NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1717984549|gb|QDY92289|]
View 

helicase-primase primase subunit [Alcelaphine gammaherpesvirus 1]

Protein Classification

PHA03142 family protein( domain architecture ID 11476172)

PHA03142 family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA03142 PHA03142
helicase-primase primase subunit BSLF1; Provisional
 1-837 0e+00

helicase-primase primase subunit BSLF1; Provisional


:

Pssm-ID: 222999  Cd Length: 835  Bit Score: 1413.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549   1 MTRVVKALFAADTDCAELLADILTGQNNSGSLYCLLHNCRPEDVSWEVTRLSLCLPVRRPGGAEgRCAEVFKIKLPTEEA 80
Cdd:PHA03142    3 APPVVKALFATDGDCAEAIADILTGTPTSGFFFCVLHNCFSYPILGEEVSLSLCLPAKRPGGGE-RCLEVFQLRLPAEEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  81 GQFLFNCGSLSAKQVYESYSKRAAYETFQPILEVLGLSGD----EYSIKNAVTWGRGKFVASLRKYFKLTTSPHWFINTF 156
Cdd:PHA03142   82 LPFLFGGKPLTADDIQTYLDRAAALKSFKPILELLTLSGKkqqpQGDFKSKVAWFRAKFVNALRKLYKMTPSPYWMISTF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 157 GAFENHFVLVSSCYYFFPvSVSTVDTLCHLAMLYSSKKGCPLSSITTLRELGAVATQSPALDRVENFYLYVCDKLARDTL 236
Cdd:PHA03142  162 GSFEAQFVLVSAFYFFEK-HECTVETLSHLARLFSPKQGQSLAAVTTLAELGEVFGTSPWLDRVPAFAAYVKEKLARDSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 237 ECEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCFNNQKFLAYSQCTNPCNLNTTMLREPMLVANIDSDFKHKMATYYNK 316
Cdd:PHA03142  241 ESEAIDRTINEFRGQLMLSNQDLVHYIYLSFFQCFNKQTFLRYSRLTSPDNINTLPPEGPILTRLLDEEFKEKMATYYNK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 317 NTYLSNYVLLRGIHLHPVVGYGQECLRSAHAtgghSIWWGESHQVSDMLKTINVEYPDICLHEEFRGLMDLAAITDRCSI 396
Cdd:PHA03142  321 STYLSTHVRIRSVKLPGPYGYDPDPCDGLLR----AYWAGQSRDVAALLKEINVWHPHLCLPEELQGLLDLAALDTSSGV 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 397 FGNPIHYLTDCATSgaIPIYRSELSHRHYFLAVFSDDIEYFWKKTIFLPPESFCLGAQDTMLTRAITYTEMHCSMSSVAE 476
Cdd:PHA03142  397 WGNPKDFLFPEALR--LPVYRCEFLNKHYFVMVAADNLEAYWKKHVLLPTDSNWCGLPDTRLTRAITYTELYYSLNTLKE 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 477 QIHVSRHEYFNPKLPVFNWVLDLDLPISEGNLHIDSIYSLCLLIRESVLDILKLLGPVEPDHEVFFFKSACINLCdpGEA 556
Cdd:PHA03142  475 QLLVSRHEYFNPRLPVFNLVLDLDLPIKEPGRTLEEIYNLCLTLRESILDVLQLLGPVEPDHPVYFFKSACPPPE--EDN 552

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 557 SWRPSTFCTCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRVIKLGCGSLLNLSAFQLSNGPFDVGIYGRGRSIRLPH 636
Cdd:PHA03142  553 MEDPLPFCTCTKKLGLRIITPLPRGVAIVGSEPLISLVKILNRTIKLDKRLREMYPKIQETEGPFDVGIYHRGRCIRLPH 632

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 637 TYKVGKCGQLERLLKLFVCHPEATDKFPYLQNSLKLNRLLHHAQSQDPRGPLKIIYRVEDINEDFLYKHTQKQLPVKHEA 716
Cdd:PHA03142  633 TYKVGSGGGLERLLKLFVCHPEEPDKRSYVKNALNLQNLLHHSLSVGWPGPLKFVYHIEDINEDFLSQKTQEQLPRTSEN 712

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 717 VIPSIERLLDTSLNCFLLSKVWPKCFGTIRSYMSEEKLQQFSRVVFHPTNHCIVQVRPDRGNNFKCLRYNHRGSSKSVRV 796
Cdd:PHA03142  713 VAEKIETLTGLDLTDWVLSKVWPKLFDTIKSYFPEDKLQQFLHVTFEQTGHNIVQVKPLRGNNFSCLRHNHRNKSKSVRV 792

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|.
gi 1717984549 797 FLILHLKEETKLIVTFMSQCFANKCQSNKAMAHFSVFVDLS 837
Cdd:PHA03142  793 FLVLHLTSEDEVTVTFMSQCFANKCNSNKPTAHFSVSVPIS 833
 
