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Conserved domains on  [gi|1707765489|gb|QDP18067|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Ochrophlegma sp. TAMUIC IGC OR279]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-336 7.60e-48

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 163.84  E-value: 7.60e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   1 MNLMKILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMILTKF 80
Cdd:MTH00160    3 MNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  81 SMNwekSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFsLMVVILSITIGA 160
Cdd:MTH00160   83 MLF---NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFI-IIIIILSAIIGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489 161 MGGLNQTS************************************************************************ 240
Cdd:MTH00160  159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489 241 ********-****************************VLTCITLYYYLRLSFSSIVLTNNELSWSTDIKMWKFKMIVPIT 319
Cdd:MTH00160  239 NLLSLGGLpPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                         330
                  ....*....|....*..
gi 1707765489 320 VMISSLGLMFSTSLTSY 336
Cdd:MTH00160  319 SFISLFGLILSSLLFLL 335
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-336 7.60e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 163.84  E-value: 7.60e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   1 MNLMKILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMILTKF 80
Cdd:MTH00160    3 MNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  81 SMNwekSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFsLMVVILSITIGA 160
Cdd:MTH00160   83 MLF---NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFI-IIIIILSAIIGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489 161 MGGLNQTS************************************************************************ 240
Cdd:MTH00160  159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489 241 ********-****************************VLTCITLYYYLRLSFSSIVLTNNELSWSTDIKMWKFKMIVPIT 319
Cdd:MTH00160  239 NLLSLGGLpPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                         330
                  ....*....|....*..
gi 1707765489 320 VMISSLGLMFSTSLTSY 336
Cdd:MTH00160  319 SFISLFGLILSSLLFLL 335
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 22-168 1.46e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 61.18  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  22 SNSWFGVWMGLEINLLSFIPLM-VNDKNLMINESSIKYFIVQAMASTMLLFSILMILT--------------KFSMNWEK 86
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNytgtlsfdelskalTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  87 SMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMN-CFILMTWQKIAPMLVM-------SYCISTNLFSLMVVILSITI 158
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170
                  ....*....|
gi 1707765489 159 GAMGGLNQTS 168
Cdd:pfam00361 161 GSLAALVQTD 170
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-114 4.61e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 44.72  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   6 ILFLSSLMmGSFISISSNSWFGVWMGLEinLLSfIPLMV----NDKNLMINESSIKYFIVQAMASTMLLFSILM------ 75
Cdd:COG1007   106 ALLLFATL-GMMLMASANDLLTLFLGLE--LLS-LSLYVlvafRRDDRRSSEAALKYFLLGALSSGFLLYGISLlygatg 181

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1707765489  76 ------ILTKFSMNWEKS---MISSMMINSSLLIKIGATPFHFWFPEV 114
Cdd:COG1007   182 slnlagIAAALAAGGANSpllLLGLVLVLAGLAFKLSAVPFHMWTPDV 229
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-168 4.72e-04

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 41.86  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   6 ILFLSSLMmGSFISISSNSWFGVWMGLEINLLSFIPLM-VNDKNLMINESSIKYFIVQAMASTMLLFSILMI-------- 76
Cdd:TIGR01770 106 ILLLFALL-GIFLLVSSNDLLSIYLGLELQSLCFYVLAgLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  77 ---LTKFSMNWEKS----MISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAP----MLVMSYCIST- 144
Cdd:TIGR01770 185 fedLLLFLSNGMLNisllLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIfavfLRLFLYILFGf 264

                         170       180
                  ....*....|....*....|....*...
gi 1707765489 145 ----NLFSLMVVILSITIGAMGGLNQTS 168
Cdd:TIGR01770 265 seawQIFLAIIAFLSMLIGNFGALAQKK 292
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-336 7.60e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 163.84  E-value: 7.60e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   1 MNLMKILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMILTKF 80
Cdd:MTH00160    3 MNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  81 SMNwekSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFsLMVVILSITIGA 160
Cdd:MTH00160   83 MLF---NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFI-IIIIILSAIIGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489 161 MGGLNQTS************************************************************************ 240
Cdd:MTH00160  159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489 241 ********-****************************VLTCITLYYYLRLSFSSIVLTNNELSWSTDIKMWKFKMIVPIT 319
Cdd:MTH00160  239 NLLSLGGLpPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                         330
                  ....*....|....*..
gi 1707765489 320 VMISSLGLMFSTSLTSY 336
Cdd:MTH00160  319 SFISLFGLILSSLLFLL 335
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-167 1.74e-32

