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Conserved domains on  [gi|1846261915|gb|QKE44345|]
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truncated DcuS [Cloning vector pLeo1243]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11086 super family cl35987
sensory histidine kinase DcuS; Provisional
 1-213 1.79e-145

sensory histidine kinase DcuS; Provisional


The actual alignment was detected with superfamily member PRK11086:

Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 416.24  E-value: 1.79e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915   1 MTSLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATD 80
Cdd:PRK11086  330 AQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISRARE 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  81 LGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFD 160
Cdd:PRK11086  410 LGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD 489

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1846261915 161 KGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR 213
Cdd:PRK11086  490 KGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-213 1.79e-145

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 416.24  E-value: 1.79e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915   1 MTSLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATD 80
Cdd:PRK11086  330 AQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISRARE 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  81 LGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFD 160
Cdd:PRK11086  410 LGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD 489

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1846261915 161 KGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR 213
Cdd:PRK11086  490 KGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 4-209 4.12e-77

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 237.05  E-value: 4.12e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915   4 LDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATDLGH 83
Cdd:COG3290   183 LEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARARERGI 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  84 TLILNSESQLPDSGSEDQVatLITTLGNLIENALEAL--GPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK 161
Cdd:COG3290   263 DLTIDIDSDLPDLPLSDTD--LVTILGNLLDNAIEAVekLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFER 340

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1846261915 162 GVSTKGSE-RGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGE 209
Cdd:COG3290   341 GFSTKLGEgRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-205 1.74e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 149.36  E-value: 1.74e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEALG--PEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKG-SERGVGLALVKQQV 181
Cdd:cd16915     1 LITIVGNLIDNALDALAatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSV 80

                          90       100
                  ....*....|....*....|....
gi 1846261915 182 ENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16915    81 ERLGGSITVESEPGGGTTFSIRIP 104
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 105-205 6.02e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 99.65  E-value: 6.02e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  105 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER-----GVGLALVKQ 179
Cdd:smart00387   6 LRQVLSNLLDNAIKY--TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*.
gi 1846261915  180 QVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 105-205 3.36e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 89.73  E-value: 3.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEALGPepGGEISVTLHyRHGWLHCEVNDDGPGIAPDKIDHIFDK---GVSTKGSERGVGLALVKQQV 181
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAK--AGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPfstADKRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....
gi 1846261915 182 ENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-213 1.79e-145

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 416.24  E-value: 1.79e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915   1 MTSLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATD 80
Cdd:PRK11086  330 AQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISRARE 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  81 LGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFD 160
Cdd:PRK11086  410 LGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD 489

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1846261915 161 KGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR 213
Cdd:PRK11086  490 KGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 4-209 4.12e-77

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 237.05  E-value: 4.12e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915   4 LDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATDLGH 83
Cdd:COG3290   183 LEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARARERGI 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  84 TLILNSESQLPDSGSEDQVatLITTLGNLIENALEAL--GPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK 161
Cdd:COG3290   263 DLTIDIDSDLPDLPLSDTD--LVTILGNLLDNAIEAVekLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFER 340

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1846261915 162 GVSTKGSE-RGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGE 209
Cdd:COG3290   341 GFSTKLGEgRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-205 1.74e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 149.36  E-value: 1.74e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEALG--PEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKG-SERGVGLALVKQQV 181
Cdd:cd16915     1 LITIVGNLIDNALDALAatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSV 80

                          90       100
                  ....*....|....*....|....
gi 1846261915 182 ENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16915    81 ERLGGSITVESEPGGGTTFSIRIP 104
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
18-205 7.84e-28

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 107.69  E-value: 7.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  18 SHEFMNKLHVILGLLHL------KSYKQLEDYILKTANNYQEEIGSLL-------GKIK--------SPVIAGFLISKIN 76
Cdd:COG0642   118 SHELRTPLTAIRGYLELlleeldEEQREYLETILRSADRLLRLINDLLdlsrleaGKLElepepvdlAELLEEVVELFRP 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  77 RATDLGHTLILNSESQLPD-SGSEDQVATLittLGNLIENALEALgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKI 155
Cdd:COG0642   198 LAEEKGIELELDLPDDLPTvRGDPDRLRQV---LLNLLSNAIKYT--PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDL 272

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1846261915 156 DHIFDKGVSTKGSER----GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:COG0642   273 ERIFEPFFRTDPSRRgggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 105-205 6.02e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 99.65  E-value: 6.02e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  105 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER-----GVGLALVKQ 179
Cdd:smart00387   6 LRQVLSNLLDNAIKY--TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*.
gi 1846261915  180 QVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
11-205 2.45e-26