Name Accession Description Interval E-value
PHA03142 PHA03142
helicase-primase primase subunit BSLF1; Provisional
 1-837 0e+00

helicase-primase primase subunit BSLF1; Provisional


Pssm-ID: 222999  Cd Length: 835  Bit Score: 1413.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549   1 MTRVVKALFAADTDCAELLADILTGQNNSGSLYCLLHNCRPEDVSWEVTRLSLCLPVRRPGGAEgRCAEVFKIKLPTEEA 80
Cdd:PHA03142    3 APPVVKALFATDGDCAEAIADILTGTPTSGFFFCVLHNCFSYPILGEEVSLSLCLPAKRPGGGE-RCLEVFQLRLPAEEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  81 GQFLFNCGSLSAKQVYESYSKRAAYETFQPILEVLGLSGD----EYSIKNAVTWGRGKFVASLRKYFKLTTSPHWFINTF 156
Cdd:PHA03142   82 LPFLFGGKPLTADDIQTYLDRAAALKSFKPILELLTLSGKkqqpQGDFKSKVAWFRAKFVNALRKLYKMTPSPYWMISTF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 157 GAFENHFVLVSSCYYFFPvSVSTVDTLCHLAMLYSSKKGCPLSSITTLRELGAVATQSPALDRVENFYLYVCDKLARDTL 236
Cdd:PHA03142  162 GSFEAQFVLVSAFYFFEK-HECTVETLSHLARLFSPKQGQSLAAVTTLAELGEVFGTSPWLDRVPAFAAYVKEKLARDSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 237 ECEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCFNNQKFLAYSQCTNPCNLNTTMLREPMLVANIDSDFKHKMATYYNK 316
Cdd:PHA03142  241 ESEAIDRTINEFRGQLMLSNQDLVHYIYLSFFQCFNKQTFLRYSRLTSPDNINTLPPEGPILTRLLDEEFKEKMATYYNK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 317 NTYLSNYVLLRGIHLHPVVGYGQECLRSAHAtgghSIWWGESHQVSDMLKTINVEYPDICLHEEFRGLMDLAAITDRCSI 396
Cdd:PHA03142  321 STYLSTHVRIRSVKLPGPYGYDPDPCDGLLR----AYWAGQSRDVAALLKEINVWHPHLCLPEELQGLLDLAALDTSSGV 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 397 FGNPIHYLTDCATSgaIPIYRSELSHRHYFLAVFSDDIEYFWKKTIFLPPESFCLGAQDTMLTRAITYTEMHCSMSSVAE 476
Cdd:PHA03142  397 WGNPKDFLFPEALR--LPVYRCEFLNKHYFVMVAADNLEAYWKKHVLLPTDSNWCGLPDTRLTRAITYTELYYSLNTLKE 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 477 QIHVSRHEYFNPKLPVFNWVLDLDLPISEGNLHIDSIYSLCLLIRESVLDILKLLGPVEPDHEVFFFKSACINLCdpGEA 556
Cdd:PHA03142  475 QLLVSRHEYFNPRLPVFNLVLDLDLPIKEPGRTLEEIYNLCLTLRESILDVLQLLGPVEPDHPVYFFKSACPPPE--EDN 552

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 557 SWRPSTFCTCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRVIKLGCGSLLNLSAFQLSNGPFDVGIYGRGRSIRLPH 636
Cdd:PHA03142  553 MEDPLPFCTCTKKLGLRIITPLPRGVAIVGSEPLISLVKILNRTIKLDKRLREMYPKIQETEGPFDVGIYHRGRCIRLPH 632

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 637 TYKVGKCGQLERLLKLFVCHPEATDKFPYLQNSLKLNRLLHHAQSQDPRGPLKIIYRVEDINEDFLYKHTQKQLPVKHEA 716
Cdd:PHA03142  633 TYKVGSGGGLERLLKLFVCHPEEPDKRSYVKNALNLQNLLHHSLSVGWPGPLKFVYHIEDINEDFLSQKTQEQLPRTSEN 712

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 717 VIPSIERLLDTSLNCFLLSKVWPKCFGTIRSYMSEEKLQQFSRVVFHPTNHCIVQVRPDRGNNFKCLRYNHRGSSKSVRV 796
Cdd:PHA03142  713 VAEKIETLTGLDLTDWVLSKVWPKLFDTIKSYFPEDKLQQFLHVTFEQTGHNIVQVKPLRGNNFSCLRHNHRNKSKSVRV 792

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|.
gi 1717984549 797 FLILHLKEETKLIVTFMSQCFANKCQSNKAMAHFSVFVDLS 837
Cdd:PHA03142  793 FLVLHLTSEDEVTVTFMSQCFANKCNSNKPTAHFSVSVPIS 833
Herpes_UL52 pfam03121
Herpesviridae UL52/UL70 DNA primase; Herpes simplex virus type 1 DNA replication in host cells ...
 761-835 6.48e-24

