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Conserved domains on  [gi|1587354739|gb|QBK56599|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Orotettix colcaensis]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 2-143 1.52e-38

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 133.02  E-value: 1.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   2 LMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSMSWENelvPS 81
Cdd:MTH00160   14 LIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNNI---SS 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1587354739  82 MMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLSYCIQLSTFMFTITI 143
Cdd:MTH00160   91 MLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIIL 152
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 2-143 1.52e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 133.02  E-value: 1.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   2 LMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSMSWENelvPS 81
Cdd:MTH00160   14 LIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNNI---SS 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1587354739  82 MMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLSYCIQLSTFMFTITI 143
Cdd:MTH00160   91 MLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIIL 152
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 12-128 8.90e-08

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 49.62  E-value: 8.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739  12 SNSWFGVWMGLEINLLSFIPKLA-NNKNMMMNESSIKYFIVQAMASTMLLFSILLI--------------QMKYSMSWEN 76
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1587354739  77 ELVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMN-CLMLMTWQKIAPMMVL 128
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLI 133
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 42-104 3.57e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 42.03  E-value: 3.57e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1587354739  42 NESSIKYFIVQAMASTMLLF----------SILLIQMKYSMSWENELVPSM-----MISSSLL*KIGAAPFHFWFPEV 104
Cdd:COG1007   152 SEAALKYFLLGALSSGFLLYgisllygatgSLNLAGIAAALAAGGANSPLLllglvLVLAGLAFKLSAVPFHMWTPDV 229
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 5-104 4.87e-04

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 38.78  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   5 GTYLSISSNSWFGVWMGLEI-NLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQ-----------MKYSM 72
Cdd:TIGR01770 114 GIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYgftgslnfedlLLFLS 193

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1587354739  73 SWENE----LVPSMMISSSLL*KIGAAPFHFWFPEV 104
Cdd:TIGR01770 194 NGMLNisllLLGIVLILVGLLFKLSAVPFHMWVPDV 229
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 2-143 1.52e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 133.02  E-value: 1.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   2 LMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSMSWENelvPS 81
Cdd:MTH00160   14 LIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNNI---SS 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1587354739  82 MMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLSYCIQLSTFMFTITI 143
Cdd:MTH00160   91 MLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIIL 152
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-143 6.85e-30

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 110.41  E-value: 6.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSIlLIQMKYSMSW----EN 76
Cdd:MTH00041   12 SIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGA-LIQAWLSGSWsingPL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587354739  77 ELVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLSYCIQLSTFMFTITI 143
Cdd:MTH00041   91 NTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILC 157
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-128 3.06e-27

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 103.36  E-value: 3.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSmSWE----N 76
Cdd:MTH00112   12 SLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTG-QWDitqlT 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1587354739  77 ELVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVL 128
Cdd:MTH00112   91 NPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLL 142
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-128 1.28e-26

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 101.85  E-value: 1.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSIlLIQMKYSMSW----EN 76
Cdd:MTH00105   12 TLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAI-IINLMYSGQWtitkLT 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1587354739  77 ELVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVL 128
Cdd:MTH00105   91 NPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSIL 142
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-128 1.05e-24

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 96.53  E-value: 1.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILL---IQMKYSMSWENE 77
Cdd:MTH00070   12 SLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTInawFTGEWTIMNMQT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1587354739  78 LVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVL 128
Cdd:MTH00070   92 PLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALL 142
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 2-145 1.81e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 93.03  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   2 LMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSMSWEnelvpS 81
Cdd:MTH00144   13 MVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS-----M 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1587354739  82 MMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLSYCIQLSTFMFTITILS 145
Cdd:MTH00144   88 SLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVIS 151
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 1-145 1.92e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 87.42  E-value: 1.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSMSweneLVP 80
Cdd:MTH00197    6 IIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYLS----LLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1587354739  81 SMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLSYCIQLSTFMFTITILS 145
Cdd:MTH00197   82 VVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLS 146
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-144 3.75e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 87.17  E-value: 3.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILL---IQMKYSMSWENE 77
Cdd:MTH00135   12 SLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTnawLTGQWDIQQMSH 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587354739  78 LVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLsycIQLSTFMFTITIL 144
Cdd:MTH00135   92 PLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALI---LQIAPTNPTLLIT 155
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-128 1.09e-20