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 101.52  E-value: 2.45e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  11 ADALRER-----SHEFMNKLHVILGLLH-LKSYKQLED--------YILKTANNYQEEIGSLL-------GKIK------ 63
Cdd:COG2205    12 LERLKSEflanvSHELRTPLTSILGAAElLLDEEDLSPeerrelleIIRESAERLLRLIEDLLdlsrlesGKLSlelepv 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  64 --SPVIAGFLISKINRATDLGHTLILNSESQLPD-SGSEDQVATLITtlgNLIENALEAlGPePGGEISVTLHYRHGWLH 140
Cdd:COG2205    92 dlAELLEEAVEELRPLAEEKGIRLELDLPPELPLvYADPELLEQVLA---NLLDNAIKY-SP-PGGTITISARREGDGVR 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1846261915 141 CEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:COG2205   167 ISVSDNGPGIPEEELERIFERFYRGDNSRGeggtGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 109-205 1.22e-24

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 100.04  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSI 188
Cdd:COG5000   322 LINLLKNAIEAI--EEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTI 399

                          90
                  ....*....|....*..
gi 1846261915 189 AVESEPGIFTQFFVQIP 205
Cdd:COG5000   400 ELESRPGGGTTFTIRLP 416
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 109-204 1.53e-24

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 93.05  E-value: 1.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQVENL 184
Cdd:cd00075     5 LSNLLDNALKYSPP--GGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREgggtGLGLAIVRRIVEAH 82

                          90       100
                  ....*....|....*....|
gi 1846261915 185 GGSIAVESEPGIFTQFFVQI 204
Cdd:cd00075    83 GGRITVESEPGGGTTFTVTL 102
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 10-205 1.85e-24

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 100.68  E-value: 1.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  10 YADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATDLGHTLILNS 89
Cdd:PRK15053  338 YVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGLKMVIVP 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  90 ESQ---LPDSGSEDQVATLittLGNLIENALEA--LGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVS 164
Cdd:PRK15053  418 GSQlsqLPPGLDSTEFAAI---VGNLLDNAFEAslRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVS 494

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1846261915 165 TKGS---ERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK15053  495 TRADepgEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
77-205 3.70e-24

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 98.47  E-value: 3.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  77 RATDLGHTLILNSESQLPD-SGSEDQVATLITtlgNLIENALEAlGPEpGGEISVTLHYRHGWLHCEVNDDGPGIAPDKI 155
Cdd:COG5002   256 LAEEKGIELELDLPEDPLLvLGDPDRLEQVLT---NLLDNAIKY-TPE-GGTITVSLREEDDQVRISVRDTGIGIPEEDL 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1846261915 156 DHIFDK--------GVSTKGSerGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:COG5002   331 PRIFERfyrvdksrSRETGGT--GLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 76-205 7.20e-24

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 97.56  E-value: 7.20e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  76 NRATDLGHTLILNSESQLPD-SGSEDQVATLITtlgNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDK 154
Cdd:COG4191   230 PRLKARGIEVELDLPPDLPPvLGDPGQLEQVLL---NLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEV 306

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1846261915 155 IDHIFDKGVSTKGSERGV--GLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:COG4191   307 LERIFEPFFTTKPVGKGTglGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
82-205 2.51e-23

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 95.68  E-value: 2.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  82 GHTLILNSESQLPD-SGSEDQvatLITTLGNLIENALEALGPepGGEISVTLHYRHG----------WLHCEVNDDGPGI 150
Cdd:COG3852   224 NIRIVRDYDPSLPEvLGDPDQ---LIQVLLNLVRNAAEAMPE--GGTITIRTRVERQvtlgglrprlYVRIEVIDNGPGI 298

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1846261915 151 APDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:COG3852   299 PEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 105-205 3.36e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 89.73  E-value: 3.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEALGPepGGEISVTLHyRHGWLHCEVNDDGPGIAPDKIDHIFDK---GVSTKGSERGVGLALVKQQV 181
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAK--AGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPfstADKRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....
gi 1846261915 182 ENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
109-213 9.67e-18

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 80.99  E-value: 9.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSI 188
Cdd:PRK10364  353 LLNLYLNAIQAIGQ--HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTI 430

                          90       100
                  ....*....|....*....|....*
gi 1846261915 189 AVESEPGIFTQFFVQIPWDGERSNR 213
Cdd:PRK10364  431 QVASQEGKGATFTLWLPVNITRRDP 455
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 109-205 1.70e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 74.84  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENAL---EAlgpepgGEISVTLHYR-----HGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER------GVGL 174
Cdd:cd16922     5 LLNLLGNAIkftEE------GEVTLRVSLEeeeedGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTrkyggtGLGL 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261915 175 ALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16922    79 AISKKLVELMGGDISVESEPGQGSTFTFTLP 109
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 111-205 3.52e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 79.44  E-value: 3.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFD-----KGVST-KGSerGVGLALVKQQVENL 184
Cdd:COG4251   401 NLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEifqrlHSRDEyEGT--GIGLAIVKKIVERH 478

