESPDLYPVGWCQLTGYQLQPP 71

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 58.78 E-value: 1.29e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGskkpIPECI---VSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20132   6 FKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDG----YSDCYdfwVNADSPDIHPVGWCEKTGHKLHPPK 75

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 58.13 E-value: 1.29e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20128   1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEY--DQWLDCESADIYPVGWCVLVNHKLEGP 71

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 58.71 E-value: 1.66e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 162 IAPGSRLECQAFQDSLST---WIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHl 238
Cdd:cd20120   4 IAEGVRVEVPNTDCNLPTkvfWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTIQH- 82

                        90
                ....*....|..
gi 67461585 239 kNEAEWQEILAK 250
Cdd:cd20120  83 -KYTNWKAFLVK 93

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 57.88 E-value: 2.26e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAV-RGSYLWLQLEGSKKPIPE---CIVSVeSMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20126   1 FKEGMKLEAIDPLNLSTICVATVRKVlANGYLMIGIDGSEAADGSdwfCYHAT-SPSIFPVGFCEINMIELTPPR 74

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 57.24 E-value: 3.12e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20138   7 HGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCY--DYWIDADSPDIHPAGWCAKTGHPLQPP 77

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 57.31 E-value: 4.12e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAV-RGSYLWLQLEGSKKPIPE--CIVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20099   1 FKVGMKLEAVDPLNLSSICVATVRKVlRFGYLVIGIDGPSADDGSdwFCCHASSPFIFPVGFAEKNGIELTPPR 74

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 56.49 E-value: 4.82e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 380 SEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIpECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20108   2 SQNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAF-DYWCRYDSRDIFPVGWCSLTGDNLQPP 74

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 56.15 E-value: 6.44e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECiVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20130   4 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQW-VDCESPDIYPVGWCELTGYQLQPP 74

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 55.15 E-value: 1.29e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFlVEMDDLRpenhARRSFVCHADSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20110   6 FKVGMKLEAVDRKNPHLICPATVGAVKDDQIF-VTFDGWR----GAFDYWCRYDSRDIFPVGWCARSGHPLQPP 74

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 54.87 E-value: 2.23e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 382 HEFKENMKLEAV---NPILpeeVCVATITAVRGSYLWLQLEGSKKPIpECIVSVESMDIFPLGWCETNGHPLSTPRRA 456
Cdd:cd20139   7 HGFQVNMKLEAVdkrNPIL---IRVATIVDKDDHRIKLHFDGWDHNY-DFWVDADSPDIHPVGWCDKTGHALQVPLGA 80

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 55.00 E-value: 2.36e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTC-EQLLLLRYDGYGEDRRAD-FWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKV 127
Cdd:cd20099   1 FKVGMKLEAVDPLNLSSICVATVRKVLrFGYLVIGIDGPSADDGSDwFCCHASSPFIFPVGFAEKNGIELTPPRGYESKP 80

                        90
                ....*....|
gi 67461585 128 SDWDEFLRQT 137
Cdd:cd20099  81 FDWEEYLEET 90

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 54.93 E-value: 2.71e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 376 PPlisEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPiPECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20106   5 PP---VNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNK-NDFWRLVDSSDIQPIGTCEKEGDMLQPP 78

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 54.28 E-value: 3.21e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgedRRA-DFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20092   3 KNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGW---RGAfDYWCRYDSRDIFPVGWCKKTGHPLQPP 74

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 54.06 E-value: 3.29e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSvESMDIFPLGWCETNGHPLSTPRR 455
Cdd:cd20137   3 HGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDA-DHPDIHPAGWCSKTGHPLQPPLG 75

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 53.05 E-value: 6.06e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVfDEKYFLVEMDDLrPENHarrSFVCHADSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20103   3 HGFEVGMKLEAVDKRNPRLIRVATVADV-EDYRVKLHFDGW-PDIY---DFWVDDDSPDIHPPGWCSKTGHPLEPP 73