Herpesviridae UL52/UL70 DNA primase; Herpes simplex virus type 1 DNA replication in host cells is known to be mediated by seven viral-encoded proteins, three of which form a heterotrimeric DNA helicase-primase complex. This complex consists of UL5, UL8, and UL52 subunits. Heterodimers consisting of UL5 and UL52 have been shown to retain both helicase and primase activities. Nevertheless, UL8 is still essential for replication: though it lacks any DNA binding or catalytic activities, it is involved in the transport of UL5-UL52 and it also interacts with other replication proteins. The molecular mechanisms of the UL5-UL52 catalytic activities are not known. While UL5 is associated with DNA helicase activity and UL52 with DNA primase activity, the helicase activity requires the interaction of UL5 and UL52. It is not known if the primase activity can be maintained by UL52 alone. The region encompassed by residues 610-636 of HSV1 UL52 is thought to contain a divalent metal cation binding motif. Indeed, this region contains several aspartate and glutamate residues that might be involved in divalent cation binding. The biological significance of UL52-UL8 interaction is not known. Yeast two-hybrid analysis together with immunoprecipitation experiments have shown that the HSV1 UL52 region between residues 366-914 is essential for this interaction, while the first 349 N-terminal residues are dispensable. This family also includes protein UL70 from cytomegalovirus (CMV, a subgroup of the Herpesviridae) strains, which, by analogy with UL52, is thought to have DNA primase activity. Indeed, CMV strains also possess a DNA helicase-primase complex, the other subunits being protein UL105 (with known similarity to HSV1 UL5) and protein UL102.


Pssm-ID: 367342 [Multi-domain]  Cd Length: 75  Bit Score: 95.95  E-value: 6.48e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1717984549 761 VFHPTNHCIVQVRP-DRGNNFKCLRYNHRGSSKSVRVFLILHLKEETkLIVTFMSQCFANKCQSNKAMAHFSVFVD 835
Cdd:pfam03121   1 VFSKEGLNLVQVKRsRRGRNFSCLNIGHRHKSNNVRVFLDLRVDGHG-LCVTLYQKCFAPKCGSNYRSTHFSVPVD 75
 
Name Accession Description Interval E-value
PHA03142 PHA03142
helicase-primase primase subunit BSLF1; Provisional
 1-837 0e+00

helicase-primase primase subunit BSLF1; Provisional


Pssm-ID: 222999  Cd Length: 835  Bit Score: 1413.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549   1 MTRVVKALFAADTDCAELLADILTGQNNSGSLYCLLHNCRPEDVSWEVTRLSLCLPVRRPGGAEgRCAEVFKIKLPTEEA 80
Cdd:PHA03142    3 APPVVKALFATDGDCAEAIADILTGTPTSGFFFCVLHNCFSYPILGEEVSLSLCLPAKRPGGGE-RCLEVFQLRLPAEEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  81 GQFLFNCGSLSAKQVYESYSKRAAYETFQPILEVLGLSGD----EYSIKNAVTWGRGKFVASLRKYFKLTTSPHWFINTF 156
Cdd:PHA03142   82 LPFLFGGKPLTADDIQTYLDRAAALKSFKPILELLTLSGKkqqpQGDFKSKVAWFRAKFVNALRKLYKMTPSPYWMISTF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 157 GAFENHFVLVSSCYYFFPvSVSTVDTLCHLAMLYSSKKGCPLSSITTLRELGAVATQSPALDRVENFYLYVCDKLARDTL 236
Cdd:PHA03142  162 GSFEAQFVLVSAFYFFEK-HECTVETLSHLARLFSPKQGQSLAAVTTLAELGEVFGTSPWLDRVPAFAAYVKEKLARDSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 237 ECEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCFNNQKFLAYSQCTNPCNLNTTMLREPMLVANIDSDFKHKMATYYNK 316
Cdd:PHA03142  241 ESEAIDRTINEFRGQLMLSNQDLVHYIYLSFFQCFNKQTFLRYSRLTSPDNINTLPPEGPILTRLLDEEFKEKMATYYNK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 317 NTYLSNYVLLRGIHLHPVVGYGQECLRSAHAtgghSIWWGESHQVSDMLKTINVEYPDICLHEEFRGLMDLAAITDRCSI 396
Cdd:PHA03142  321 STYLSTHVRIRSVKLPGPYGYDPDPCDGLLR----AYWAGQSRDVAALLKEINVWHPHLCLPEELQGLLDLAALDTSSGV 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 397 FGNPIHYLTDCATSgaIPIYRSELSHRHYFLAVFSDDIEYFWKKTIFLPPESFCLGAQDTMLTRAITYTEMHCSMSSVAE 476
Cdd:PHA03142  397 WGNPKDFLFPEALR--LPVYRCEFLNKHYFVMVAADNLEAYWKKHVLLPTDSNWCGLPDTRLTRAITYTELYYSLNTLKE 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 477 QIHVSRHEYFNPKLPVFNWVLDLDLPISEGNLHIDSIYSLCLLIRESVLDILKLLGPVEPDHEVFFFKSACINLCdpGEA 556
Cdd:PHA03142  475 QLLVSRHEYFNPRLPVFNLVLDLDLPIKEPGRTLEEIYNLCLTLRESILDVLQLLGPVEPDHPVYFFKSACPPPE--EDN 552

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 557 SWRPSTFCTCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRVIKLGCGSLLNLSAFQLSNGPFDVGIYGRGRSIRLPH 636
Cdd:PHA03142  553 MEDPLPFCTCTKKLGLRIITPLPRGVAIVGSEPLISLVKILNRTIKLDKRLREMYPKIQETEGPFDVGIYHRGRCIRLPH 632

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 637 TYKVGKCGQLERLLKLFVCHPEATDKFPYLQNSLKLNRLLHHAQSQDPRGPLKIIYRVEDINEDFLYKHTQKQLPVKHEA 716
Cdd:PHA03142  633 TYKVGSGGGLERLLKLFVCHPEEPDKRSYVKNALNLQNLLHHSLSVGWPGPLKFVYHIEDINEDFLSQKTQEQLPRTSEN 712