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 123.78  E-value: 1.74e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   1 MNLM-KILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSIlMILTK 79
Cdd:MTH00112    1 MNPHaKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSS-TTNAW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  80 FSMNWEKSM----ISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPM---LVMSYCISTNLFSLMvV 152
Cdd:MTH00112   80 NTGQWDITQltnpTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLtllLMTSNSLNPTLLLTL-A 158

                         170
                  ....*....|....*
gi 1707765489 153 ILSITIGAMGGLNQT 167
Cdd:MTH00112  159 ILSTLIGGWGGLNQT 173
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 6-167 1.97e-30

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 118.02  E-value: 1.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   6 ILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSI---LMILTKFSM 82
Cdd:MTH00105    7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIiinLMYSGQWTI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  83 NWEKSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVM---SYCISTNLFsLMVVILSITIG 159
Cdd:MTH00105   87 TKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqiSPSINPNLL-LTLAILSILIG 165


                  ....*...
gi 1707765489 160 AMGGLNQT 167
Cdd:MTH00105  166 GWGGLNQT 173
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 6-168 4.55e-30

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 117.34  E-value: 4.55e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   6 ILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSIL---MILTKFSM 82
Cdd:MTH00041    7 IFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALiqaWLSGSWSI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  83 NWEKSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFSLMVV--ILSITIGA 160
Cdd:MTH00041   87 NGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILcgILSVLVGG 166


                  ....*...
gi 1707765489 161 MGGLNQTS 168
Cdd:MTH00041  167 WGGLNQTQ 174
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 8-167 7.88e-29

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 113.86  E-value: 7.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   8 FLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILM---ILTKFSMNW 84
Cdd:MTH00070    9 LLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTInawFTGEWTIMN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  85 EKSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPM---LVMSYCISTNLFSLMvVILSITIGAM 161
Cdd:MTH00070   89 MQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMallIQISHLLNSNLLIIM-GLLSTLIGGW 167


                  ....*.
gi 1707765489 162 GGLNQT 167
Cdd:MTH00070  168 GGLNQT 173
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-168 1.52e-26

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 107.28  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   1 MNLMKILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMiltkf 80
Cdd:MTH00144    2 SSPSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLI----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  81 SMNWEKSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFSLMVVILSI---T 157
Cdd:MTH00144   77 MYNLSFSWFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVISVlsaL 156

                         170
                  ....*....|.
gi 1707765489 158 IGAMGGLNQTS 168
Cdd:MTH00144  157 VGSIGGLNQTQ 167
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 7-167 4.94e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 103.35  E-value: 4.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   7 LFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILM---ILTKFSMN 83
Cdd:MTH00135    8 ILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTnawLTGQWDIQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  84 WEKSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMsYCISTNLFSLMVV--ILSITIGAM 161
Cdd:MTH00135   88 QMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALI-LQIAPTNPTLLITlgLTSTLVGGW 166


                  ....*.
gi 1707765489 162 GGLNQT 167
Cdd:MTH00135  167 GGLNQT 172
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 7-168 4.22e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 97.44  E-value: 4.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   7 LFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMILtkfsMNWEK 86
Cdd:MTH00197    2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSF----SNLYL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  87 SMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFSLMVVILSITIGAMGGLNQ 166
Cdd:MTH00197   78 SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQ 157


                  ..
gi 1707765489 167 TS 168
Cdd:MTH00197  158 SN 159
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 7-167 3.61e-22

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 95.23  E-value: 3.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   7 LFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMILTKFSMnweK 86
Cdd:MTH00011   10 LFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSL---L 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  87 SMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFSLMVVI--LSITIGAMGGL 164
Cdd:MTH00011   87 KNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMaaMSALAGGLGGM 166


                  ...
gi 1707765489 165 NQT 167
Cdd:MTH00011  167 NQT 169
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 3-167 6.85e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 94.65  E-value: 6.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   3 LMKILFLSSLMMGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMILT---K 79
Cdd:MTH00200    4 LILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWtsgQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  80 FSMNWEKSMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAP--MLVMSYCISTNLFSLMVVILSIT 157
Cdd:MTH00200   84 WGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPfaLLIQLAPALNSNILLLLGLLSVL 163

                         170
                  ....*....|
gi 1707765489 158 IGAMGGLNQT 167
Cdd:MTH00200  164 VGGWGGLNQT 173
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 22-168 1.46e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 61.18  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  22 SNSWFGVWMGLEINLLSFIPLM-VNDKNLMINESSIKYFIVQAMASTMLLFSILMILT--------------KFSMNWEK 86
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNytgtlsfdelskalTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  87 SMISSMMINSSLLIKIGATPFHFWFPEVMKASSWMN-CFILMTWQKIAPMLVM-------SYCISTNLFSLMVVILSITI 158
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170
                  ....*....|
gi 1707765489 159 GAMGGLNQTS 168
Cdd:pfam00361 161 GSLAALVQTD 170
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 14-167 8.27e-10

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 59.27  E-value: 8.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  14 MGSFISISSNSWFGVWMGLEINLLSFIPLMVNDKN-LMINESSIKYFIVQAMASTMLLFSILMI----------LTKFSM 82
Cdd:MTH00196    4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGsGYSAEAGLKYFVLGALSSGLFLFGCALLcgttgglhlsYINLVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  83 NWEKSM------ISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFSLMVVILSI 156
Cdd:MTH00196   84 NSGQSFssvsvpIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSL 163

                         170
                  ....*....|.
gi 1707765489 157 TIGAMGGLNQT 167
Cdd:MTH00196  164 FVGAIGALNQT 174
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 14-168 2.68e-09

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 58.10  E-value: 2.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  14 MGSFISISSNSWFGVWMGLEINLLS-FIPLMVNDKNLMINESSIKYFIVQAMASTMLLF------------SILMILTKF 80
Cdd:MTH00199  108 LGSLLLVSSINWLSIYLAIELQTLTlFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFgcallygltgetSIQGINSIL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  81 SMNWEKSMISSmminsSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLFSLMVVILSITIGA 160
Cdd:MTH00199  188 TGDVGKILITI-----SLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSIIYGA 262


                  ....*...
gi 1707765489 161 MGGLNQTS 168
Cdd:MTH00199  263 IGALNQTK 270
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 14-167 1.72e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 49.47  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  14 MGSFISISSNSWFGVWMGLEINLLSFIPL---------MVNDKNLMINESSIKYFIVQAMASTMLLFSIL---------- 74
Cdd:MTH00198  199 LGGLLLIESANWLTIYLALEFQTLALFILagegsqpgsHFPSPGNTPPESGLKYWILGAMSSGFYLFGCAlyfgftgneg 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  75 MILTKFSMNWEKSMIS-------SMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAPMLVMSYCISTNLF 147
Cdd:MTH00198  279 MLGTILSATLETTNIElrqgslgYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKL 358

                         170       180
                  ....*....|....*....|
gi 1707765489 148 SLMVVILSITIGAMGGLNQT 167
Cdd:MTH00198  359 LLSVAIISLVVGAFGALNQT 378
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
6-114 1.91e-05

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 45.97  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   6 ILFLSSLMmGSFISISSNSWFGVWMGLEI-NLLSFIPLMVNDKNLMINESSIKYFIVQAMASTMLLFSILMI-------- 76
Cdd:PRK05777  107 LLVLFALL-GMMVMVSANDLLTLFLGLELlSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLygatgsls 185

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1707765489  77 LTKFSMNWEKSMISSM-------MINSSLLIKIGATPFHFWFPEV 114
Cdd:PRK05777  186 FAGIAKALADGSGNSLlllfglvFLLVGLAFKLSAVPFHMWTPDV 230
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-114 4.61e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 44.72  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   6 ILFLSSLMmGSFISISSNSWFGVWMGLEinLLSfIPLMV----NDKNLMINESSIKYFIVQAMASTMLLFSILM------ 75
Cdd:COG1007   106 ALLLFATL-GMMLMASANDLLTLFLGLE--LLS-LSLYVlvafRRDDRRSSEAALKYFLLGALSSGFLLYGISLlygatg 181

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1707765489  76 ------ILTKFSMNWEKS---MISSMMINSSLLIKIGATPFHFWFPEV 114
Cdd:COG1007   182 slnlagIAAALAAGGANSpllLLGLVLVLAGLAFKLSAVPFHMWTPDV 229
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-168 4.72e-04

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 41.86  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489   6 ILFLSSLMmGSFISISSNSWFGVWMGLEINLLSFIPLM-VNDKNLMINESSIKYFIVQAMASTMLLFSILMI-------- 76
Cdd:TIGR01770 106 ILLLFALL-GIFLLVSSNDLLSIYLGLELQSLCFYVLAgLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707765489  77 ---LTKFSMNWEKS----MISSMMINSSLLIKIGATPFHFWFPEVMKASSWMNCFILMTWQKIAP----MLVMSYCIST- 144
Cdd:TIGR01770 185 fedLLLFLSNGMLNisllLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIfavfLRLFLYILFGf 264

                         170       180
                  ....*....|....*....|....*...
gi 1707765489 145 ----NLFSLMVVILSITIGAMGGLNQTS 168
Cdd:TIGR01770 265 seawQIFLAIIAFLSMLIGNFGALAQKK 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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