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 53.39 E-value: 6.21e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 376 PPliseHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKpIPECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20138   5 PP----HGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNN-CYDYWIDADSPDIHPAGWCAKTGHPLQPP 77

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 53.02 E-value: 9.82e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585 379 ISEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLS 451
Cdd:cd20098  10 LKSTPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDDFWCHMKSPLIHPVGWSQAVGHKIR 82

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 52.45 E-value: 1.12e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgedRRA-DFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20110   4 NLFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGW---RGAfDYWCRYDSRDIFPVGWCARSGHPLQPP 74

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 53.39 E-value: 1.16e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 376 PPlisEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPiPECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20107   5 PP---KNEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNK-NDFWRLVDSTEIHPIGHCEKNGGMLQPP 78

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.

Pssm-ID: 425739 Cd Length: 64 Bit Score: 51.50 E-value: 2.26e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585   795 KWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLtlpTVQECMDL---KLGPAIKLCHHIERIK 857
Cdd:pfam00536   2 GWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQL---TEDDLLKLgvtLLGHRKKILYAIQRLK 64

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 52.42 E-value: 2.29e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  52 PGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgEDRRAD---FWCDIRkadLYPIGWCEQNKKTLEAPEGIRD--K 126
Cdd:cd20114   6 VGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGL-EDESHDqwlFYLDTR---LRPVGWCQENNLRMEPPTEICDlkS 81

                        90
                ....*....|....*
gi 67461585 127 VSDWDEFLRQTLIGA 141
Cdd:cd20114  82 ASEWKEALEKSLAEA 96

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 52.57 E-value: 2.66e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKkpipEC---IVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20131  14 FKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYS----EChdfWVNANSPDIHPAGWFEKTGHKLQPPK 83

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 51.48 E-value: 2.93e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67461585  47 QNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgedRRA-DFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20108   3 QNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGW---RGAfDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 51.42 E-value: 3.31e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIpECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20109   6 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAF-DYWCKYDSRDIFPVGWCRLTGDVLQPP 74

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 50.98 E-value: 3.57e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  48 NGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRraDFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20137   3 HGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGY--DFWIDADHPDIHPAGWCSKTGHPLQPP 73

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 51.51 E-value: 4.18e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67461585 381 EHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSK-KPIPECIVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20093   1 QSGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYEdDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPA 75

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 51.78 E-value: 4.24e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTCEQ-LLLLRYDGYGEDRR-ADFWC-DIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20125   1 FKEGMKLEAVDPLNLSAICVATVMKVLRFgYLMIRIDSYEPDASgSDWFCyHESSPCIFPAGFCEVNNITLTPPNGYDGR 80

                        90       100
                ....*....|....*....|....*
gi 67461585 127 VSDWDEFLRQTliGACSPPVPLLEG 151
Cdd:cd20125  81 TFTWEGYLRQT--GATAAPQHLFHR 103

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 50.76 E-value: 7.36e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 165 GSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGlesSDNY-EHWLYYLDPFLHHVGWAAQQGYELQPPSAIRhlKNEAE 243
Cdd:cd20091  13 GMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDG---SDNKnDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFR--MNPSS 87


                ....*..
gi 67461585 244 WQEILAK 250
Cdd:cd20091  88 WPMFLQK 94

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 51.92 E-value: 9.01e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 130 WDEFLRQTligaCSPPVPLLEGLRNGRNPLDLIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGlesSDNYEHWL 209
Cdd:cd20105   4 WDKYLKET----GAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDG---SDNKNDFW 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 67461585 210 YYLDPF-LHHVGWAAQQGYELQPPSAIRhlKNEAEWQEILAK 250
Cdd:cd20105  77 RLVDSSeIQPIGNCEKNGGMLQPPLGFR--LNASSWPMFLLK 116

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 50.39 E-value: 9.38e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585 383 EFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIpECIVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20136   4 EFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSY-DYWCDVNSPYIQPVGWCQENGRTLVAPQ 74

