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Conserved domains on  [gi|20532005|sp|Q9Y576|]
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RecName: Full=Ankyrin repeat and SOCS box protein 1; Short=ASB-1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-219 1.69e-28

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.58  E-value: 1.69e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  38 DTRLHDAAYVGDLQTLRSLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYV 117
Cdd:COG0666  88 NTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 118 AVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV--NHHLTpdvqprfsrrltslvvcP 195
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT-----------------A 222

                       170       180
                ....*....|....*....|....
gi 20532005 196 LYISAAYHNLQCFRLLLLAGANPD 219
Cdd:COG0666 223 LDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 294-335 1.31e-19

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239690  Cd Length: 42  Bit Score: 80.54  E-value: 1.31e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 20532005 294 SVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03720   1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-219 1.69e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.58  E-value: 1.69e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  38 DTRLHDAAYVGDLQTLRSLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYV 117
Cdd:COG0666  88 NTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 118 AVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV--NHHLTpdvqprfsrrltslvvcP 195
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT-----------------A 222

                       170       180
                ....*....|....*....|....
gi 20532005 196 LYISAAYHNLQCFRLLLLAGANPD 219
Cdd:COG0666 223 LDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 294-335 1.31e-19

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 80.54  E-value: 1.31e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 20532005 294 SVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03720   1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
82-173 5.85e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 5.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005    82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEaGADPNGSRHHRsTPVYHASRVGRADILK 161
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 20532005   162 ALIRYGADVDVN 173
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 94-275 8.90e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.67  E-value: 8.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   94 VDFLIRKGAEVDLVDV-KGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV 172
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  173 nhhltpdvqprfsrrLTSLVVCPLYISAAY-HNLQCFRLLLLAGANpdfncngpVNTQGFYRG-SPgcvMDAVLRhgcEA 250
Cdd:PHA02878 230 ---------------RDKCGNTPLHISVGYcKDYDILKLLLEHGVD--------VNAKSYILGlTA---LHSSIK---SE 280

                        170       180
                 ....*....|....*....|....*
gi 20532005  251 AFVSLLVEFGANLNLVKWESLGPES 275
Cdd:PHA02878 281 RKLKLLLEYGADINSLNSYKLTPLS 305
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 296-333 1.23e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.72  E-value: 1.23e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20532005   296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLL 333
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-182 4.86e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 4.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  38 DTRLHDAAYVGDLQTLRSLLqeESYRSRINEKsvwccGWLPCTPLRIAATAGHGSCVDFLIRkgAEVDLVDV-------K 110
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLL--KCPSCDLFQR-----GALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 111 GQTALYVAVVNGHLESTQILLEAGADPNGSR--------------HHRSTPVYHASRVGRADILKALIRYGADV------ 170
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGADIraqdsl 168

                       170
                ....*....|....
gi 20532005 171 --DVNHHLTpdVQP 182
Cdd:cd22192 169 gnTVLHILV--LQP 180
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 297-335 5.18e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.48  E-value: 5.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20532005    297 RTLLCLCRVAVRRALGKhrlhlIPSLPLPDPIKKFLLHE 335
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 110-138 4.12e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 4.12e-04
                           10        20
                   ....*....|....*....|....*....
gi 20532005    110 KGQTALYVAVVNGHLESTQILLEAGADPN 138
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 99-315 8.66e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.22  E-value: 8.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005    99 RKGAE-----VDLVDVKGQTALYVAVV-NGHLESTQILLEagadpNGSRHHRSTPVYHASRVGRADILKALIRYGADVD- 171
Cdd:TIGR00870  35 RDLEEpkklnINCPDRLGRSALFVAAIeNENLELTELLLN-----LSCRGAVGDTLLHAISLEYVDAVEAILLHLLAAFr 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   172 --VNHHLTPDVQ-PRFSRRLTslvvcPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSpgcvmdavLRHG- 247
Cdd:TIGR00870 110 ksGPLELANDQYtSEFTPGIT-----ALHLAAHRQNYEIVKLLLERGASVPARACGDFFVKSQGVDS--------FYHGe 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20532005   248 -------CEA--AFVSLLVEFGANLNLVkwESLGPESRgrrkvdpEALQVFKEARSVPRTLLCLCRVAVRRALGKHR 315
Cdd:TIGR00870 177 splnaaaCLGspSIVALLSEDPADILTA--DSLGNTLL-------HLLVMENEFKAEYEELSCQMYNFALSLLDKLR 244
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-219 1.69e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.58  E-value: 1.69e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  38 DTRLHDAAYVGDLQTLRSLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYV 117
Cdd:COG0666  88 NTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 118 AVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV--NHHLTpdvqprfsrrltslvvcP 195
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT-----------------A 222