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 717 VIPSIERLLDTSLNCFLLSKVWPKCFGTIRSYMSEEKLQQFSRVVFHPTNHCIVQVRPDRGNNFKCLRYNHRGSSKSVRV 796
Cdd:PHA03142  713 VAEKIETLTGLDLTDWVLSKVWPKLFDTIKSYFPEDKLQQFLHVTFEQTGHNIVQVKPLRGNNFSCLRHNHRNKSKSVRV 792

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|.
gi 1717984549 797 FLILHLKEETKLIVTFMSQCFANKCQSNKAMAHFSVFVDLS 837
Cdd:PHA03142  793 FLVLHLTSEDEVTVTFMSQCFANKCNSNKPTAHFSVSVPIS 833
PHA03139 PHA03139
helicase-primase primase subunit; Provisional
 1-835 3.95e-77

helicase-primase primase subunit; Provisional


Pssm-ID: 165411 [Multi-domain]  Cd Length: 860  Bit Score: 268.01  E-value: 3.95e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549   1 MTRVVkalFAADTDCAELLADILTGQNNSGSLYCLLHNCRPEDvswevtRLSLCLPVRRPGGAEgRCAEVFKIKLPTEEA 80
Cdd:PHA03139    1 MTIVV---FATEYDAANVIFSILCRSPSEHLIFPIIVKYKPSN------NVSFCLQTQKCKNSK-RIDTVFVCHAEKLNL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  81 GQFLFNCGSLSAKQVYESYSKRAA---YETFqpILEVLGLSGDEYSIKNAVTWGRGKFVASLRKYFKLTTSPHWFINTFG 157
Cdd:PHA03139   71 SHYIQTASPIKAEDVANSLNDKETenlYVDM--ILSQTGKESEDVEFKYMAYFHKSLIIKYLTGKFLLPTSPFWFLSTYG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 158 AFENhFVLVSSCYYFFPVSVSTVDTLCHLAMLYSSKKGCPLSSITTLRELGAVATQSPALDRVENFYLYVCDKLARDTLE 237
Cdd:PHA03139  149 QTEG-MLLLTMYYYLFEEQKSTITTTKNYVQCFTENTGDMVFTYSSMSEFINITLKSKFRKLFADFSTYARQKNLRDKEE 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 238 CEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCFNNQKFLAYSQCT--NPCNLNTTMLREPM--LVANIDSDFKHKMATY 313
Cdd:PHA03139  228 FKYLDTQINLFRKSSHLTNTFRVHYIYIAYNTALETTKFVNYCNLTsyDSNLPIGQQCQRNMhiLGNSLHENLLCIMKQY 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 314 YNKNTYLSNYVLLRGIhLHPVVGYGQecLRSAHATGGHSIWWGESHQVSDMLKTINVEYPDIC--LHEEFRGLMDLAAIT 391
Cdd:PHA03139  308 FNADCYFKTYIDIKRL-KNPKLNVTE--YEYALNSKKKTIQALTSEQITRAIAKCNKNGEGLFspVKPGLQGLLEISASD 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 392 DRCSIFGNPIH---YLTDcATSGAIPIYRSELSHRHYFLAVFSDDieyfWKKTI-------FLPPESFclgaQDTMLTRA 461
Cdd:PHA03139  385 KYVQIQDKRIYrrqHLHK-DYHRPFPVFRVQLLHKNIFCFGNSED----WYENMgfnrilqYLPDEYI----SDEALTRA 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 462 ITYTEMHCSMSSVAEQIHVSRHEYFNPKLPVFNWVLDLDLPISEGNLHIDSIY-SLCLLIRESVLDILKLLGP-VEPD-H 538
Cdd:PHA03139  456 IWLQDTHFLCDDIEKQFYTTRHEIFNERIPVTNYIGDLDLPLQDTATITEETFfSMCRLIRLTLINAWKKIFPsIDTDtH 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 539 EVFFFKSACINLCDPGEASWRPS---TFCTCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRVIKLGCGSLLNLSAFQ 615
Cdd:PHA03139  536 PIFFFKTQCDTTNDPLDYTEDPTeikQFCVCRKKIGLRISIPLPNGTAIAGGEPLKQLSKILNHVMCLDQELSQILNSVT 615

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 616 LSNGPFDVGIYGRGRSIRLPHTYKVG-KCGQL--ERLLKLFVChPEATDKF--PYLQNSLKLNRLLHHAQSQDPrgPLKI 690
Cdd:PHA03139  616 FPGECFDIGIYHTGHCIRIGYMYKTDmDKGKMlhGRLTPIFIV-PEGYRNSckTFIQMQMDLNNLLHHGTKKAP--IEEL 692

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 691 IYRVEDI-----NEDFLYKHTQKQLPVKHEAVIPSIERLL------------DTSLNCFLLSKVWPKCFGTIRSYMSEEK 753
Cdd:PHA03139  693 IYSITDKgcpkeNLSFMDLKSRQLWNKVNIATETLITKYLnthgfnnnatsaDDSLLSFIRLIGWPIIKTQLITHYETRI 772