                          90       100
                  ....*....|....*....|.
gi 1846261915 185 GGSIAVESEPGIFTQFFVQIP 205
Cdd:COG4251   479 GGRIWVESEPGEGATFYFTLP 499
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-205 1.21e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 72.82  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEALGPEpGGEISVTLHYRHGW----------LHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGL 174
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGS-GGEIILRTRTQRQVtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261915 175 ALVKQQVENLGGSIAVESEPGiFTQFFVQIP 205
Cdd:cd16918    80 AIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
84-205 3.40e-16

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 76.55  E-value: 3.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  84 TLILNSESQLP----DSGSEDQVatlittLGNLIENALEALgpEPGGEISVTLHY-RHGWLHCEVNDDGPGIAPDKIDHI 158
Cdd:PRK11360  482 DFETELDNELPpiwaDPELLKQV------LLNILINAVQAI--SARGKIRIRTWQySDGQVAVSIEDNGCGIDPELLKKI 553

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1846261915 159 FDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK11360  554 FDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 105-205 1.33e-14

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 69.15  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENAL----------EALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKI------------------- 155
Cdd:cd16916    39 LADPLTHLLRNAVdhgieapeerLAAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDREKIrekaierglitadeaatls 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 156 -----DHIFDKGVSTKG-----SERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16916   119 ddevlNLIFAPGFSTAEqvtdvSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 111-205 1.76e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 66.65  E-value: 1.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEAL--GPEPGGEISVTLHYR-HGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGS 187
Cdd:cd16920     7 NLVRNGIEAMseGGCERRELTIRTSPAdDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGR 86

                          90
                  ....*....|....*...
gi 1846261915 188 IAVESEPGIFTQFFVQIP 205
Cdd:cd16920    87 LSVESPAGGGATFQFTLP 104
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 111-205 3.18e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 63.60  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEALGPEpgGEISV--TLHYRHGWLhcEVNDDGPGIAPDKIDHIFDKGVSTK--GSERGVGLALVKQQVENLGG 186
Cdd:cd16943    10 NLLVNAAQAMEGR--GRITIrtWAHVDQVLI--EVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRIIQKHGG 85

                          90
                  ....*....|....*....
gi 1846261915 187 SIAVESEPGIFTQFFVQIP 205
Cdd:cd16943    86 TIRVASVPGGGTRFTIILP 104
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
112-205 4.95e-13

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 67.51  E-value: 4.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 112 LIENAL----------EALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKI-------------------DH----- 157
Cdd:COG0643   285 LVRNAVdhgietpeerLAAGKPETGTITLSAYHEGGRVVIEVSDDGRGLDLEKIrakaiekglitaeeaaalsDEellel 364

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1846261915 158 IFDKGVSTKG-----SERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:COG0643   365 IFAPGFSTAEevtdlSGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
108-209 5.37e-13

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 67.35  E-value: 5.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 108 TLGNLIENALE-ALGP-EPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFdKGVSTKGSERGVGLALVKQQVENL- 184
Cdd:COG2972   340 ILQPLVENAIEhGIEPkEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLL-EELSSKGEGRGIGLRNVRERLKLYy 418

                          90       100
                  ....*....|....*....|....*..
gi 1846261915 185 --GGSIAVESEPGIFTQFFVQIPWDGE 209
Cdd:COG2972   419 geEYGLEIESEPGEGTTVTIRIPLEEE 445
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-194 9.86e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 63.03  E-value: 9.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALE-ALGpepggEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKG--VSTKGSERGVGLALVKQQV 181
Cdd:cd16954    38 LMELLGNLLDNACKwCLE-----FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGqrLDEQRPGQGLGLAIAKEIV 112

                          90
                  ....*....|...
gi 1846261915 182 ENLGGSIAVESEP 194
Cdd:cd16954   113 EQYGGELSLSDSP 125
PRK09303 PRK09303
histidine kinase;
111-195 1.48e-12

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 65.74  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEAlgPEPGGEISVT-LHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQVENLG 185
Cdd:PRK09303  279 NLLDNAIKY--TPEGGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGtegyGIGLSVCRRIVRVHY 356

                          90
                  ....*....|
gi 1846261915 186 GSIAVESEPG 195
Cdd:PRK09303  357 GQIWVDSEPG 366
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 111-205 2.10e-12

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 65.52  E-value: 2.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEALgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAV 190
Cdd:COG5805   402 NLIKNAIEAM--PNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDI 479