                       170       180
                ....*....|....*....|....
gi 20532005 196 LYISAAYHNLQCFRLLLLAGANPD 219
Cdd:COG0666 223 LDLAAENGNLEIVKLLLEAGADLN 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-214 6.35e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.26  E-value: 6.35e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  38 DTRLHDAAYVGDLQTLRSLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYV 117
Cdd:COG0666 121 ETPLHLAAYNGNLEIVKLLLE---AGADVNAQDND--GN---TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 118 AVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLY 197
Cdd:COG0666 193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272

                       170
                ....*....|....*..
gi 20532005 198 ISAAYHNLQCFRLLLLA 214
Cdd:COG0666 273 LALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
80-265 5.38e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 5.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADI 159
Cdd:COG0666  56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 160 LKALIRYGADVDVnhhltpdvqpRFSRRLTslvvcPLYISAAYHNLQCFRLLLLAGANpdfncngpVNTQGFYRGSPgcV 239
Cdd:COG0666 136 VKLLLEAGADVNA----------QDNDGNT-----PLHLAAANGNLEIVKLLLEAGAD--------VNARDNDGETP--L 190

                       170       180
                ....*....|....*....|....*.
gi 20532005 240 MDAVlRHGCEAAfVSLLVEFGANLNL 265
Cdd:COG0666 191 HLAA-ENGHLEI-VKLLLEAGADVNA 214
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 294-335 1.31e-19

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 80.54  E-value: 1.31e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 20532005 294 SVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03720   1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
82-173 5.85e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 5.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005    82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEaGADPNGSRHHRsTPVYHASRVGRADILK 161
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 20532005   162 ALIRYGADVDVN 173
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-138 3.24e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 3.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005    41 LHDAAYVGDLQTLRSLLQEESyrsriNEKSVWCCGWlpcTPLRIAATAGHGSCVDFLIRKgAEVDLVDvKGQTALYVAVV 120
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-----DANLQDKNGR---TALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAAR 70

                          90
                  ....*....|....*...
gi 20532005   121 NGHLESTQILLEAGADPN 138
Cdd:pfam12796  71 SGHLEIVKLLLEKGADIN 88
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 296-335 2.21e-15

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 69.06  E-value: 2.21e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03716   3 PRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
80-266 2.99e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 2.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADI 159
Cdd:COG0666  23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 160 LKALIRYGADVDVnhhltpdvqpRFSRRLTslvvcPLYISAAYHNLQCFRLLLLAGANpdfncngpVNTQGFYRGSPgcV 239
Cdd:COG0666 103 VKLLLEAGADVNA----------RDKDGET-----PLHLAAYNGNLEIVKLLLEAGAD--------VNAQDNDGNTP--L 157

                       170       180
                ....*....|....*....|....*..
gi 20532005 240 MDAVlRHGCEAAfVSLLVEFGANLNLV 266
Cdd:COG0666 158 HLAA-ANGNLEI-VKLLLEAGADVNAR 182
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 296-335 8.49e-14

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.80  E-value: 8.49e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
115-221 6.15e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 6.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   115 LYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTpdvqprfsrrltslvvc 194
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT----------------- 63