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549 754 LQQFSRVVFHPTNHCIVQVRP---DRGNNFKCLRYNHRGSSKSVRVFLILHLkEETKLIVTFMSQCFANKCQSNKAMAHF 830
Cdd:PHA03139  773 AQQFSQVTFLKIDSKNLQIKKtqfGRVSDFSCLNRQHRGNRDNVLVYIQLKA-DGNRLILILWSTCFATKCQSNSKQVHC 851


                  ....*
gi 1717984549 831 SVFVD 835
Cdd:PHA03139  852 SIALE 856
PHA03146 PHA03146
helicase-primase primase subunit; Provisional
 134-835 5.95e-33

helicase-primase primase subunit; Provisional


Pssm-ID: 177543  Cd Length: 1075  Bit Score: 137.39  E-value: 5.95e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  134 KFVASLRK-YFKLTTSPHWFINTFGAFENHFVLVSSCYYFFPV---SVSTVDTLCHLAMLYSSKKGCP----------LS 199
Cdd:PHA03146   203 KTLAAFRRlYSNNNTTPFWFLSKFGPGEKTLVLATRYYLFQAIrsgDGGTYDLQAVKDFLATYNVPAPpnpsgldlthLT 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  200 SITTLREL--------GAVATQSPAldrvenfylYVCDKLARDTLECEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCF 271
Cdd:PHA03146   283 SFAALSAFccqsgyarGPVAAAAPR---------YVDLRIQADVAEVSALREYIAHDRQSLKVSDREFVTYVYLAHFESF 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  272 NNQKF---LAYSQCTNPCNLNTTMLREPMLVANIDSDFKHKMATYyNKNTYLSNYVLLRGIHLHPVVG--YGQE----CL 342
Cdd:PHA03146   354 NRRQLyehLLAVSITDPADIPRITGTSSLKERAIEAFFRHVRAQL-NIRDYIAQNVAPAVVRLPPAIGeqYARDrtyaPL 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  343 RSAHATGGHSIwwGESHQVSDMLK----------------TINVEYPDICLHEEF---------------------RGLM 385
Cdd:PHA03146   433 ATTMSTGNAPR--GICDTATALLKlldrvesslaghgwvqTSVSANKPQGVDAAPpldapdgeelspgvpsqcgvsRRLL 510

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  386 DLAAITDRC-------SIFGNPihyltdcATSGAIPIYRSELSHRHYFLAVFSDDIeyfWKKT---IFLPPES------- 448
Cdd:PHA03146   511 ELAAAPPRDgahlpleVLFGQR-------GTAGPAPVYRVELPSKRQAFAVIAGDR---WETVtqnAALDPGEvayevaa 580

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  449 ----------FCLGAQDTMLTRAITYTEMHCSMSSVA-EQIHVSRHEYFNPKLPVFNWVLDLDL----PISEGNLHIdSI 513
Cdd:PHA03146   581 alagaaemddDALAERDLQLTRAAGGVCRTALASSNPsAQMYVNRNEIFNARLAVTNIVLDVDFrlkrPVPLGMLHL-AM 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  514 YSLclliRESVLDILKLLGPVE----PDHEVFFFKSAC----------------INLCDPGEASWRPSTF---------- 563
Cdd:PHA03146   660 RGF----RRGILTALALLFPEAavdwDAHPCYFYKSACppaaaralaageasslSDYVDGVEECYMESDFlddyaameed 735

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  564 -------------------------------------------------CTCTEKLGMRVVTRFPPGICLKGSEPLTQLT 594
Cdd:PHA03146   736 egwddyemavaregeaqyacddvevpaggtppnkagaktplqraaetdaCGCTEKMGFRVTVPVPPPYLLAGPEALRGLA 815

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  595 KILNRVIKL------GCGSLLNLSAFqlsngpFDVGIYGRGRSIRLPHTYKVGKCGQLE-RLLKLFVCHPEATDKFPYLQ 667
Cdd:PHA03146   816 RIIQQAVVLertfteSMCSYLRDFSF------VDTGVYSHGRSLRLPFFCKVGDSGEVYgGLLPFYVVPPRCNDVAEFVA 889

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  668 NSLKLNRLLHHAQsqdPRGPlKIIYRVEDINEDFLyKHTQKQLPVKHEAVI---PSIERLLdTSLNCFLLSKVWPKCF-- 742
Cdd:PHA03146   890 AHSDPANFHFHAA---PRAP-TVTHVITDLGGEYV-SFFERKAARNREAFMtkrATLESLL-SSVNVSIKSREAVEAFva 963

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  743 ----GTIRSYMSEEKLQQ--------FSRVVFHPtNHCIVQVRPD----RGNNFKCLRYNH-RGSSKSVRVFLILHLKEE 805
Cdd:PHA03146   964 dvvlAEVVPHLAAHFPQAageyqgagAHTVVAKP-DWILAQLNRSgaayRSQGFSCLRAKHlRSARGLARTFVSLSVDAH 1042