                          90
                  ....*....|....*
gi 1846261915 191 ESEPGIFTQFFVQIP 205
Cdd:COG5805   480 DSKVGKGTTFTITLP 494
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-205 3.24e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 61.05  E-value: 3.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALeALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTK------GSERGVGLALVK 178
Cdd:cd16953     1 LGQVLRNLIGNAI-SFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERpaneafGQHSGLGLSISR 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1846261915 179 QQVENLGGSIAVE--SEPGIFT--QFFVQIP 205
Cdd:cd16953    80 QIIEAHGGISVAEnhNQPGQVIgaRFTVQLP 110
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
111-205 3.31e-12

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 65.08  E-value: 3.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEALgpEPGGEISVTLHYR---------HGWL------HCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLA 175
Cdd:PRK13837  567 NLCSNAAQAM--DGAGRVDISLSRAklrapkvlsHGVLppgryvLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLA 644

                          90       100       110
                  ....*....|....*....|....*....|
gi 1846261915 176 LVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK13837  645 TVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 111-205 3.53e-12

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 64.61  E-value: 3.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEALGPepGGEISVTLHY-RHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIA 189
Cdd:COG5809   386 NLLKNAIEAMPE--GGNITIETKAeDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKIT 463

                          90
                  ....*....|....*.
gi 1846261915 190 VESEPGIFTQFFVQIP 205
Cdd:COG5809   464 VESEVGKGTTFSITLP 479
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-188 5.29e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 60.16  E-value: 5.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEalgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSerGVGLALVKQQVE 182
Cdd:cd16950     5 LSNLVDNALR----YGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFqpfyrgDNARGTSGT--GLGLAIVQRISD 78


                  ....*.
gi 1846261915 183 NLGGSI 188
Cdd:cd16950    79 AHGGSL 84
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-200 2.05e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 58.62  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTK--GSERGVGLALVKQQVE 182
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVE 80

                          90
                  ....*....|....*...
gi 1846261915 183 NLGGSIAVESEPGIFTQF 200
Cdd:cd16976    81 EHGGRLSVANEEGAGARF 98
envZ PRK09467
osmolarity sensor protein; Provisional
 109-190 5.57e-11

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 61.08  E-value: 5.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEaLGpepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSerGVGLALVKQQVE 182
Cdd:PRK09467  336 LANLVVNAAR-YG---NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFqpftrgDSARGSSGT--GLGLAIVKRIVD 409


                  ....*...
gi 1846261915 183 NLGGSIAV 190
Cdd:PRK09467  410 QHNGKVEL 417
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
109-194 1.08e-10

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 60.42  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENA----LEALgpepggEISVTLHYRHgwLHCEVNDDGPGIAPDKIDHIFDKG--VSTKGSERGVGLALVKQQVE 182
Cdd:PRK10815  383 MGNVLDNAckycLEFV------EISARQTDEH--LHIVVEDDGPGIPESKRELIFDRGqrADTLRPGQGLGLSVAREITE 454

                          90
                  ....*....|..
gi 1846261915 183 NLGGSIAVESEP 194
Cdd:PRK10815  455 QYEGKISAGDSP 466
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 109-195 2.00e-10

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 59.47  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEaLGPePGGEISVTLHYRHGWLHCEVNDDGPGIaPD-KIDHIFDKGVST-------KGSerGVGLALVKQQ 180
Cdd:PRK11100  373 LGNLLDNAID-FSP-EGGTITLSAEVDGEQVALSVEDQGPGI-PDyALPRIFERFYSLprpangrKST--GLGLAFVREV 447

                          90
                  ....*....|....*
gi 1846261915 181 VENLGGSIAVESEPG 195
Cdd:PRK11100  448 ARLHGGEVTLRNRPE 462
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
124-209 4.97e-10

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 57.71  E-value: 4.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 124 PGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIdhifdkgvstkgSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQ 203
Cdd:COG4585   179 GATRVTVTLEVDDGELTLTVRDDGVGFDPEAA------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRAT 246


                  ....*.
gi 1846261915 204 IPWDGE 209
Cdd:COG4585   247 LPLAAA 252
PRK10490 PRK10490
sensor protein KdpD; Provisional
 109-205 7.84e-10

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 58.12  E-value: 7.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK-----------GVstkgserGVGLALV 177
Cdd:PRK10490  783 LINLLENAVKYAGA--QAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKfargnkesaipGV-------GLGLAIC 853

                          90       100
                  ....*....|....*....|....*...
gi 1846261915 178 KQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK10490  854 RAIVEVHGGTIWAENRPEGGACFRVTLP 881
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 112-211 8.74e-10

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 57.99  E-value: 8.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 112 LIENALE-ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDkidhiFDKGVStkgseRGVGLALVKQQVENLGGSIAV 190
Cdd:COG3920   407 LVTNALKhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----VDPPAR-----KGLGLRLIRALVRQLGGTLEL 476