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 50.32 E-value: 9.75e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 183 TVVENIGGRLKLRYEGLESSdnYEHWLYYLDPFLHHVGWAAQQGYELQPPSaiRHLKNEAEWQEILAKVK 252
Cdd:cd20102  25 TVTDVIGNRFLVHFDGWDDS--YDYWCDPDSPYIHPVGWCEENGKTLQPPK--GYSPGNFSWDKYLEETN 90

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 51.53 E-value: 1.11e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 244 WQEILakvKEEEEEPLPSYLFKDKQVIGIHTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLvEMDDLRPENHARRSf 323
Cdd:cd20105   4 WDKYL---KETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRL-RLDGSDNKNDFWRL- 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 67461585 324 vchADSPGIFPVQWSLKNGLHISPPPGYPSQDFDWADYLKQC--GAEAAPQRCF 375
Cdd:cd20105  79 ---VDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTlnGAEMAPVRIF 129

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.

Pssm-ID: 197735 Cd Length: 68 Bit Score: 49.22 E-value: 1.33e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585    793 PLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLT-LPTVQECMDLKLGPAIKLCHHIERIK 857
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLLTsEEDLKELGITKLGHRKKILKAIQKLK 66

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.

Pssm-ID: 188886 [Multi-domain] Cd Length: 56 Bit Score: 48.39 E-value: 1.76e-07

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 800 DVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIER 855
Cdd:cd09487   1 DVAEWLESLGLEQYADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQR 56

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 49.46 E-value: 1.80e-07

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67461585 164 PGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNyEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20122  16 LGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDD-GFWCHEDSPLIHPVGWAQTVGHNLAAS 83

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 49.05 E-value: 1.98e-07

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVfDEKYFLVEMDDLrpeNHArRSFVCHADSPGIFPVQWSLKNGLHISPPPG 350
Cdd:cd20137   3 HGFQVNMKLEAVDRRNPALIRVASVEDV-EDHRIKIHFDGW---SHG-YDFWIDADHPDIHPAGWCSKTGHPLQPPLG 75

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 49.58 E-value: 2.36e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 181 IVTVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPsaiRHLKNEA-EWQEILakvKEEEEEPL 259
Cdd:cd20101  25 VLSVAEVRGYRLRLHFDGY--SECYDFWVNADSPDIFPVGWCEKTGHKLQPP---KGYTSETfSWSAYL---KLTKAQAA 96


                ....*
gi 67461585 260 PSYLF 264
Cdd:cd20101  97 PKHLF 101

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 48.73 E-value: 2.46e-07

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585  46 LQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgedRRA-DFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20109   2 PLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGW---RGAfDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 48.71 E-value: 2.73e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVfdekyflvemDDLRPENH-----ARRSFVCHADSPGIFPVQWSLKNGLHISP 347
Cdd:cd20139   7 HGFQVNMKLEAVDKRNPILIRVATIVDK----------DDHRIKLHfdgwdHNYDFWVDADSPDIHPVGWCDKTGHALQV 76


                ....
gi 67461585 348 PPGY 351
Cdd:cd20139  77 PLGA 80

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 49.46 E-value: 3.64e-07

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAV-RGSYLWLQLEgSKKPIPECI----VSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20125   1 FKEGMKLEAVDPLNLSAICVATVMKVlRFGYLMIRID-SYEPDASGSdwfcYHESSPCIFPAGFCEVNNITLTPPN 75

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 48.11 E-value: 4.50e-07

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIvSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20128   1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWL-DCESADIYPVGWCVLVNHKLEGP 71

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 48.26 E-value: 5.12e-07

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLW------LQLEGSKkpiPECIVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20116   1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHYFqvtvddLRPEASE---NSMLCHADSLGILPVQWCLKNGVNLTPPK 76

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 46.86 E-value: 1.28e-06

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKyFLVEMDDLRpenhARRSFVCHADSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20108   6 FKTGMKLEAVDRKNPHFICPATIGEVRGSE-VLVTFDGWR----GAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 47.13 E-value: 1.36e-06

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585  49 GFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYgEDRRADFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20118   1 GFTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGL-QNPVPEYIVDVESMDIFPVGWCEANGYPLTPP 71