                          890       900       910
                   ....*....|....*....|....*....|
gi 1717984549  806 TKLIVTFMSQCFANKCQSNKAMAHFSVFVD 835
Cdd:PHA03146  1043 DRLCASLSQQCFATKCGSNKMCTIFTLEVS 1072
PHA03145 PHA03145
helicase-primase primase subunit; Provisional
 137-832 2.58e-30

helicase-primase primase subunit; Provisional


Pssm-ID: 165416  Cd Length: 1058  Bit Score: 128.96  E-value: 2.58e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  137 ASLRKYFKLTTSPHWFINTFGAFENHFVLVSScYYFFPV----------SVSTVDTLC-HLAMLYSSKKGCPlsSITTLR 205
Cdd:PHA03145   210 AYRRAYYGSAQNPFWFVSKFGPDEKSLVLVAR-YYLLQAlrlggagatyDLQAIKDVCaTYAVPHAPRADAP--SAAALT 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  206 ELGAVA--------TQSPAldrVENFYLYVCDKLARDTLECEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCFNNQKFL 277
Cdd:PHA03145   287 SFAAVTrfcctsqyARGPA---AAGFPLYVERRIAADVRETGALKEFIAHDRGCLRVSDREFITYIYLAHFECFSPPRLA 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  278 AYSQCT---NPCNLNTTMLREPMLVANIDSDFKHKMATYyNKNTYLSNYVLLRGIHLHPVVG--------YGQECLRSAH 346
Cdd:PHA03145   364 GHLRAVttrDPDPAAATDRPSGLGREAVERFFSHVRAQL-NIREYVRQNVTPREAVLRGATAeaylrartYAPAALEPAP 442

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  347 ATGG---------------------HSiwWGESHQVSDMLKTINVEYPDIClhEEFRGLMDLAAiTDRCSIFGNPIHYLT 405
Cdd:PHA03145   443 RYRGavdsatgmlgrlaeaerllvpHG--WPAFAPPKPGEGDGGATAPPGC--GIVRRLLRLAA-TEQQADTPPAIAALT 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  406 -DCATSGAIPIYRSELSHR-HYFLAVFSDDieyfWKKTI---------------FLPPESFCLGAQDTMLTRAITYTEMH 468
Cdd:PHA03145   518 rDARTQTPLPVYRIAMAPRgQAFAALARDD----WARITrdarlpaadvsaaaaAAPRDPGALGLRLTWRVHARNPVTAP 593

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  469 CSMSSVAEQIHVSRHEYFNPKLPVFNWVLDLDLPISEgNLHIDSIYSLCLLIRESVLDILKLLGP---VEPD-HEVFFFK 544
Cdd:PHA03145   594 PTGPTAAGQMYVNRNEIFNGALAVTNIILDLDVALRE-PIPFERLHEALGHFRRGALAAVALLFPaarVDPDaYPCYFFK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  545 SAC------------INLCDPGEASWRP------------------------------------------------STFC 564
Cdd:PHA03145   673 SACrpraaavdpglgPDGEYDGDGPWFPagggpgdeeddedpdaealahggvdeeaayldalheqppaeaapaepeSPRC 752

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  565 TCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRVIKLGCGSLLNLSAFQLSNGPFDVGIYGRGRSIRLPHTYKVG--- 641
Cdd:PHA03145   753 TCADKIGLRVCLPVPAPYVVHGSLTMRGVARVIQQAVLLDRDFVEAVGGYVRDFLLVDTGVYAHGHSLRLPYFAKVTdeg 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  642 -KCGqleRLLKLFVCHPEATDKFPYLQNSLKLNRLLHHAQ---SQDPRgPLKIIYRV-------------EDINEDFLYK 704
Cdd:PHA03145   833 lACG---RLLPVFVVPPACPDVPAFVAAHADPRRFHFHAPpatAPDAG-ELRVLHSLggdyisfferkasHNAIEHFGRR 908

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  705 HTQKQLPVKHEA---VIPSIE----RLLDTSLNCflLSKVWPKCFGTIRSYMSEEKLQQFSRVvfhptnhcIVQVRPDRG 777
Cdd:PHA03145   909 ETLAEVLGRYDArlgAGETVEafalELLGRIVAC--LETHFPEHAHEYQSVSVQRAVVQDDRA--------LLQLVPSRG 978

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1717984549  778 ---NNFKCLRYNH-RGSSKSVRVFLILHLKEETKLIVTFMSQCFANKCQSNKAMAHFSV 832
Cdd:PHA03145   979 glqQGLSCLRFKHgRASRATARTFLALSVGARNGLCVSLCQQCFASKCDSNRLRTLFTV 1037
PHA03119 PHA03119
helicase-primase primase subunit; Provisional
 140-834 1.06e-28