                          90       100
                  ....*....|....*....|.
gi 1846261915 191 ESEPGifTQFFVQIPWDGERS 211
Cdd:COG3920   477 DRPEG--TRVRITFPLAELAA 495
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
98-195 1.19e-09

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 54.53  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  98 SEDQVATLITTLGNLIENALE-ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDkgvstKGSERGVGLAL 176
Cdd:COG2172    28 DEDDADDLVLAVSEAVTNAVRhAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS-----TLAEGGRGLFL 102

                          90
                  ....*....|....*....
gi 1846261915 177 VKQQVENLGgsiaVESEPG 195
Cdd:COG2172   103 IRRLMDEVE----YESDPG 117
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
83-205 1.47e-09

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 56.94  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  83 HTLILNSESQLPDSGSEDQVATLITtlgNLIENALEAlgPEPGGEISVTlhyrhgWLHC------EVNDDGPGIAPDKID 156
Cdd:PRK11006  299 HTITFEVDNSLKVFGNEDQLRSAIS---NLVYNAVNH--TPEGTHITVR------WQRVpqgaefSVEDNGPGIAPEHIP 367

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1846261915 157 HI------FDKGVS--TKGSerGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK11006  368 RLterfyrVDKARSrqTGGS--GLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 66-199 1.69e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 54.12  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  66 VIAGFLISKINRATDLG--HTLILNSESQLPDSgsedqVATLITTLGNLIENALEALGPEPGGE--ISVTLHYRHGWL-- 139
Cdd:cd16935     1 ALDSLLSEKLELAREKGieFTIEIDIPILLPIS-----PLDLCIIFGNLLDNAIEACAKIDKENrfIHLKIRQKKGFLii 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1846261915 140 HCEVNDDGpgiapdKIDHIFDKGVSTKG-SERGVGLALVKQQVENLGGSIAVESEPGIFTQ 199
Cdd:cd16935    76 SIENSYEG------ELKKKNGLFLSTKKdKNHGIGLKSIREIVKKYNGNLSIEYENGIFTL 130
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-205 3.04e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 52.71  E-value: 3.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALGPEPGGEISVtlHYR---HGWLHCeVNDDGPGIAPD---KIDHIFDKGVSTKGSE-RGVGLALVKQQV 181
Cdd:cd16921     5 LTNLLGNAIKFRRPRRPPRIEV--GAEdvgEEWTFY-VRDNGIGIDPEyaeKVFGIFQRLHSREEYEgTGVGLAIVRKII 81

                          90       100
                  ....*....|....*....|....
gi 1846261915 182 ENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16921    82 ERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 111-205 4.02e-09

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 52.49  E-value: 4.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEAlGPEpGGEISVTLH-YRHGWLHCEVNDDGPGIAPDKIDHIF--------DKGVSTKGSerGVGLALVKQQV 181
Cdd:cd16925    11 NLLSNAFKF-TPD-GGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFerfrqgdgSSTRAHGGT--GLGLSIVKEFV 86

                          90       100
                  ....*....|....*....|....
gi 1846261915 182 ENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16925    87 ELHGGTVTVSDAPGGGALFQVELP 110
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 105-199 5.88e-09

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 51.83  E-value: 5.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEALGPEPGG-EISVTLHYRHGWL--HCEvNDDGPGIapDKIDHIFDKgvSTKGSERGVGLALVKQQV 181
Cdd:pfam14501   6 LCVIFGNLLDNAIEACSKIDDNrFIRLKIREKQNFLiiRIE-NTYEGEL--KFEGKLPST--KTKGDGHGIGLKSIRRIV 80

                          90
                  ....*....|....*...
gi 1846261915 182 ENLGGSIAVESEPGIFTQ 199
Cdd:pfam14501  81 KKYGGNLSTEIENGIFTL 98
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 109-205 6.85e-09

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 55.33  E-value: 6.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEAlgpEPGGEISVTLHYRHG-WLHCEVNDDGPGIAPDKIDHIFD---------KGVSTKGSerGVGLALVK 178
Cdd:PRK11091  403 LWNLISNAVKF---TQQGGVTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAmyyqvkdshGGKPATGT--GIGLAVSK 477

                          90       100
                  ....*....|....*....|....*..
gi 1846261915 179 QQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK11091  478 RLAQAMGGDITVTSEEGKGSCFTLTIH 504
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 112-205 9.15e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 51.66  E-value: 9.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 112 LIENALEALGPE--PGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVStkgSERGVGLALVK--QQVENLGGS 187
Cdd:cd16957     9 LVENAIRHAFPKrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVT---SEKGTGTALENlnRRLIGLFGS 85