                          90       100
                  ....*....|....*....|....*..
gi 20532005   195 PLYISAAYHNLQCFRLLLLAGANPDFN 221
Cdd:pfam12796  64 ALHYAARSGHLEIVKLLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 94-275 8.90e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.67  E-value: 8.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   94 VDFLIRKGAEVDLVDV-KGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV 172
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  173 nhhltpdvqprfsrrLTSLVVCPLYISAAY-HNLQCFRLLLLAGANpdfncngpVNTQGFYRG-SPgcvMDAVLRhgcEA 250
Cdd:PHA02878 230 ---------------RDKCGNTPLHISVGYcKDYDILKLLLEHGVD--------VNAKSYILGlTA---LHSSIK---SE 280

                        170       180
                 ....*....|....*....|....*
gi 20532005  251 AFVSLLVEFGANLNLVKWESLGPES 275
Cdd:PHA02878 281 RKLKLLLEYGADINSLNSYKLTPLS 305
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 296-333 1.23e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.72  E-value: 1.23e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20532005   296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLL 333
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 80-175 6.98e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 60.27  E-value: 6.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQIL--LEAGADPngsrHHRSTPVYHASRVGRA 157
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDP----HAAGDLLCTAAKRNDL 635

                         90
                 ....*....|....*...
gi 20532005  158 DILKALIRYGADVDVNHH 175
Cdd:PLN03192 636 TAMKELLKQGLNVDSEDH 653
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 94-223 1.25e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.21  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   94 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVN 173
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 20532005  174 HHltpdvqprfsrrltsLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCN 223
Cdd:PHA02874 187 DN---------------NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCK 221
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 80-266 2.61e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.08  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVK-GQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  159 ILKALIRygadvdvnHHLTPDVQPRFSrrltslvVCPLYISAAYHNLQCFRLLLLAGANPDfncngpvntqgfYRGSPGC 238
Cdd:PHA02875 150 GIELLID--------HKACLDIEDCCG-------CTPLIIAMAKGDIAICKMLLDSGANID------------YFGKNGC 202

                        170       180       190
                 ....*....|....*....|....*....|.
gi 20532005  239 VmdAVLRHGCE---AAFVSLLVEFGANLNLV 266
Cdd:PHA02875 203 V--AALCYAIEnnkIDIVRLFIKRGADCNIM 231
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 86-166 5.42e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.22  E-value: 5.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   86 ATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIR 165
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169


                 .
gi 20532005  166 Y 166
Cdd:PTZ00322 170 H 170
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 94-172 6.36e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.98  E-value: 6.36e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20532005   94 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV 172
Cdd:PHA03100 175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 98-223 1.01e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 55.76  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   98 IRKGAEVDLVDVkgqtaLYVAVVNGHLESTQILLEAGADPN----GSRHHRSTPVYHASRVGRADILKALIRYGADVDvn 173
Cdd:PHA02884  25 IKKKNKICIANI-----LYSSIKFHYTDIIDAILKLGADPEapfpLSENSKTNPLIYAIDCDNDDAAKLLIRYGADVN-- 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 20532005  174 hhltpdvqpRFSRRLtslVVCPLYISAAYHNLQCFRLLLLAGANPDFNCN 223
Cdd:PHA02884  98 ---------RYAEEA---KITPLYISVLHGCLKCLEILLSYGADINIQTN 135
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 296-335 1.06e-08

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 50.34  E-value: 1.06e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03743   3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 296-335 1.24e-08

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 50.38  E-value: 1.24e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-273 2.28e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.45  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   28 FCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESyrSRINEKSVwccgwLPCTPLRIAATAGHGS-CVDFLIRKGAEVDL 106
Cdd:PHA02876 264 FSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERG--ADVNAKNI-----KGETPLYLMAKNGYDTeNIRTLIMLGADVNA 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  107 VDVKGQTALYVAVVNGHLESTQI-LLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVnhhltpdvqprFS 185
Cdd:PHA02876 337 ADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA-----------LS 405

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  186 RRLTSLVVCPLYISAAYHNLqcfRLLLLAGANpdfncngpVNTQGFYRGSPgcvMDAVLRHGCEAAFVSLLVEFGANLNL 265
Cdd:PHA02876 406 QKIGTALHFALCGTNPYMSV---KTLIDRGAN--------VNSKNKDLSTP---LHYACKKNCKLDVIEMLLDNGADVNA 471