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 46.80 E-value: 1.38e-06

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFlVEMDDLRpenhARRSFVCHADSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20109   6 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVF-ITFDGWR----GAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 46.86 E-value: 1.42e-06

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 164 PGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYeHWLYYLDPFLHHVGWAAQQGYEL 229
Cdd:cd20098  17 VGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDD-FWCHMKSPLIHPVGWSQAVGHKI 81

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 46.84 E-value: 1.43e-06

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVfDEKYFLVEMDDLRPEnharRSFVCHADSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20138   7 HGFQKNMKLEVVDKRNPMLIRVATVADT-DDHRVKVHFDGWNNC----YDYWIDADSPDIHPAGWCAKTGHPLQPP 77

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 47.22 E-value: 1.65e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 181 IVTVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRhlKNEAEWQEILAKVKEEEEeplP 260
Cdd:cd20132  25 VLTVAEVCGYRIRLHFDGY--SDCYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYK--EEEFNWQSYLKTCKAQAA---P 97


                ....
gi 67461585 261 SYLF 264
Cdd:cd20132  98 KSLF 101

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 46.48 E-value: 2.22e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTC-EQLLLLRYDGYGEDRRAD--FWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20095   1 FKVGMKLEALHPKNPSTICPATVTKVFnEYYFLVEIDDLRPEESEKitFVCHANSPGIFPVGWCAKNGLRLTPPPGYPKS 80

                        90
                ....*....|.
gi 67461585 127 VSDWDEFLRQT 137
Cdd:cd20095  81 EFDWDSYLKLC 91

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 46.38 E-value: 2.26e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  39 FKHVDTRLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDrRADFWCDIRKADLYPIGWCEQNKKTLE 118
Cdd:cd20122   3 HNKVNESLRSRFRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPD-DDGFWCHEDSPLIHPVGWAQTVGHNLA 81


                ..
gi 67461585 119 AP 120
Cdd:cd20122  82 AS 83

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 45.21 E-value: 5.40e-06

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 67461585 188 IGGRLKLRYEGLESSDNYehWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20124  40 IGGRLRLLYEDGDSDDDF--WCHMWSPLIHPVGWSRRVGHSIKMS 82

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 44.55 E-value: 7.95e-06

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENharrSFVCHADSPGIFPVQWSLKNG 342
Cdd:cd20098  13 TPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDD----DFWCHMKSPLIHPVGWSQAVG 78

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 44.55 E-value: 1.07e-05

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGyGEDRRADFWCDIRKADLYPIGWCEQ 112
Cdd:cd20098  15 FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVD-SEDDDDDFWCHMKSPLIHPVGWSQA 76

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 43.82 E-value: 1.17e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKV--------FD--EKYFlvemDDLrpenharrsfvCHADSPGIFPVQWSLKNG 342
Cdd:cd20100   1 HGFKVGMKLEAVDLMEPRLICVATVTRVvgrllrvhFDgwDDEF----DQW-----------VDCDSPDIYPVGWCELVG 65


                ....*.
gi 67461585 343 LHISPP 348
Cdd:cd20100  66 YPLQPP 71

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 44.84 E-value: 1.21e-05

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67461585 180 WIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIrHLKnEAEWQEILAK 250
Cdd:cd20121  25 WIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTI-HAK-FTDWRGYLMK 93

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 44.41 E-value: 1.26e-05

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPE-CIVSveSMDIFPLGWCETNGHPLSTP 453
Cdd:cd20135   6 FRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYwCDAS--SPYIHPVGYCQEHGRTLTTP 74

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 44.05 E-value: 1.56e-05

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAV-RGSYLWLQLEGSkkPIPE-----CiVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20127   1 FEEGMKLEAIDPLNLGNICVATVCKVlLDGYLMIGIDGG--PSTDgsdwfC-YHASSHAIFPVGFCQKNDIELTPPK 74