                          90       100
                  ....*....|....*....|.
gi 1846261915 188 IA---VESEPGIFTQFFVQIP 205
Cdd:cd16957    86 EAclhIESEVHGGTEVWFVIP 106
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-204 1.01e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 51.75  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALGPepGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER------GVGLALVKQQVE 182
Cdd:cd16947    25 LKNLISNAIKYGSD--GKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqgnGLGLTITKRLAE 102

                          90       100
                  ....*....|....*....|..
gi 1846261915 183 NLGGSIAVESEPGIFTQFFVQI 204
Cdd:cd16947   103 SMGGSIYVNSKPYEKTVFTVTL 124
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-195 1.50e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 51.00  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALGPEPGGEISVTLHY---RHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLG 185
Cdd:cd16944     9 LTNILKNAAEAIEGRPSDVGEVRIRVeadQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEEHG 88

                          90
                  ....*....|
gi 1846261915 186 GSIAVESEPG 195
Cdd:cd16944    89 GRISLSNREA 98
glnL PRK11073
nitrogen regulation protein NR(II);
111-205 1.79e-08

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 53.55  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEALGPEpGGEIsvTLHYR-------HGWLH-----CEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVK 178
Cdd:PRK11073  244 NIVRNALQALGPE-GGTI--TLRTRtafqltlHGERYrlaarIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIAR 320

                          90       100
                  ....*....|....*....|....*..
gi 1846261915 179 QQVENLGGSIAVESEPGiFTQFFVQIP 205
Cdd:PRK11073  321 NLIDQHSGKIEFTSWPG-HTEFSVYLP 346
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 111-195 1.97e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 50.40  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEaLGPEpggEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSERGVGLALVKQQVENL 184
Cdd:cd16949     7 NVLRNALR-YSPS---KILLDISQDGDQWTITITDDGPGVPEDQLEQIFlpfyrvDSARDRESGGTGLGLAIAERAIEQH 82

                          90
                  ....*....|..
gi 1846261915 185 GGSI-AVESEPG 195
Cdd:cd16949    83 GGKIkASNRKPG 94
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-194 3.44e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 50.15  E-value: 3.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER------GVGLALVKQQVE 182
Cdd:cd16946     9 FVNLLENSLRY--TDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasggsGLGLAICHNIAL 86

                          90
                  ....*....|..
gi 1846261915 183 NLGGSIAVESEP 194
Cdd:cd16946    87 AHGGTISAEHSP 98
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 111-205 8.12e-08

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 49.30  E-value: 8.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEALGPepGGEISVT-----------LHYRH----GWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLA 175
Cdd:cd16919     7 NLAVNARDAMPE--GGRLTIEtsnqrvdadyaLNYRDlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLG 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1846261915 176 L--VKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16919    85 LsmVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
PRK10604 PRK10604
sensor protein RstB; Provisional
 109-194 1.65e-07

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 50.76  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEALGPEPggEISVTLHYRHGWLHceVNDDGPGIAPDKIDHIFDKGV--------STKGSerGVGLALVKQQ 180
Cdd:PRK10604  324 LDNLLNNALRYAHSRV--RVSLLLDGNQACLI--VEDDGPGIPPEERERVFEPFVrldpsrdrATGGC--GLGLAIVHSI 397

                          90
                  ....*....|....
gi 1846261915 181 VENLGGSIAVESEP 194
Cdd:PRK10604  398 ALAMGGSVNCDESE 411
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-194 2.07e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 47.81  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEalgpEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIF------DKGVSTKGSERGVGLALVKQQVE 182
Cdd:cd16939     5 LDNLLRNALR----YAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFepfvrlDPSRDRATGGFGLGLAIVHRVAL 80

                          90
                  ....*....|..
gi 1846261915 183 NLGGSIAVESEP 194
Cdd:cd16939    81 WHGGHVECDDSE 92
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
90-205 3.09e-07

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 50.36  E-value: 3.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  90 ESQLPDSGSEDQVaTLITTLGNLIENALEALGPepgGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK--GVSTkG 167
Cdd:PRK10841  549 EPDVPVALNGDPM-RLQQVISNLLSNAIKFTDT---GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPffQVGT-G 623

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1846261915 168 SER-----GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK10841  624 VQRnfqgtGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-195 3.82e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 47.40  E-value: 3.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEaLGPEpGGEISVTLHYRHGWLhCEVNDDGPGIAPDKIDHIFDK-----GVSTKGSerGVGLALVKQQVEN 183
Cdd:cd16940    18 LRNLVDNAVR-YSPQ-GSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERfyrsdGQNYGGS--GLGLSIVKRIVEL 92