                 ....*...
gi 20532005  266 VKWESLGP 273
Cdd:PHA02876 472 INIQNQYP 479
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 296-335 2.69e-08

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 49.36  E-value: 2.69e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03723   3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLE 42
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 296-335 7.61e-08

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 47.94  E-value: 7.61e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03721   3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 296-335 1.05e-07

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 47.67  E-value: 1.05e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 70-256 1.06e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.10  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   70 SVWCCGWLPCTPLriaATAGHGSC------VDFLIRKGAEVDLVDVKGQTALYVAVVNGH-LESTQILLEAGADPNGSRH 142
Cdd:PHA03095  39 DVNFRGEYGKTPL---HLYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDK 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  143 HRSTP--VYHASRVGRADILKALIRYGADV-DVNHHLtpdvqprfsrrLTSLVVcplYISAAYHNLQCFRLLLLAGANP- 218
Cdd:PHA03095 116 VGRTPlhVYLSGFNINPKVIRLLLRKGADVnALDLYG-----------MTPLAV---LLKSRNANVELLRLLIDAGADVy 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 20532005  219 --DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLL 256
Cdd:PHA03095 182 avDDRFRSLLHHHLQSFKPRARIVRELIRAGCDPAATDML 221
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 80-248 1.50e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.57  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHA-SRVGRAD 158
Cdd:PHA02878 170 TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYD 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  159 ILKALIRYGADVDVNHHLtpdvqprfsRRLTslvvcPLYISaaYHNLQCFRLLLLAGANPdfncngpvNTQGFYRGSPgc 238
Cdd:PHA02878 250 ILKLLLEHGVDVNAKSYI---------LGLT-----ALHSS--IKSERKLKLLLEYGADI--------NSLNSYKLTP-- 303

                        170
                 ....*....|
gi 20532005  239 VMDAVLRHGC 248
Cdd:PHA02878 304 LSSAVKQYLC 313
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 294-332 3.83e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 46.02  E-value: 3.83e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 20532005 294 SVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFL 332
Cdd:cd03724   1 ATPSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-182 4.86e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 4.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  38 DTRLHDAAYVGDLQTLRSLLqeESYRSRINEKsvwccGWLPCTPLRIAATAGHGSCVDFLIRkgAEVDLVDV-------K 110
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLL--KCPSCDLFQR-----GALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005 111 GQTALYVAVVNGHLESTQILLEAGADPNGSR--------------HHRSTPVYHASRVGRADILKALIRYGADV------ 170
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGADIraqdsl 168

                       170
                ....*....|....
gi 20532005 171 --DVNHHLTpdVQP 182
Cdd:cd22192 169 gnTVLHILV--LQP 180
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 297-335 5.18e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.48  E-value: 5.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20532005    297 RTLLCLCRVAVRRALGKhrlhlIPSLPLPDPIKKFLLHE 335
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 79-267 9.03e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 9.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   79 CTPLRIAATA--GHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGH--LESTQILLEAGADPNGsrhhrstpvyhasrv 154
Cdd:PHA03100 107 ITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINA--------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  155 grADILKALIRYGADVDVnhhltPDVqprfsRRLTslvvcPLYISAAYHNLQCFRLLLLAGANP-DFNCNGpvNTqgfyr 233
Cdd:PHA03100 172 --KNRVNYLLSYGVPINI-----KDV-----YGFT-----PLHYAVYNNNPEFVKYLLDLGANPnLVNKYG--DT----- 227

                        170       180       190
                 ....*....|....*....|....*....|....
gi 20532005  234 gspgCVMDAVLRhgCEAAFVSLLVEFGANLNLVK 267
Cdd:PHA03100 228 ----PLHIAILN--NNKEIFKLLLNNGPSIKTII 255
Ank_4 pfam13637
Ankyrin repeats (many copies);
80-131 1.19e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 1.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20532005    80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILL 131
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 296-335 2.33e-06