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 43.76 E-value: 1.69e-05

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 67461585 181 IVTVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20138  28 VATVADTDDHRVKVHFDGW--NNCYDYWIDADSPDIHPAGWCAKTGHPLQPP 77

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 43.76 E-value: 2.88e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 165 GSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYehWLYYLDPFLHHVGWAAQQGYELQPPSAIRhlKNEAEW 244
Cdd:cd20107  13 GMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNKNDF--WRLVDSTEIHPIGHCEKNGGMLQPPLGFR--MNASSW 88


                ....*..
gi 67461585 245 QEILAKV 251
Cdd:cd20107  89 PMFLLKT 95

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 42.55 E-value: 5.76e-05

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 382 HEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPEC----IVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20115   1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDLRPEEAGahsfVCHRDSPGIFPVQWSLKNGLHLSPP 76

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 42.55 E-value: 5.99e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTC-EQLLLLRYDGYGEDRRAD--FWCDIRKADLYPIGWCEQNKKTLEAPEGIRDK 126
Cdd:cd20115   3 FSEGMKLEAVDPAAPFTISPATVAKVFnEKFFLVEMDDLRPEEAGAhsFVCHRDSPGIFPVQWSLKNGLHLSPPPGYPGQ 82

                        90
                ....*....|
gi 67461585 127 VSDWDEFLRQ 136
Cdd:cd20115  83 DFDWADYLKQ 92

SAM domain (Sterile alpha motif);

Pssm-ID: 429573 Cd Length: 66 Bit Score: 41.87 E-value: 6.06e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585   796 WSVADVVRFIRSTDCAPLARIFLDQEIDG-QALLLLTLPTVQECMDLKLGPAIKLCHHIERIK 857
Cdd:pfam07647   4 WSLESVADWLRSIGLEQYTDNFRDQGITGaELLLRLTLEDLKRLGITSVGHRRKILKKIQELK 66

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 42.25 E-value: 6.43e-05

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 67461585 182 VTVVEN-IGGRLKLRYEglESSDNYEH-WLYYLDPFLHHVGWAAQQGYELQ 230
Cdd:cd20123  33 VAVVESvIGGRLRLVYE--ESEDGTDDfWCHMYSPLIHHIGWSRSIGHRFK 81

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 42.86 E-value: 6.54e-05

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585 181 IVTVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRhlKNEAEWQEILAKVK 252
Cdd:cd20133  25 VLSVAEVQGYRLRLHFDGY--SECYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYK--DGEFNWSSYLKTCK 92

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 42.14 E-value: 7.37e-05

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67461585 275 FSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENharrSFVCHADSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20122  14 FRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDD----GFWCHEDSPLIHPVGWAQTVGHNLAAS 83

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 42.17 E-value: 1.14e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 165 GSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRhlKNEAEW 244
Cdd:cd20131  17 GMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGY--SECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYK--EEEFSW 92

                        90       100
                ....*....|....*....|
gi 67461585 245 QEILAKVKEEEEeplPSYLF 264
Cdd:cd20131  93 SQYLRSTRAQAA---PKHLF 109

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 40.73 E-value: 1.60e-04

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 165 GSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLEssDNYEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20129   6 GMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWE--DEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 40.34 E-value: 1.88e-04

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 67461585 183 TVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20103  26 TVADVEDYRVKLHFDGW--PDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 40.97 E-value: 1.94e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  50 FAPGMKLEVavrTDPETYWVATVITTCEQLL----LLRYDGYGEDRRADFWC-DIRKADLYPIGWCEQNKKTLEAPEGIR 124
Cdd:cd20127   1 FEEGMKLEA---IDPLNLGNICVATVCKVLLdgylMIGIDGGPSTDGSDWFCyHASSHAIFPVGFCQKNDIELTPPKGYD 77

                        90
                ....*....|...
gi 67461585 125 DKVSDWDEFLRQT 137
Cdd:cd20127  78 AQTFNWENYLEKT 90

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 40.58 E-value: 2.12e-04

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 67461585 181 IVTVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20137  24 VASVEDVEDHRIKIHFDGW--SHGYDFWIDADHPDIHPAGWCSKTGHPLQPP 73

