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Conserved domains on  [gi|1756480366|gb|QFF92218|]
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14.5 kDa protein [Human adenovirus E4]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_E3_14_5 super family cl04788
Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. ...
 35-146 7.52e-04

Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm. It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis. It achieves this through the interaction with E3 10.4 kDa protein.


The actual alignment was detected with superfamily member pfam04834:

Pssm-ID: 461451  Cd Length: 100  Bit Score: 36.98  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756480366  35 CKFQEPWKFLKCYQLKSDMHPSWIIIMGIVNILACTLFSFVIYPRFDFGWNAPKALWLP--PAPDTPPQQqqnQAHAPPP 112
Cdd:pfam04834   2 CRFTIFVLIIFCALKQLCLQEAALPAIHISCRFCQIIFALACYNKLDDGSEAIDAAIHPtfPFCATIFAL---AIIAPID 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1756480366 113 QPRPqympildyeaePQQAMlPAISYFNLTGEDD 146
Cdd:pfam04834  79 IGRN-----------AIDAM-NEISFFNLAGGDD 100
 
Name Accession Description Interval E-value
Adeno_E3_14_5 pfam04834
Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. ...
 35-146 7.52e-04

Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm. It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis. It achieves this through the interaction with E3 10.4 kDa protein.


Pssm-ID: 461451  Cd Length: 100  Bit Score: 36.98  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756480366  35 CKFQEPWKFLKCYQLKSDMHPSWIIIMGIVNILACTLFSFVIYPRFDFGWNAPKALWLP--PAPDTPPQQqqnQAHAPPP 112
Cdd:pfam04834   2 CRFTIFVLIIFCALKQLCLQEAALPAIHISCRFCQIIFALACYNKLDDGSEAIDAAIHPtfPFCATIFAL---AIIAPID 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1756480366 113 QPRPqympildyeaePQQAMlPAISYFNLTGEDD 146
Cdd:pfam04834  79 IGRN-----------AIDAM-NEISFFNLAGGDD 100
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 76-141 2.20e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 37.09  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1756480366  76 IYPRFDFGWNAPKALWLPPAPDTPPQQQQNQAHAPPPQPrPQYMPILDYEAEPQQAMLPAISYFNL 141
Cdd:TIGR01628 423 PTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQP-VMYPPNYQSLPLSQDLPQPQSTASQG 487
 
Name Accession Description Interval E-value
Adeno_E3_14_5 pfam04834
Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. ...
 35-146 7.52e-04

Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm. It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis. It achieves this through the interaction with E3 10.4 kDa protein.


Pssm-ID: 461451  Cd Length: 100  Bit Score: 36.98  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756480366  35 CKFQEPWKFLKCYQLKSDMHPSWIIIMGIVNILACTLFSFVIYPRFDFGWNAPKALWLP--PAPDTPPQQqqnQAHAPPP 112
Cdd:pfam04834   2 CRFTIFVLIIFCALKQLCLQEAALPAIHISCRFCQIIFALACYNKLDDGSEAIDAAIHPtfPFCATIFAL---AIIAPID 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1756480366 113 QPRPqympildyeaePQQAMlPAISYFNLTGEDD 146
Cdd:pfam04834  79 IGRN-----------AIDAM-NEISFFNLAGGDD 100
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 76-141 2.20e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 37.09  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1756480366  76 IYPRFDFGWNAPKALWLPPAPDTPPQQQQNQAHAPPPQPrPQYMPILDYEAEPQQAMLPAISYFNL 141
Cdd:TIGR01628 423 PTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQP-VMYPPNYQSLPLSQDLPQPQSTASQG 487
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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