helicase-primase primase subunit; Provisional


Pssm-ID: 222991  Cd Length: 1085  Bit Score: 123.87  E-value: 1.06e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  140 RKYFKLTTSPHWFINTFGAFENHFVLVSScYYFFPVSVS--TVDTLCH-------LAMLYS-----SKKGCPLSSITTLR 205
Cdd:PHA03119   212 RIYWGYNCTPFWYVARFGPGEKTLVLATR-YYLLQTTTSylTHTGACYdlqaikdLICTYNvpvtdNTSGYDISDLASFA 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  206 ELGAVATQSPALDRV--ENFYLYVCDKLARDTLECEAVDRCINEFRGQLMLSDQDLVHYIYLSFFQCFNNQKFLAYSQ-- 281
Cdd:PHA03119   291 KLSRFCCSSGYTRGSaaANACDYIHYRITADISEISTVGEYITNDRKGLRVSDREFVDYIYLAHFECFNRKQIRDHLRav 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  282 -CTNPCNLNTTMLREPMLVANIDSDFKH-----KMATYYNKN--------------------TY---------------- 319
Cdd:PHA03119   371 tLTDIALIPDVVSASSLGRSAIENFFSHvrsrlNISDYISKNvicdvvvlneklgrkyaaskTYpivnsltaqsggyigm 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  320 -----------------LSNYVLLRGIHLHPVVGYGQ-----------ECLRS---AHATGGHSIWWGESHQVSDMLkti 368
Cdd:PHA03119   451 cdvagaltkriegieksFARRGWPSTITSQTQGIFSQhdnpsgstvsvEAIKAanqANSINSHKPAWEYSSSITRRL--- 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  369 nveypdicLHeeFRGLMDLAAITDRCSIFGNPIHYLTDCA-TSGAIPIYRSELSHRHYFLAVFSDDieyFWK--KTIFLP 445
Cdd:PHA03119   528 --------LF--FVASTSISEQNSLTATYKSPVNALLGRRdLHGPIPVYRISLPEGKQAFAVIHQD---DWSivTRRYTS 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  446 PESFCLGAQ----------------DTMLTRAITYTEMHCS--MSSV-AEQIHVSRHEYFNPKLPVFNWVLDLDL----P 502
Cdd:PHA03119   595 VNSLNLLPEslknitgkdehtaalrDMYLTHVLHQRVKSTSgiASSIpSSQMYINRNELFNGGLLISNIILDVDFhlrkP 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  503 ISEGNLHI-------DSIYSLCLLIRESVLDILKllgpvepdHEVFFFKSAC----------INLCDPGEAS-------- 557
Cdd:PHA03119   675 IPLGVLHAgmrafrhGVLTALQLLFSEAVVDWNS--------HPCYFYKTSCppqprhticdINSQDINEIQdfmwdadi 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  558 --------------WRPSTF-----------------------CTCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRV 600
Cdd:PHA03119   747 lyqdvelnelhdegAYDLNFkvsedvvnmeskeqlgkldttyvCGCTEKLGFRVCIPIPPPYLLFGSSTLKGMARIIQQA 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  601 IKLGcgsllnlSAFQLSNGPF-------DVGIYGRGRSIRLPHTYKVGKCGQLE-RLLKLFVCHPEATDKFPYLQNSLKL 672
Cdd:PHA03119   827 VLLE-------RTFVETMGPYlkdfsfiDTGVYSHGHSLRLPFFSKVTDGGTFNgLLLPFYVVPIGCKDILTFLYAHTNP 899

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  673 NRLLHHAQsqdPRGPLKIIYRVEDINEDFLYKHTQKQLPVKHEAVIPSIErlLDTSLNCFLLSKVWPKCFGTIRSYMSEE 752
Cdd:PHA03119   900 NNFHFHSM---PAYNTPTHIILHNLGGEYASFFERKVASNKTAFLSPKTS--LRKALQKLGIQPDDAETIEAFIDSIVLE 974

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  753 KLQQFSRVVF--------HPTNHCIVqVRPD-------------RGNNFKCLRYNHRGSSKSVRVFLILHLKEETKLIVT 811
Cdd:PHA03119   975 SITGYIRVHFpgrdreyqATSSKCIV-LKRDwvllqlvrtgcysRMQGFTCLRYPHRGGRTAPRTFVSLRVDHHNRLCAS 1053

                          890       900
                   ....*....|....*....|...
gi 1717984549  812 FMSQCFANKCQSNKAMAHFSVFV 834
Cdd:PHA03119  1054 LSQQCFATKCDSNRMHTIFTLEV 1076
PHA03180 PHA03180
helicase-primase primase subunit; Provisional
 140-835 1.39e-28