                          90
                  ....*....|..
gi 1846261915 184 LGGSIAVESEPG 195
Cdd:cd16940    93 HGGQIFLGNAQG 104
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-205 4.02e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 46.90  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER-----GVGLALVKQ 179
Cdd:cd16948     6 LSFIIGQIVSNALKY--SKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNfqestGMGLYLVKK 83

                          90       100
                  ....*....|....*....|....*.
gi 1846261915 180 QVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16948    84 LCDKLGHKIDVESEVGEGTTFTITFP 109
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
109-205 4.19e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.12  E-value: 4.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  109 LGNLIENALEaLGPEPGGEISVTLHY---RHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER----GVGLALVKQQV 181
Cdd:PRK09959   833 LSNLLSNALK-FTTEGAVKITTSLGHiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtgsGLGLMICKELI 911

                           90       100
                   ....*....|....*....|....
gi 1846261915  182 ENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK09959   912 KNMQGDLSLESHPGIGTTFTITIP 935
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 105-205 4.45e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 46.81  E-value: 4.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHI------FDKGVSTKGSERGVGLALVK 178
Cdd:cd16952     1 LRSAFSNLVSNAVKY--TPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLterfyrVDIERCRNTGGTGLGLAIVK 78

                          90       100
                  ....*....|....*....|....*..
gi 1846261915 179 QQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16952    79 HVMSRHDARLLIASELGKGSRFTCLFP 105
SPOB_a pfam14689
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B ...
 12-54 8.69e-07

Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.


Pssm-ID: 434130 [Multi-domain]  Cd Length: 62  Bit Score: 44.93  E-value: 8.69e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1846261915  12 DALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEE 54
Cdd:pfam14689  14 KALRHQRHDFLNHLQVISGYLQLGRYDRAEEYIKEVVKDLKEE 56
PRK15347 PRK15347
two component system sensor kinase;
105-205 2.31e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 47.71  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 105 LITTLGNlienaleALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLAL-VKQQVEN 183
Cdd:PRK15347  518 LVNLLGN-------AVKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLtIASSLAK 590

                          90       100
                  ....*....|....*....|...
gi 1846261915 184 L-GGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK15347  591 MmGGELTLFSTPGVGSCFSLVLP 613
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 124-205 3.00e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 44.08  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 124 PGGEISVTLHYRHGWLHCEVNDDGPGIAPDkidhifdkgvsTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQ 203
Cdd:cd16917    17 GASRVRVTLSYTADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTAR 85


                  ..
gi 1846261915 204 IP 205
Cdd:cd16917    86 LP 87
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 112-179 4.99e-06

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 43.41  E-value: 4.99e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1846261915 112 LIENALE-ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKidhifDKGVSTKGSERGVGLALVKQ 179
Cdd:cd16936     8 AVTNAVRhAYRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLR-----PADPDAGLREGGRGLALIRA 71
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
115-179 5.10e-06

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 44.20  E-value: 5.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1846261915 115 NALE-ALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQ 179
Cdd:pfam13581  42 NAVEhAYREGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEPDEDRKEGGRGLALIRG 107
PRK13557 PRK13557
histidine kinase; Provisional
 143-216 1.40e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 45.05  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 143 VNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLAL------VKQQvenlGGSIAVESEPGIFTQFFVQIPWDGERSNRASA 216
Cdd:PRK13557  329 VTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLsmvygfAKQS----GGAVRIYSEVGEGTTVRLYFPASDQAENPEQE 404
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
93-194 2.04e-05

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 44.62  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  93 LPDS----GSEDQVATLITtlgNLIENALEAlgPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGS 168
Cdd:PRK10549  340 LPDSatvfGDPDRLMQLFN---NLLENSLRY--TDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGS 414

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1846261915 169 ER------GVGLALVKQQVENLGGSIAVESEP 194
Cdd:PRK10549  415 RNrasggsGLGLAICLNIVEAHNGRIIAAHSP 446
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 109-195 2.15e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 42.06  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALeALGPEpGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVS-----TKGSERGVGLALVKQQVEN 183
Cdd:cd16945     9 INNLLDNAI-DFSPE-GGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQL 86

                          90
                  ....*....|..
gi 1846261915 184 LGGSIAVESEPG 195
Cdd:cd16945    87 HGGRITLRNRPD 98
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
109-205 4.21e-05

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 43.61  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEAlgpEPGGEiSVTLHYRHGWLHCEVNDDGPG--IAPDKIDHIFDK------GVSTKGSERGVGLALVKQQ 180
Cdd:PRK09835  380 ISNLLSNALRY---TPAGE-AITVRCQEVDHQVQLVVENPGtpIAPEHLPRLFDRfyrvdpSRQRKGEGSGIGLAIVKSI 455