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 43.86  E-value: 2.33e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03719   3 PHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
22-108 9.44e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 9.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005    22 EWLREQFCD-HPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKsvwccgwlpcTPLRIAATAGHGSCVDFLIRK 100
Cdd:pfam12796  14 KLLLENGADaNLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR----------TALHYAARSGHLEIVKLLLEK 83


                  ....*...
gi 20532005   101 GAEVDLVD 108
Cdd:pfam12796  84 GADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 76-266 1.55e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.20  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGH-----LESTQILLEAGADPNGSRHHRSTPVYH 150
Cdd:PHA03100  33 KKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005  151 AS--RVGRADILKALIRYGADVDVNHhltpdvqprfSRRLTSLvvcPLYISAAYHNLQCFRLLLLAGANPD--------F 220
Cdd:PHA03100 113 AIskKSNSYSIVEYLLDNGANVNIKN----------SDGENLL---HLYLESNKIDLKILKLLIDKGVDINaknrvnylL 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 20532005  221 NCNGPVNTQGFYRGSPgcVMDAVLRHGCEaaFVSLLVEFGANLNLV 266
Cdd:PHA03100 180 SYGVPINIKDVYGFTP--LHYAVYNNNPE--FVKYLLDLGANPNLV 221
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 41-171 1.69e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSvwccgwlPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVV 120
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKD-------GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVM 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 20532005  121 NGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD 171
Cdd:PHA02875 145 MGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 294-334 2.35e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 40.92  E-value: 2.35e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 20532005 294 SVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLH 334
Cdd:cd03729   1 STPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 296-334 3.31e-05

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 40.54  E-value: 3.31e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLH 334
Cdd:cd03728   3 PPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLY 41
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 296-335 4.56e-05

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 40.22  E-value: 4.56e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
Cdd:cd03726   3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHK 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-164 5.82e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 5.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20532005   113 TALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALI 164
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 80-165 7.60e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 7.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   80 TPLRIAATagHGSC----VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVG 155
Cdd:PHA03095 224 TPLHSMAT--GSSCkrslVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNN 301

                         90
                 ....*....|
gi 20532005  156 RADILKALIR 165
Cdd:PHA03095 302 NGRAVRAALA 311
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 128-170 1.44e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 1.44e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 20532005  128 QILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADV 170
Cdd:PTZ00322  99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADP 141
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 39-138 1.64e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   39 TRLHDAAYVGDLQTLRSLLQeesYRSRINEKSvwCCGwlpCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQ-TALYV 117
Cdd:PHA02875 137 SPLHLAVMMGDIKGIELLID---HKACLDIED--CCG---CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCY 208