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 40.68 E-value: 3.07e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 165 GSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGleSSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRhlKNEAEW 244
Cdd:cd20106  13 GMKLEARDPRNATSVCIATVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQ--MNASSW 88


                ....*..
gi 67461585 245 QEILAKV 251
Cdd:cd20106  89 PMFLLRT 95

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 40.16 E-value: 3.94e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585  50 FAPGMKLEVavrTDP---ETYWVATVITTC-EQLLLLRYDGYGEDRRADFWC-DIRKADLYPIGWCEQNKKTLEAPEGIR 124
Cdd:cd20126   1 FKEGMKLEA---IDPlnlSTICVATVRKVLaNGYLMIGIDGSEAADGSDWFCyHATSPSIFPVGFCEINMIELTPPRGYK 77

                        90
                ....*....|...
gi 67461585 125 DKVSdWDEFLRQT 137
Cdd:cd20126  78 KPFK-WFDYLRET 89

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 40.35 E-value: 4.28e-04

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 381 EHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEG---SKKPIPECivSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20112   1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGygdDRRADFWC--DVMTADLHPVGWCTQNNKVLMPP 74

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 38.43 E-value: 1.09e-03

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67461585 164 PGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSdnYEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20130   8 VGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSE--YDQWVDCESPDIYPVGWCELTGYQLQPP 74

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 39.04 E-value: 1.15e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEG---SKKPIPECivSVESMDIFPLGWCETNGHPLSTPRRAR 457
Cdd:cd20111   4 FSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGygeDRRADFWC--DIMTADLHPIGWCEQNGKTLRPPEGIR 78

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 38.01 E-value: 1.76e-03

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585  42 VDTRLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDgYGEDRRADFWCDIRKADLYPIGW 109
Cdd:cd20123   6 VSESMQYPFKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYE-ESEDGTDDFWCHMYSPLIHHIGW 72

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 37.90 E-value: 1.88e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461585 384 FKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTP 453
Cdd:cd20122  14 FRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDGFWCHEDSPLIHPVGWAQTVGHNLAAS 83

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 38.58 E-value: 2.10e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585 388 MKLEAVN-----PILPEEVCVATITAVRGSYLWLQLEG-SKKPIPECIVSVESMDIFPLGWCETNGHPLSTPR 454
Cdd:cd20119   8 MKVEVENtdtdlIEDPTSFWIATVLKIAGYKALMRYEGfGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPR 80

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 37.94 E-value: 2.43e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461585  49 GFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGyGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAP 120
Cdd:cd20117   2 CFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEG-SKKPIPECIVHVESMDIFPVGWCETNGYPLLHP 72

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 37.26 E-value: 2.45e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461585 273 HTFSVNMKLEAVDPWSPFGISPATVVKVFdEKYFLVEMDDLrpENHARRSFVChaDSPGIFPVQWSLKNGLHISPP 348
Cdd:cd20129   1 HGFRVGMKLEAVDLMEPRLVCVATVTRII-HRLLRIHFDGW--EDEYDQWVDC--ESPDLYPVGWCQLTGYQLQPP 71

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 36.17 E-value: 6.01e-03

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461585 165 GSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLesSDNYEHWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20128   6 GMSLECADLMDPRLVCVATVARVVGRLLKVHFDGW--TDEYDQWLDCESADIYPVGWCVLVNHKLEGP 71

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 35.97 E-value: 8.93e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67461585  50 FAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDrrADFWCDIRKADLYPIGWCEQNKKTLEAPEG 122
Cdd:cd20124  14 FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSD--DDFWCHMWSPLIHPVGWSRRVGHSIKMSDR 84

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 35.80 E-value: 9.52e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 67461585 183 TVVENIGGRLKLRYEGLESSDNYehWLYYLDPFLHHVGWAAQQGYELQPP 232
Cdd:cd20092  27 TVGDVDGDEIHISFDGWRGAFDY--WCRYDSRDIFPVGWCKKTGHPLQPP 74