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 85.60  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSMSwenELVP 80
Cdd:MTH00011   14 TMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSLL---KNIT 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1587354739  81 SMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVL 128
Cdd:MTH00011   91 ALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSIL 138
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-145 2.54e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 84.64  E-value: 2.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   1 SLMMGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYSMSWENELVP 80
Cdd:MTH00200   12 SLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWGISEMLG 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739  81 SM---MISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVLS--YCIQLSTFMFTITILS 145
Cdd:MTH00200   92 PLsetLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIqlAPALNSNILLLLGLLS 161
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 4-115 1.27e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 51.95  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   4 MGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMN-ESSIKYFIVQAMASTMLLFSI----------------LLI 66
Cdd:MTH00196    4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSGYSaEAGLKYFVLGALSSGLFLFGCallcgttgglhlsyinLVL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1587354739  67 QMKYSMSWENELVPSMMISSSLL*KIGAAPFHFWFPEVM-GASSWMNCLM 115
Cdd:MTH00196   84 NSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYeGAPTKTTALL 133
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 4-128 8.86e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 49.63  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   4 MGTYLSISSNSWFGVWMGLEINLLSFIPKLANNKNMMMN-ESSIKYFIVQAMASTMLLFSILLIqmkYSMSWE------- 75
Cdd:MTH00199  108 LGSLLLVSSINWLSIYLAIELQTLTLFILVALKRDSAYStEAGLKYFVLGAVSSGLFLFGCALL---YGLTGEtsiqgin 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587354739  76 ---NELVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMNCLMLMTWQKIAPMMVL 128
Cdd:MTH00199  185 silTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSIL 240
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 12-128 8.90e-08

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 49.62  E-value: 8.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739  12 SNSWFGVWMGLEINLLSFIPKLA-NNKNMMMNESSIKYFIVQAMASTMLLFSILLI--------------QMKYSMSWEN 76
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1587354739  77 ELVPSMMISSSLL*KIGAAPFHFWFPEVMGASSWMN-CLMLMTWQKIAPMMVL 128
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLI 133
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
10-104 1.43e-06

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 46.35  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739  10 ISSNSWFGVWMGLEI-NLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLI--------------QMKYSMSW 74
Cdd:PRK05777  120 VSANDLLTLFLGLELlSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLygatgslsfagiakALADGSGN 199

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1587354739  75 ENELVPSM-MISSSLL*KIGAAPFHFWFPEV 104
Cdd:PRK05777  200 SLLLLFGLvFLLVGLAFKLSAVPFHMWTPDV 230
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 42-104 3.57e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 42.03  E-value: 3.57e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1587354739  42 NESSIKYFIVQAMASTMLLF----------SILLIQMKYSMSWENELVPSM-----MISSSLL*KIGAAPFHFWFPEV 104
Cdd:COG1007   152 SEAALKYFLLGALSSGFLLYgisllygatgSLNLAGIAAALAAGGANSPLLllglvLVLAGLAFKLSAVPFHMWTPDV 229
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 5-104 4.87e-04

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 38.78  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739   5 GTYLSISSNSWFGVWMGLEI-NLLSFIPKLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQ-----------MKYSM 72
Cdd:TIGR01770 114 GIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYgftgslnfedlLLFLS 193

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1587354739  73 SWENE----LVPSMMISSSLL*KIGAAPFHFWFPEV 104
Cdd:TIGR01770 194 NGMLNisllLLGIVLILVGLLFKLSAVPFHMWVPDV 229
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 43-116 1.57e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 37.38  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587354739  43 ESSIKYFIVQAMASTMLLFSILL--------------IQMKYSMSWENELVPSMMISSsLL*KIGAAPFHFWFPEVMGAS 108
Cdd:PRK08376  172 EAGIKYMFVGSLASSMVLLGIALlygqygtlnmaylaVKMSENPTVVAKIALALFIAG-LAMKSGAVPVHMWLPDAYPAA 250


                  ....*....
gi 1587354739 109 -SWMNCLML 116
Cdd:PRK08376  251 pSSISAMLL 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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