                          90       100
                  ....*....|....*....|....*
gi 1846261915 181 VENLGGSIAVESEPgIFTQFFVQIP 205
Cdd:PRK09835  456 VVAHKGTVAVTSDA-RGTRFVISLP 479
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 18-205 5.95e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 43.36  E-value: 5.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  18 SHEFMNKLHVILGLLHLKSYKQL----EDYiLKTANNYQEEIGSLLGKI--KSPVIAGfliskinratdlGHTLILNSE- 90
Cdd:PRK11466  452 SHEIRTPLYGILGTAQLLADNPAlnaqRDD-LRAITDSGESLLTILNDIldYSAIEAG------------GKNVSVSDEp 518

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  91 ---SQLPDSG---------------SEDQVATLITTLG-----------NLIENALEAlgPEPGGEISVTLHYRHGWLhC 141
Cdd:PRK11466  519 fepRPLLESTlqlmsgrvkgrpirlATDIADDLPTALMgdprrirqvitNLLSNALRF--TDEGSIVLRSRTDGEQWL-V 595

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1846261915 142 EVNDDGPGIAPDKIDHIFDKGVSTKGSE--RGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:PRK11466  596 EVEDSGCGIDPAKLAEIFQPFVQVSGKRggTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
PRK10547 PRK10547
chemotaxis protein CheA; Provisional
 71-195 2.69e-04

chemotaxis protein CheA; Provisional


Pssm-ID: 236712 [Multi-domain]  Cd Length: 670  Bit Score: 41.25  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  71 LISKINRATDLghTLiLNSESQLPDSGSEdqvaTLITTLGNLIENALE----------ALGPEPGGEISVTLHYRHGWLH 140
Cdd:PRK10547  359 LAGKLGKQVEL--TL-VGSSTELDKSLIE----RIIDPLTHLVRNSLDhgielpekrlAAGKNSVGNLILSAEHQGGNIC 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 141 CEVNDDGPGIAPDKI------------DH---------IFDKGVSTKG-----SERGVGLALVKQQVENLGGSIAVESEP 194
Cdd:PRK10547  432 IEVTDDGAGLNRERIlakaasqglavsENmsdeevgmlIFAPGFSTAEqvtdvSGRGVGMDVVKRNIQEMGGHVEIQSKQ 511


                  .
gi 1846261915 195 G 195
Cdd:PRK10547  512 G 512
PRK10337 PRK10337
sensor protein QseC; Provisional
 92-179 2.72e-04

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 41.17  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915  92 QLPDSGSEDQVATLITTL--GNLIENALEAlgPEPGGEISVTLHYRHgwlhCEVNDDGPGIAPDKIDHIFDK-----GVS 164
Cdd:PRK10337  338 TLNAHPVIRTGQPLLLSLlvRNLLDNAIRY--SPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERfyrppGQE 411

                          90
                  ....*....|....*
gi 1846261915 165 TKGSerGVGLALVKQ 179
Cdd:PRK10337  412 ATGS--GLGLSIVRR 424
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 109-205 2.15e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 37.71  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 109 LGNLIENALEA---------LGPEPggeISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSER--------- 170
Cdd:cd16929    48 LFELLKNAMRAtveshgddsDDLPP---IKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdlis 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1846261915 171 ----------GVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIP 205
Cdd:cd16929   125 gtqpsplagfGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 111-191 2.21e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 36.67  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846261915 111 NLIENALEaLGPEpGGEISVTLHYRHGWLHCEVNDDGPGIAPD---KIDHIF--DKGVSTKGSERGVGLALVKQQVENLG 185
Cdd:cd16975    11 NIISNACQ-YAPE-GGTVSISIYDEEEYLYFEIWDNGHGFSEQdlkKALELFyrDDTSRRSGGHYGMGLYIAKNLVEKHG 88


                  ....*.
gi 1846261915 186 GSIAVE 191
Cdd:cd16975    89 GSLIIE 94
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
92-150 5.79e-03

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 37.25  E-value: 5.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1846261915  92 QLPDSGSEDQV---ATLIT-TLGNLIENAlEALGPEpGGEISVTLHYRHGWLHCEVNDDGPGI 150
Cdd:PRK10755  231 LLPESAADITVqgdATLLRlLLRNLVENA-HRYSPE-GSTITIKLSQEDGGAVLAVEDEGPGI 291
HATPase_TopVIB-like cd16933
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
 105-161 9.68e-03

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.


Pssm-ID: 340410 [Multi-domain]  Cd Length: 203  Bit Score: 35.79  E-value: 9.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1846261915 105 LITTLGNLIENALEALgpEPGG---EISVTLH-YRHGWLHCEVNDDGPGIAPDKIDHIFDK 161
Cdd:cd16933    20 LYTTVRELVENSLDAT--EEAGilpDIKVEIEeIGKDHYKVIVEDNGPGIPEEQIPKVFGK 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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