helicase-primase primase subunit; Provisional


Pssm-ID: 165451  Cd Length: 1071  Bit Score: 123.41  E-value: 1.39e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  140 RKYFKLTTSPHWFINTFGAFENHFVLVSScYYFF--------------------------------PVSVSTVDtLCHLA 187
Cdd:PHA03180   214 RIYGGSTTTAFWYVSKFGPDEKSLVLALR-YYLLqaqdectgiatdydlqaikdicgtyavpvgpnPTGFSTAD-LTSFA 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  188 MLyssKKGCPLSSITTlrelGAVATQSPaldrvenfyLYVCDKLARDTLECEAVDRCINEFRGQLMLSDQDLVHYIYLSF 267
Cdd:PHA03180   292 RL---SRFCCSSNYAR----GRIARAFP---------TYVERRIAADVAEVDALREYIERDRPSLKISDLEFVKYIYLAY 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  268 FQCFNNQkflaysQCTNpcNLNTTMLREP---------MLVANIDSDFKHkMATYYNKNTYLSNYVLLRGIHLHPVVG-- 336
Cdd:PHA03180   356 FECYNRE------QLKR--HLNDVTVREPeediykkssLGKRAVENFFTH-VRSRLNVNDHIAQNVSPEQVELGNDLAra 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  337 ------YGQECLRS-AHATGghsIW---------------------WGESHQVSDMLKTINVEYPD---------ICLHE 379
Cdd:PHA03180   427 fvrartYHPDTMTHgSTFTG---ICecatviakrldkleaklqkygWPESRPDGPNLMSDNQNDPSdssydrdrcDGLQL 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  380 EFRGLMD---------LAAITDRCSIFGN--PIHYLT--DCATSGAIPIYRSELSHRHYFLAVFSDDIeyfWKKTIfLPP 446
Cdd:PHA03180   504 EQPDTHPrggpmivkrLLALVSADPRAGTigPANMLMgiSSASNGPLPVYRIGMSKGKQAFGVLTADC---WERII-PSP 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  447 ESFC----------------LGAQDTMLTRAIT-----YTEM-HCSMSSVAEQIHVSRHEYFNPKLPVFNWVLDLDLpis 504
Cdd:PHA03180   580 GTFKahlsklgmseglstddLIARDMFITSEVErsfgnVQELpYIACGPAEEQQYINRNEVFNGNLAIGNIILDVDV--- 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  505 egnlHIDSIYSLCLL------IRESVLDILKLLGP-VEPDHE---VFFFKSACINLCDPGEASWRPSTF----------- 563
Cdd:PHA03180   657 ----HLKQAVPLILLhaamrgFRSGALRALSLLLPkANIDHGsypCYFYKSSCKKSRVVKTAKWMDNTHesaldydgspf 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  564 ------------------------------------------CTCTEKLGMRVVTRFPPGICLKGSEPLTQLTKILNRVI 601
Cdd:PHA03180   733 esadfdlemgiddpllidqidespsrwcsesaesidsdadlpCGCHDKIGMRVCIPVPPPYLLVGSKTMVGIARIIQQAV 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  602 klgcgsLLNLSaFQLSNGPF-------DVGIYGRGRSIRLPHTYKVGKCGQLERLLKLFVCHPEA---TDKF--PYLQ-- 667
Cdd:PHA03180   813 ------LLERS-FVETIGPYlknydiiDSGVYGHGRSLRLPFFGKIDEEGLISGRLLPFIVIPEScndVESFilSHFEpr 885

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  668 ----NSLKLNRLLHHAQSQDPRGPLKIIY-RVEDINED-FLYKHTQKQLPVKHEAVIPSIERLLDTSLNCFLLSKVWPKC 741
Cdd:PHA03180   886 nfhfHSPPPVEEMASHVIKSLGGEYAGFFeKKITVNRDrFFGPRLSLSEALRERGVDINDSAAIEEFVTDFILEDIIRYM 965

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717984549  742 FGTIRSYMSEEKLQQFSRVVFHPtNHCIVQVRPD----RGNNFKCLRYNH-RGSSKSVRVFLILHLKEETKLIVTFMSQC 816
Cdd:PHA03180   966 EEHIPDHAHEYKNASVSCCVVKA-DWILLQLIPNktasRLHGFTCVRYKHtRTTRGSARSYLALNVDAHGRLCACVIQQC 1044

                          890
                   ....*....|....*....
gi 1717984549  817 FANKCQSNKAMAHFSVFVD 835
Cdd:PHA03180  1045 FATKCGNNKLRTLFTVDID 1063
Herpes_UL52 pfam03121
Herpesviridae UL52/UL70 DNA primase; Herpes simplex virus type 1 DNA replication in host cells ...
 761-835 6.48e-24

Herpesviridae UL52/UL70 DNA primase; Herpes simplex virus type 1 DNA replication in host cells is known to be mediated by seven viral-encoded proteins, three of which form a heterotrimeric DNA helicase-primase complex. This complex consists of UL5, UL8, and UL52 subunits. Heterodimers consisting of UL5 and UL52 have been shown to retain both helicase and primase activities. Nevertheless, UL8 is still essential for replication: though it lacks any DNA binding or catalytic activities, it is involved in the transport of UL5-UL52 and it also interacts with other replication proteins. The molecular mechanisms of the UL5-UL52 catalytic activities are not known. While UL5 is associated with DNA helicase activity and UL52 with DNA primase activity, the helicase activity requires the interaction of UL5 and UL52. It is not known if the primase activity can be maintained by UL52 alone. The region encompassed by residues 610-636 of HSV1 UL52 is thought to contain a divalent metal cation binding motif. Indeed, this region contains several aspartate and glutamate residues that might be involved in divalent cation binding. The biological significance of UL52-UL8 interaction is not known. Yeast two-hybrid analysis together with immunoprecipitation experiments have shown that the HSV1 UL52 region between residues 366-914 is essential for this interaction, while the first 349 N-terminal residues are dispensable. This family also includes protein UL70 from cytomegalovirus (CMV, a subgroup of the Herpesviridae) strains, which, by analogy with UL52, is thought to have DNA primase activity. Indeed, CMV strains also possess a DNA helicase-primase complex, the other subunits being protein UL105 (with known similarity to HSV1 UL5) and protein UL102.


Pssm-ID: 367342 [Multi-domain]  Cd Length: 75  Bit Score: 95.95  E-value: 6.48e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1717984549 761 VFHPTNHCIVQVRP-DRGNNFKCLRYNHRGSSKSVRVFLILHLKEETkLIVTFMSQCFANKCQSNKAMAHFSVFVD 835
Cdd:pfam03121   1 VFSKEGLNLVQVKRsRRGRNFSCLNIGHRHKSNNVRVFLDLRVDGHG-LCVTLYQKCFAPKCGSNYRSTHFSVPVD 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH