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Conserved domains on  [gi|1760494663|gb|QFN25117|]
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polyprotein, partial [dengue virus type 2]

Protein Classification

Flavi_E_C and flavi_E_stem domain-containing protein( domain architecture ID 10187331)

Flavi_E_C and flavi_E_stem domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 2-83 5.11e-41

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


:

Pssm-ID: 213392  Cd Length: 91  Bit Score: 133.58  E-value: 5.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1760494663   2 AETQHGTIVVRVQYEGDGSPCKIPFEIMD-LEKRHVLGRLITVNPIATGKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSW 80
Cdd:cd12149     9 ADTGHGTVVMEVKYSGTDAPCRIPVRVVDsGSGGENVGRLITVNPIITNANSKVFIEVEPPFGDSYIVVGVGDTRLKHQW 88


                  ...
gi 1760494663  81 FKK 83
Cdd:cd12149    89 FQK 91
flavi_E_stem TIGR04240
flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal ...
 88-160 5.14e-37

flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins.


:

Pssm-ID: 213897  Cd Length: 97  Bit Score: 123.52  E-value: 5.14e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1760494663  88 GQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSR 160
Cdd:TIGR04240   1 GKAFELTMRGAERMAILGDAAWDFGSVGGVFTSIGKALHQVFGGAFRALFGGVSWITKILIGVLLIWLGLNSR 73
 
Name Accession Description Interval E-value
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 2-83 5.11e-41

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


Pssm-ID: 213392  Cd Length: 91  Bit Score: 133.58  E-value: 5.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1760494663   2 AETQHGTIVVRVQYEGDGSPCKIPFEIMD-LEKRHVLGRLITVNPIATGKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSW 80
Cdd:cd12149     9 ADTGHGTVVMEVKYSGTDAPCRIPVRVVDsGSGGENVGRLITVNPIITNANSKVFIEVEPPFGDSYIVVGVGDTRLKHQW 88


                  ...
gi 1760494663  81 FKK 83
Cdd:cd12149    89 FQK 91
flavi_E_stem TIGR04240
flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal ...
 88-160 5.14e-37

flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins.


Pssm-ID: 213897  Cd Length: 97  Bit Score: 123.52  E-value: 5.14e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1760494663  88 GQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSR 160
Cdd:TIGR04240   1 GKAFELTMRGAERMAILGDAAWDFGSVGGVFTSIGKALHQVFGGAFRALFGGVSWITKILIGVLLIWLGLNSR 73
Flavi_glycop_C pfam02832
Flavivirus glycoprotein, immunoglobulin-like domain;
1-82 3.72e-33

Flavivirus glycoprotein, immunoglobulin-like domain;


Pssm-ID: 280922  Cd Length: 97  Bit Score: 113.98  E-value: 3.72e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1760494663   1 IAETQHGTIVVRVQYEGDGSPCKIPFEIMDLEKRHVL-GRLITVNPIATGKDSPVNIEAEPPFGDSYIIIGVEPGQLKLS 79
Cdd:pfam02832  15 PADTGHGTVLMQVKVEGKDAPCKIPVFSADDEKAAINkGILITANPIASDKDDEVLIEAEPPFGDSYIIVGAGDKALKLQ 94


                  ...
gi 1760494663  80 WFK 82
Cdd:pfam02832  95 WFK 97
 
Name Accession Description Interval E-value
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 2-83 5.11e-41

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


Pssm-ID: 213392  Cd Length: 91  Bit Score: 133.58  E-value: 5.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1760494663   2 AETQHGTIVVRVQYEGDGSPCKIPFEIMD-LEKRHVLGRLITVNPIATGKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSW 80
Cdd:cd12149     9 ADTGHGTVVMEVKYSGTDAPCRIPVRVVDsGSGGENVGRLITVNPIITNANSKVFIEVEPPFGDSYIVVGVGDTRLKHQW 88


                  ...
gi 1760494663  81 FKK 83
Cdd:cd12149    89 FQK 91
flavi_E_stem TIGR04240
flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal ...
 88-160 5.14e-37

flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins.


Pssm-ID: 213897  Cd Length: 97  Bit Score: 123.52  E-value: 5.14e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1760494663  88 GQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSR 160
Cdd:TIGR04240   1 GKAFELTMRGAERMAILGDAAWDFGSVGGVFTSIGKALHQVFGGAFRALFGGVSWITKILIGVLLIWLGLNSR 73
Flavi_glycop_C pfam02832
Flavivirus glycoprotein, immunoglobulin-like domain;
1-82 3.72e-33

Flavivirus glycoprotein, immunoglobulin-like domain;


Pssm-ID: 280922  Cd Length: 97  Bit Score: 113.98  E-value: 3.72e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1760494663   1 IAETQHGTIVVRVQYEGDGSPCKIPFEIMDLEKRHVL-GRLITVNPIATGKDSPVNIEAEPPFGDSYIIIGVEPGQLKLS 79
Cdd:pfam02832  15 PADTGHGTVLMQVKVEGKDAPCKIPVFSADDEKAAINkGILITANPIASDKDDEVLIEAEPPFGDSYIIVGAGDKALKLQ 94


                  ...
gi 1760494663  80 WFK 82
Cdd:pfam02832  95 WFK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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