                         90       100
                 ....*....|....*....|.
gi 20532005  118 AVVNGHLESTQILLEAGADPN 138
Cdd:PHA02875 209 AIENNKIDIVRLFIKRGADCN 229
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-98 1.65e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20532005    37 EDTRLHDAAYVGDLQTLRSLLQeesYRSRINEksVWCCGWlpcTPLRIAATAGHGSCVDFLI 98
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE---KGADINA--VDGNGE---TALHFAASNGNVEVLKLLL 54
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 290-333 1.84e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 38.43  E-value: 1.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 20532005    290 KEARSVPRTLLCLCRVAVRRALgkhRLHLIPSLPLPDPIKKFLL 333
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCT---RTDQIKTLPLPPKLKDYLS 41
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 80-131 2.69e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 2.69e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 20532005   80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILL 131
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 80-178 3.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADI 159
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                         90       100
                 ....*....|....*....|.
gi 20532005  160 LKALIRYGADVDV--NHHLTP 178
Cdd:PHA02874 206 IKLLIDHGNHIMNkcKNGFTP 226
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 110-138 4.12e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 4.12e-04
                           10        20
                   ....*....|....*....|....*....
gi 20532005    110 KGQTALYVAVVNGHLESTQILLEAGADPN 138
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 124-172 6.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 6.13e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 20532005  124 LESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV 172
Cdd:PHA02876 158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI 206
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 294-333 8.22e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 36.42  E-value: 8.22e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20532005 294 SVPRTLLCLCRVAVRRALGKhrlHLIPSLPLPDPIKKFLL 333
Cdd:cd03717   1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLK 37
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 99-315 8.66e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.22  E-value: 8.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005    99 RKGAE-----VDLVDVKGQTALYVAVV-NGHLESTQILLEagadpNGSRHHRSTPVYHASRVGRADILKALIRYGADVD- 171
Cdd:TIGR00870  35 RDLEEpkklnINCPDRLGRSALFVAAIeNENLELTELLLN-----LSCRGAVGDTLLHAISLEYVDAVEAILLHLLAAFr 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   172 --VNHHLTPDVQ-PRFSRRLTslvvcPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSpgcvmdavLRHG- 247
Cdd:TIGR00870 110 ksGPLELANDQYtSEFTPGIT-----ALHLAAHRQNYEIVKLLLERGASVPARACGDFFVKSQGVDS--------FYHGe 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20532005   248 -------CEA--AFVSLLVEFGANLNLVkwESLGPESRgrrkvdpEALQVFKEARSVPRTLLCLCRVAVRRALGKHR 315
Cdd:TIGR00870 177 splnaaaCLGspSIVALLSEDPADILTA--DSLGNTLL-------HLLVMENEFKAEYEELSCQMYNFALSLLDKLR 244
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 297-333 9.60e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 36.24  E-value: 9.60e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 20532005 297 RTLLCLCRVAVRRalgKHRLHLIPSLPLPDPIKKFLL 333
Cdd:cd03740   4 RSLQYLCRFVIRQ---YTRIDLIQKLPLPNKMKGYLL 37
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 143-172 1.83e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 20532005    143 HRSTPVYHASRVGRADILKALIRYGADVDV 172
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 110-138 2.80e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.80e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 20532005   110 KGQTALYVAVV-NGHLESTQILLEAGADPN 138
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVN 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 94-171 3.28e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.27  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   94 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADI--LKALIRYGADVD 171
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIerINLLVQYGAKIN 134
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 294-335 3.28e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 35.11  E-value: 3.28e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 20532005 294 SVPRTLLCLCRVAVRRALGKHRLHL-IPSLPLPDPIKKFLLHE 335
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVkVKALPLPDRLKWYLLPE 43
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 296-335 5.11e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 34.82  E-value: 5.11e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 20532005 296 PRTLLCLCRVAVRRALGKHRLH---LIPSLPLPDPIKKFLLHE 335
Cdd:cd03730   3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 61-136 5.86e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.11  E-value: 5.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20532005   61 SYRSRINEKSVwcCGWlpcTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGAD 136
Cdd:PHA03100 180 SYGVPINIKDV--YGF---TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 110-170 6.06e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 38.32  E-value: 6.06e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20532005 110 KGQTALYVAVVNGHLESTQILLEAGAD----PNGSRHHRST---------PVYHASRVGRADILKALIRYGADV 170
Cdd:cd21882  72 QGQTALHIAIENRNLNLVRLLVENGADvsarATGRFFRKSPgnlfyfgelPLSLAACTNQEEIVRLLLENGAQP 145
Ank_5 pfam13857
Ankyrin repeats (many copies);
97-151 6.11e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 6.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 20532005    97 LIRKG-AEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHA 151
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 79-108 7.42e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 7.42e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 20532005    79 CTPLRIAAT-AGHGSCVDFLIRKGAEVDLVD 108
Cdd:pfam00023   3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 39-151 8.86e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 37.64  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20532005   39 TRLHDAAYVGDLQTLRSLLQeesYRSRINEKSVwccgwLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVA 118
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFE---YGADVNIEDD-----NGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNA 197

                         90       100       110
                 ....*....|....*....|....*....|...
gi 20532005  119 VVNGHLESTQILLEAGADPNGSRHHRSTPVYHA 151
Cdd:PHA02874 198 AEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 110-138 9.68e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 9.68e-03
                          10        20
                  ....*....|....*....|....*....
gi 20532005   110 KGQTALYVAVVNGHLESTQILLEAGADPN 138
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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